Glycoside Hydrolase Family 5 / Subf 38

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (26); Uniprot accession (8);
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 SAMN00777080_2486   Aquiflexum balticum DSM 16537 SMD43874.1     38
 Bacsa_1914   Bacteroides salanitronis DSM 18170 ADY36470.1     38
 Cpin_6252   Chitinophaga pinensis DSM 2588 ACU63658.1 C7PI96   38
 CK934_25185   Chitinophaga sp. MD30 ASZ14011.1     38
 SAMN06298216_3461   Cytophagales bacterium TFI 002 SOE23070.1     38
 Verru16b_00652   Lacunisphaera limnophila IG16b AOS43600.1     38
 Oter_3317   Opitutus terrae PB90-1 ACB76596.1 B1ZTE2   38
 cellulase   Prevotella ruminicola AND66077.1     38
 endo-β-1,4-glucanase (PRU_1856) 3.2.1.4 Prevotella ruminicola 23 ADE83057.1
BAA74515.1
D5EU37
Q9ZN63
  38
 ORF (fragment)   Prevotella sp. Sc00066 AGH14129.1     38
 ORF (fragment)   Prevotella sp. Sc00066 AGH14128.1     38
 Tter_2195   Thermobaculum terrenum ATCC BAA-798 ACZ43095.1 D1CH74   38
 glycoside hydrolase   uncultured bacterium AMO13174.1     38
 ORF (fragment)   uncultured bacterium ADV57584.1     38
 ORF (fragment)   uncultured bacterium ADV57602.1     38
 ORF (fragment)   uncultured bacterium ADV57611.1     38
 EndoG endoglucanase   uncultured bacterium Csd4 AKF17200.1     38
 ORF   uncultured bacterium fosmid pJB89E1 AIF26760.1     38
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