Activities in Sub Family	Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (9); Uniprot accession (1);

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
D9T22_26445		Klebsiella pneumoniae 675920	AYP09600.1			41
CI946_24570		Klebsiella pneumoniae 721005	ASV93294.1 QHP02580.1			41
BB783_01105		Klebsiella pneumoniae 825795-1	APU33998.1			41
CJU70_18365		Klebsiella pneumoniae 911021	ASV26842.1			41
HJW69_05615		Klebsiella pneumoniae A16KP0012	QJM56908.1			41
HJW70_05905		Klebsiella pneumoniae A16KP0016	QJM51788.1			41
HJW71_05625		Klebsiella pneumoniae A16KP0119	QJM41253.1			41
HJW72_05560		Klebsiella pneumoniae A16KP0127	QJM46511.1			41
HJW73_05255		Klebsiella pneumoniae A16KP0135	QJM35874.1			41
HJW74_05420		Klebsiella pneumoniae A17KP0004	QJM30809.1			41
HJW75_05420		Klebsiella pneumoniae A17KP0008	QJM25418.1			41
HJW76_05855		Klebsiella pneumoniae A17KP0038	QJM20066.1			41
WM86_20425		Klebsiella pneumoniae AATZP	ANF42670.1			41
WN05_21735		Klebsiella pneumoniae ABFPV	QBI26239.1			41
WN11_04770		Klebsiella pneumoniae ABFQB	QBI33173.1			41
ES964_05285		Klebsiella pneumoniae AP8555	QAV77964.1			41
CSC13_4439		Klebsiella pneumoniae AR376	AWF47580.1			41
CSC25_1161		Klebsiella pneumoniae AR438	AWF08082.1			41
AM425_13670		Klebsiella pneumoniae AR_0046	AXZ59252.1			41
AM426_24580		Klebsiella pneumoniae AR_0047	ARW99955.1			41
AM428_09895		Klebsiella pneumoniae AR_0049	APR47000.1			41
AM445_21035		Klebsiella pneumoniae AR_0066	AVF13449.1			41
AM447_17660		Klebsiella pneumoniae AR_0068	ARA47866.1			41
AM454_18855		Klebsiella pneumoniae AR_0075	AXZ08856.1			41
AM455_03535		Klebsiella pneumoniae AR_0076	AXZ11885.1			41
AM458_25135		Klebsiella pneumoniae AR_0079	AWE03616.1			41
AM459_21785		Klebsiella pneumoniae AR_0080	AVO79591.1			41
AM466_22565		Klebsiella pneumoniae AR_0087	AWS75631.1			41
AM476_17250		Klebsiella pneumoniae AR_0097	AXZ19774.1			41
AM477_20905		Klebsiella pneumoniae AR_0098	ARA60057.1			41
AM488_04220		Klebsiella pneumoniae AR_0109	AXZ51772.1			41
AM359_23140		Klebsiella pneumoniae AR_0112	ARX05548.1			41
AM360_20835		Klebsiella pneumoniae AR_0113	ASA00469.1			41
AM362_00845		Klebsiella pneumoniae AR_0115	ARA50607.1			41
AM364_00580		Klebsiella pneumoniae AR_0117	ARA39047.1			41
AM367_15065		Klebsiella pneumoniae AR_0120	ASB06945.1			41
AM372_11780		Klebsiella pneumoniae AR_0125	ASB12187.1			41
AM373_24460		Klebsiella pneumoniae AR_0126	ARZ95728.1			41
AM376_17225		Klebsiella pneumoniae AR_0129	ARX51245.1			41
AM382_04685		Klebsiella pneumoniae AR_0135	AXZ30634.1			41
AM385_10455		Klebsiella pneumoniae AR_0138	ASA09130.1			41
AM386_03725		Klebsiella pneumoniae AR_0139	ASC20973.1			41
AM390_26115		Klebsiella pneumoniae AR_0143	ARX47121.1			41
AM392_24890		Klebsiella pneumoniae AR_0145	ASC42117.1			41
AM393_04605		Klebsiella pneumoniae AR_0146	ARX18190.1			41
AM395_22595		Klebsiella pneumoniae AR_0148	ASC36079.1			41
AM399_05685		Klebsiella pneumoniae AR_0152	ASC27412.1			41
AM400_11575		Klebsiella pneumoniae AR_0153	AWC02052.1			41
AM404_13010		Klebsiella pneumoniae AR_0158	ARX39190.1			41
AM406_06065		Klebsiella pneumoniae AR_0160	AXZ25623.1			41
CSB98_3095		Klebsiella pneumoniae AR_0361	AVK30558.1			41
CSC00_3415		Klebsiella pneumoniae AR_0363	AVJ84821.1			41
CSB99_1445		Klebsiella pneumoniae AR_362	AWZ74012.1			41
WM93_00820		Klebsiella pneumoniae ATCC 35657	APS93226.1			41
Kpn2146_4313		Klebsiella pneumoniae ATCC BAA-2146	AHI37663.1			41
CWN90_05820		Klebsiella pneumoniae AUSMDU00003562	ATZ97885.1			41
CWN89_05810		Klebsiella pneumoniae AUSMDU00008119	AUA03395.1			41
C2M23_05955		Klebsiella pneumoniae B12(AN)	QAW94025.1			41
HJW77_05355		Klebsiella pneumoniae B16KP0048	QJN64433.1			41
HJW78_20640		Klebsiella pneumoniae B16KP0078	QJN34569.1			41
HJW79_05730		Klebsiella pneumoniae B16KP0089	QJM14757.1			41
HJW80_05505		Klebsiella pneumoniae B16KP0102	QJM03609.1			41
HJW81_05985		Klebsiella pneumoniae B16KP0141	QJM08966.1			41
HJW82_05725		Klebsiella pneumoniae B16KP0157	QJL98037.1			41
HJW83_05970		Klebsiella pneumoniae B16KP0177	QJO44338.1			41
HJW84_05465		Klebsiella pneumoniae B16KP0183	QJK64243.1			41
HJW85_05465		Klebsiella pneumoniae B16KP0198	QJL87204.1			41
HJW87_05740		Klebsiella pneumoniae B16KP0226	QJL92572.1			41
HJW88_05465		Klebsiella pneumoniae B17KP0020	QJL76462.1			41
HJW89_05675		Klebsiella pneumoniae B17KP0021	QJL81820.1			41
HJW90_05480		Klebsiella pneumoniae B17KP0067	QJL65632.1			41
HJW91_05520		Klebsiella pneumoniae B17KP0069	QJL33453.1			41
KpB31_1160		Klebsiella pneumoniae B31	QBF19721.1			41
HBJ44_005430		Klebsiella pneumoniae BA10835	QLF62844.1			41
EX352_08760		Klebsiella pneumoniae BA1559	QBF95919.1			41
C5707_010425		Klebsiella pneumoniae BA2275	QKE14262.1			41
C3E96_015145		Klebsiella pneumoniae BA28434	QBH58614.1			41
CAK82_23660		Klebsiella pneumoniae BA33875	QAT11299.1			41
EX353_22775		Klebsiella pneumoniae BA34918	QBG03701.1			41
EXC92_04180		Klebsiella pneumoniae BA4656	QBE71118.1			41
HC680_21685		Klebsiella pneumoniae Bckp021	QIV30252.1			41
HC709_05580		Klebsiella pneumoniae Bckp067	QIV08856.1			41
HC645_05285		Klebsiella pneumoniae Bckp091	QIU98614.1			41
HC692_05580		Klebsiella pneumoniae Bckp101	QIV33057.1			41
HC697_05600		Klebsiella pneumoniae Bckp186	QIV38214.1			41
HC704_05355		Klebsiella pneumoniae Bckp206	QIV43425.1			41
HC649_05350		Klebsiella pneumoniae Bckp212	QIV03687.1			41
GQY17_05530		Klebsiella pneumoniae BD_DM_697	QGZ81888.1			41
GM011_05530		Klebsiella pneumoniae BD_DM_782	QGT63200.1			41
GQY16_05530		Klebsiella pneumoniae BD_DM_914	QGZ76397.1			41
CHX41_19360		Klebsiella pneumoniae BIC-1	ASS81074.1			41
EH202_05775		Klebsiella pneumoniae BJCFK909	AZH19092.1			41
B9G35_22840		Klebsiella pneumoniae BK13043	ARS96113.1			41
FH42_11370		Klebsiella pneumoniae blaNDM-1	AIJ41286.1			41
EYB55_25615		Klebsiella pneumoniae BP327	QBH10519.1			41
HBJ33_020705		Klebsiella pneumoniae BP3636	QLF60155.1			41
A9J37_05705		Klebsiella pneumoniae BR	ANK15456.1			41
AA595_05775		Klebsiella pneumoniae BWHC1	AVU24145.1			41
EJJ23_22005		Klebsiella pneumoniae C1398	QGM54236.1			41
HJW92_05645		Klebsiella pneumoniae C16KP0024	QJK43095.1			41
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