Glycoside Hydrolase Family 57

Activities in Family	[retaining] α-1,4-glucan branching enzyme (EC 2.4.1.18); [retaining] 4-α-glucanotransferase / amylomaltase (EC 2.4.1.25); [retaining] α-amylase (EC 3.2.1.1); [retaining] maltogenic α-amylase (EC 3.2.1.133); α-galactosidase (EC 3.2.1.22); [retaining] pullulanase (EC 3.2.1.41); [retaining] cyclomaltodextrinase (EC 3.2.1.54);
Mechanism	Retaining a
3D Structure Status	( β / α ) ₇ barrel
Catalytic Nucleophile/Base	Glu
Catalytic Proton Donor	Asp
External resources	CAZypedia;
Statistics	GenBank accession (5285); Uniprot accession (30); PDB accession (12); 3D entries (7); cryst (0)

Summary

Download GH57 (5178) Taxonomic display Structure (7) Characterized (34)


Archaea
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
4-α-glucanotransferase (formerly cyclodextrin glucanotransferase)	2.4.1.25	pubmed	Archaeoglobus fulgidus 7324 / DSM8774	ABW95829.1	A9QMB3
bifunctional amylopullulanase cyclomaltodextrinase (CMApu;Cmaq_1371)	3.2.1.1 3.2.1.41 3.2.1.54	doi doi	Caldivirga maquilingensis IC-167	ABW02197.1	A8M8X8
amylopullulanase (DApu)	3.2.1.1 3.2.1.41	pubmed pubmed	Desulfurococcus amylolyticus Z-533	WP_042667248.1
α-amylase (MJ1611)	3.2.1.1	pubmed	Methanocaldococcus jannaschii DSM 2661	AAB99631.1 NP_248621.1	Q59006
amylopullulanase (Pcal-apu; Pcal_1616)	3.2.1.1 3.2.1.41	URL URL	Pyrobaculum calidifontis JCM 11548	ABO09033.1
4-α-glucanotransferase (AmyA; PfuAmyGT; PF0272) (Amy57A)	2.4.1.25	pubmed	Pyrococcus furiosus DSM 3638	NP_578001.1 AAA72035.1 AAL80396.1	P49067
amylopullulanase (Apu; PFAPU; Apu-Pf; PF1935; PF1935) (Amy57B)*	3.2.1.1 3.2.1.41	pubmed pubmed	Pyrococcus furiosus DSM 3638	NP_579664.1 AAB71229.1 AAL82059.1 ABA33719.1	O30772 Q3HUR3 Q8TZQ1
maltogenic α-amylase (PF0870)	3.2.1.133	pubmed	Pyrococcus furiosus DSM 3638	AAL80994.1 NP_578599.1	Q8U2G5
α-galactosidase (GalA;PF0444) (Gal57)	3.2.1.22	doi	Pyrococcus furiosus DSM 3638	AAG28455.1 AAL80568.1 NP_578173.1	E7FHU9 Q9HHB5
glycogen branching enzyme (GBE;PhGBE;PH1386)	2.4.1.18 3.2.1.1	pubmed pubmed	Pyrococcus horikoshii OT3	BAA30492.1 NP_143265.1	O50094	5WU7[A,B]
maltose-forming α-amylase (PSMA;Py04_0872)	3.2.1.133	pubmed	Pyrococcus sp. ST04	AFK22464.1	I3RE04	4CMR[A,B]
amylopullulanase (PulPY; PYCH_17120)	3.2.1.1 3.2.1.41	pubmed	Pyrococcus yayanosii CH1	AEH25371.1
α-amylase (AmyA; SSO1172)	3.2.1.1	pubmed	Saccharolobus solfataricus P2	AAK41420.1 NP_342630.1	Q97YY0
bifunctional amylopullulanase cyclomaltodextrinase (Apu-Sm;SMApu;Smar_1407) (intracellular)	3.2.1.1 3.2.1.41 3.2.1.54	pubmed pubmed	Staphylothermus marinus F1	ABN70497.1	A3DPD7	7E1Y[A,B,C,D,E,F,G,H]
amylopullulanase (AmyA;Saci_1162)	3.2.1.1 3.2.1.41	pubmed pubmed	Sulfolobus acidocaldarius DSM 639	AAY80509.1	Q4J9M2
maltose-forming α-amylase (TCMA;CL1_0868)	3.2.1.133	pubmed	Thermococcus cleftensis	AFL95073.1	I3ZTN9
amylopullulanase (ApuA)	3.2.1.1 3.2.1.41	pubmed	Thermococcus hydrothermalis AL662	AAD28552.1	Q9Y8I8
amylopullulanase (Apu-Tk;TK1774)	3.2.1.1 3.2.1.41	doi	Thermococcus kodakarensis KOD1	BAD85963.1 CAT69104.1	Q5JJ55
branching enzyme (TkGBE; TK1436)	2.4.1.18	pubmed	Thermococcus kodakarensis KOD1	BAD85625.1 CAT71088.1	Q5JDJ7	3N8T[A] 3N92[A] 3N98[A]
4-α-glucanotransferase (GtpK; TK1809)	2.4.1.25	doi	Thermococcus kodakarensis KOD1	BAA22062.1 BAD85998.1 CAT70994.1	O32450
amylopullulanase (Apu; TLAPU)	3.2.1.1 3.2.1.41	pubmed pubmed	Thermococcus litoralis	BAC10983.1	Q8NKS8
4-α-glucanotransferase (Jgt)	2.4.1.25	pubmed	Thermococcus litoralis	BAA22063.1	O32462	1K1W[A] 1K1X[A,B] 1K1Y[A,B]
4-α-glucanotransferase / amylomaltase (TonAmyGT; TON_1716)	2.4.1.25	pubmed	Thermococcus onnurineus NA1	ACJ17206.1	B6YUX8
amylopullulanase (TsiApu;Apu-Ts)	3.2.1.1 3.2.1.41	pubmed pubmed	Thermococcus sp. HJ21	ACJ03924.1	B6SED6
amylopullulanase (TPApu; Tpen_0210)	3.2.1.1 3.2.1.41	pubmed	Thermofilum pendens Hrk 5	ABL77620.1	A1RWP0
Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D
amylopullulanase (APU_Aquae; Aq_720)	3.2.1.1 3.2.1.41	doi doi	Aquifex aeolicus VF5	AAC06900.1 NP_213494.1
amylopullulanase (Apu; CEApu; CSE_07380)	3.2.1.1 3.2.1.41	doi doi	Caldisericum exile AZM16c01	BAL80864.1
4-α-glucanotransferase / α-amylase A (AmyA)	2.4.1.25	pubmed	Dictyoglomus thermophilum	CAA30735.1	P09961
pullulanase (Dtur_0675)	3.2.1.41	pubmed	Dictyoglomus turgidum DSM 6724	ACK41960.1
α-1,4-glucan branching enzyme (GlgB57; PmGBE57; Pmob_0588)	2.4.1.18	pubmed	Petrotoga mobilis SJ95	ABX31322.1	A9BH92
[retaining] α-1,4-glucan branching enzyme / α-amylase (AmyC; GBE; TM1438)	2.4.1.18 3.2.1.1	pubmed pubmed	Thermotoga maritima MSB8	AHD18669.1 AGL50368.1 AKE29197.1 QFD27285.1	R4P360	2B5D[X]
glycogen branching enzyme (GBE; TtGBE; TTHA1902; TT1467)	2.4.1.18	pubmed	Thermus thermophilus HB8	BAD71725.1	Q5SH28	1UFA[A] 3P0B[A]
α-amylase (Amy_GH57)	3.2.1.1	pubmed	uncultured bacterium	AEC23345.1	F4ZW71
α-amylase (Amy2; persiAmy2)	3.2.1.1	doi	uncultured bacterium	QJT73070.1
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