Glycoside Hydrolase Family 5 / Subf 24

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (16); Uniprot accession (2);
All (15) Bacteria (2) Eukaryota (13)
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 EGX47679.1   Arthrobotrys oligospora ATCC 24927 EGX47679.1     24
 FFUJ_01044   Fusarium fujikuroi IMI 58289 CCT62409.1     24
 unnamed protein product (fragment)   Fusarium graminearum PH-1 CEF72475.1     24
 cellulase, partial   Humicola grisea var. thermoidea APD14599.1     24
 MG00530.4   Magnaporthe oryzae 70-15 XP_368714.1 G4NBI5   24
 NECHADRAFT_90120   Nectria haematococca mpVI 77-13-4 EEU48583.1     24
 NCU03254.1   Neurospora crassa OR74A XP_330690.1     24
 NCU03254   Neurospora crassa OR74A EAA35171.2     24
 Pa_1_2850   Podospora anserina S mat+ CAP59961.1
CDP22603.1
B2AA50   24
 MYCTH_43356   Thermothelomyces thermophila ATCC 42464 AEO53175.1     24
 THITE_2120948   Thielavia terrestris NRRL 8126 AEO70062.1     24
 ZT1A5_G3200 (fragment)   Zymoseptoria tritici ST99CH_1A5 SMY21762.1     24
 ZT3D7_G3218 (fragment)   Zymoseptoria tritici ST99CH_3D7 SMQ48069.1     24
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