Activities in Family	Endo-α-sialidase (EC 3.2.1.129);
Mechanism	Inverting e
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	water activated by carboxylate of substrate
Catalytic Proton Donor	Glu
External resources	CAZypedia; PRINTS;
Statistics	GenBank accession (227); Uniprot accession (6); PDB accession (7); 3D entries (2); cryst (0)

Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
ECRS218_0003		Enterobacteria phage CUS-3	ABQ88383.1 CAY90197.1 CAZ00764.1 CAZ00804.1
endosialidase (Gp90;End;Endo-N;PK1E)	3.2.1.129	Enterobacteria phage K1	CAA55120.1 CAA85449.2	P49714
endosialidase (PK1A)	3.2.1.129	Enterobacteria phage K1A	ABP02011.1	A4UUQ0
tail spike protein (fragment)		Escherichia phage 2307YX22	WPH64569.1
ECO340P2_00118		Escherichia phage ECO340P2	WAX14660.1
neuraminidase		Escherichia phage ESCO5	AOT23219.1
G_1		Escherichia phage G AB-2017	AQN31758.1
neuraminidase		Escherichia phage JSSK01	WFD55387.1
endosialidase NF (SiA;EndoNF;PK1F)	3.2.1.129	Escherichia phage K1F	CAD44528.2 AAC37340.1 AAZ73001.1 CAJ29390.1	Q04830 Q858B1	1V0E[A,B,C,D,E,F] 1V0F[A,B,C,D,E,F] 3GVJ[A] 3GVK[A,B,C] 3GVL[A] 3JU4[A]
tailspike 63D sialidase		Escherichia phage K1G	ADA82273.1
tailspike 63D sialidase		Escherichia phage K1H	ADA82322.1
L_66		Escherichia phage L AB-2017	AQN31891.1
ORF		Escherichia phage Mt1B1_P10	QNR52595.1
ORF		Escherichia phage Mt1B1_P3	QNJ49132.1
neuraminidase		Escherichia phage nepoznato	QHR65696.1
P_4		Escherichia phage P AB-2017	AQN31942.1
phAPEC8_00171		Escherichia phage phAPEC8	AFU62742.1
α-2,8-/α-2,9-specific endosialidase (endoN92;PHI92_143)	3.2.1.129	Escherichia phage phi92 ATCC 35860-B1	CBY99572.1	I7HXG2	4HIZ[A,B,C]
tail fiber protein		Escherichia phage phiv205-1	QGF19902.1
tail fiber protein		Escherichia phage PNJ1809-36	QPI13004.1
endosialidase		Escherichia phage UE-S5a	WVP99841.1
neuraminidase		Escherichia phage ULINTec2	UCR81107.1
neuraminidase		Escherichia phage ULINTec4	UCR91807.1
neuraminidase		Escherichia phage ULINTec6	UCR91863.1
neuraminidase		Escherichia phage ULINTec7	UCR91920.1
tailspike		Escherichia phage UTI-CM001	UMW88000.1
ASO2B_043		Escherichia phage vB_EcoA_ASO2B	UAW58429.1
tail spike endosialidase		Escherichia phage vB_EcoA_fTuEco01	QVW53780.1
ASO2A_173		Escherichia phage vB_EcoM_ASO2A	UAW58282.1
ORF		Escherichia phage vB_EcoM_IME392	AXY86125.1
neuraminidase		Escherichia phage vB_EcoM_REC	UPW40272.1
tail fibers protein		Escherichia phage vB_EcoP-720R6	URC09763.1
UTI89UKE2_052		Escherichia phage vB_EcoP-UTI89UKE2	QZI84586.1
UTI89UKE3_052		Escherichia phage vB_EcoP-UTI89UKE3	QZI84653.1
ACG-C91_0053		Escherichia phage vB_EcoP_ACG-C91 vB_EcoP_C91	AFH19879.1
B_36		Escherichia phage vB_EcoP_B	AQN31620.1
C_10		Escherichia phage vB_EcoP_C	AQN31649.1
D_40		Escherichia phage vB_EcoP_D	AQN31738.1
F_2		Escherichia phage vB_EcoP_F	AQT25396.1
catalytic beta propeller domain of endosialidase		Escherichia phage vB_EcoP_FFK3	UTQ72503.1
K_17		Escherichia phage vB_EcoP_K	AQN31909.1
KAW1A4500_00056		Escherichia phage vB_EcoP_KAW1A4500	QBQ76762.1
neuraminidase		Escherichia phage vB_EcoP_PR_Kaz2018	QFP92956.1
R_42		Escherichia phage vB_EcoP_R	AQN32042.1
tail fiber domain-containing protein		Escherichia phage vB_EcoP_ZX5	QTH80017.1
KE1_029		Escherichia phage vB_EcoS_fKuEco01	QNO11744.1
TE1_028		Escherichia phage vB_EcoS_fTaEco01	QNO11892.1
TE3_029		Escherichia phage vB_EcoS_fTaEco03	QNO11966.1
GT371_00076		Escherichia phage vB_EcoS_XY1	QIG59267.1
1127AP1_21		Mannheimia phage vB_MhM_1127AP1	AJA73073.1
587AP1_21		Mannheimia phage vB_MhM_587AP1	AJA72945.1
endosialidase (endoN63D)	3.2.1.129	Phage #D	BAA32990.1	O80102
ORF		Phage E	CAA03522.1 AAO31362.1
tail fibers protein		Salmonella phage IME207	ANW46772.1
endosialidase		Vectrevirus AAPEc6	ANT40789.1
K1 endosialidase		Vectrevirus K15	AAG59822.1
Gp47		Vectrevirus K1E	CAJ29458.1 AQY55045.1
mutPK1A2_p60		Vectrevirus mutPK1A2	ATS93359.1
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