Glycoside Hydrolase Family 5 / Subf 26

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (36); Uniprot accession (16); PDB accession (9); 3D entries (2); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 cellulase (CelA24) 3.2.1.4 bacterium enrichment culture clone CelA24 ACR23659.1 C5HG56   26
 endo-β-1,4-glucanase A (CelA) (Cel5A) 3.2.1.4 Cellvibrio mixtus ATCC 12120 AAB61461.1 O07652   26
 endo-β-1,4-glucanase 5F (SdGluc5_26A;Sde_1572) (Cel5F) 3.2.1.4 Saccharophagus degradans 2-40 ABD80834.1 Q21KE5 5A8M[A,B,C]
5A8N[A]
5A8O[A]
5A8P[A]
5A8Q[A]
5A94[A,B,C,D,E,F]
5A95[A,B,C]
26
 endoglucanase / cellulase (cMGL504) (Cel5A) 3.2.1.4 uncultured bacterium AFJ05146.1   4HTY[A]
4HU0[A]
26
 endo-β-1,4-glucanase (CelA) (Cel5A) 3.2.1.4
3.2.1.73
uncultured bacterium ABA02176.1 Q2I8W1   26
 endoglucanase (RuCelB;RuCel5B;6C6) (Cel5B) 3.2.1.4 uncultured rumen bacterium ADM89627.1     26
 endo-β-1,4-glucanase (CelA) (Cel5A) 3.2.1.4 uncultured rumen bacterium CAP07661.1 A8E1B1   26
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 endoglucanase (UmCel5K) (Cel5K) 3.2.1.4 uncultured microorganism ADB80108.1 D3JVT9   26
 cellulase (DC9-2) 3.2.1.4 uncultured microorganism ACA61152.1 B1PLJ5   26
 β-glucanase (DC20-2) 3.2.1.- uncultured microorganism ACA61156.1 B1PLJ9   26
 β-glucanase (M11-2) 3.2.1.4 uncultured microorganism ACA61168.1 B1PLL1   26
 endo-β-1,4-glucanase (G08-17) (fragment) 3.2.1.4 uncultured organism ACY24829.1 D8VN44   26
 SARM_0081 / 0_14031 / TW-4 3.2.1.4 uncultured organism ADX05751.1     26
 SARM_0069 / 3271578_13460 / TW-9 3.2.1.- uncultured organism ADX05740.1     26
 SARM_0061 / 2463295_41230 / MH-3 3.2.1.4 uncultured organism ADX05732.1     26
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