Glycoside Hydrolase Family 5 / Subf 21

Activities in Familyendo-β-1,4-glucanase / cellulase (EC; endo-β-1,4-xylanase (EC; β-glucosidase (EC; β-mannosidase (EC; β-glucosylceramidase (EC; glucan β-1,3-glucosidase (EC; licheninase (EC; exo-β-1,4-glucanase / cellodextrinase (EC; glucan endo-1,6-β-glucosidase (EC; mannan endo-β-1,4-mannosidase (EC; cellulose β-1,4-cellobiosidase (EC; steryl β-glucosidase (EC; endoglycoceramidase (EC; chitosanase (EC; β-primeverosidase (EC; xyloglucan-specific endo-β-1,4-glucanase (EC; endo-β-1,6-galactanase (EC; hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC; β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (23); Uniprot accession (9);
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 endoxylanase (ORF1299;BACEGG_01299) (BeXyn5A) Bacteroides eggerthii DSM 20697 EEC54456.1 B7AFX5   21
 endo-β-1,4-xylanase (BiXyn5A;ORF4213;BACINT_04213) (Xyn5A) Bacteroides intestinalis DSM 17393 EDV05070.1 B3CET2   21
 xylanase (ORF0336) (Xyn5B) Prevotella bryantii B14 ADI70667.1 D7SFG3   21
 xylanase (ORF0150) (Xyn5A) Prevotella bryantii B14 ADI70668.1 D7SFG4   21

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