Glycoside Hydrolase Family 5 / Subf 26

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (36); Uniprot accession (16); PDB accession (9); 3D entries (2); cryst (0)
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 CDL62_08210   Alkalitalea saponilacus DSM 24412 ASB49124.1     26
 cellulase (CelA24) 3.2.1.4 bacterium enrichment culture clone CelA24 ACR23659.1 C5HG56   26
 CJA_3369 (Cel5C)   Cellvibrio japonicus Ueda107 ACE83249.1 B3PF55   26
 endo-β-1,4-glucanase A (CelA) (Cel5A) 3.2.1.4 Cellvibrio mixtus ATCC 12120 AAB61461.1 O07652   26
 CBR65_15365   Cellvibrio sp. PSBB006 ARU30105.1     26
 B0D95_16360   Cellvibrio sp. PSBB023 AQT61503.1     26
 FAES_1496 (Cela3)   Fibrella aestuarina BUZ 2 CCG99506.1     26
 A6C57_20225   Fibrella sp. ES10-3-2-2 ARK12473.1     26
 D770_09035   Flammeovirgaceae bacterium 311 AHM60064.1     26
 Verru16b_02388 (CelA)   Lacunisphaera limnophila IG16b AOS45308.1     26
 LPB138_13910   Lutibacter sp. LPB0138 AOW21709.1     26
 MROS_0504   Melioribacter roseus P3M-2 AFN73747.1     26
 Oter_1089   Opitutus terrae PB90-1 ACB74377.1 B1ZMN2   26
 LPB03_10165   Polaribacter vadi LPB0003 AOW17796.1     26
 PKOR_02475   Pontibacter korlensis X14-1T AKD02203.1     26
 Rmar_0025   Rhodothermus marinus DSM 4252 ACY46934.1     26
 Rhom172_0025   Rhodothermus marinus SG0.5JP17-172 AEN71978.1     26
 Runsl_3648   Runella slithyformis DSM 19594 AEI50006.1     26
 endo-β-1,4-glucanase 5F (SdGluc5_26A;Sde_1572) (Cel5F) 3.2.1.4 Saccharophagus degradans 2-40 ABD80834.1 Q21KE5 5A8M[A,B,C]
5A8N[A]
5A8O[A]
5A8P[A]
5A8Q[A]
5A94[A,B,C,D,E,F]
5A95[A,B,C]
26
 TERTU_0183   Teredinibacter turnerae T7901 ACR12128.1 C5BLG4   26
 cellulase   uncultured bacterium AOI28235.1     26
 endoglucanase / cellulase (cMGL504) (Cel5A) 3.2.1.4 uncultured bacterium AFJ05146.1   4HTY[A]
4HU0[A]
26
 endo-β-1,4-glucanase (CelA) (Cel5A) 3.2.1.4
3.2.1.73
uncultured bacterium ABA02176.1 Q2I8W1   26
 endoglucanase (RuCelB;RuCel5B;6C6) (Cel5B) 3.2.1.4 uncultured rumen bacterium ADM89627.1     26
 endo-β-1,4-glucanase (CelA) (Cel5A) 3.2.1.4 uncultured rumen bacterium CAP07661.1 A8E1B1   26
 β-endoglucanase (EgxA;Eng) (frameshift)   Xanthomonas albilineans XAI-I AAA27599.1 Q60100   26
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