Glycoside Hydrolase Family 5 / Subf 13

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (488); Uniprot accession (47);
All (466) Archaea (1) Bacteria (465)
| 1 | 2 | 3 | 4 | 5 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 RN13_3318   Mycobacterium tuberculosis 37004 AMC83137.1     13
 MT49_3375   Mycobacterium tuberculosis 49-02 CDM11507.1     13
 IQ44_02775   Mycobacterium tuberculosis 6A024XDR AIH16349.1     13
 MT7199_3129   Mycobacterium tuberculosis 7199-99 CCG12977.1     13
 LJ70_16660   Mycobacterium tuberculosis 96075 AIQ05740.1     13
 LJ80_16855   Mycobacterium tuberculosis 96121 AIQ09757.1     13
 TM57_20070   Mycobacterium tuberculosis Beijing AOT76776.1     13
 UB21_16380   Mycobacterium tuberculosis Beijing-like AJW50337.1     13
 HKBT1_3252   Mycobacterium tuberculosis BT1 AHJ52198.1     13
 HKBT2_3257   Mycobacterium tuberculosis BT2 AHJ48054.1     13
 J113_21610   Mycobacterium tuberculosis CAS/NITR204 AGL28543.1     13
 CCDC5079_2853   Mycobacterium tuberculosis CCDC5079 AEJ48043.1
AGM01698.1
    13
 CFBR_3267   Mycobacterium tuberculosis CCDC5180 AHJ56352.1     13
 MT3180   Mycobacterium tuberculosis CDC1551 AAK47518.1
NP_337704.1
    13
 MTCTRI2_3159   Mycobacterium tuberculosis CTRI-2 AEN01560.1     13
 BTU11_17000   Mycobacterium tuberculosis DK9897 APR58398.1     13
 M943_15980   Mycobacterium tuberculosis EAI5 AGQ36295.1     13
 J114_16565   Mycobacterium tuberculosis EAI5/NITR206 AGL32598.1     13
 RN03_3345   Mycobacterium tuberculosis F1 AMC43303.1     13
 TBFG_13113   Mycobacterium tuberculosis F11 ABR07440.1 A1QW24
A5WS01
  13
 RN05_3286   Mycobacterium tuberculosis F28 AMC47562.1     13
 MRA_3128   Mycobacterium tuberculosis H37Ra ABQ74911.1 A5U7B1   13
 Rv3096   Mycobacterium tuberculosis H37Rv CAB08388.1
AFN51087.1
CCP45905.1
NP_217612.1
    13
 LH57_16900   Mycobacterium tuberculosis H37Rv H37Rv; TMC 102 AIR15877.1     13
 Y980_3096   Mycobacterium tuberculosis H37RvSiena AJF04461.1     13
 HKBS1_3263   Mycobacterium tuberculosis HKBS1 AHJ43909.1     13
 MTBK_32600   Mycobacterium tuberculosis K AIB49804.1     13
 ER17_16415   Mycobacterium tuberculosis KIT87190 AID06160.1     13
 TBMG_00871   Mycobacterium tuberculosis KZN 1435 ACT23910.1     13
 TBSG_00877   Mycobacterium tuberculosis KZN 4207 AEB03006.1     13
 TBXG_000863   Mycobacterium tuberculosis KZN 605 AFM48252.1     13
 NCGM946K2_3436   Mycobacterium tuberculosis NCGM946K2 BAW14200.1     13
 K651_18245   Mycobacterium tuberculosis PR08 AJP80764.1     13
 UZ39_18175   Mycobacterium tuberculosis PR10 AMP29623.1     13
 MRGA327_19050   Mycobacterium tuberculosis RGTB327 AFE17898.1     13
 MRGA423_19305   Mycobacterium tuberculosis RGTB423 AFE14226.1     13
 AFL40_3204   Mycobacterium tuberculosis SCAID 187.0 ALB20304.1     13
 BEE64_3207   Mycobacterium tuberculosis SCAID 252.0 AOE37514.1     13
 BEE65_3221   Mycobacterium tuberculosis SCAID 320.0 ANZ83824.1     13
 J112_16595   Mycobacterium tuberculosis str. Beijing/NITR203 AGJ69214.1     13
 ERDMAN_3388   Mycobacterium tuberculosis str. Erdman = ATCC 35801 BAL67164.1     13
 TBHG_03026   Mycobacterium tuberculosis str. Haarlem EBA43281.1     13
 KURONO_3477   Mycobacterium tuberculosis str. Kurono BAQ07256.1     13
 UDA_3096   Mycobacterium tuberculosis UT205 CCE38552.1     13
 TBPG_000881   Mycobacterium tuberculosis W-148 EGE49615.1     13
 IZ84_16510   Mycobacterium tuberculosis ZMC13-264 AII91689.1     13
 JE53_16490   Mycobacterium tuberculosis ZMC13-88 AII95605.1     13
 MUL_3476   Mycobacterium ulcerans Agy99 ABL05635.1 A0PTG6   13
 SHTP_1495   Mycobacterium ulcerans subsp. shinshuense ATCC 33728 BAV40748.1     13
 MYVA_5724   Mycobacterium vaccae 95051 ANI42752.1     13
 Mvan_5801   Mycobacterium vanbaalenii PYR-1 ABM16566.1 A1THB6   13
 OEM_19970   Mycobacterium yongonense 05-1390 AGP63532.1     13
 OEM_02990   Mycobacterium yongonense 05-1390 AGP61835.1     13
 MOTT27_00299 (fragment)   Mycobacterium yongonense Asan 36527 ARR81120.1     13
 MOTT27_01957 (fragment)   Mycobacterium yongonense Asan 36527 ARR82778.1     13
 MOTT12_01996   Mycobacterium yongonense Asan 36912 ARR77660.1     13
 MOTT12_00303   Mycobacterium yongonense Asan 36912 ARR75967.1     13
 A8C56_06885   Niabella ginsenosidivorans BS26 ANH83758.1     13
 NIASO_06495   Niabella soli DSM 19437 AHF14902.1     13
 Niako_1305   Niastella koreensis GR20-10 AEV97676.1     13
 BES08_21405   Novosphingobium resinovorum SA1 AOR79398.1     13
 Pjdr2_1620   Paenibacillus sp. JDR-2 ACT00287.1 C6CX74   13
 BSF38_03341   Paludisphaera borealis PX4 APW61812.1     13
 Phep_0506   Pedobacter heparinus DSM 2366 ACU02730.1 C6Y0G9   13
 Phep_2643   Pedobacter heparinus DSM 2366 ACU04844.1 C6Y0D2   13
 ING2E5A_1583   Petrimonas mucosa DSM 28695 SCM57941.1     13
 H744_2c2342   Photobacterium gaetbulicola Gung47 AJR09005.1     13
 L21SP3_00676   Phycisphaerae bacterium L21-RPul-D3 AQQ08883.1     13
 STSP1_00281   Phycisphaerae bacterium ST-PulAB-D4 ARN55914.1     13
 STSP1_00355   Phycisphaerae bacterium ST-PulAB-D4 ARN55985.1     13
 VT85_25250   Planctomyces sp. SH-PL62 AMV40764.1     13
 Ping_2508   Psychromonas ingrahamii 37 ABM04229.1 A1SXL4   13
 Rahaq2_2228   Rahnella aquatilis CIP 78.65 = ATCC 33071 AEX52084.1     13
 Q7S_12120   Rahnella aquatilis HX2 AFE58647.1     13
 Rahaq_2397   Rahnella sp. Y9602 ADW74004.1     13
 AN237_05130   Raoultella ornithinolytica 18 AOO55913.1     13
 HY59_12410   Raoultella ornithinolytica A14 ANZ06140.1     13
 RORB6_05970   Raoultella ornithinolytica B6 AGJ85887.1     13
 BK817_13595   Raoultella ornithinolytica MG APB05964.1     13
 CA210_22285   Raoultella ornithinolytica Ro24724 ASI60800.1     13
 TE10_03825   Raoultella ornithinolytica S12 AJF71233.1     13
 TH63_15600   Rufibacter sp. DG31D AKQ46723.1     13
 DC20_05970   Rufibacter tibetensis 1351 ALI98600.1     13
 Runsl_3697   Runella slithyformis DSM 19594 AEI50055.1     13
 AO058_17570   Salegentibacter sp. T436 APS40571.1     13
 AO058_17550   Salegentibacter sp. T436 APS40567.1     13
 2921_05   Serratia marcescens ACO52883.1 C1KH54   13
 Sinac_2792   Singulisphaera acidiphila DSM 18658 AGA27084.1     13
 CA265_01515   Sphingobacteriaceae bacterium GW460-11-11-14-LB5 ARS42851.1     13
 CA265_20575   Sphingobacteriaceae bacterium GW460-11-11-14-LB5 ARS43076.1     13
 Sph21_0597   Sphingobacterium sp. 21 ADZ77177.1     13
 SIDU_18050   Sphingobium indicum B90A APL96557.1     13
 SJA_C2-00220   Sphingobium japonicum UT26S UT26S (= NBRC 101211) BAI98385.1 D4Z7B6   13
 EP837_03619   Sphingobium sp. EP60837 ANI80003.1     13
 TZ53_07865   Sphingobium sp. YBL2 AJR23642.1     13
 TZ53_08230   Sphingobium sp. YBL2 AJR23707.1     13
 NX02_27800   Sphingomonas sanxanigenens DSM 19645 = NX02 AHE57143.1     13
 BXU08_18065   Sphingomonas sp. LM7 AQR75313.1     13
 BXU08_13420   Sphingomonas sp. LM7 AQR75896.1     13
 SKP52_01970   Sphingopyxis fribergensis Kp5.2 AJA07331.1     13
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