Glycoside Hydrolase Family 5 / Subf 19

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (104); Uniprot accession (32);
Archaea
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 ASAC_0734   Acidilobus saccharovorans 345-15 ADL19140.1 D9Q1F2   19
 SE86_04550 (fragment)   Acidilobus sp. 7A AMD30698.1     19
 SE86_03690 (fragment)   Acidilobus sp. 7A AMD30586.1     19
 SE86_03695 (fragment)   Acidilobus sp. 7A AMD30587.1     19
 Cmaq_0936   Caldivirga maquilingensis IC-167 ABW01768.1 A8MDB2   19
 CSP5_0161   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM33477.1     19
 Igag_0312   Ignisphaera aggregans DSM 17230 ADM27158.1 E0SQT4   19
 PTO1452   Picrophilus torridus DSM 9790 AAT44037.1 Q6KZ15   19
 SiH_2292   Sulfolobus islandicus HVE10/4 ADX83632.1     19
 LD85_2652   Sulfolobus islandicus L.D.8.5 ADB88268.1 D2PGC8   19
 LS215_2522   Sulfolobus islandicus L.S.2.15 ACP36477.1 C3ML75   19
 SiL_2199   Sulfolobus islandicus LAL14/1 AGJ63637.1     19
 M1425_2350   Sulfolobus islandicus M.14.25 ACP39078.1 C3MSD5   19
 M1627_2428   Sulfolobus islandicus M.16.27 ACP56280.1 C3N1Q3   19
 M164_2357   Sulfolobus islandicus M.16.4 ACR42955.1 C4KL74   19
 SiRe_2238   Sulfolobus islandicus REY15A ADX86291.1     19
 YG5714_2494   Sulfolobus islandicus Y.G.57.14 ACP46730.1 C3NAD7   19
 YN1551_0410   Sulfolobus islandicus Y.N.15.51 ACP47578.1 C3NL64   19
 Ssol98_010100014313   Sulfolobus solfataricus 98/2 AET42931.1     19
 SULC_0786   Sulfolobus solfataricus 98/2 SULC AKA75856.1     19
 SSOP1_3102   Sulfolobus solfataricus P1 SAI86656.1     19
 SSO3007   Sulfolobus solfataricus P2 CAC24030.1
AAK43109.1
NP_344319.1
Q97UK4   19
 SULA_0786   Sulfolobus solfataricus SULA AKA78548.1     19
 SULB_0788   Sulfolobus solfataricus SULB AKA73158.1     19
 BFU36_07080   Sulfolobus sp. A20 AOL16496.1     19
 Tpen_1672   Thermofilum pendens Hrk 5 ABL79067.1 A1S0T7   19
 TVG0696003   Thermoplasma volcanium GSS1 BAB59829.1
NP_111209.1
Q97AX2   19
 TUZN_0393   Thermoproteus uzoniensis 768-20 AEA11889.1     19
 Vdis_1602   Vulcanisaeta distributa DSM 14429 ADN50980.1 E1QTR3   19
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 PACID_31000   Acidipropionibacterium acidipropionici ATCC 4875 AFV90860.1     19
 AXH35_08510   Acidipropionibacterium acidipropionici ATCC 55737 AMS05481.1     19
 A8L58_09955   Acidipropionibacterium acidipropionici F3E8 AOZ46953.1     19
 CDG81_12880   Actinopolyspora erythraea YIM 90600 ASU79031.1     19
 CDG81_11260   Actinopolyspora erythraea YIM 90600 ASU78759.1     19
 Amir_4131   Actinosynnema mirum DSM 43827 ACU37986.1 C6WH67   19
 CNX65_20680   Actinosynnema pretiosum X47 ATE55400.1     19
 TTE0061   Caldanaerobacter subterraneus subsp. tengcongensis MB4 AAM23368.1
NP_621764.1
Q8RDH1   19
 AX769_17310   Frondihabitans sp. PAMC 28766 AMM21576.1     19
 SAMN04488563_4967   Jiangella alkaliphila DSM 45079 SDU75429.1     19
 SAMN04515683_1603   Leifsonia sp. 157MF SDJ88705.1     19
 SAMN04515690_2641   Leifsonia sp. 197AMF SDH46304.1     19
 SAMN04515680_1182   Leifsonia sp. 21MFCrub1.1 SEA68811.1     19
 SAMN04515684_1145   Leifsonia sp. 466MF SDI91190.1     19
 SAMN04515685_1588   Leifsonia sp. 467MF SEN10636.1     19
 SAMN04515686_3348   Leifsonia sp. 509MF SDN94865.1     19
 SAMN04515691_1378   Leifsonia sp. 98AMF SFM05091.1     19
 A0130_05130   Leifsonia xyli SE134 ANF31143.1     19
 LIP_0945   Limnochorda pilosa HC45 BAS26802.1     19
 VV02_19175   Luteipulveratus mongoliensis MN07-A0370 AKU17471.1     19
 BKM31_24085   Nonomuraea sp. ATCC 55076 AQZ64131.1     19
 OPIT5_10225   Opitutaceae bacterium TAV5 AHF90519.1     19
 OPIT5_16360   Opitutaceae bacterium TAV5 AHF91565.1     19
 BWO91_02210   Plantibacter flavus 251 AQX78969.1     19
 Tlet_0851   Pseudothermotoga lettingae TMO ABV33417.1 A8F5I3   19
 β-mannosidase (Tth Man5;Theth_0949) 3.2.1.25 Pseudothermotoga thermarum DSM 5069 AEH51033.1     19
 SACE_1893   Saccharopolyspora erythraea NRRL 2338 CAM01205.1 A4FAY0   19
 sce0661   Sorangium cellulosum So ce56 CAN90818.1 A9EN48   19
 SCE1572_04445   Sorangium cellulosum So0157-2 AGP33812.1     19
 Salbus254_0085   Streptomyces albus SM254 AMM06643.1     19
 SAMR0906   Streptomyces ambofaciens ATCC 23877 CAJ88615.1
CAS97456.1
A0ADQ8   19
 SAM23877_6669   Streptomyces ambofaciens ATCC 23877 AKZ59714.1     19
 SAM40697_6005   Streptomyces ambofaciens DSM 40697 ANB09958.1     19
 BV401_37195   Streptomyces autolyticus CGMCC0516 AQA15211.1     19
 SBI_00277   Streptomyces bingchenggensis BCW-1 ADI03398.1 D7BWP2   19
 SBI_02918   Streptomyces bingchenggensis BCW-1 ADI06039.1 D7C4I8   19
 SCO0457 or SCF51A.35   Streptomyces coelicolor A3(2) CAB56687.1
NP_624777.1
Q9RL30   19
 WQO_33325   Streptomyces globisporus C-1027 ALU97802.1     19
 SHXM_02185   Streptomyces hygroscopicus XM201 AQW48722.1     19
 SIRAN1856   Streptomyces iranensis CDR04864.1     19
 SLIV_35655   Streptomyces lividans TK24 AIJ18007.1     19
 Dst13   Streptomyces netropsis AIS24858.1     19
 ORF   Streptomyces netropsis CGMCC 4.1650 AHF81543.1     19
 BC342_33920   Streptomyces pactum KLBMP 5084 AOW90699.1     19
 Spa2297_31190   Streptomyces parvulus 2297 ANJ11065.1     19
 Sfla_4124   Streptomyces pratensis ATCC 33331 ADW05534.1 C9NAS2   19
 M271_08980   Streptomyces rapamycinicus NRRL 5491 AGP53414.1     19
 CGL27_39810   Streptomyces sp. 11-1-2 ASQ98352.1     19
 SAMN05428941_0512   Streptomyces sp. 2114.2 SDS45321.1     19
 NI25_00975   Streptomyces sp. CCM_MD2014 AIV32265.1     19
 SFR_0080   Streptomyces sp. FR-008 ALM36695.1     19
 F750_2591   Streptomyces sp. PAMC 26508 AGJ55076.1     19
 CAG99_16915   Streptomyces sp. SCSIO 03032 ARQ70300.1     19
 SACTE_5461   Streptomyces sp. SirexAA-E AEN13270.1     19
 TK78_00435   Streptomyces sp. Tue 6075 Tue6075 APS17566.1     19
 Strvi_3247   Streptomyces violaceusniger Tu 4113 AEM82935.1     19
 Tmar_1534   Thermaerobacter marianensis DSM 12885 ADU51645.1     19
 Thebr_2228   Thermoanaerobacter brockii subsp. finnii Ako-1 ADV80733.1 C5UDA3   19
 Thit_0052   Thermoanaerobacter italicus Ab9 ADD01381.1 D3T580   19
 TKV_c00670   Thermoanaerobacter kivui DSM 2030 AIS51277.1     19
 Tmath_0111 (fragment)   Thermoanaerobacter mathranii subsp. mathranii str. A3 ADH59896.1 D7AQL0   19
 Teth39_2182   Thermoanaerobacter pseudethanolicus ATCC 33223 ABY95804.1 B0K7Y4   19
 Thet_0061   Thermoanaerobacter sp. X513 ADN53733.1 E1T1V3   19
 Teth514_1790   Thermoanaerobacter sp. X514 ABY93075.1 B0K2C4   19
 Thewi_0074   Thermoanaerobacter wiegelii Rt8.B1 AEM77584.1     19
 Tsac_2322   Thermoanaerobacterium saccharolyticum JW/SL-YS485 AFK87324.1     19
 Tthe_1930   Thermoanaerobacterium thermosaccharolyticum DSM 571 ADL69415.1 D9TTF6   19
 Thethe_01938   Thermoanaerobacterium thermosaccharolyticum M0795 AGB19547.1     19
 Thert_00325 (CelA)   Thermoanaerobacterium thermosaccharolyticum TG57 AST56543.1     19
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