Glycoside Hydrolase Family 58

Activities in Familyendo-N-acetylneuraminidase or endo-sialidase (EC 3.2.1.129)
Mechanism Inverting
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/Basewater activated by carboxylate of substrate
Catalytic Proton DonorGlu
External resourcesCAZypedia; PRINTS;
Statistics GenBank accession (64); Uniprot accession (19); PDB accession (7); 3D entries (2); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 L282_0469   Escherichia coli APEC IMT5155 AJB35461.1    
 APECO1_4216   Escherichia coli APEC O1 ABJ01737.1 A1ADJ7  
 APECO1_4058   Escherichia coli APEC O1 ABJ01894.1 A1AE04  
 APECO18_08060   Escherichia coli APEC O18 AKK34054.1    
 BE939_19340   Escherichia coli Ecol_AZ159 AQW03046.1    
 AVR74_12210   Escherichia coli G749 AML05483.1    
 ECIAI39_2657   Escherichia coli IAI39 CAR18780.1 B7NQQ5  
 ECOK1_2807   Escherichia coli IHE3034 ADE90020.1 D5CWU1  
 ECOK1_2632   Escherichia coli IHE3034 ADE92784.1 D5D7W7  
 endoNK1 (SiaK1)   Escherichia coli K1 PHAGE CAJ29292.1 Q2L3B7  
 ERS451419_04682 (SiA)   Escherichia coli NCTC9001 CKI30283.1    
 NMECO18_11580 (fragment)   Escherichia coli NMEC O18 AKK43502.1    
 B0908_13470   Escherichia coli NU14 AQX97566.1    
 CE10_2889   Escherichia coli O7:K1 str. CE10 AEQ13642.1    
 PA45B_4018   Escherichia coli PA45B ASW60461.1    
 ECOPMV1_02507   Escherichia coli PMV-1 CDH65916.1    
 ECS88_2497   Escherichia coli S88 CAR03775.1 B7MGW6  
 AN205_07530   Escherichia coli SF-173 ALD29529.1    
 AN206_07500   Escherichia coli SF-468 ALD24287.1    
 AN206_08445   Escherichia coli SF-468 ALD24460.1    
 UM146_05075   Escherichia coli UM146 ADN70420.1 E1RT14  
 UTI89_C2636   Escherichia coli UTI89 ABE08102.1 Q1R962  
 ECVR50_2712   Escherichia coli VR50 AKA91559.1    
 ECVR50_1087   Escherichia coli VR50 AKA90025.1    
 J450_01565   Mannheimia haemolytica D171 AGQ37890.1    
 J450_10730   Mannheimia haemolytica D171 AGQ39559.1    
 B824_11440   Mannheimia haemolytica USDA-ARS-USMARC-184 AJE07939.1
AJE07939.2
   
 B824_20550   Mannheimia haemolytica USDA-ARS-USMARC-184 AJE08850.1    
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ECRS218_0003   Enterobacteria phage CUS-3 ABQ88383.1
CAY90197.1
CAZ00764.1
CAZ00804.1
A5VW57  
 endosialidase (Gp90;End;Endo-N;PK1E) 3.2.1.129 Enterobacteria phage K1 CAA55120.1
CAA85449.2
P49714  
 endosialidase (PK1A) 3.2.1.129 Enterobacteria phage K1A ABP02011.1 A4UUQ0  
 endosialidase NF (SiA;EndoNF;PK1F) 3.2.1.129 Enterobacteria phage K1F CAD44528.2
AAC37340.1
AAZ73001.1
CAJ29390.1
Q04830
Q858B1
1V0E[A,B,C,D,E,F]
1V0F[A,B,C,D,E,F]
3GVJ[A]
3GVK[A,B,C]
3GVL[A]
3JU4[A]
 α-2,8-/α-2,9-specific endosialidase (endoN92;PHI92_143) 3.2.1.129 Enterobacteria phage phi92 ATCC 35860-B1 CBY99572.1   4HIZ[A,B,C]
 ACG-C91_0053   Enterobacteria phage vB_EcoP_ACG-C91 vB_EcoP_C91 AFH19879.1    
 neuraminidase   Escherichia phage ESCO5 AOT23219.1    
 G_1   Escherichia phage G AB-2017 AQN31758.1    
 tailspike 63D sialidase   Escherichia phage K1-dep(1) ADA82322.1 D2XJE4  
 tailspike 63D sialidase   Escherichia phage K1-dep(4) ADA82273.1 D2XJ95  
 L_66   Escherichia phage L AB-2017 AQN31891.1    
 P_4   Escherichia phage P AB-2017 AQN31942.1    
 phAPEC8_00171   Escherichia phage phAPEC8 AFU62742.1    
 B_36   Escherichia phage vB_EcoP_B AQN31620.1    
 C_10   Escherichia phage vB_EcoP_C AQN31649.1    
 D_40   Escherichia phage vB_EcoP_D AQN31738.1    
 F_2   Escherichia phage vB_EcoP_F AQT25396.1    
 K_17   Escherichia phage vB_EcoP_K AQN31909.1    
 R_42   Escherichia phage vB_EcoP_R AQN32042.1    
 endosialidase   Escherichia virus AAPEc6 ANT40789.1    
 K1 endosialidase   Escherichia virus K1-5 AAG59822.1 Q9AZ46  
 Gp47   Escherichia virus K1E CAJ29458.1 Q2WC58  
 1127AP1_21   Mannheimia phage vB_MhM_1127AP1 AJA73073.1    
 587AP1_21   Mannheimia phage vB_MhM_587AP1 AJA72945.1    
 endosialidase (endoN63D) 3.2.1.129 Phage #D BAA32990.1 O80102  
 ORF   Phage E CAA03522.1
AAO31362.1
   
 tail fibers protein   Salmonella phage IME207 ANW46772.1    
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