Glycoside Hydrolase Family 58

Activities in Familyendo-N-acetylneuraminidase or endo-sialidase (EC 3.2.1.129)
Mechanism Inverting
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/Basewater activated by carboxylate of substrate
Catalytic Proton DonorGlu
External resourcesCAZypedia; PRINTS;
Statistics GenBank accession (207); Uniprot accession (19); PDB accession (7); 3D entries (2); cryst (0)
All (197) Bacteria (157) Viruses (40) Structure (2) Characterized (5)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 FNJ72_10315   Escherichia coli 144 QDN15196.1    
 FNJ72_11255   Escherichia coli 144 QDN15365.1    
 L282_0469   Escherichia coli APEC IMT5155 AJB35461.1    
 APECO1_4216   Escherichia coli APEC O1 ABJ01737.1 A1ADJ7  
 APECO1_4058   Escherichia coli APEC O1 ABJ01894.1 A1AE04  
 APECO18_08060   Escherichia coli APEC O18 AKK34054.1    
 AM344_01840   Escherichia coli AR_0017 ATY17636.1    
 FQU84_19775   Escherichia coli BCE049 QDX45441.1    
 APEC2908_2483   Escherichia coli BEN2908 CAA0094175.1    
 APEC5202_2533   Escherichia coli BEN5202 VZZ88880.1    
 APEC5202_2366 (fragment)   Escherichia coli BEN5202 VZZ88713.1    
 APEC5202_2369 (fragment)   Escherichia coli BEN5202 VZZ88716.1    
 EAS44_24155   Escherichia coli DSM 30083 = JCM 1649 = ATCC 11775 AYO74985.1    
 G5V60_07545   Escherichia coli EC28 QIE81248.1    
 BE939_19340   Escherichia coli Ecol_AZ159 AQW03046.1    
 DV870_25925   Escherichia coli Es_ST80_L1_NDM_10_2017 AXH20969.1    
 DV870_00005   Escherichia coli Es_ST80_L1_NDM_10_2017 AXH16509.1    
 CXG97_04460   Escherichia coli ExPEC XM AUG63726.1    
 CXG97_14715   Escherichia coli ExPEC XM AUG65528.1    
 CXG97_13770   Escherichia coli ExPEC XM AUG65359.1    
 AVR74_12210   Escherichia coli G749 AML05483.1    
 C3K24_06465   Escherichia coli HS13-1 AUY43386.1    
 ECIAI39_2657   Escherichia coli IAI39 CAR18780.1 B7NQQ5  
 ECOK1_2807   Escherichia coli IHE3034 ADE90020.1 D5CWU1  
 ECOK1_2632   Escherichia coli IHE3034 ADE92784.1 D5D7W7  
 endoNK1 (SiaK1)   Escherichia coli K1 PHAGE CAJ29292.1 Q2L3B7  
 MS7163_02454   Escherichia coli MS7163 AVQ76833.1    
 MS8345_02647   Escherichia coli MS8345 AUG94238.1    
 NCTC11151_01568 (Sia_1) (fragment)   Escherichia coli NCTC11151 VDY74550.1    
 NCTC11151_01570 (Sia_2) (fragment)   Escherichia coli NCTC11151 VDY74551.1    
 ERS451419_04682 (SiA)   Escherichia coli NCTC9001 CKI30283.1    
 NMECO18_11580 (fragment)   Escherichia coli NMEC O18 AKK43502.1    
 B0908_13470   Escherichia coli NU14 AQX97566.1    
 CE10_2889   Escherichia coli O7:K1 str. CE10 AEQ13642.1    
 PA45B_4018   Escherichia coli PA45B ASW60461.1    
 ECOPMV1_02507   Escherichia coli PMV-1 CDH65916.1    
 FQU83_08875   Escherichia coli PU-1 QDX35856.1    
 FQU83_18530   Escherichia coli PU-1 QDX37596.1    
 FQU83_09805   Escherichia coli PU-1 QDX36028.1    
 ECS88_2497   Escherichia coli S88 CAR03775.1 B7MGW6  
 HHJ26_05630   Escherichia coli SCU-108 QJG01986.1    
 HHJ36_05635   Escherichia coli SCU-123 QJG34256.1    
 HHJ37_07075   Escherichia coli SCU-124 QJG39403.1    
 HHJ38_22710   Escherichia coli SCU-125 QJG46703.1    
 AN205_07530   Escherichia coli SF-173 ALD29529.1    
 AN206_07500   Escherichia coli SF-468 ALD24287.1    
 AN206_08445   Escherichia coli SF-468 ALD24460.1    
 F3J96_17495   Escherichia coli ST95-32 QER71611.1    
 F3J96_18465   Escherichia coli ST95-32 QER71785.1    
 UM146_05075   Escherichia coli UM146 ADN70420.1 E1RT14  
 UTI89_C2636   Escherichia coli UTI89 ABE08102.1 Q1R962  
 ECVR50_2712   Escherichia coli VR50 AKA91559.1    
 ECVR50_1087   Escherichia coli VR50 AKA90025.1    
 BG543_07340   Mannheimia haemolytica 1329 QEA86680.1    
 BG543_03700   Mannheimia haemolytica 1329 QEA86013.1    
 BG543_07080   Mannheimia haemolytica 1329 QEA86631.1    
 BG558_03690   Mannheimia haemolytica 1367 QEA91165.1    
 BG558_06090   Mannheimia haemolytica 1367 QEA91597.1    
 BG558_07430   Mannheimia haemolytica 1367 QEA91844.1    
 BG544_06920   Mannheimia haemolytica 1567 QEB41148.1    
 BG544_06660   Mannheimia haemolytica 1567 QEB41099.1    
 BG544_03690   Mannheimia haemolytica 1567 QEB40556.1    
 BG559_03710   Mannheimia haemolytica 1571 QEB42981.1    
 BG559_07145   Mannheimia haemolytica 1571 QEB43599.1    
 BG545_06655   Mannheimia haemolytica 1583 QEB51087.1    
 BG545_03695   Mannheimia haemolytica 1583 QEB50548.1    
 BG545_06920   Mannheimia haemolytica 1583 QEB51137.1    
 BG563_06820   Mannheimia haemolytica 22604 QEB61385.1    
 BG563_07080   Mannheimia haemolytica 22604 QEB61434.1    
 BG563_03865   Mannheimia haemolytica 22604 QEB60848.1    
 BG564_03865   Mannheimia haemolytica 22650 QEB63259.1    
 BG564_06820   Mannheimia haemolytica 22650 QEB63793.1    
 BG564_07080   Mannheimia haemolytica 22650 QEB63842.1    
 BG560_06975   Mannheimia haemolytica 23217 QEB66246.1    
 BG560_06715   Mannheimia haemolytica 23217 QEB66197.1    
 BG560_03685   Mannheimia haemolytica 23217 QEB65646.1    
 BG546_06670   Mannheimia haemolytica 23278 QEB68588.1    
 BG546_03695   Mannheimia haemolytica 23278 QEB68049.1    
 BG546_06930   Mannheimia haemolytica 23278 QEB68637.1    
 BG573_03990   Mannheimia haemolytica 23311 QEB70451.1    
 BG573_07010   Mannheimia haemolytica 23311 QEB70999.1    
 BG553_06645   Mannheimia haemolytica 23533 QEB73254.1    
 BG553_03685   Mannheimia haemolytica 23533 QEB72715.1    
 BG553_06905   Mannheimia haemolytica 23533 QEB73303.1    
 BG554_06655   Mannheimia haemolytica 23558 QEB75669.1    
 BG554_03690   Mannheimia haemolytica 23558 QEB75131.1    
 BG554_06915   Mannheimia haemolytica 23558 QEB75718.1    
 BG555_06655   Mannheimia haemolytica 23570 QEB78088.1    
 BG555_06915   Mannheimia haemolytica 23570 QEB78137.1    
 BG555_03690   Mannheimia haemolytica 23570 QEB77550.1    
 BG556_06910   Mannheimia haemolytica 23579 QEB80554.1    
 BG556_06650   Mannheimia haemolytica 23579 QEB80505.1    
 BG556_03690   Mannheimia haemolytica 23579 QEB79968.1    
 BG574_08945   Mannheimia haemolytica 28226 QEB83334.1    
 BG574_09115   Mannheimia haemolytica 28226 QEB83367.1    
 BG565_06670   Mannheimia haemolytica 28240 QEB85296.1    
 BG565_03700   Mannheimia haemolytica 28240 QEB84755.1    
 BG565_06930   Mannheimia haemolytica 28240 QEB85345.1    
 BG566_06930   Mannheimia haemolytica 28253 QEB87769.1    
 BG566_03700   Mannheimia haemolytica 28253 QEB87180.1    
 BG566_06670   Mannheimia haemolytica 28253 QEB87720.1    
 BG575_03985   Mannheimia haemolytica 32795 QEB97486.1    
 BG575_07005   Mannheimia haemolytica 32795 QEB98036.1    
 BG561_06715   Mannheimia haemolytica 32852 QEC00301.1    
 BG561_03685   Mannheimia haemolytica 32852 QEB99751.1    
 BG561_06975   Mannheimia haemolytica 32852 QEC00350.1    
 BG562_06720   Mannheimia haemolytica 33690 QEC05241.1    
 BG562_06980   Mannheimia haemolytica 33690 QEC05290.1    
 BG562_03690   Mannheimia haemolytica 33690 QEC04691.1    
 BG576_09140   Mannheimia haemolytica 33702 QEC08078.1    
 BG576_06125   Mannheimia haemolytica 33702 QEC07531.1    
 BG577_07005   Mannheimia haemolytica 33980 QEC09998.1    
 BG577_03990   Mannheimia haemolytica 33980 QEC09453.1    
 BG547_06930   Mannheimia haemolytica 34142 QEC12300.1    
 BG547_03700   Mannheimia haemolytica 34142 QEC11712.1    
 BG547_06670   Mannheimia haemolytica 34142 QEC12251.1    
 BG557_06645   Mannheimia haemolytica 37121 QEC14663.1    
 BG557_06905   Mannheimia haemolytica 37121 QEC14712.1    
 BG557_03685   Mannheimia haemolytica 37121 QEC14125.1    
 BG548_03695   Mannheimia haemolytica 37778 QEC16542.1    
 BG548_06925   Mannheimia haemolytica 37778 QEC17133.1    
 BG548_06665   Mannheimia haemolytica 37778 QEC17084.1    
 BG567_06820   Mannheimia haemolytica 38089 QEC19519.1    
 BG567_03865   Mannheimia haemolytica 38089 QEC18982.1    
 BG567_07080   Mannheimia haemolytica 38089 QEC19568.1    
 BG568_06820   Mannheimia haemolytica 38120 QEC21930.1    
 BG568_03860   Mannheimia haemolytica 38120 QEC21392.1    
 BG568_07080   Mannheimia haemolytica 38120 QEC21979.1    
 BG569_06820   Mannheimia haemolytica 38202 QEC24339.1    
 BG569_03865   Mannheimia haemolytica 38202 QEC23805.1    
 BG569_07080   Mannheimia haemolytica 38202 QEC24388.1    
 BG549_06930   Mannheimia haemolytica 39107 QEC29315.1    
 BG549_06670   Mannheimia haemolytica 39107 QEC29266.1    
 BG549_03700   Mannheimia haemolytica 39107 QEC28724.1    
 BG570_06665   Mannheimia haemolytica 39309 QEC31685.1    
 BG570_06925   Mannheimia haemolytica 39309 QEC31734.1    
 BG570_03695   Mannheimia haemolytica 39309 QEC31142.1    
 BG550_03695   Mannheimia haemolytica 39373 QEC33570.1    
 BG550_06665   Mannheimia haemolytica 39373 QEC34112.1    
 BG550_06925   Mannheimia haemolytica 39373 QEC34161.1    
 BG551_06925   Mannheimia haemolytica 39382 QEC36578.1    
 BG551_06665   Mannheimia haemolytica 39382 QEC36529.1    
 BG551_03695   Mannheimia haemolytica 39382 QEC35989.1    
 BG552_06920   Mannheimia haemolytica 39394 QEC38996.1    
 BG552_06660   Mannheimia haemolytica 39394 QEC38947.1    
 BG552_03690   Mannheimia haemolytica 39394 QEC38404.1    
 BG571_03700   Mannheimia haemolytica 39409 QEC59261.1    
 BG571_06670   Mannheimia haemolytica 39409 QEC59803.1    
 BG571_06930   Mannheimia haemolytica 39409 QEC59852.1    
 BG572_06665   Mannheimia haemolytica 39433 QED07518.1    
 BG572_06925   Mannheimia haemolytica 39433 QED07567.1    
 BG572_03695   Mannheimia haemolytica 39433 QED06977.1    
 J450_01565   Mannheimia haemolytica D171 AGQ37890.1    
 J450_10730   Mannheimia haemolytica D171 AGQ39559.1    
 B824_11440   Mannheimia haemolytica USDA-ARS-USMARC-184 AJE07939.1
AJE07939.2
   
 B824_20550   Mannheimia haemolytica USDA-ARS-USMARC-184 AJE08850.1    
 AOX55_00001726   Sinorhizobium fredii CCBAU 25509 AWM24983.1    
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ECRS218_0003   Enterobacteria phage CUS-3 ABQ88383.1
CAY90197.1
CAZ00764.1
CAZ00804.1
A5VW57  
 endosialidase (Gp90;End;Endo-N;PK1E) 3.2.1.129 Enterobacteria phage K1 CAA55120.1
CAA85449.2
P49714  
 endosialidase (PK1A) 3.2.1.129 Enterobacteria phage K1A ABP02011.1 A4UUQ0  
 α-2,8-/α-2,9-specific endosialidase (endoN92;PHI92_143) 3.2.1.129 Enterobacteria phage phi92 ATCC 35860-B1 CBY99572.1   4HIZ[A,B,C]
 neuraminidase   Escherichia phage ESCO5 AOT23219.1    
 G_1   Escherichia phage G AB-2017 AQN31758.1    
 endosialidase NF (SiA;EndoNF;PK1F) 3.2.1.129 Escherichia phage K1F CAD44528.2
AAC37340.1
AAZ73001.1
CAJ29390.1
Q04830
Q858B1
1V0E[A,B,C,D,E,F]
1V0F[A,B,C,D,E,F]
3GVJ[A]
3GVK[A,B,C]
3GVL[A]
3JU4[A]
 tailspike 63D sialidase   Escherichia phage K1G ADA82273.1 D2XJ95  
 tailspike 63D sialidase   Escherichia phage K1H ADA82322.1 D2XJE4  
 L_66   Escherichia phage L AB-2017 AQN31891.1    
 ORF   Escherichia phage Mt1B1_P10 QNR52595.1    
 ORF   Escherichia phage Mt1B1_P3 QNJ49132.1    
 neuraminidase   Escherichia phage nepoznato QHR65696.1    
 P_4   Escherichia phage P AB-2017 AQN31942.1    
 phAPEC8_00171   Escherichia phage phAPEC8 AFU62742.1    
 tail fiber protein   Escherichia phage phiv205-1 QGF19902.1    
 tail fiber protein   Escherichia phage PNJ1809-36 QPI13004.1    
 ORF   Escherichia phage vB_EcoM_IME392 AXY86125.1    
 ACG-C91_0053   Escherichia phage vB_EcoP_ACG-C91 vB_EcoP_C91 AFH19879.1    
 B_36   Escherichia phage vB_EcoP_B AQN31620.1    
 C_10   Escherichia phage vB_EcoP_C AQN31649.1    
 D_40   Escherichia phage vB_EcoP_D AQN31738.1    
 F_2   Escherichia phage vB_EcoP_F AQT25396.1    
 K_17   Escherichia phage vB_EcoP_K AQN31909.1    
 KAW1A4500_00056   Escherichia phage vB_EcoP_KAW1A4500 QBQ76762.1    
 neuraminidase   Escherichia phage vB_EcoP_PR_Kaz2018 QFP92956.1    
 R_42   Escherichia phage vB_EcoP_R AQN32042.1    
 KE1_029   Escherichia phage vB_EcoS_fKuEco01 QNO11744.1    
 TE1_028   Escherichia phage vB_EcoS_fTaEco01 QNO11892.1    
 TE3_029   Escherichia phage vB_EcoS_fTaEco03 QNO11966.1    
 GT371_00076   Escherichia phage vB_EcoS_XY1 QIG59267.1    
 endosialidase   Escherichia virus AAPEc6 ANT40789.1    
 K1 endosialidase   Escherichia virus K1-5 AAG59822.1 Q9AZ46  
 Gp47   Escherichia virus K1E CAJ29458.1
AQY55045.1
Q2WC58  
 mutPK1A2_p60   Escherichia virus mutPK1A2 ATS93359.1    
 1127AP1_21   Mannheimia phage vB_MhM_1127AP1 AJA73073.1    
 587AP1_21   Mannheimia phage vB_MhM_587AP1 AJA72945.1    
 endosialidase (endoN63D) 3.2.1.129 Phage #D BAA32990.1 O80102  
 ORF   Phage E CAA03522.1
AAO31362.1
   
 tail fibers protein   Salmonella phage IME207 ANW46772.1    
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