Activities in Sub Family	Endo-β-1,4-glucanase (EC 3.2.1.4); Endo-β-1,3(4)-glucanase / lichenase-laminarinase (EC 3.2.1.6); Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (76); Uniprot accession (16); PDB accession (11); 3D entries (3); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)	Subf
CJA_3369 (Cel5C)		Cellvibrio japonicus Ueda107	ACE83249.1		8BN7[A,B,C] 8BQB[A,B,C] <carb_like_YLL> 2.70	26
endo-β-1,4-glucanase 5F (SdGluc5_26A;Sde_1572) (Cel5F)	3.2.1.4	Saccharophagus degradans 2-40	ABD80834.1	Q21KE5	5A8M[A,B,C] 1.86 5A8N[A] 2.05 5A8O[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.30 5A8P[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-3)-β-D-Glcp 2.20 5A8Q[A] β-D-Glcp-(1-3)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 1.90 5A94[A,B,C,D,E,F] β-D-Glcp-(1-3)-β-D-Glcp-(1-4)-β-D-Glcp 1.99 5A95[A,B,C] β-D-Glcp-(1-3)-β-D-Glcp-(1-4)-β-D-Glcp 1.35	26
endoglucanase / cellulase (cMGL504) (Cel5A)	3.2.1.4	uncultured bacterium	AFJ05146.1	I6PLH5	4HTY[A] 2.00 4HU0[A] β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp 2.38	26
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