Glycoside Hydrolase Family 5 / Subf 10

Activities in Sub Family	Xylan β-1,4-xylosidase (EC 3.2.1.37); Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) ₈ barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (2); Uniprot accession (8); PDB accession (5); 3D entries (4); cryst (0)

Summary

Download GH5_10 (49) Taxonomic display Structure (4) Characterized (8)


Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
endo-β-1,4-mannanase (AkMan;AkManA)	3.2.1.78	Aplysia kurodai	BAJ60954.1	E5RSM0	3VUP[A,B]	10
endo-β-1,4-mannanase 2 (S48) (fragment)		Biomphalaria glabrata	AAV91524.1			10
endo-β-1,4-mannanase 1 (S58)		Biomphalaria glabrata	AAV91523.1			10
β-mannanase (CMA3; CmacGH5-3; GH5-3)	3.2.1.78	Callosobruchus maculatus	ADU33273.1	E7CIR1		10
CmacGH5-4 / Gh5-4		Callosobruchus maculatus	ADU33274.1			10
CmacGH5-1 / Gh5-1		Callosobruchus maculatus	ADU33271.1			10
endo-β-1,4-xylanase (CMA2; CmacGH5-2; GH5-2)	3.2.1.37	Callosobruchus maculatus	ADU33272.1	E7CIR0		10
mannanase (fragment)		Cherax quadricarinatus	AIN40245.1			10
endo-β-1,4-mannanase (Man;CaMan)	3.2.1.78	Cryptopygus antarcticus	ABV68808.1	B4XC07	4OOU[A,B] 4OOZ[A,B]	10
endo-1,4-β-mannanase	3.2.1.78	Eisenia fetida	BBB35836.1	A0A2Z5VGG0	5Y6T[A]	10
104152		Emiliania huxleyi (Emihu1)				10
213300		Emiliania huxleyi (Emihu1)				10
β-mannanase (GVI1; GH5-1)	3.2.1.78	Gastrophysa viridula	ADU33333.1	E7CIX1		10
GFXJ01006156		Gecarcoidea natalis	AYM45055.1			10
endo-β-1,4-mannanase		Haliotis discus discus	ACJ12612.1			10
β-1,4-mannanase (ManHDD)		Haliotis discus discus	BAI99559.1			10
endo-β-1,4-mannanase (Man1;HdMan)	3.2.1.78	Haliotis discus hannai	BAE78456.1	Q2MH89		10
GH5A		Limnoria quadripunctata	ADE58567.1			10
GH5C		Limnoria quadripunctata	ADE58568.1			10
GH5E		Limnoria quadripunctata	ADE58569.1			10
EOG090X0A8N (fragment)		Megafenestra aurita	SVE92541.1			10
EOG090X0A8N (fragment)		Megafenestra aurita	CAG4647256.1			10
MAR_000621		Mya arenaria isolate MELC-2E11	WAR18783.1			10
endo-β-1,4-mannanase (Man5A)	3.2.1.78	Mytilus edulis	CAC81056.1	Q8WPJ2	2C0H[A]	10
NMOB1V02_LOCUS10593 (fragment)		Notodromas monacha	CAD7282975.1			10
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