Glycoside Hydrolase Family 5 / Subf 22

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (64); Uniprot accession (12);
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 SAMN04489721_1976   Agromyces flavus CPCC 202695 SDS82590.1     22
 GFC28_925   Anoxybacillus sp. B2M1 ANB56319.1     22
 GFC29_701   Anoxybacillus sp. B7M1 ANB65284.1     22
 SAMN02745906_1927   [Clostridium] sphenoides JCM 1415 ATCC 19403 SET79047.1     22
 Dgeo_2693   Deinococcus geothermalis DSM 11300 ABF44126.1 Q1J308   22
 SAMN04488544_0020   Friedmanniella sagamiharensis DSM 21743 SDU79665.1     22
 M493_09730   Geobacillus sp. JF8 AGT32208.1     22
 GE39   Geobacillus thermodenitrificans T81 ATG84609.1     22
 SAMN04488563_5797   Jiangella alkaliphila DSM 45079 SDU78492.1     22
 SAMN04515669_1193   Jiangella sp. DSM 45060 SDS48120.1     22
 Kfla_2097   Kribbella flavida DSM 17836 ADB31179.1 D2PS55   22
 LACOL_1705 (fragment)   Lactobacillus oligofermentans DSM 15707 = LMG 22743 CUS27063.1     22
 LACOL_1704 (fragment)   Lactobacillus oligofermentans DSM 15707 = LMG 22743 CUS27061.1     22
 LIP_2120   Limnochorda pilosa HC45 BAS27961.1     22
 Mahau_1070   Mahella australiensis 50-1 BON AEE96268.1     22
 SAMN04489812_2284   Microlunatus soli DSM 21800 SDS56085.1     22
 BN4615_P2261   Nonomuraea gerenzanensis ATCC 39727 SBO92747.1     22
 BKM31_37165   Nonomuraea sp. ATCC 55076 AQZ66343.1     22
 Pjdr2_6111   Paenibacillus sp. JDR-2 ACT04714.1 C6D6Y2   22
 AWM70_12165   Paenibacillus yonginensis DCY84 ANS75263.1     22
 Palpr_0671   Paludibacter propionicigenes WB4 ADQ78827.1 E4T283   22
 CIK06_12690 (fragment)   Plantactinospora sp. KBS50 ASW54859.1     22
 Tbis_2319   Thermobispora bispora DSM 43833 ADG89029.1 D6Y3S7   22
 A0O31_02347 (fragment)   Thermus brockianus GE-1 APD10372.1     22
 VAR608DRAFT_2679   Variovorax sp. HW608 SCK31328.1     22
 VAR608DRAFT_0511   Variovorax sp. HW608 SCK10904.1     22
 Veis_0943   Verminephrobacter eiseniae EF01-2 ABM56721.1 A1WGG4   22
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