Glycoside Hydrolase Family 5 / Subf 13

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (557); Uniprot accession (47);
All (535) Archaea (1) Bacteria (534)
| 1 | 2 | 3 | 4 | 5 | 6 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 IU24_02755   Mycobacterium tuberculosis 0A093DS AIH73536.1     13
 IU18_02750   Mycobacterium tuberculosis 0A094DS AIH69812.1     13
 IU17_02765   Mycobacterium tuberculosis 0A115DS AIH66481.1     13
 IU16_02805   Mycobacterium tuberculosis 0A117DS AIH63110.1     13
 IU13_02825   Mycobacterium tuberculosis 0B026XDR AIH59859.1     13
 IQ41_02720   Mycobacterium tuberculosis 0B070XDR AIH54122.1     13
 IQ38_02885   Mycobacterium tuberculosis 0B076XDR AIH51480.1     13
 IQ39_02730   Mycobacterium tuberculosis 0B123ND AIH47865.1     13
 IQ40_02795   Mycobacterium tuberculosis 0B169XDR AIH44817.1     13
 IQ48_02795   Mycobacterium tuberculosis 0B218DS AIH41459.1     13
 IQ42_02815   Mycobacterium tuberculosis 0B222DS AIH38174.1     13
 IQ47_02765   Mycobacterium tuberculosis 0B228DS AIH34715.1     13
 IQ45_02780   Mycobacterium tuberculosis 0B229DS AIH31259.1     13
 T209_02790   Mycobacterium tuberculosis 0B235DS AIH27722.1     13
 IQ46_02720   Mycobacterium tuberculosis 0B259XDR AIH23941.1     13
 IQ43_02735   Mycobacterium tuberculosis 0B329XDR AIH20157.1     13
 BTB1458_3420   Mycobacterium tuberculosis 1458 AOZ44416.1     13
 MT18B_4114   Mycobacterium tuberculosis 18b AJK63134.1     13
 RN14_3282   Mycobacterium tuberculosis 22103 AMC87330.1     13
 RN12_3325   Mycobacterium tuberculosis 22115 AMC78934.1     13
 RN10_3491   Mycobacterium tuberculosis 2242 AMC70037.1     13
 RN11_3605   Mycobacterium tuberculosis 2279 AMC74615.1     13
 RN15_3302   Mycobacterium tuberculosis 26105 AMC91534.1     13
 RN13_3318   Mycobacterium tuberculosis 37004 AMC83137.1     13
 MT49_3375   Mycobacterium tuberculosis 49-02 CDM11507.1     13
 IQ44_02775   Mycobacterium tuberculosis 6A024XDR AIH16349.1     13
 MT7199_3129   Mycobacterium tuberculosis 7199-99 CCG12977.1     13
 LJ70_16660   Mycobacterium tuberculosis 96075 AIQ05740.1     13
 LJ80_16855   Mycobacterium tuberculosis 96121 AIQ09757.1     13
 TM57_20070   Mycobacterium tuberculosis Beijing AOT76776.1     13
 UB21_16380   Mycobacterium tuberculosis Beijing-like AJW50337.1     13
 HKBT1_3252   Mycobacterium tuberculosis BT1 AHJ52198.1     13
 HKBT2_3257   Mycobacterium tuberculosis BT2 AHJ48054.1     13
 J113_21610   Mycobacterium tuberculosis CAS/NITR204 AGL28543.1     13
 CCDC5079_2853   Mycobacterium tuberculosis CCDC5079 AEJ48043.1
AGM01698.1
    13
 CFBR_3267   Mycobacterium tuberculosis CCDC5180 AHJ56352.1     13
 MT3180   Mycobacterium tuberculosis CDC1551 AAK47518.1
NP_337704.1
    13
 MTCTRI2_3159   Mycobacterium tuberculosis CTRI-2 AEN01560.1     13
 BTU11_17000   Mycobacterium tuberculosis DK9897 APR58398.1     13
 M943_15980   Mycobacterium tuberculosis EAI5 AGQ36295.1     13
 J114_16565   Mycobacterium tuberculosis EAI5/NITR206 AGL32598.1     13
 RN03_3345   Mycobacterium tuberculosis F1 AMC43303.1     13
 TBFG_13113   Mycobacterium tuberculosis F11 ABR07440.1 A1QW24
A5WS01
  13
 RN05_3286   Mycobacterium tuberculosis F28 AMC47562.1     13
 MRA_3128   Mycobacterium tuberculosis H37Ra ABQ74911.1 A5U7B1   13
 Rv3096   Mycobacterium tuberculosis H37Rv CAB08388.1
AFN51087.1
CCP45905.1
NP_217612.1
    13
 LH57_16900   Mycobacterium tuberculosis H37Rv H37Rv; TMC 102 AIR15877.1     13
 Y980_3096   Mycobacterium tuberculosis H37RvSiena AJF04461.1     13
 HKBS1_3263   Mycobacterium tuberculosis HKBS1 AHJ43909.1     13
 MTBK_32600   Mycobacterium tuberculosis K AIB49804.1     13
 ER17_16415   Mycobacterium tuberculosis KIT87190 AID06160.1     13
 TBMG_00871   Mycobacterium tuberculosis KZN 1435 ACT23910.1     13
 TBSG_00877   Mycobacterium tuberculosis KZN 4207 AEB03006.1     13
 TBXG_000863   Mycobacterium tuberculosis KZN 605 AFM48252.1     13
 NCGM946K2_3436   Mycobacterium tuberculosis NCGM946K2 BAW14200.1     13
 K651_18245   Mycobacterium tuberculosis PR08 AJP80764.1     13
 UZ39_18175   Mycobacterium tuberculosis PR10 AMP29623.1     13
 MRGA327_19050   Mycobacterium tuberculosis RGTB327 AFE17898.1     13
 MRGA423_19305   Mycobacterium tuberculosis RGTB423 AFE14226.1     13
 AFL40_3204   Mycobacterium tuberculosis SCAID 187.0 ALB20304.1     13
 BEE64_3207   Mycobacterium tuberculosis SCAID 252.0 AOE37514.1     13
 BEE65_3221   Mycobacterium tuberculosis SCAID 320.0 ANZ83824.1     13
 J112_16595   Mycobacterium tuberculosis str. Beijing/NITR203 AGJ69214.1     13
 ERDMAN_3388   Mycobacterium tuberculosis str. Erdman = ATCC 35801 BAL67164.1     13
 TBHG_03026   Mycobacterium tuberculosis str. Haarlem EBA43281.1     13
 KURONO_3477   Mycobacterium tuberculosis str. Kurono BAQ07256.1     13
 UDA_3096   Mycobacterium tuberculosis UT205 CCE38552.1     13
 TBPG_000881   Mycobacterium tuberculosis W-148 EGE49615.1     13
 IZ84_16510   Mycobacterium tuberculosis ZMC13-264 AII91689.1     13
 JE53_16490   Mycobacterium tuberculosis ZMC13-88 AII95605.1     13
 MUL_3476   Mycobacterium ulcerans Agy99 ABL05635.1 A0PTG6   13
 SHTP_1495   Mycobacterium ulcerans subsp. shinshuense ATCC 33728 BAV40748.1     13
 GR01_23470   Mycobacteroides chelonae ATCC 35752 AKC40943.1     13
 BB28_24455   Mycobacteroides chelonae CCUG 47445 ANB00698.1     13
 ABG82_26960   Mycobacteroides immunogenum CCUG 47286 AMT73362.1     13
 BAB75_27220   Mycobacteroides immunogenum FLAC016 ANO06525.1     13
 JDM601_1620   Mycolicibacter sinensis JDM601 AEF35620.1     13
 SAMEA4434518_01533   Mycolicibacter terrae NCTC10856 SNV67673.1     13
 Mycch_5155   Mycolicibacterium chubuense NBB4 AFM19841.1     13
 XA26_09700   Mycolicibacterium fortuitum CT6 ALI24830.1     13
 XA26_60140   Mycolicibacterium fortuitum CT6 ALI29797.1     13
 ATO49_28450   Mycolicibacterium fortuitum subsp. fortuitum DSM 46621 = ATCC 6841 AMD56219.1     13
 ATO49_04625   Mycolicibacterium fortuitum subsp. fortuitum DSM 46621 = ATCC 6841 AMD53999.1     13
 Mflv_1032   Mycolicibacterium gilvum PYR-GCK ABP43515.1 A4T485   13
 Mspyr1_51560   Mycolicibacterium gilvum Spyr1 ADU01683.1     13
 AFA91_11345   Mycolicibacterium goodii X7B AKS36268.1     13
 AFA91_05335   Mycolicibacterium goodii X7B AKS36099.1     13
 D174_02715   Mycolicibacterium neoaurum VKM Ac-1815D AHC23565.1     13
 D174_25885   Mycolicibacterium neoaurum VKM Ac-1815D AIL29994.1     13
 MycrhN_1746   Mycolicibacterium rhodesiae NBB3 AEV72358.1     13
 LI99_32720   Mycolicibacterium smegmatis INHR1 AIU18216.1     13
 LI99_29070   Mycolicibacterium smegmatis INHR1 AIU17506.1     13
 LI98_32725   Mycolicibacterium smegmatis INHR2 AIU24838.1     13
 LI98_29075   Mycolicibacterium smegmatis INHR2 AIU24129.1     13
 MSMEG_5877   Mycolicibacterium smegmatis MC2 155 ABK71060.1
AFP42152.1
AIU10881.1
A0R4L5   13
 MSMEG6581   Mycolicibacterium smegmatis MC2 155 ABJ96330.1
AFP42867.1
AIU11591.1
A4ZHU0   13
 D806_057590   Mycolicibacterium smegmatis MKD8 AWT56700.1     13
 D806_065000   Mycolicibacterium smegmatis MKD8 AWT57433.1     13
 ERS451418_05695   Mycolicibacterium smegmatis NCTC8159 CKI39998.1     13
 ERS451418_06440   Mycolicibacterium smegmatis NCTC8159 CKI60198.1     13
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