Glycoside Hydrolase Family 5 / Subf 1

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (510); Uniprot accession (102); PDB accession (15); 3D entries (3); cryst (0)
Archaea
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 Igag_0570   Ignisphaera aggregans DSM 17230 ADM27405.1 E0SSD3   1
 Igag_0224   Ignisphaera aggregans DSM 17230 ADM27073.1 E0SQC3   1
 endo-β-1,4-glucanase (EglB;TCel4;PAB0632) 3.2.1.4 Pyrococcus abyssi GE5 CAB49854.1
AEG76944.1
NP_126623.1
Q9V052   1
 endo-β-1,4-glucanase (EGPh;EglB;TCel3;PH1171) 3.2.1.4 Pyrococcus horikoshii OT3 AAQ31833.1
AAQ31832.1
BAA30271.1
NP_143072.1
O58925 2ZUM[A]
2ZUN[A,B,C]
3AXX[A,B,C]
3QHM[A,B,C]
3QHN[A,B,C]
3QHO[A,B,C]
3VVG[A,B,C]
3W6L[A,B,C]
3W6M[A,B,C]
4DM1[A,B,C]
4DM2[A,B,C]
1
 Py04_1787   Pyrococcus sp. ST04 AFK23355.1     1
 Shell_0798   Staphylothermus hellenicus DSM 12710 ADI31911.1 D7D815   1
 CHITON_2145   Thermococcus chitonophagus DSM 10152 CUX78924.1     1
 A3L04_02950   Thermococcus chitonophagus GC74 ASJ17552.1     1
 ADU37_CDS22600   Thermococcus sp. 2319x1 ALV63957.1     1
 Sequence 2 from patent US 6329187 (fragment)   unidentified archaeon AEPII1a AAQ77850.1     1
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