Glycoside Hydrolase Family 5 / Subf 37

Activities in Sub Family	Endo-β-1,4-glucanase (EC 3.2.1.4); Endo-β-1,3(4)-glucanase / lichenase-laminarinase (EC 3.2.1.6); Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); Exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); Cellobiohydrolase (EC 3.2.1.91);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) ₈ barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (59); Uniprot accession (14); PDB accession (3); 3D entries (1); cryst (0)

Summary

Download GH5_37 (59) Taxonomic display Structure (1) Characterized (15)


Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
AD2_00399		Acetivibrio thermocellus AD2	ALX07407.1			37
Cthe_2807 (CelC)		Acetivibrio thermocellus ATCC 27405	ABN54006.1			37
Clo1313_0395		Acetivibrio thermocellus DSM 1313	ADU73485.1			37
LQRI_0399		Acetivibrio thermocellus DSM 2360 LQRI	ANV75146.1			37
endo-β-1,4-glucanase C (CelC)	3.2.1.4	Acetivibrio thermocellus F7	CAC27410.1	Q9AL36		37
N1236_02010		Acetivibrio thermocellus M3	UWV47316.1			37
endo-β-1,4-glucanase C (LC2;CelC;EgC) (Cel5B)	3.2.1.4	Acetivibrio thermocellus NCIB 10682EL	AAA23220.1	P07985 P0C2S3	1CEC[A] 1CEN[A] 1CEO[A]	37
endoglucanase (Glu1E)		Alicyclobacillus tengchongensis CGMCC 1504	AJD08472.1			37
ANT_03660		Anaerolinea thermophila UNI-1	BAJ62400.1			37
bsdtb5_07820		Anaeromicropila herbilytica TB5	BCN29487.1			37
H6X83_10050		Caproicibacterium amylolyticum LBM18003	QNO17286.1			37
JS518_10320		Clostridiales bacterium FE2010	QTE75915.1			37
JRC49_05830		Clostridiales bacterium FE2011	QTE72806.1			37
JYE49_14435		Clostridiales bacterium R-7	QUC68710.1			37
JYE50_14270		Clostridiales bacterium WTE2008	QUA54630.1			37
JNO48_02635		Clostridiales bacterium XBB3002	QTE68823.1			37
endo-β-1,4-glucanase C307 (CelC307)	3.2.1.4	Clostridium sp. F1	BAA00793.1	P23340		37
NQ536_11725		Coprococcus eutactus ATCC 27759	UWP16699.1			37
CCU_08490		Coprococcus sp. ART55/1	CBK82603.1			37
LGT36_009985		Demequina sp. TMPB413	UPU87585.1			37
EUS_04280		[Eubacterium] siraeum 70/3	CBK95738.1			37
NQ549_02480		[Eubacterium] siraeum DSM 15702	UWP25730.1			37
ES1_10060		[Eubacterium] siraeum V10Sc8a	CBL34054.1			37
SD1D_1744 (Celc307)		Herbinix luporum SD1D	CUH93289.1			37
CE91St56_42950		Lachnospiraceae bacterium CE91-St56	BDF47172.1			37
hrd7_12770		Leptolinea sp. HRD-7	BCY17428.1			37
J3L18_27315 (fragment)		Mucilaginibacter gossypii P3	QTE40559.1			37
R50912_24910		Paenibacillus sp. FSL R5-0912	AIQ42917.1			37
PSTEL_08595 (fragment)		Paenibacillus stellifer DSM 14472	AIQ63143.1			37
KDC22_23410		Paenibacillus tritici PH55-1	QUL53328.1			37
cellulase 5A (Cel5A)		Ruminococcus albus	QPZ86390.1			37
Rumal_1792		Ruminococcus albus 7 = DSM 20455	ADU22290.1			37
lichenase (Ra0453;CUS_6741) (β-1,3-specific;cellobiose releasing)	3.2.1.73	Ruminococcus albus 8	EGC02962.1	E9SCY7		37
RBI_II00453		Ruminococcus bicirculans (ex Wegman et al. 2014) 80/3	CCO06210.1			37
cellodextrinase (CelA)	3.2.1.74	Ruminococcus flavefaciens FD-1	CAA36207.1	P16169		37
H9Q77_15645		Simiaoa sunii NSJ-8	QNM02456.1			37
TRBR_25610		Treponema bryantii JCM 32280	BDC94464.1			37
IWA51_10300		Treponema peruense RCC2812	QQA00641.1			37
Tresu_2549		Treponema succinifaciens DSM 2489	AEB15411.1			37
endo-β-1,4-glucanase / acidic cellulase (En1;CMC01D10-ORF18)	3.2.1.4	uncultured bacterium	AEV59734.1	G9BYB5		37
cellobiohydrolase (Scaffold00024.3;En4)	3.2.1.91	uncultured bacterium	AEV59731.1	G9BYB2		37
cellobiohydrolase (Exo_contig136_11;En6)		uncultured bacterium	AEV59739.1			37
exo-β-1,4-glucanase		uncultured bacterium	QLR06861.1			37
cellulase		uncultured bacterium	UZH98429.1			37
endoglucanase C (EgC) (endo-1,4-β-glucanase C) (cellulase C)		uncultured bacterium contig00033	AGS53072.1			37
ORF		uncultured bacterium Contig1468_n_1482_cl	AHF26427.1			37
endoglucanase	3.2.1.4	uncultured bacterium Contig15	AHF23845.1	W0FLK6		37
ORF		uncultured bacterium Contig27	AHF24623.1			37
ORF		uncultured bacterium Contig52	AHF25090.1			37
ORF		uncultured bacterium Contigcl_1149	AHF25829.1			37
endo-β-1,4-glucanase (CelA;Cel)	3.2.1.4	unidentified bacterium	AAA91966.1	Q60054		37
WAL19_34670		Waltera intestinalis 19YCFAH0.3Co2	BEU19631.1			37
unclassified
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
endoglucanase (umCel5N)	3.2.1.4	uncultured microorganism	ACH67609.1	B5LZ80		37
endo-β-1,4-glucanase (cel3623)	3.2.1.4	uncultured microorganism	AOA60286.1			37
endo-β-1,4-glucanase (cel7482)	3.2.1.4	uncultured microorganism	AOA60285.1			37
cellulase (DM1-1)		uncultured microorganism	ACA61162.1			37
β-glucanase (M8-2)	3.2.1.73	uncultured microorganism	ACA61165.1	B1PLK8		37
β-glucanase	3.2.1.6	uncultured organism	ADD61786.1	D9ZEN2		37
SARM_0068 / 3004993_158220 / TW-3	3.2.1.4	uncultured organism	ADX05739.1	E9NSP4		37
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