Glycoside Hydrolase Family 5 / Subf 12

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (241); Uniprot accession (33);
All (231) Bacteria (40) Eukaryota (191) Characterized (5)
| 1 | 2 |
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 secreted protein   Achlya hypogyna ATCC 48635 AIG56220.1     12
 ALNC14_001090 (Alnc14c1g102)   Albugo laibachii Nc14 CCA13966.1     12
 EGX47422.1   Arthrobotrys oligospora ATCC 24927 EGX47422.1     12
 EGX45042.1   Arthrobotrys oligospora ATCC 24927 EGX45042.1     12
 glucosylceramidase / EGCase related protein 1 (EGCrP1) 3.2.1.45 Aspergillus fumigatus BAL46041.1     12
 AN3013.2   Aspergillus nidulans FGSC A4 EAA63584.1 C8VIW0
Q5B8W7
  12
 An16g02100   Aspergillus niger CBS 513.88 CAL00434.1 A2R731   12
 AO090005001389   Aspergillus oryzae RIB40 BAE56314.1 Q2UQ51   12
 glycoside hydrolase family 5 protein (Bofut4_p067310.1) (fragment)   Botrytis cinerea T4 CCD43323.1     12
 Sequence 15038 from patent US 6747137   Candida albicans AAV03081.1     12
 CAALFM_C505360CA   Candida albicans SC5314 AOW29940.1     12
 CD36_54960   Candida dubliniensis CD36 CAX41875.1 B9WI78   12
 CAGL0L09493g   Candida glabrata CBS 138 CAG62156.1 Q6FKQ8   12
 SAMEA4029010_CIC11G00000004496   [Candida] intermedia CBS 141442 SGZ57837.1     12
 SAMEA4029009_CIC11G00000004340   [Candida] intermedia PYCC 4715 SGZ58843.1     12
 CORT_0F00270   Candida orthopsilosis Co 90-125 CCG24256.1     12
 CPAR2_100160   Candida parapsilosis CDC317 CCE39978.1     12
 ORF   Coccidioides posadasii ABA54914.1 Q3HYB8   12
 CGB_A6500C   Cryptococcus gattii WM276 ADV19799.1     12
 CGB_L3160C   Cryptococcus gattii WM276 ADV25373.1     12
 β-glucocerebrosidase (EGCrP1;CNAG_00623) 3.2.1.45 Cryptococcus neoformans var. grubii H99 BAL46040.1
AFR92751.1
AFR92751.2
    12
 steryl β-glucosidase (EGCrP2;CNAG_05607) (vacuolar) 3.2.1.104 Cryptococcus neoformans var. grubii H99 AFR99035.1     12
 CNA06030   Cryptococcus neoformans var. neoformans JEC21 AAW41138.1 Q5KNL9   12
 CNH02490   Cryptococcus neoformans var. neoformans JEC21 AAW45118.1
AAW45117.1
Q5KCW8
Q5KCW9
  12
 CYFA0S_03e01992g   Cyberlindnera fabianii YJS4271 CDR39305.1     12
 DEHA0D15136g   Debaryomyces hansenii CBS767 CAG87248.1 Q6BRU0   12
 Ecym_1266   Eremothecium cymbalariae DBVPG#7215 AET37508.1     12
 AAR017W   Eremothecium gossypii ATCC 10895 AAS50382.1 Q75ER2   12
 FAGOS_FAAR017W   Eremothecium gossypii FDAG1 AEY94668.1     12
 AW171_hschr63925   Eremothecium sinecaudum ATCC 58844 AMD21928.1     12
 FFUJ_13562   Fusarium fujikuroi IMI 58289 CCT67355.1     12
 FFUJ_07722   Fusarium fujikuroi IMI 58289 CCT68897.1     12
 unnamed protein product   Fusarium graminearum PH-1 CEF88748.1     12
 unnamed protein product   Fusarium graminearum PH-1 CEF75026.1     12
 ORF   Hypocrella siamensis MTCC 10142 ANH56410.1     12
 KAFR_0G00170 (Kafr0g00170)   Kazachstania africana CBS 2517 CCF59050.1     12
 KAFR_0K01030 (Kafr0k01030)   Kazachstania africana CBS 2517 CCF60459.1     12
 KNAG_0E03600 (Knag0e03600)   Kazachstania naganishii CBS 8797 type strain:CBS 8797 CCK70617.1     12
 KLLA0B11704g   Kluyveromyces lactis NRRL Y-1140 CAH02444.1 Q6CVI8   12
 KLMA_70317   Kluyveromyces marxianus DMKU3-1042 BAO42165.1     12
 KMAR_70289   Kluyveromyces marxianus NBRC 1777 BAP73573.1     12
 ATY40_BA7502971 (Yir007W)   Komagataella pastoris ATCC 28485 ANZ75469.1     12
 AT249_GQ6704659 (Yir007W)   Komagataella phaffii ATCC 76273 AOA65127.1     12
 PP7435_Chr4-0672   Komagataella phaffii CBS 7435 CCA40830.1     12
 PAS_chr4_0321   Komagataella phaffii GS115 CAY71564.1
AOA70086.1
C4R7I9   12
 KLTH0F13706g   Lachancea thermotolerans CBS 6340 CAR24346.1     12
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX97977.1 E5A3V3   12
 LRAMOSA05754   Lichtheimia ramosa CDS13578.1     12
 LRAMOSA07974   Lichtheimia ramosa CDS05446.1     12
 MG00882.4   Magnaporthe oryzae 70-15 XP_368362.1 G4NDR4   12
 MSYG_2409 (fragment)   Malassezia sympodialis ATCC 42132 SHO78067.1     12
 BN887_02040   Melanopsichium pennsylvanicum 4 CDI51196.1     12
 BN887_04738   Melanopsichium pennsylvanicum 4 CDI54550.1     12
 GNLVRS01_PISO0L01419g (Piso0_003735)   Millerozyma farinosa CBS 7064 CCE84194.1     12
 GNLVRS01_PISO0K01418g (Piso0_003735)   Millerozyma farinosa CBS 7064 CCE83163.1     12
 NCAS_0F01050 (Ncas0f01050)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC70589.1     12
 NDAI_0H01560 (Ndai0h01560)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD26330.1     12
 NCU02233.1   Neurospora crassa OR74A XP_331009.1 Q7S4G1   12
 Pc16g10690   Penicillium rubens Wisconsin 54-1255 CAP93739.1 B6H988   12
 Pc20g03840   Penicillium rubens Wisconsin 54-1255 CAP85713.1 B6HH54   12
 unnamed protein product   Podospora anserina S mat+ CAP64662.1
CDP30059.1
B2AKZ0   12
 β-glucosylceramidase (EGCrP1;RO3G_04172) 3.2.1.45 Rhizopus delemar RA 99-880 EIE79467.1     12
 RHTO0S_07e07690g   Rhodotorula toruloides CECT1137 CDR43066.1     12
 RHTO0S_18e01464g   Rhodotorula toruloides CECT1137 CDR48502.1     12
 EC1118_1I12_2124g   Saccharomyces cerevisiae EC1118 Lalvin EC1118 CAY80519.1 C8ZAQ6   12
 flavonoid β-glucosidase (YIR007W;YIB7W) 3.2.1.21 Saccharomyces cerevisiae S288c NP_012272.1
CAA86077.1
CAA86209.1
P40566   12
 F842_YJM1078I00182   Saccharomyces cerevisiae YJM1078 AJP39472.1     12
 H635_YJM1083I00180   Saccharomyces cerevisiae YJM1083 AJR43000.1     12
 H668_YJM1129I00186   Saccharomyces cerevisiae YJM1129 AJR43193.1     12
 H781_YJM1133I00183   Saccharomyces cerevisiae YJM1133 AJR43385.1     12
 H782_YJM1190I00184   Saccharomyces cerevisiae YJM1190 AJR43579.1     12
 H783_YJM1199I00184   Saccharomyces cerevisiae YJM1199 AJR43771.1     12
 H784_YJM1202I00182   Saccharomyces cerevisiae YJM1202 AJR43959.1     12
 H785_YJM1208I00182   Saccharomyces cerevisiae YJM1208 AJR44151.1     12
 H786_YJM1242I00180   Saccharomyces cerevisiae YJM1242 AJR44346.1     12
 H787_YJM1244I00181   Saccharomyces cerevisiae YJM1244 AJR44539.1
AJR44539.1
    12
 H788_YJM1248I00179   Saccharomyces cerevisiae YJM1248 AJR44732.1     12
 H789_YJM1250I00184   Saccharomyces cerevisiae YJM1250 AJR44924.1     12
 H790_YJM1252I00182   Saccharomyces cerevisiae YJM1252 AJR45305.1     12
 H791_YJM1273I00182   Saccharomyces cerevisiae YJM1273 AJR45496.1     12
 H792_YJM1304I00186   Saccharomyces cerevisiae YJM1304 AJR45688.1     12
 H793_YJM1307I00177   Saccharomyces cerevisiae YJM1307 AJR45876.1     12
 H794_YJM1311I00178   Saccharomyces cerevisiae YJM1311 AJR46065.1     12
 H795_YJM1326I00182   Saccharomyces cerevisiae YJM1326 AJR46254.1     12
 H796_YJM1332I00183   Saccharomyces cerevisiae YJM1332 AJR46447.1
AJR46447.1
    12
 H797_YJM1336I00184   Saccharomyces cerevisiae YJM1336 AJR46639.1     12
 H798_YJM1338I00187   Saccharomyces cerevisiae YJM1338 AJR46832.1     12
 H799_YJM1341I00183   Saccharomyces cerevisiae YJM1341 AJR47026.1     12
 H800_YJM1342I00181   Saccharomyces cerevisiae YJM1342 AJR47215.1     12
 H801_YJM1355I00178   Saccharomyces cerevisiae YJM1355 AJR47404.1     12
 H802_YJM1356I00184   Saccharomyces cerevisiae YJM1356 AJR47599.1     12
 H803_YJM1381I00179   Saccharomyces cerevisiae YJM1381 AJR47790.1     12
 H804_YJM1383I00161   Saccharomyces cerevisiae YJM1383 AJR47957.1     12
 H805_YJM1385I00184   Saccharomyces cerevisiae YJM1385 AJR48148.1     12
 H806_YJM1386I00182   Saccharomyces cerevisiae YJM1386 AJR48339.1
AJR48339.1
    12
 H807_YJM1387I00187   Saccharomyces cerevisiae YJM1387 AJR48533.1     12
 H808_YJM1388I00181   Saccharomyces cerevisiae YJM1388 AJR48726.1     12
 H809_YJM1389I00179   Saccharomyces cerevisiae YJM1389 AJR48918.1     12
 H811_YJM1400I00187   Saccharomyces cerevisiae YJM1400 AJR49247.1     12
 H812_YJM1401I00180   Saccharomyces cerevisiae YJM1401 AJR49432.1     12
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