Activities in Family	endo-N-acetylneuraminidase or endo-sialidase (EC 3.2.1.129)
Mechanism	Inverting
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	water activated by carboxylate of substrate
Catalytic Proton Donor	Glu
External resources	CAZypedia; PRINTS;
Statistics	GenBank accession (77); Uniprot accession (19); PDB accession (7); 3D entries (2); cryst (0)

Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
endosialidase NF (SiA;EndoNF;PK1F)	3.2.1.129	Enterobacteria phage K1F	CAD44528.2 AAC37340.1 AAZ73001.1 CAJ29390.1	Q04830 Q858B1	1V0E[A,B,C,D,E,F] 1.9 1V0F[A,B,C,D,E,F] α-D-Neup5Ac-(2-8)-α-D-Neup5Ac β-D-Neup5Ac 2.55 3GVJ[A] α-D-Neup5Ac-(2-8)-α-D-Neup5Ac-(2-8)-α-D-Neup5Ac-(2-8)-α-D-Neup5Ac-(2-8)-β-D-Neup5Ac α-D-Neup5Ac-(2-8)-α-D-Neup5Ac-(2-8)-α-D-Neup5Ac-(2-8)-β-D-Neup5Ac 1.48 3GVK[A,B,C] α-D-Neup5Ac-(2-8)-α-D-Neup5Ac-(2-8)-β-D-Neup5Ac α-D-Neup5Ac-(2-8)-β-D-Neup5Ac 1.84 3GVL[A] α-D-Neup5Ac-(2-8)-β-D-Neup5Ac β-D-Neup5Ac 1.41 3JU4[A] β-D-Neup5Ac 0.98
α-2,8-/α-2,9-specific endosialidase (endoN92;PHI92_143)	3.2.1.129	Enterobacteria phage phi92 ATCC 35860-B1	CBY99572.1		4HIZ[A,B,C] α-D-Glcp-(1-2)-β-D-Fruf α-D-Neup5Ac-(2-9)-β-D-Neup5Ac 1.60
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