Glycoside Hydrolase Family 5 / Subf 12

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (246); Uniprot accession (33);
All (235) Bacteria (42) Eukaryota (193) Characterized (5)
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 Arad_12368   Agrobacterium radiobacter K84 ACM31353.1 B9JQD4   12
 ANT_22130   Anaerolinea thermophila UNI-1 BAJ64239.1     12
 BN1012_Phect2408   Candidatus Phaeomarinobacter ectocarpi Ec32 CDO60621.1     12
 CSW64_03055   Caulobacter mirabilis FWC 38 ATQ41465.1     12
 CSW64_08300   Caulobacter mirabilis FWC 38 ATQ42414.1     12
 A0128_21340   Leptospira alstonii GWTS #1 AOP36551.1     12
 LBF_0966   Leptospira biflexa serovar Patoc strain Patoc 1 (Ames) ABZ93493.1 B0SEF0   12
 LEPBI_I0998   Leptospira biflexa serovar Patoc strain Patoc 1 (Paris) ABZ97122.1 B0SMH8   12
 LBBP_04305   Leptospira borgpetersenii serovar Ballum 56604 ALO28419.1     12
 LBK30_17140   Leptospira borgpetersenii serovar Hardjo BK-30 AMX66455.1     12
 LBK6_17210   Leptospira borgpetersenii serovar Hardjo BK-6 AMX59981.1     12
 LBK9_17150   Leptospira borgpetersenii serovar Hardjo BK-9 AMX63211.1     12
 LBHA_17095   Leptospira borgpetersenii serovar Hardjo NVSL S 1343 AMX69682.1     12
 LBHB_17010   Leptospira borgpetersenii serovar Hardjo NVSL S 818 AMX72839.1     12
 LBJ_4208   Leptospira borgpetersenii serovar Hardjo-bovis str. JB197 ABJ77589.1 Q04ND1   12
 LBL_4222   Leptospira borgpetersenii serovar Hardjo-bovis str. L550 ABJ80534.1 Q04WL1   12
 LB4E_3780   Leptospira borgpetersenii str. 4E ANH02483.1
APY25321.1
    12
 LB4E_3822   Leptospira borgpetersenii str. 4E ANH02523.1     12
 BRAT_19440   Leptospira interrogans serovar Bratislava PigK151 AKH79335.1     12
 B2G47_20680   Leptospira interrogans serovar Canicola 114 ASV08036.1     12
 B2G50_20770   Leptospira interrogans serovar Canicola 115 ASV10369.1     12
 A6J42_00785   Leptospira interrogans serovar Copenhageni FDAARGOS_203 ARB94289.1     12
 LIC20191   Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 AAS72219.1     12
 A9P81_3958   Leptospira interrogans serovar Copenhageni/Icterohaemorrhagiae Piscina APH43389.1     12
 G436_4756   Leptospira interrogans serovar Hardjo str. Norma ALE41883.1     12
 LIH_18805   Leptospira interrogans serovar Hardjo-prajitno Hardjoprajitno ALO02393.1     12
 LB_251   Leptospira interrogans serovar Lai str. 56601 AAN51810.1
NP_714795.1
Q8EXG1   12
 LIF_B199   Leptospira interrogans serovar Lai str. IPAV AER04442.1     12
 LIL_20205   Leptospira interrogans serovar Linhai str. 56609 AJR16407.1     12
 LIMHP_18835   Leptospira interrogans serovar Manilae UP-MMC-NIID HP AKP31874.1     12
 LIMLP_18830   Leptospira interrogans serovar Manilae UP-MMC-NIID LP AKP28092.1     12
 LSS_08974   Leptospira santarosai serovar Shermani str. LT 821 EKT87232.1     12
 Plav_0833   Parvibaculum lavamentivorans DS-1 ABS62456.1 A7HRC3   12
 SAMN05216210_0339   Pseudomonas salegens CECT 8338 SDT90175.1     12
 LH19_20275   Sphingopyxis macrogoltabida 203 ALJ15217.1     12
 ATM17_20820   Sphingopyxis macrogoltabida 203N AMU91463.1     12
 BWQ93_03360   Sphingopyxis sp. QXT-31 APZ97630.1     12
 STHERM_c19870   Spirochaeta thermophila DSM 6192 ADN02922.1 E0RQE6   12
 Spith_2037   Spirochaeta thermophila DSM 6578 AEJ62294.1     12
 TREAZ_2883   Treponema azotonutricium ZAS-9 AEF81891.1     12
 Spica_2572   Treponema caldarium DSM 7334 AEJ20673.1     12
 TREPR_0485   Treponema primitia ZAS-2 AEF86563.1     12
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