Glycoside Hydrolase Family 5 / Subf 12

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (246); Uniprot accession (33);
All (235) Bacteria (42) Eukaryota (193) Characterized (5)
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 glucosylceramidase / EGCase related protein 1 (EGCrP1) 3.2.1.45 Aspergillus fumigatus BAL46041.1     12
 β-glucocerebrosidase (EGCrP1;CNAG_00623) 3.2.1.45 Cryptococcus neoformans var. grubii H99 BAL46040.1
AFR92751.1
AFR92751.2
    12
 steryl β-glucosidase (EGCrP2;CNAG_05607) (vacuolar) 3.2.1.104 Cryptococcus neoformans var. grubii H99 AFR99035.1     12
 β-glucosylceramidase (EGCrP1;RO3G_04172) 3.2.1.45 Rhizopus delemar RA 99-880 EIE79467.1     12
 flavonoid β-glucosidase (YIR007W;YIB7W) 3.2.1.21 Saccharomyces cerevisiae S288c NP_012272.1
CAA86077.1
CAA86209.1
P40566   12
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