Glycoside Hydrolase Family 5 / Subf 44

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (102); Uniprot accession (16);
All (101) Bacteria (101) Characterized (1)
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 BADO_1350   Bifidobacterium adolescentis 22L AII76760.1     44
 BADO_1348   Bifidobacterium adolescentis 22L AII76759.1     44
 BAD_1202   Bifidobacterium adolescentis ATCC 15703 BAF39983.1 A1A2Q0   44
 BAD_1204   Bifidobacterium adolescentis ATCC 15703 BAF39985.1 A1A2Q2   44
 BBMN23_1378   Bifidobacterium adolescentis BBMN23 AJE06350.1     44
 BBMN23_1380   Bifidobacterium adolescentis BBMN23 AJE06352.1     44
 B12L_1363   Bifidobacterium breve 12L AHJ16099.1     44
 B689b_1459   Bifidobacterium breve 689b AHJ23454.1     44
 HMPREF9228_1484   Bifidobacterium breve ACS-071-V-Sch8b AEF27080.1     44
 RY69_391   Bifidobacterium breve BR3 ALE12653.1     44
 BBBR_1476   Bifidobacterium breve DSM 20213 = JCM 1192 BAR00515.1     44
 B7017_1627   Bifidobacterium breve JCM 7017 AHJ17874.1     44
 B7019_1610   Bifidobacterium breve JCM 7019 AHJ19787.1     44
 BBL520_07960   Bifidobacterium breve LMC520 AQM43480.1     44
 B2258_1417   Bifidobacterium breve NCFB 2258 AHJ21603.1     44
 BS27_1462   Bifidobacterium breve S27 AHJ25238.1     44
 Bbr_1438   Bifidobacterium breve UCC2003 ABE96110.1     44
 BBCT_1303   Bifidobacterium catenulatum DSM 16992 = JCM 1194 = LMG 11043 BAR02271.1     44
 BBCT_1301   Bifidobacterium catenulatum DSM 16992 = JCM 1194 = LMG 11043 BAR02269.1     44
 BDP_1678   Bifidobacterium dentium Bd1 ADB10270.1 D2Q5Q5   44
 BDP_1679   Bifidobacterium dentium Bd1 ADB10271.1 D2Q5Q6   44
 BBDE_1592   Bifidobacterium dentium JCM 1195 = DSM 20436 BAQ27586.1     44
 BBDE_1593   Bifidobacterium dentium JCM 1195 = DSM 20436 BAQ27587.1     44
 BBKW_1501   Bifidobacterium kashiwanohense JCM 15439 = DSM 21854 BAQ29636.1     44
 AH68_07950   Bifidobacterium kashiwanohense PV20-2 AIZ14998.1     44
 AH68_07940   Bifidobacterium kashiwanohense PV20-2 AIZ14996.1     44
 BL105A_1466   Bifidobacterium longum 105-A BAP84090.1     44
 B624_1382   Bifidobacterium longum 35624 AOL10833.1     44
 BBG7_1592   Bifidobacterium longum BG7 ALE36779.1     44
 GS08_07990   Bifidobacterium longum BXY01 AIF91045.1     44
 BLD_1938 (BglC)   Bifidobacterium longum DJO10A ACD99383.1     44
 BL1761   Bifidobacterium longum NCC2705 AAN25544.1
NP_696908.1
Q8G3J8   44
 SAMN04489749_0603   Bifidobacterium longum Su859 SDO39948.1     44
 BLIF_1557   Bifidobacterium longum subsp. infantis 157F BAJ71695.1     44
 Blon_0621   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ51728.1 B7GPJ8   44
 BLIJ_0626   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 BAJ68219.1     44
 RY67_1342   Bifidobacterium longum subsp. infantis BT1 ALE09362.1     44
 BL1206_1618   Bifidobacterium longum subsp. longum AH1206 AOP01655.1     44
 BBMN68_1793   Bifidobacterium longum subsp. longum BBMN68 ADQ02850.1 E4R3Z1   44
 BBL306_1734   Bifidobacterium longum subsp. longum CCUG30698 ALO75263.1     44
 BIL_02210   Bifidobacterium longum subsp. longum F8 CBK69899.1 D6DBM8   44
 BLGT_08000   Bifidobacterium longum subsp. longum GT15 AIW44128.1     44
 BLLJ_1498 (possible fragment)   Bifidobacterium longum subsp. longum JCM 1217 BAJ67165.1     44
 BLJ_1536   Bifidobacterium longum subsp. longum JDM301 ADH00979.1 D6ZVS3   44
 BLNIAS_00618   Bifidobacterium longum subsp. longum KACC 91563 AEI96988.1     44
 B8809_1374   Bifidobacterium longum subsp. longum NCIMB8809 ALO73045.1     44
 BIP_14810   Bifidobacterium pseudocatenulatum D2CA CBK72652.1     44
 BBPC_1381   Bifidobacterium pseudocatenulatum DSM 20438 = JCM 1200 = LMG 10505 BAR04059.1     44
 BBPC_1383   Bifidobacterium pseudocatenulatum DSM 20438 = JCM 1200 = LMG 10505 BAR04061.1     44
 BBSC_1966   Bifidobacterium scardovii JCM 12489 = DSM 13734 BAQ32046.1     44
 D805_0070 (fragment)   Bifidobacterium thermophilum RBL67 AGH40337.1     44
 ADH70_005020   Blautia coccoides YL58 ASU28285.1     44
 A4V09_06660   Blautia sp. YL58 ANU75476.1     44
 TW87_02815   Clostridioides difficile 08ACD0030 AMM55516.1     44
 CD0032   Clostridioides difficile 630 CAJ66846.1
AJP09721.1
Q18CC0   44
 CDIF630erm_00094 (ExgA)   Clostridioides difficile 630 delta erm ARE60931.1     44
 CD630DERM_00320   Clostridioides difficile 630Derm CEJ96534.1     44
 CDIF1296T_00094   Clostridioides difficile ATCC 9689 = DSM 1296 AKP41043.1     44
 BZ168_18160   Clostridioides difficile BR81 AQU11467.1     44
 CD196_0033   Clostridioides difficile CD196 CBA60100.1 C9XIE4   44
 CGC51_00450   Clostridioides difficile DH/NAP11/106/ST-42 ASN87869.1     44
 A6J95_10160   Clostridioides difficile FDAARGOS_267 ARC15263.1     44
 ERS445050_03881 (CelC)   Clostridioides difficile NCTC13307 CKH92486.1     44
 CDR20291_0021   Clostridioides difficile R20291 CBE01499.1 C9YHI0   44
 PCZ31_0034 (CelC)   Clostridioides difficile Z31 ALP01995.1     44
 NPD4_3781   Clostridium butyricum CDC_51208 APF21429.1     44
 ATD26_17820   Clostridium butyricum JKY6D1 ALS18744.1     44
 ATN24_18870   Clostridium butyricum KNU-L09 ALR90505.1     44
 BBB49_17315   Clostridium butyricum TK520 AOR95840.1     44
 AZ909_17850   Clostridium butyricum TOA ANF15927.1     44
 Corgl_1695   Coriobacterium glomerans PW2 AEB07793.1     44
 A4V08_30205   Lachnoclostridium sp. YL32 ARE65151.1     44
 LBLM1_08840   Lactobacillus mucosae LM1 AJT51054.1     44
 LACOL_0428   Lactobacillus oligofermentans DSM 15707 = LMG 22743 CUS25736.1     44
 AYI71_03150   Lactobacillus oris J-1 AMS07884.1     44
 LL158_1138   Lactococcus lactis subsp. cremoris 158 ARD91423.1     44
 llh_6495   Lactococcus lactis subsp. cremoris A76 AEU40475.1     44
 LLJM2_1174   Lactococcus lactis subsp. cremoris JM2 ARE25933.1     44
 LLJM3_1220   Lactococcus lactis subsp. cremoris JM3 ARE23414.1     44
 LLJM4_1217   Lactococcus lactis subsp. cremoris JM4 ARE18296.1     44
 kw2_1119   Lactococcus lactis subsp. cremoris KW2 AGV73077.1     44
 llmg_1321   Lactococcus lactis subsp. cremoris MG1363 CAL97912.1 A2RKU6   44
 LLNZ_06830   Lactococcus lactis subsp. cremoris NZ9000 ADJ60316.1 D8KIS0   44
 LACR_1290   Lactococcus lactis subsp. cremoris SK11 ABJ72818.1 Q02Z04   44
 LLUC109_1120   Lactococcus lactis subsp. cremoris UC109 ARE06033.1     44
 uc509_1185   Lactococcus lactis subsp. cremoris UC509.9 AFW91715.1     44
 LMES_0770 (fragment)   Leuconostoc mesenteroides KFRI-MG AHF18986.1     44
 LEMES_01031   Leuconostoc mesenteroides LK-151 BAX72474.1     44
 LEUM_0847   Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 ABJ61955.1 Q03XW7   44
 A0F18_04365   Leuconostoc mesenteroides subsp. mesenteroides BD1710 ARN63298.1     44
 ARA01_04110   Leuconostoc mesenteroides subsp. mesenteroides DRC0211 AQU49227.1     44
 MI1_03925   Leuconostoc mesenteroides subsp. mesenteroides J18 AET30243.1     44
 A6B45_04085   Leuconostoc mesenteroides subsp. suionicum DSM 20241 API71899.1     44
 LEUCM_01047   Leuconostoc mesenteroides subsp. suionicum LT-38 BAX70485.1     44
 CBW60_01615   Leuconostoc mesenteroides WiKim33 ASR68144.1     44
 MLP_07030   Microlunatus phosphovorus NM-1 BAK33717.1     44
 PSDT_0440 (fragment)   Parascardovia denticolens DSM 10105 = JCM 12538 BAR04959.1     44
 ORF (fragment)   uncultured bacterium APO34736.1     44
 CW-EG1 3.2.1.- uncultured bacterium AFS18545.1     44
 WSWS_00768   Weissella soli KACC 11848 AOT56404.1     44
 WSWS_00768   Weissella soli KACC 11848 AOT56404.1     44
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