Glycoside Hydrolase Family 5 / Subf 38

Activities in Familyendo-β-1,4-glucanase / cellulase (EC; endo-β-1,4-xylanase (EC; β-glucosidase (EC; β-mannosidase (EC; β-glucosylceramidase (EC; glucan β-1,3-glucosidase (EC; licheninase (EC; exo-β-1,4-glucanase / cellodextrinase (EC; glucan endo-1,6-β-glucosidase (EC; mannan endo-β-1,4-mannosidase (EC; cellulose β-1,4-cellobiosidase (EC; steryl β-glucosidase (EC; endoglycoceramidase (EC; chitosanase (EC; β-primeverosidase (EC; xyloglucan-specific endo-β-1,4-glucanase (EC; endo-β-1,6-galactanase (EC; hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC; β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (27); Uniprot accession (8);
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 SAMN00777080_2486   Aquiflexum balticum DSM 16537 SMD43874.1     38
 Bacsa_1914   Bacteroides salanitronis DSM 18170 ADY36470.1     38
 Cpin_6252   Chitinophaga pinensis DSM 2588 ACU63658.1 C7PI96   38
 CK934_25185   Chitinophaga sp. MD30 ASZ14011.1     38
 SAMN06298216_3461   Cytophagales bacterium TFI 002 SOE23070.1     38
 C1H87_21710   Flavivirga eckloniae ECD14 AUP81187.1     38
 Verru16b_00652   Lacunisphaera limnophila IG16b AOS43600.1     38
 Oter_3317   Opitutus terrae PB90-1 ACB76596.1 B1ZTE2   38
 cellulase   Prevotella ruminicola AND66077.1     38
 endo-β-1,4-glucanase (PRU_1856) Prevotella ruminicola 23 ADE83057.1
 ORF (fragment)   Prevotella sp. Sc00066 AGH14129.1     38
 ORF (fragment)   Prevotella sp. Sc00066 AGH14128.1     38
 Tter_2195   Thermobaculum terrenum ATCC BAA-798 ACZ43095.1 D1CH74   38
 glycoside hydrolase   uncultured bacterium AMO13174.1     38
 ORF (fragment)   uncultured bacterium ADV57584.1     38
 ORF (fragment)   uncultured bacterium ADV57602.1     38
 ORF (fragment)   uncultured bacterium ADV57611.1     38
 EndoG endoglucanase   uncultured bacterium Csd4 AKF17200.1     38
 ORF   uncultured bacterium fosmid pJB89E1 AIF26760.1     38
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 cellodextrinase (UmCel5Q) (UmCel5Q)   uncultured microorganism ADB80112.1 D3JVU3   38
 cellodextrinase (UmCel5O) (Cel5O)   uncultured microorganism ADB80113.1 D3JVU4   38
 β-glucanase (M40-2) 3.2.1.- uncultured microorganism ACA61171.1 B1PLL4   38
 SARM_0054 / 1557092_108510 / MH-18 uncultured organism ADX05725.1     38
 SARM_0046 / 1029836_111030 / MH-2 uncultured organism ADX05717.1     38
 SARM_0004 / 3671981_90060 / MH-13 (fragment)   uncultured organism ADX05675.1     38
 exo-cellulase (CelEx-BR12) 3.2.1.- uncultured organism AGK74985.1     38

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