Glycoside Hydrolase Family 58

Activities in Familyendo-N-acetylneuraminidase or endo-sialidase (EC 3.2.1.129)
Mechanism Inverting
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/Basewater activated by carboxylate of substrate
Catalytic Proton DonorGlu
External resourcesCAZypedia; PRINTS;
Statistics GenBank accession (64); Uniprot accession (19); PDB accession (7); 3D entries (2); cryst (0)
Viruses
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 endosialidase NF (SiA;EndoNF;PK1F) 3.2.1.129 Enterobacteria phage K1F CAD44528.2
AAC37340.1
AAZ73001.1
CAJ29390.1
Q04830
Q858B1
1V0E[A,B,C,D,E,F] 1.9
1V0F[A,B,C,D,E,F] α-D-Neup5Ac-(2-8)-α-D-Neup5Ac
β-D-Neup5Ac
2.55
3GVJ[A] α-D-Neup5Ac-(2-8)-α-D-Neup5Ac-(2-8)-α-D-Neup5Ac-(2-8)-α-D-Neup5Ac-(2-8)-β-D-Neup5Ac
α-D-Neup5Ac-(2-8)-α-D-Neup5Ac-(2-8)-α-D-Neup5Ac-(2-8)-β-D-Neup5Ac
1.48
3GVK[A,B,C] α-D-Neup5Ac-(2-8)-α-D-Neup5Ac-(2-8)-β-D-Neup5Ac
α-D-Neup5Ac-(2-8)-β-D-Neup5Ac
1.84
3GVL[A] α-D-Neup5Ac-(2-8)-β-D-Neup5Ac
β-D-Neup5Ac
1.41
3JU4[A] β-D-Neup5Ac
0.98
 α-2,8-/α-2,9-specific endosialidase (endoN92;PHI92_143) 3.2.1.129 Enterobacteria phage phi92 ATCC 35860-B1 CBY99572.1  
4HIZ[A,B,C] α-D-Glcp-(1-2)-β-D-Fruf
α-D-Neup5Ac-(2-9)-β-D-Neup5Ac
1.60
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