Glycoside Hydrolase Family 5 / Subf 2

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (1039); Uniprot accession (275); PDB accession (41); 3D entries (14); cryst (0)
All (924) Bacteria (756) Eukaryota (154) unclassified (14) Structure (14) Characterized (119)
unclassified
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 cellulase   uncultured microorganism AOA60287.1     2
 cellulase CM4   uncultured organism ARI46376.1     2
 endo-β-1,4-glucanase (G10-10) 3.2.1.4 uncultured organism ACY24859.1 D8VN74   2
 ORF   uncultured organism ADD61407.1
ADD62012.1
D9ZDK3   2
 multimodular β-glucanase 3.2.1.- uncultured organism ADD61840.1 D9ZET6   2
 SARM_0026 / 457020_01700 / TW-40 3.2.1.4 uncultured organism ADX05697.1   5UHX[A] 2
 SARM_0013 / 3932955_213080 / TW-1 3.2.1.4 uncultured organism ADX05684.1     2
 SARM_0055 / 1696514_56150 / TW-29 (fragment)   uncultured organism ADX05726.1     2
 SARM_0016 /3953955_160820 / TW-27 (fragment) 3.2.1.- uncultured organism ADX05687.1     2
 ORF   uncultured prokaryote CRY96302.1     2
 Sequence 10 from patent US 7465571.   unidentified ACM94257.1     2
 Sequence 63 from patent US 6368844 7EG1   unidentified AAM56798.1     2
 Sequence 22 from patent US 7026152   unidentified ABH12705.1     2
 endoglucanase (RR.13;RR.13-2) 3.2.1.- unidentified microorganism CAJ19149.1 Q2YI54   2
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