Activities in Sub Family	Endo-β-1,4-glucanase (EC 3.2.1.4); Endo-β-1,3(4)-glucanase / lichenase-laminarinase (EC 3.2.1.6); Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (76); Uniprot accession (16); PDB accession (11); 3D entries (3); cryst (0)

Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
cellulase (CelA24)	3.2.1.4	doi	bacterium enrichment culture clone CelA24	ACR23659.1	C5HG56		26
endo-β-1,4-glucanase A (CelA) (Cel5A)	3.2.1.4	pubmed	Cellvibrio mixtus ATCC 12120	AAB61461.1	O07652		26
endo-β-1,4-glucanase	3.2.1.4	pubmed	Muricauda sp. MAR_2010_75	WP_197062539.1			26
endo-β-1,4-glucanase 5F (SdGluc5_26A;Sde_1572) (Cel5F)	3.2.1.4	pubmed	Saccharophagus degradans 2-40	ABD80834.1	Q21KE5	5A8M[A,B,C] 5A8N[A] 5A8O[A] 5A8P[A] 5A8Q[A] 5A94[A,B,C,D,E,F] 5A95[A,B,C]	26
endoglucanase / cellulase (cMGL504) (Cel5A)	3.2.1.4	pubmed	uncultured bacterium	AFJ05146.1	I6PLH5	4HTY[A] 4HU0[A]	26
endo-β-1,4-glucanase (CelA) (Cel5A)	3.2.1.4 3.2.1.73	pubmed pubmed	uncultured bacterium	ABA02176.1	Q2I8W1		26
endoglucanase (RuCelB;RuCel5B;6C6) (Cel5B)	3.2.1.4	doi	uncultured rumen bacterium	ADM89627.1	G3BJX5		26
endo-β-1,4-glucanase (CelA) (Cel5A)	3.2.1.4	pubmed	uncultured rumen bacterium	CAP07661.1	A8E1B1		26
β-endoglucanase (EgxA;Eng) (frameshift)	3.2.1.4	doi	Xanthomonas albilineans XAI-I	AAA27599.1	Q60100		26
unclassified
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
endoglucanase (UmCel5K) (Cel5K)	3.2.1.4	URL	uncultured microorganism	ADB80108.1	D3JVT9		26
cellulase (DC9-2)	3.2.1.4	pubmed	uncultured microorganism	ACA61152.1	B1PLJ5		26
β-glucanase (DC20-2)	3.2.1.73	pubmed	uncultured microorganism	ACA61156.1	B1PLJ9		26
β-glucanase (M11-2)	3.2.1.4	pubmed	uncultured microorganism	ACA61168.1	B1PLL1		26
endo-β-1,4-glucanase (G08-17) (fragment)	3.2.1.4	pubmed	uncultured organism	ACY24829.1	D8VN44		26
SARM_0081 / 0_14031 / TW-4	3.2.1.4	pubmed	uncultured organism	ADX05751.1	E9NSQ6		26
endo-β-1,3(4)-glucanase (SARM_0069 / 3271578_13460 / TW-19)	3.2.1.6	pubmed	uncultured organism	ADX05740.1	E9NSP5		26
SARM_0061 / 2463295_41230 / MH-3	3.2.1.4	pubmed	uncultured organism	ADX05732.1	E9NSN7		26
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