Glycoside Hydrolase Family 57

Known Activities	α-amylase (EC 3.2.1.1); 4-α-glucanotransferase (EC 2.4.1.25); α-galactosidase (EC 3.2.1.22); amylopullulanase (EC 3.2.1.41); branching enzyme (EC 2.4.1.18)
Mechanism	Retaining
3D Structure Status	( β / α ) ₇
Catalytic Nucleophile/Base	Glu
Catalytic Proton Donor	Not known
External resources	CAZypedia; InterPro; PFAM;
Statistics	GenBank accession (765); Uniprot accession (493); PDB accession (9); 3D entries (4); cryst (0)

Summary

All (701) Archaea (182) Bacteria (517) unclassified (2) Structure (4 ) Characterized (17)

Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
4-α-glucanotransferase (formerly cyclodextrin glucanotransferase)	2.4.1.25	Archaeoglobus fulgidus 7324 / DSM8774	ABW95829.1	A9QMB3
α-amylase (MJ1611)	3.2.1.1	Methanocaldococcus jannaschii DSM 2661	AAB99631.1 NP_248621.1	Q59006
4-α-glucanotransferase (AmyA;PF0272) (Amy57A)	2.4.1.25	Pyrococcus furiosus DSM 3638	AAA72035.1 AAL80396.1 NP_578001.1	P49067
amylopullulanase (Apu;PF1935;PF1935) (Amy57B)*	3.2.1.41	Pyrococcus furiosus DSM 3638	AAB71229.1 AAL82059.1 ABA33719.1 NP_579664.1	O30772 Q3HUR3 Q8TZQ1
α-galactosidase (GalA;PF0444) (Gal57)	3.2.1.22	Pyrococcus furiosus DSM 3638	AAG28455.1 AAL80568.1 NP_578173.1	Q9HHB5
α-amylase (AmyA;SSO1172)	3.2.1.1	Sulfolobus solfataricus P2	AAK41420.1 NP_342630.1	Q97YY0
α-galactosidase	3.2.1.22	Thermococcus alcaliphilus AEDII12RA	AAE28307.1
amylopullulanase (ApuA)	3.2.1.41	Thermococcus hydrothermalis AL662	AAD28552.1	Q9Y8I8
branching enzyme (TK1436)	2.4.1.18	Thermococcus kodakarensis KOD1	BAD85625.1 CAT71088.1	Q5JDJ7	3N8T[A] 3N92[A] 3N98[A]
4-α-glucanotransferase (GtpK;TK1809)	2.4.1.25	Thermococcus kodakarensis KOD1	BAA22062.1 BAD85998.1 CAT70994.1	O32450.1
amylopullulanase (Apu)	3.2.1.1 3.2.1.41	Thermococcus litoralis	BAC10983.1	Q8NKS8
4-α-glucanotransferase (Jgt)	2.4.1.25	Thermococcus litoralis	BAA22063.1	O32462.1	1K1W[A] 1K1X[A,B] 1K1Y[A,B]
amylopullulanase (TsiApu)	3.2.1.41	Thermococcus sp. HJ21	ACJ03924.1	B6SED6
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
4-α-glucanotransferase / α-amylase A (AmyA)	2.4.1.25	Dictyoglomus thermophilum	CAA30735.1	P09961.2
α-amylase (AmyC;TM1438)	3.2.1.1	Thermotoga maritima MSB8			2B5D[X]
glycogen branching enzyme (GBE;TTHA1902;TT1467)	2.4.1.18	Thermus thermophilus HB8	BAD71725.1	Q5SH28	1UFA[A] 3P0B[A]
α-amylase (Amy_GH57) (fragment)	3.2.1.1	uncultured bacterium	AEC23345.1

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.