Glycoside Hydrolase Family 5 / Subf 1

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (491); Uniprot accession (102); PDB accession (15); 3D entries (3); cryst (0)
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 ORF (fragment)   Coptotermes formosanus AGM32171.1     1
 ORF (fragment)   Coptotermes formosanus AGM32613.1     1
 ORF (fragment)   Coptotermes formosanus AGM33013.1     1
 cellulase (Cmc-08) (partial)   Epidinium ecaudatum CAL91968.1 B7FBJ3   1
 ORF (fragment)   Pristionchus pacificus JU1089 ADV58290.1     1
 ORF (fragment)   Pristionchus pacificus JU138 ADV58291.1     1
 Cel-3 (fragment)   Pristionchus pacificus JU138 ADV58344.1     1
 ORF (fragment)   Pristionchus pacificus JU150 ADV58292.1     1
 ORF (fragment)   Pristionchus pacificus JU150 ADV58328.1     1
 ORF (fragment)   Pristionchus pacificus JU482 ADV58293.1     1
 ORF (fragment)   Pristionchus pacificus PS1843 ADV58314.1     1
 ORF (fragment)   Pristionchus pacificus PS312 ADV58289.1     1
 ORF (fragment)   Pristionchus pacificus PS312 ADV58313.1     1
 Cel-3 (fragment)   Pristionchus pacificus PS312 ADV58337.1     1
 ORF (fragment)   Pristionchus pacificus RS106 ADV58296.1     1
 Cel-3 (fragment)   Pristionchus pacificus RS106 ADV58342.1     1
 ORF (fragment)   Pristionchus pacificus RS5134 ADV58320.1     1
 ORF (fragment)   Pristionchus pacificus RS5171 ADV58298.1     1
 Cel-2 (fragment)   Pristionchus pacificus RS5171 ADV58322.1     1
 ORF (fragment)   Pristionchus pacificus RS5194 ADV58299.1     1
 Cel-3 (fragment)   Pristionchus pacificus RS5194 ADV58341.1     1
 Cel-3 (fragment)   Pristionchus pacificus RS5195 ADV58345.1     1
 ORF (fragment)   Pristionchus pacificus RS5200 ADV58301.1     1
 ORF (fragment)   Pristionchus pacificus RS5200 ADV58315.1     1
 ORF (fragment)   Pristionchus pacificus RS5202 ADV58302.1     1
 ORF (fragment)   Pristionchus pacificus RS5202 ADV58316.1     1
 Cel-3 (fragment)   Pristionchus pacificus RS5202 ADV58338.1     1
 ORF (fragment)   Pristionchus pacificus RS5205 ADV58303.1     1
 ORF (fragment)   Pristionchus pacificus RS5266 ADV58304.1     1
 ORF (fragment)   Pristionchus pacificus RS5270 ADV58305.1     1
 Cel-3 (fragment)   Pristionchus pacificus RS5270 ADV58317.1     1
 ORF (fragment)   Pristionchus pacificus RS5279 ADV58321.1     1
 ORF (fragment)   Pristionchus pacificus RS5282 ADV58308.1     1
 Cel-3 (fragment)   Pristionchus pacificus RS5282 ADV58346.1     1
 ORF (fragment)   Pristionchus pacificus RS5296 ADV58310.1     1
 ORF (fragment)   Pristionchus pacificus RS5297 ADV58311.1     1
 ORF (fragment)   Pristionchus pacificus RS5302 ADV58312.1     1
 ORF (fragment)   Pristionchus pacificus RS5302 ADV58333.1     1
 SM2739B21 (fragment)   uncultured symbiotic protist of Cryptocercus punctulatus BAF57461.1 A4UX51   1
 NT0283A44   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57326.1 A4UWR6   1
 NT0285B44   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57331.1 A4UWS1   1
 NT0288B91   uncultured symbiotic protist of Hodotermopsis sjoestedti BAF57335.1 A4UWS5   1
 SM2763A16   uncultured symbiotic protist of Mastotermes darwiniensis BAF57414.1 A4UX04   1
 SM2765A45   uncultured symbiotic protist of Mastotermes darwiniensis BAF57415.1 A4UX05   1
 SM2632A58   uncultured symbiotic protist of Neotermes koshunensis BAF57362.1 A4UWV2   1
 SM2635A05;SM2636A42;SM2649A74;SM2649A87   uncultured symbiotic protist of Neotermes koshunensis BAF57364.1
BAF57365.1
BAF57371.1
BAF57372.1
A4UWV4   1
 SM2030A48   uncultured symbiotic protist of Reticulitermes speratus BAF57288.1 A4UWM8   1
 SM2040A21   uncultured symbiotic protist of Reticulitermes speratus BAF57289.1 A4UWM9   1
 SM2041A08 (possible fragment)   uncultured symbiotic protist of Reticulitermes speratus BAF57291.1 A4UWN1   1
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