Glycoside Hydrolase Family 5 / Subf 39

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (23); Uniprot accession (6);
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 BF49_3464   Bradyrhizobium sp. CUT12384.1     39
 S23_66150   Bradyrhizobium sp. S23321 BAL79794.1     39
 NIES4071_51460   Calothrix sp. NIES-4071 BAZ13307.1     39
 NIES4105_51410   Calothrix sp. NIES-4105 BAZ59454.1     39
 Acid345_1689   Candidatus Koribacter versatilis Ellin345 ABF40690.1 Q1IR10   39
 AL346_22105   Chelatococcus sp. CO-6 ALA20142.1     39
 OP10G_0861   Fimbriimonas ginsengisoli Gsoil 348 AIE84229.1     39
 Glo7428_1428   Gloeocapsa sp. PCC 7428 AFZ29990.1     39
 Glo7428_4830   Gloeocapsa sp. PCC 7428 AFZ33259.1     39
 AciX9_1473   Granulicella tundricola MP5ACTX9 ADW68526.1     39
 Haur_1902   Herpetosiphon aurantiacus DSM 785 ABX04545.1 A9AUL8   39
 O77CONTIG1_02053   Leptolyngbya sp. O-77 BAU42234.1     39
 LA76x_2681   Lysobacter antibioticus 76 ALN80811.1     39
 GLA29479_2967   Lysobacter antibioticus ATCC 29479 ALN63830.1     39
 GLE_2459   Lysobacter enzymogenes C3 ALN57808.1     39
 Oscil6304_4217   Oscillatoria acuminata PCC 6304 AFY83745.1     39
 RPA4584   Rhodopseudomonas palustris CGA009 CAE30024.1
NP_949918.1
Q6N125   39
 Rpal_5064   Rhodopseudomonas palustris TIE-1 ACF03553.1 B3QA75   39
 Rcas_0182   Roseiflexus castenholzii DSM 13941 ABU56316.1 A7NFT5   39
 NIES970_21890   Synechococcus sp. NIES-970 BAW97238.1     39
 Syn6312_0711   Synechococcus sp. PCC 6312 AFY59930.1     39
 endo-β-1,4-glucanase (UmCel5F) 3.2.1.4 uncultured bacterium ABE60666.1 Q1NZ59   39
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