Glycoside Hydrolase Family 57

Activities in Familyα-amylase (EC 3.2.1.1); α-galactosidase (EC 3.2.1.22); amylopullulanase (EC 3.2.1.41); cyclomaltodextrinase (EC 3.2.1.54); branching enzyme (EC 2.4.1.18); 4-α-glucanotransferase (EC 2.4.1.25); [retaining] maltogenic α-amylase (EC 3.2.1.133)
Mechanism Retaining
3D Structure Status( β / α ) 7 barrel
Catalytic Nucleophile/BaseGlu
Catalytic Proton DonorNot known
External resourcesCAZypedia;
Statistics GenBank accession (4705); Uniprot accession (30); PDB accession (11); 3D entries (6); cryst (0)
Archaea
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 4-α-glucanotransferase (formerly cyclodextrin glucanotransferase) 2.4.1.25 pubmed
Archaeoglobus fulgidus 7324 / DSM8774 ABW95829.1 A9QMB3  
 amylopullulanase (CMApu;Cmaq_1371) 3.2.1.41
3.2.1.54
doi
doi
Caldivirga maquilingensis IC-167 ABW02197.1 A8M8X8  
 amylopullulanase (DApu) 3.2.1.41 pubmed
Desulfurococcus amylolyticus WP_042667248.1    
 α-amylase (MJ1611) 3.2.1.1 pubmed
Methanocaldococcus jannaschii DSM 2661 AAB99631.1
NP_248621.1
Q59006  
 4-α-glucanotransferase (AmyA; PfuAmyGT; PF0272) (Amy57A) 2.4.1.25 pubmed
Pyrococcus furiosus DSM 3638 NP_578001.1
AAA72035.1
AAL80396.1
P49067  
 amylopullulanase (Apu; PFAPU; Apu-Pf; PF1935; PF1935*) (Amy57B) 3.2.1.1
3.2.1.41
pubmed
pubmed
Pyrococcus furiosus DSM 3638 NP_579664.1
AAB71229.1
AAL82059.1
ABA33719.1
O30772
Q3HUR3
Q8TZQ1
 
 β-amylase or maltogenic α-amylase (PF0870) 3.2.1.133 pubmed
Pyrococcus furiosus DSM 3638 AAL80994.1
NP_578599.1
Q8U2G5  
 α-galactosidase (GalA;PF0444) (Gal57) 3.2.1.22 doi
Pyrococcus furiosus DSM 3638 AAG28455.1
AAL80568.1
NP_578173.1
E7FHU9
Q9HHB5
 
 glycogen branching enzyme (GBE;PhGBE;PH1386) 2.4.1.18
3.2.1.1
pubmed
pubmed
Pyrococcus horikoshii OT3 BAA30492.1
NP_143265.1
O50094 5WU7[A,B]
 maltose-forming α-amylase (PSMA;Py04_0872) 3.2.1.133 pubmed
Pyrococcus sp. ST04 AFK22464.1 I3RE04  
 α-amylase (AmyA;SSO1172) 3.2.1.1 pubmed
Saccharolobus solfataricus P2 AAK41420.1
NP_342630.1
Q97YY0  
 bifunctional amylopullulanase cyclomaltodextrinase (Apu-Sm;SMApu;Smar_1407) (intracellular) 3.2.1.41
3.2.1.54
pubmed
pubmed
Staphylothermus marinus F1 ABN70497.1 A3DPD7 7E1Y[A,B,C,D,E,F,G,H]
 α-amylase (AmyA;Saci_1162) 3.2.1.1
3.2.1.41
pubmed
pubmed
Sulfolobus acidocaldarius DSM 639 AAY80509.1 Q4J9M2  
 maltose-forming α-amylase (TCMA;CL1_0868) 3.2.1.133 pubmed
Thermococcus cleftensis AFL95073.1 I3ZTN9  
 amylopullulanase (ApuA) 3.2.1.41 pubmed
Thermococcus hydrothermalis AL662 AAD28552.1 Q9Y8I8  
 amylopullulanase (Apu-Tk;TK1774) 3.2.1.41 doi
Thermococcus kodakarensis KOD1 BAD85963.1
CAT69104.1
Q5JJ55  
 branching enzyme (TkGBE;TK1436) 2.4.1.18 pubmed
Thermococcus kodakarensis KOD1 BAD85625.1
CAT71088.1
Q5JDJ7 3N8T[A]
3N92[A]
3N98[A]
 4-α-glucanotransferase (GtpK;TK1809) 2.4.1.25 doi
Thermococcus kodakarensis KOD1 BAA22062.1
BAD85998.1
CAT70994.1
O32450  
 amylopullulanase (Apu) 3.2.1.1
3.2.1.41
pubmed
pubmed
Thermococcus litoralis BAC10983.1 Q8NKS8  
 4-α-glucanotransferase (Jgt) 2.4.1.25 pubmed
Thermococcus litoralis BAA22063.1 O32462 1K1W[A]
1K1X[A,B]
1K1Y[A,B]
 [retaining] 4-α-glucanotransferase / amylomaltase (TonAmyGT; TON_1716) 2.4.1.25 pubmed
Thermococcus onnurineus NA1 ACJ17206.1 B6YUX8  
 amylopullulanase (TsiApu;Apu-Ts) 3.2.1.1
3.2.1.41
pubmed
pubmed
Thermococcus sp. HJ21 ACJ03924.1 B6SED6  
 amylopullulanase (TPApu; Tpen_0210) 3.2.1.41 pubmed
Thermofilum pendens Hrk 5 ABL77620.1 A1RWP0  
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 4-α-glucanotransferase / α-amylase A (AmyA) 2.4.1.25 pubmed
Dictyoglomus thermophilum CAA30735.1 P09961  
 [retaining] α-1,4-glucan branching enzyme (Pmob_0588) 2.4.1.18 pubmed
Petrotoga mobilis SJ95 ABX31322.1 A9BH92  
 [retaining] α-1,4-glucan branching enzyme / α-amylase (AmyC; GBE; TM1438) 2.4.1.18
3.2.1.1
pubmed
pubmed
Thermotoga maritima MSB8 AHD18669.1
AGL50368.1
AKE29197.1
QFD27285.1
R4P360 2B5D[X]
 glycogen branching enzyme (GBE;TTHA1902;TT1467) 2.4.1.18 pubmed
Thermus thermophilus HB8 BAD71725.1 Q5SH28 1UFA[A]
3P0B[A]
 α-amylase (Amy_GH57) 3.2.1.1 pubmed
uncultured bacterium AEC23345.1 F4ZW71  
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