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Glycoside Hydrolase Family 56

Known Activitieshyaluronidase (EC 3.2.1.35); chondroitin hydrolase (EC 3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 7
Catalytic Nucleophile/Basecarbonyl oxygen of C-2 acetamido group of substrate
Catalytic Proton DonorGlu
External resourcesInterPro; PFAM; PRINTS;
Statistics GenBank accession (311); Uniprot accession (134); PDB accession (6); 3D entries (3); cryst (0)
Summary
All (159) Eukaryota (158) Viruses (1) Structure (3 ) Characterized (22)
Eukaryota
Protein Name EC#OrganismGenBankUniprotPDB/3D
 hyaluronidase (HyaL)   Anoplius samariensis BAF93867.1 A9EDG0  
 hyaluronidase 2   Apis cerana cerana AAK51798.2 Q95PD7  
 hyaluronidase (HYA;Api m 2;Apim2;LOC406146) 3.2.1.35 Apis mellifera AAA27730.1
AAB45920.1
AAR78242.1
ABH87698.1
NP_001011619.1		 Q08169 1FCQ[A]
1FCU[A]
1FCV[A]
2J88[A]
 ORF   Ascaris suum ADY46439.1    
 Hyal1 (fragment)   Balaenoptera acutorostrata AEB78445.1    
 Hyal1 (fragment)   Balaenoptera omurai ADZ57824.1    
 hyaluronidase (fragment)   Bitis arietans ABI33944.1
ABI33945.1
ABI33946.1
ABI33947.1
ABI33948.1		 A3QVN9  
 Hyal2   Bos taurus AAI02043.1
AAL78385.1
AAX46601.1
AAX46657.1
ABG66994.1
NP_776772.1		 Q8SQG8  
 hyaluronidase (Spam1;PH-20;p80) 3.2.1.35 Bos taurus AAI10184.1
AAP55713.1
AAV41022.1		 Q2YDK3
Q7YS45		  
 HYAL1 (fragment)   Bos taurus AAX08792.1 Q5E985  
 HYAL1   Bos taurus AAI02474.1
AAX09052.1		 Q5E985  
 hyaluronidase (Hyase) (fragment)   Bothrops neuwiedi pauloensis ACN58137.1 C0L2W4  
 hyaluronidase / chondroitinase (Hyα-1;T22C8.2) 3.2.1.-
3.2.1.35		 Caenorhabditis elegans Bristol N2 BAG48551.1
CAA88874.1
NP_495830.1		 Q22675  
 PH-20 (fragment)   Callimico goeldii ABD94489.1 A4K509  
 HYAL3-like protein (fragment)   Callithrix jacchus ABQ22669.1 A6MKS8  
 Hyal1 (fragment)   Camelus bactrianus AEB78448.1    
 sperm membrane protein (PH-20) (fragment)   Capra hircus ABI31753.1 Q0GIJ1  
 hyaluronidase PH-20 3.2.1.35 Cavia porcellus AAB45922.1
CAA39768.1		 P23613.1  
 hyaluronidase   Cerastes cerastes ABI33938.1
ABI33939.1
ABI33940.1		 A3QVN3  
 Hyal1 (fragment)   Ceratotherium simum AEB78449.1    
 PH-20 (fragment)   Cercopithecus mitis ABD94493.1 A4K513  
 venom protein (A4YE08CM1) (fragment)   Chelonus inanitus CBN72517.1 E3PQY1  
 venom protein (A3YM10CM1) (fragment)   Chelonus inanitus CBN72518.1 E3PQY2  
 venom protein (A2YM17CM2) (fragment)   Chelonus inanitus CBN72519.1 E3PQY3  
 venom protein (A1YB14CM3) (fragment)   Chelonus inanitus CBN72520.1 E3PQY4  
 posterior head protein 20, partial (Ph-20)   Chlorocebus aethiops AEX20366.1    
 posterior head protein 20, partial (Ph-20)   Colobus guereza AEX20365.1    
 hyaluronidase (fragment)   Crotalus adamanteus AEJ31976.1    
 ORF (probable fragment)   Culex quinquefasciatus VERO BEACH AAR18444.1 Q6TRZ3  
 hyaluronidase   Culicoides nubeculosus ACM40915.1 B9URL8  
 hyaluronidase / Cul n 2 allergen   Culicoides nubeculosus ADJ67266.1 D9IL12  
 hyaluronidase (Hgs1;CsHGS1) (fragment)   Culicoides sonorensis AAU06477.1 Q66UD2  
 Unknown (protein for MGC:136804)   Danio rerio AAI14278.1 Q29RC1  
 DKEY-42I9.14-001 (Hyal2)   Danio rerio CAK11026.1 Q1LXC3  
 DKEY-72L14.3-001   Danio rerio CAK11158.1 Q1LVE3  
 Unknown (protein for MGC:158626)   Danio rerio AAI29331.1 A1L235  
 Unknown (protein for MGC:158668) (fragment)   Danio rerio AAI29368.1
AAI52242.1		 A1L264  
 DKEY-20D21.13-001   Danio rerio CAP19590.1 A9C3S9  
 Hyal1 (fragment)   Delphinapterus leucas ADZ57829.1    
 Hyal1 (fragment)   Delphinus capensis ADZ57818.1    
 hyaluronidase (Dol m 2) 3.2.1.35 Dolichovespula maculata AAA68279.1
AAR78243.1
ABH87699.1
CAJ98548.1		 P49371  
 hyaluronidase (fragment)   Echis carinatus sochureki ABI33949.1 A3QVP4  
 hyaluronidase (fragment)   Echis carinatus sochureki ABI33950.1 A3QVP5  
 hyaluronidase (fragment)   Echis ocellatus ABI33937.1 A3QVN2  
 hyaluronidase (fragment)   Echis pyramidum leakeyi ABI33941.1 A3QVN6  
 hyaluronidase (fragment)   Echis pyramidum leakeyi ABI33942.1
ABI33943.1		 A3QVN7  
 Hyal1 (fragment)   Elaphurus davidianus ADZ57827.1    
 sperm adhesion molecule 1 (Spam1) (fragment)   Equus caballus AET34452.1    
 sperm adhesion molecule 1 (Spam1) (fragment)   Equus caballus AET34452.1    
 PH-20 (fragment)   Erythrocebus patas ABD94492.1 A4K512  
 venom hyaluronidase (Hya1)   Eumenes pomiformis ACZ37402.1 D1MEJ6  
 hyaluronidase-Ginf1 (fragment)   Gerrhonotus infernalis ADK39240.1 E2E4F9  
 GFP_L7_0750 (possible fragment)   Glyptapanteles flavicoxis ACE75133.1 B7S8A9  
 GFP_L7_0760 (possible fragment)   Glyptapanteles flavicoxis ACE75134.1 B7S8B0  
 GFP_L7_0770 (fragment)   Glyptapanteles flavicoxis ACE75135.1 B7S8B1  
 GIP_L1_00710   Glyptapanteles indiensis ABK57057.1 A0JCZ2  
 posterior head protein 20, partial (Ph-20)   Gorilla gorilla AEX20363.1    
 Hyal1 (fragment)   Grampus griseus ADZ57819.1    
 hyaluronidase toxin (fragment)   Heloderma suspectum cinctum ACE95063.1 C6EVG3  
 Hyal1 (fragment)   Hippopotamus amphibius AEB78446.1    
 hyaluronidase (PH-20;SPAM1;HYAL3;PH20) (sperm) 3.2.1.35 Homo sapiens AAC16482.1
AAC60607.2
AAH26163.1
AAQ96882.1
AAX13985.1
AAX13986.1
AAX13987.1
AAX13988.1
AAY03322.1
ABJ38775.1
ACM84481.1
BAF84918.1
CAA59086.1
NP_003108.2
NP_694859.1		 P38567
Q8TC30		  
 chondroitin sulfate hydrolase / hyaluronidase 3 (HYAL3;LUCA-3;LUCA14.2) 3.2.1.-
3.2.1.35		 Homo sapiens AAC02729.1
AAC70915.1
AAD04257.1
AAH05896.1
AAH12892.1
AAM60775.1
AAM60776.1
AAM60777.1
AAM60778.1
ABA67787.1
BAG36242.1
NP_003540.2		 O43820
O60540
Q8NFK2
Q8NFK3
Q8NFK4
Q96E56
Q9BRW9		  
 chondroitin sulfate hydrolase / hyaluronidase 1 (HYAL1;Hyal-1;LUCA1;LUCA-1) 3.2.1.-
3.2.1.35		 Homo sapiens AAB67046.1
AAC02730.1
AAD04190.1
AAD09137.2
AAD53277.1
AAE60457.1
AAE60459.1
AAH25774.1
AAH35695.1
AAM60770.1
AAM60771.1
AAM60772.1
AAM60773.1
AAM60774.1
ABJ38770.1
ABJ38772.1
ACK03148.1
BAF83505.1
BAG53447.1
CAC60225.1
CAG46731.1
NP_009296.1
NP_149349.2
NP_695013.1
NP_695014.1
NP_695015.1
NP_695016.1
NP_695017.1
NP_695018.1		 Q12794.2
Q6FH23		 2PE4[A]
 chondroitin sulfate hydrolase / hyaluronidase 2 (Hyal2;LUCA2;LUCA-2) 3.2.1.-
3.2.1.35		 Homo sapiens AAB67045.1
AAC28656.1
AAC62823.1
AAH00692.1
ABA82488.1
ACK03149.1
BAG52554.1
BAG54602.1
CAA03924.1
NP_003764.3
NP_149348.2		 B3KRZ2
Q12891.3		  
 chondroitin sulfate hydrolase / hyaluronoglucosaminidase 4 / hyaluronidase 4 (Hyal4) 3.2.1.- Homo sapiens AAC98883.1
AAD43186.1
AAI04789.1
AAI04791.1
ACM81328.1
ACM82678.1
ACM82678.1
ACV97636.1
BAI49593.1
NP_036401.1		 D0VXG1
Q2M3T9
Q9UL99		  
 ENSP00000194108 (fragment)   Homo sapiens XP_069745.1
XP_069745.2		    
 ORF (fragment)   Hottentotta judaicus ADY39497.1    
 PH-20 (fragment)   Hylobates lar ABD94497.1 A4K517  
 Hyal1 (fragment)   Kogia sima ADZ57825.1    
 PH-20 (fragment)   Lemur catta ABD94483.1 A4K503  
 v-hyaluronidase-Lio1 (fragment)   Liophis poecilogyrus ABU68570.1 A7XQ50  
 Hyal1 (fragment)   Lipotes vexillifer ADZ57817.1    
 PH-20 (fragment)   Lophocebus aterrimus ABD94495.1 A4K515  
 HyaL   Lutzomyia longipalpis AAD32195.1 Q9XZ48  
 hyaluronidase 3.2.1.35 Macaca fascicularis ABD94494.1
BAE01371.1		 P38568  
 Hyal1 (fragment)   Manis pentadactyla AEB78450.1    
 venom hyaluronidase (BmHYA1) (fragment) 3.2.1.35 Mesobuthus martensii ACY69673.1 D1MBU1  
 SPAM1   Mesocricetus auratus ADB94578.1 D6C448  
 hyaluronidase 5 (Hyal5)   Mesocricetus auratus ADB94579.1 D6C449  
 hyaluronoglucosaminidase 1 (Hyal1) (fragment)   Mesoplodon densirostris ADZ53990.1    
 PH-20 (fragment)   Microcebus murinus ABD94486.1 A4K506  
 Hyal1 (fragment)   Moschus moschiferus ADZ57828.1    
 hyaluronidase 3 (Hyal3)   Mus musculus AAH18457.1
AAL06145.1
CAP19324.1
NP_821139.1		 Q8VEI3  
 hyaluronidase (Spam1;Hyal1;PH-20;Spam) 3.2.1.35 Mus musculus AAA76603.1
AAP49832.1
AAX13989.1
AAX13990.1
BAB24161.1
BAC55070.1
NP_033267.1		 P48794
P48794.2
Q5D1J0		  
 hyaluronoglucosaminidase 1 3.2.1.35 Mus musculus AAC15949.1
AAH21636.1
AAL17822.1
BAC26206.1
CAP19319.1
CAP19320.1
CAP19321.1
CAP19322.1
NP_032343.2		 O70229
Q8CE62
Q8VDK0
Q91ZJ9		  
 hyaluronidase (Hyal-5;Hyal5)   Mus musculus AAI45993.1
AAI45995.1
BAB30602.2
BAB30602.3
BAC55071.1
BAE21628.1		 Q812F3
Q9CUA5		  
 hyaluronidase 2 (Hyal2;Hyal-2)   Mus musculus AAH60047.1
AAK28481.1
AAK28482.1
AAL17823.1
AAO49503.1
BAC39851.1
BAC40583.1
BAE21913.1
CAA03888.1
CAA03889.1
NP_034619.1		 O35632.2
Q3UZE4
Q8C309		  
 4932701A20 or 4930503G08   Mus musculus C57BL/6J BAB30316.1
BAC26578.1		 Q8CDQ9
Q9D4E9		  
 Hyal4   Mus musculus C57BL/6J AAI25403.1
AAI32097.1
BAB29454.1		 Q05A56
Q9D660		  
 ORF (fragment)   Mustela putorius furo AER99997.1    
 hyaluronoglucosaminidase 1 (fragment)   Mustela putorius furo AER99995.1    
 hyaluronoglucosaminidase 2   Mustela putorius furo AER99996.1    
 ORF (fragment)   Mustela putorius furo AES10768.1    
 ORF (fragment)   Mustela putorius furo AES10769.1    
 posterior head protein 20, partial (Ph-20)   Nasalis larvatus AEX20364.1    
 Hyal1 (fragment)   Neophocaena phocaenoides ADZ57816.1    
 hyaluronidase   Orancistrocerus drewseni ACD61711.1 B2ZP63  
 hyaluronidase 2 (Hyal2)   Oryctolagus cuniculus AAT35556.1 Q6J2L1  
 hyaluronidase (Hyal1;Spam1;PH20) 3.2.1.35 Oryctolagus cuniculus AAA88913.1 P38566  
 PH-20 (fragment)   Otolemur crassicaudatus ABD94481.1 A4K501  
 Hyal2   Ovis aries AAL78386.1 Q8SQG7  
 ORF   Pan troglodytes BAK64019.1    
 ORF   Pan troglodytes BAK62198.1    
 ORF (fragment)   Pan troglodytes BAK62386.1    
 PH-20 (fragment)   Pan troglodytes ABD94498.1 A4K518  
 PH-20 (fragment)   Papio hamadryas ABD94496.1 A4K516  
 PH-20 (fragment)   Perodicticus potto ABD94482.1 A4K502  
 salivary hyaluronidase   Phlebotomus arabicus ACS93505.1 C6FX65  
 ORF (fragment)   Phlebotomus tobbi AEK98519.1    
 ORF (fragment)   Pipa carvalhoi AEQ16640.1    
 Hyal1 (fragment)   Platanista gangetica ADZ57826.1    
 hyaluronidase (Pol a 2) 3.2.1.35 Polistes annularis AAD52616.1
AAR78239.1
ABH87695.1		 Q9U6V9  
 HyaL (fragment)   Polybia paulista ADL09135.1 E0AD89  
 DKFZp469J0738   Pongo abelii CAH89756.1 Q5REQ1  
 PH-20 (fragment)   Propithecus verreauxi ABD94485.1 A4K505  
 PH-20 (fragment)   Pygathrix nemaeus ABD94490.1 A4K510  
 hyaluronidase 1 (Hyal1)   Rattus norvegicus BAD14368.1 Q76HN1  
 hyaluronidase 4 (Hyal4) (fragment)   Rattus norvegicus BAD14369.1 Q76HN0  
 hyaluronidase 3 (Hyal3)   Rattus norvegicus AAH97259.1
BAD14370.1		 Q76HM9  
 Unknown (protein for MGC:94293)   Rattus norvegicus AAH82016.1 Q66H49  
 Unknown (protein for MGC:108951)   Rattus norvegicus AAH91219.1 Q5BK36  
 2B1 antigen   Rattus norvegicus AAH81748.1
CAA62016.1
EDM15179.1
NP_446419.1		 Q62803  
 hyaluronidase 2 (Hyal2) 3.2.1.35 Rattus norvegicus AAD01980.1
AAH62410.1
AAO49504.1
NP_742037.1		 Q80ZC7
Q9Z2Q3		  
 venom hyaluronidase   Rhynchium brunneum ACC93934.1 B2MVK6  
 PH-20 (fragment)   Saguinus fuscicollis ABD94488.1 A4K508  
 posterior head protein 20, partial (Ph-20)   Saguinus oedipus AEX20362.1    
 PH-20 (fragment)   Saimiri sciureus ABD94487.1 A4K507  
 hyaluronidase-2 (Hyal2)   Salmo salar ACI32917.1 B5X0T6  
 hyaluronidase-2 (Hyal2)   Salmo salar ACI33835.1 B5X3F4  
 hyaluronidase-2 (Hyal2)   Salmo salar ACI33947.1
ACN10738.1		 B5X3R6  
 PH-20 (fragment)   Semnopithecus entellus ABD94491.1 A4K511  
 salivary hyaluronidase   Simulium guianense AEB96520.1    
 Hyal1 (fragment)   Sousa chinensis ADZ57823.1    
 Hyal1 (fragment)   Stenella attenuata ADZ57820.1    
 Hyal1 (fragment)   Stenella coeruleoalba ADZ57822.1    
 sperm adhesion molecule 1 (SPAM-1)   Sus scrofa CAC83973.2 Q8MI02  
 hyaluronoglucosaminidase 3   Sus scrofa AAR33037.1
AAR91601.1		 Q6RHW2  
 hyaluronoglucosaminidase 1   Sus scrofa AAR91599.1
ACH56985.1
ACH56986.1		 Q6RHW4  
 hyaluronidase 2 (Hyal2)   Sus scrofa AAR91600.1
ACH56987.1		 Q6RHW3  
 Hyal1 (fragment)   Sus scrofa AEB78447.1    
 hyaluronidase (HYA1;SfHya1) 3.2.1.35 Synanceia horrida AAO74499.1 Q801Z8  
 hyaluronidase (Hya1;SvHya1;Sv-Hya)   Synanceia verrucosa BAJ54082.1    
 allergen (Tab y 2)   Tabanus yao ADM18346.1 E0XKJ9  
 Hyal1 (fragment)   Tursiops aduncus ADZ57821.1    
 Hyal1 (fragment)   Tursiops truncatus AEB78444.1    
 PH-20 (fragment)   Varecia variegata ABD94484.1 A4K504  
 hyaluronidase   Vespa magnifica CBY83816.1    
 hyaluronidase (Ves g 2a)   Vespula germanica CAL59818.1 Q05FZ2  
 hyaluronidase homologue (Ves g 2b) (fragment)   Vespula germanica CAL59819.1 Q05FZ1  
 Ves v 2 / Hya_B   Vespula vulgaris AAX14718.1
CAI77218.1		 Q5D7H4  
 hyaluronidase (Ves v 2 allergen) 3.2.1.35 Vespula vulgaris AAB48073.1
AAR78244.1
ABH87700.1		 P49370 2ATM[A]
 fPH-20 protein   Vulpes vulpes AAB86588.1 Q29152  
 Unknown (protein for MGC:121214)   Xenopus (Silurana) tropicalis AAI35205.1 A4IGQ6  
 Unknown (protein for MGC:184955)   Xenopus (Silurana) tropicalis AAI58240.1 B0BM11  
 hyaluronidase XKH1 3.2.1.35 Xenopus laevis AAI69767.1
AAI69795.1
AAL67683.1		 Q8UVT7  
 lysosomal hyaluronidase (Hyal2) 3.2.1.35 Xenopus laevis AAL55823.1 Q8UVY6  
 ORF   Xenopus laevis AAH47252.1 Q801T1  
 hyaluronidase (embryonic) XEH1 3.2.1.35 Xenopus laevis AAD28281.1 Q9W6K5  
Viruses
Protein Name EC#OrganismGenBankUniprotPDB/3D
 GIP_L8_0010 (fragment)   Glyptapanteles indiensis bracovirus ACE75387.1    




Last update: 2012-01-31 © Copyright 1998-2012
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