Known Activities	endo-N-acetylneuraminidase or endo-sialidase (EC 3.2.1.129)
Mechanism	Inverting
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	water activated by carboxylate of substrate
Catalytic Proton Donor	Glu
External resources	CAZypedia; InterPro; PRINTS;
Statistics	GenBank accession (26); Uniprot accession (14); PDB accession (6); 3D entries (1); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
APECO1_4216		Escherichia coli APEC O1	ABJ01737.1	A1ADJ7
APECO1_4058		Escherichia coli APEC O1	ABJ01894.1	A1AE04
ECIAI39_2657		Escherichia coli IAI39	CAR18780.1	B7NQQ5
ECOK1_2807		Escherichia coli IHE3034	ADE90020.1
ECOK1_2632		Escherichia coli IHE3034	ADE92784.1
SiaK1		Escherichia coli K1 PHAGE	CAJ29292.1	Q2L3B7
ECS88_2497		Escherichia coli S88	CAR03775.1	B7MGW6
UTI89_C2636		Escherichia coli UTI89	ABE08102.1	Q1R962
Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
ECRS218_0003		Enterobacteria phage CUS-3	ABQ88383.1 CAY90197.1 CAZ00764.1 CAZ00804.1	A5VW57
endosialidase (Gp90;End;Endo-N;PK1E)	3.2.1.129	Enterobacteria phage K1	CAA55120.1 CAA85449.2	P49714
K1 endosialidase		Enterobacteria phage K1-5	AAG59822.1	Q9AZ46
endosialidase (PK1A)	3.2.1.129	Enterobacteria phage K1A	ABP02011.1	A4UUQ0
Gp47		Enterobacteria phage K1E	CAJ29458.1	Q2WC58
endosialidase NF (SiA;EndoNF;PK1F)	3.2.1.129	Enterobacteria phage K1F	AAC37340.1 AAZ73001.1 CAD44528.2 CAJ29390.1	Q04830 Q858B1	1V0E[A,B,C,D,E,F] 1V0F[A,B,C,D,E,F] 3GVJ[A] 3GVK[A,B,C] 3GVL[A] 3JU4[A]
tailspike 63D sialidase		Escherichia phage K1G	ADA82273.1
tailspike 63D sialidase		Escherichia phage K1H	ADA82322.1
endosialidase	3.2.1.129	Phage #D	BAA32990.1	O80102
ORF		Phage E	AAO31362.1 CAA03522.1