Glycoside Hydrolase Family 5 / Subf 25

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (135); Uniprot accession (23); PDB accession (16); 3D entries (3); cryst (0)
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 CDL62_01845   Alkalitalea saponilacus DSM 24412 ASB47982.1     25
 ANT_18750   Anaerolinea thermophila UNI-1 BAJ63901.1     25
 SAMN00777080_1515   Aquiflexum balticum DSM 16537 SMD42944.1     25
 Astex_2497   Asticcacaulis excentricus CB 48 ADU14148.1 C5SQ05   25
 NK6_7446   Bradyrhizobium diazoefficiens NK6 BAR60597.1     25
 AAV28_13865   Bradyrhizobium diazoefficiens USDA 110 AND88774.1     25
 blr3367   Bradyrhizobium diazoefficiens USDA 110 NP_770007.1
BAC48632.1
Q89PW3   25
 BD122_29925   Bradyrhizobium diazoefficiens USDA 122 APO54584.1     25
 RN69_31130   Bradyrhizobium japonicum E109 AJA64257.1     25
 BKD09_RS33400   Bradyrhizobium japonicum J5 APG13256.1     25
 BJS_06698   Bradyrhizobium japonicum SEMIA 5079 AHY51746.1     25
 BJ6T_64240   Bradyrhizobium japonicum USDA 6 BAL11673.1     25
 BN2626_G22_6460   Bradyrhizobium sp. CUU20044.1     25
 BF49_0114   Bradyrhizobium sp. CUT09034.1     25
 BCCGELA001_14935   Bradyrhizobium sp. CCGE-LA001 AMA57428.1     25
 Cabys_1971   Caldithrix abyssi DSM 13497 LF13 APF18720.1     25
 Cseg_2049   Caulobacter segnis ATCC 21756 ADG10516.1 D5VGS3   25
 Caul_1283 (Cel5A) 3.2.1.4 Caulobacter sp. K31 ABZ70413.1 B0SYT2   25
 ATE48_16720   Caulobacteraceae bacterium OTSz_A_272 ANP47437.1     25
 BN1096_520152   Clostridioides difficile CDS85201.1     25
 TW87_15900   Clostridioides difficile 08ACD0030 AMM58636.1     25
 CD2546   Clostridioides difficile 630 CAJ69433.1
AJP12293.1
Q182N3   25
 CDIF630erm_02798   Clostridioides difficile 630 delta erm ARE63472.1     25
 CD630DERM_25460   Clostridioides difficile 630Derm CEJ99169.1     25
 BN1095_620120   Clostridioides difficile 7032989 CDT65567.1     25
 BN1097_680032   Clostridioides difficile 7032994 CDS88444.1     25
 CDIF1296T_02673   Clostridioides difficile ATCC 9689 = DSM 1296 AKP43506.1     25
 BZ168_05215   Clostridioides difficile BR81 AQU09054.1     25
 CD196_2386   Clostridioides difficile CD196 CBA64573.1 C9XMR5   25
 CGC51_13185   Clostridioides difficile DH/NAP11/106/ST-42 ASN90242.1     25
 A6J95_16270   Clostridioides difficile FDAARGOS_267 ARC16276.1     25
 ERS445050_02541 (CelH)   Clostridioides difficile NCTC13307 CKH36269.1     25
 CDR20291_2433   Clostridioides difficile R20291 CBE05753.1 C9YPB9   25
 PCZ31_1913 (CelH)   Clostridioides difficile Z31 ALP03840.1     25
 NPD4_734   Clostridium butyricum CDC_51208 APF24128.1     25
 ATD26_15375   Clostridium butyricum JKY6D1 ALS18212.1     25
 ATN24_16655   Clostridium butyricum KNU-L09 ALP91715.1     25
 BBB49_14670   Clostridium butyricum TK520 AOR95284.1     25
 AZ909_15110   Clostridium butyricum TOA ANF15335.1     25
 endo-β-1,4-glucanase D (CelD;CelCCD;EGCCD;Ccel_0840) (Cel5D) 3.2.1.4 [Clostridium] cellulolyticum H10 ACL75216.1
BAA14354.1
P25472.1
P25472   25
 A9D14_07150   Croceicoccus marinus E4A9 ARU16008.1     25
 AEP_03465 (CelH)   Curvibacter sp. AEP1-3 ARV20385.1     25
 SAMN06298216_1039   Cytophagales bacterium TFI 002 SOE20551.1     25
 DICTH_0008 (Cel5A) 3.2.1.4 Dictyoglomus thermophilum H-6-12 ACI18520.1 B5YAS2   25
 DICTH_0506   Dictyoglomus thermophilum H-6-12 ACI19154.1 B5YCY0   25
 DICTH_0505   Dictyoglomus thermophilum H-6-12 ACI19692.1 B5YCX9   25
 cellulase (Dtur_0276)   Dictyoglomus turgidum DSM 6724 ACK41602.1 B8DYX6   25
 endoglucanase (LC1;CelA;Dtur_0670) (Cel5B) 3.2.1.4 Dictyoglomus turgidum DSM 6724 ACK41955.1 B8DZM2   25
 Dtur_0669   Dictyoglomus turgidum DSM 6724 ACK41954.1 B8DZM1   25
 endoglucanase (FgCel5A;Cel14.1) (Cel5A) 3.2.1.4 Fervidobacterium gondwanense AB39 AFY97404.1     25
 NA23_08975   Fervidobacterium islandicum AW-1 AMW33355.1     25
 endo-β-1,4-glucanase (FnCel5A;Fnod_1560) (Cel5A) 3.2.1.4 Fervidobacterium nodosum Rt17-B1 ABS61403.1
ADD73709.1
A7HNC0 3NCO[A,B]
3RJX[A]
3RJY[A]
25
 Ferpe_1841   Fervidobacterium pennivorans DSM 9078 AFG35892.1     25
 JM64_06420   Fervidobacterium pennivorans DYC ANE42311.1     25
 MY04_5155   Flammeovirga sp. MY04 ANQ52487.1     25
 J421_5858   Gemmatirosa kalamazoonesis KBS708 AHG93393.1     25
 Hbal_1973   Hirschia baltica ATCC 49814 ATCC 59814 ACT59657.1 C6XKU0   25
 AEM38_08310   Hyphomonadaceae bacterium UKL13-1 AMS30920.1     25
 Isop_0323   Isosphaera pallida ATCC 43644 ADV60918.1     25
 IX53_01755   Kosmotoga pacifica SLHLJ1 AKI98197.1     25
 Mahau_0466   Mahella australiensis 50-1 BON AEE95680.1     25
 SAMN04489810_2829   Microbacterium pygmaeum DSM 23142 SDH33403.1     25
 A7982_03354   Minicystis rosea DSM 24000 APR78007.1     25
 SAMN05216490_2516   Mucilaginibacter mallensis MP1X4 SDT11367.1     25
 RG1141_CH32600   Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 CDN55595.1     25
 RG540_CH33430   Neorhizobium galegae bv. orientalis str. HAMBI 540 CDN49507.1     25
 Cel5A   Paenibacillus curdlanolyticus B-6 AKP16689.1     25
 B9T62_03945   Paenibacillus donghaensis KCTC 13049 ASA20023.1     25
 BSF38_02917   Paludisphaera borealis PX4 APW61403.1     25
 Psesu_1585   Pseudoxanthomonas suwonensis 11-1 ADV27430.1     25
 UC35_16420   Ramlibacter tataouinensis 5-10 AMO25510.1     25
 Rta_10360   Ramlibacter tataouinensis TTB310 AEG92121.1     25
 RB5256   Rhodopirellula baltica SH 1 CAD78375.1
NP_866594.1
Q7UGF4   25
 Rpdx1_4768   Rhodopseudomonas palustris DX-1 ADU46314.1 D2M8H1   25
 AD2_02267   Ruminiclostridium thermocellum AD2 ALX09255.1     25
 bifunctional endo-β-1,4-glucanase / β-1,4-xylanase H (CelH;EgH;CtCelH;CtCel5E;Cthe_1472) (Lic26A;Cel5E) 3.2.1.4
3.2.1.8
Ruminiclostridium thermocellum ATCC 27405 ABN52701.1
CCF82162.1
P16218 4U3A[A,B]
4U5I[A,B]
4U5K[A,B]
5BYW[A,B,C,D,E]
25
 Clo1313_2234   Ruminiclostridium thermocellum DSM 1313 ADU75267.1     25
 LQRI_2266   Ruminiclostridium thermocellum DSM 2360 LQRI ANV77007.1     25
 endo-β-1,4-glucanase / β-1,3:1,4-glucanase H (CelH) (Lic26A;Cel5E) 3.2.1.4
3.2.1.73
Ruminiclostridium thermocellum NCIB 10682 AAA23225.1 H6SHY4
P16218
  25
 MC45_17220   Sphingomonas taxi ATCC 55669 AIT08352.1     25
 LPB140_05385   Sphingopyxis sp. LPB0140 APG62326.1     25
 BWQ93_10755 (fragment)   Sphingopyxis sp. QXT-31 APZ98920.1     25
 Sgly_1611   Syntrophobotulus glycolicus DSM 8271 ADY55909.1     25
 THTE_0890   Thermogutta terrifontis R1 ASV73492.1     25
 endoglucanase / β-mannanase (Tm_Cel5A;TM1751) (Cel5A) 3.2.1.4
3.2.1.78
Thermotoga maritima MSB8 AAD36816.1
AGL50683.1
AHD18355.1
AKE29506.1
NP_229549.1
Q9X273 3AMC[A,B]
3AMD[A,B,C,D]
3AMG[A,B]
3AOF[A,B]
3AZR[A,B]
3AZS[A,B]
3AZT[A,B,C,D]
3MMU[A,B,C,D,E,F,G,H]
3MMW[A,B,C,D]
25
 THMB_1793   Thermotoga maritima Tma100 AKE31377.1     25
 THMC_1793   Thermotoga maritima Tma200 AKE27633.1     25
 Sequence 27 from patent US 6368844   Thermotoga sp. CAH68695.1
AAM56794.1
CAT81458.1
    25
 TRQ2_1074   Thermotoga sp. RQ2 ACB09420.1 B1LAS2   25
 GH5   uncultured bacterium AQQ75170.1     25
 endo-β-1,4-glucanase (UmCel5L) (Cel5A) 3.2.1.4 uncultured bacterium ABE60714.1 Q1PDD8   25
 ORF (fragment)   uncultured bacterium ADV57600.1     25
 ORF (fragment)   uncultured bacterium ADV57604.1     25
 ORF (fragment)   uncultured bacterium ADV57605.1     25
 ORF (fragment)   uncultured bacterium ADV57607.1     25
 ORF (fragment)   uncultured bacterium ADV57608.1     25
 ORF (fragment)   uncultured bacterium ADV57609.1     25
 ORF (fragment)   uncultured bacterium ADV57610.1     25
 ORF (fragment)   uncultured bacterium ADV57618.1     25
 ORF (fragment)   uncultured bacterium ADV57619.1     25
 ORF (fragment)   uncultured bacterium ADV57620.1     25
 ORF (fragment)   uncultured bacterium ADV57621.1     25
 ORF (fragment)   uncultured bacterium ADV57622.1     25
 ORF (fragment)   uncultured bacterium ADV57625.1     25
 ORF (fragment)   uncultured bacterium ADV57626.1     25
 ORF (fragment)   uncultured bacterium ADV57628.1     25
 ORF (fragment)   uncultured bacterium ADV57629.1     25
 ORF (fragment)   uncultured bacterium ADV57631.1     25
 ORF (fragment)   uncultured bacterium ADV57633.1     25
 ORF   uncultured bacterium BAO65808.1     25
 endoglucanase (CellMM5.1;Cell5.1_3) 3.2.1.4 uncultured bacterium AID57617.1     25
 ORF   uncultured bacterium A2_10 AEW47942.1     25
 B1_GH5   uncultured bacterium B1_8 AEW47944.1     25
 B2_GH5   uncultured bacterium B2_18 AEW47949.1     25
 ORF   uncultured bacterium G2_7 AEW47966.1     25
 H2_GH5   uncultured bacterium H2_7 AEW47975.1     25
 endoglucanase   uncultured Dictyoglomus sp. ARO76321.1     25
 IMCC26134_05880   Verrucomicrobia bacterium IMCC26134 AKC82422.1     25
 SAMN05444156_2102   Verrucomicrobiaceae bacterium GAS474 SDU12473.1     25
unclassified
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 ORF   uncultured organism AGU10231.1     25
 ORF   uncultured organism AGU11488.1     25
 ORF (fragment)   uncultured organism AGU10498.1     25
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