Glycoside Hydrolase Family 4

Activities in Familymaltose-6-phosphate glucosidase (EC 3.2.1.122); α-glucosidase (EC 3.2.1.20); α-galactosidase (EC 3.2.1.22); 6-phospho-β-glucosidase (EC 3.2.1.86); α-glucuronidase (EC 3.2.1.139); α-galacturonase (EC 3.2.1.67); palatinase (EC 3.2.1.-)
Mechanism Retaining
Catalytic Nucleophile/BaseNot applicable
Catalytic Proton DonorNot known
NoteThe enzymes in this family display an unusual mechanism involving NAD+.
External resourcesCAZypedia; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (7580); Uniprot accession (703); PDB accession (11); 3D entries (7); cryst (0)
All (7346) Archaea (38) Bacteria (7307) unclassified (1) Structure (7) Characterized (27)
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Cmaq_0830   Caldivirga maquilingensis IC-167 ABW01665.1 A8MD09  
 Cmaq_1215   Caldivirga maquilingensis IC-167 ABW02042.1 A8ME36  
 ABY42_15275   Haloferax gibbonsii ARA6 AKU09170.1    
 HVO_B0343 (LplD)   Haloferax volcanii DS2 ADE01358.1 D4GPZ0  
 Halxa_3609   Halopiger xanaduensis SH-6 AEH38218.1    
 Halxa_3781   Halopiger xanaduensis SH-6 AEH38387.1    
 Halxa_0450   Halopiger xanaduensis SH-6 AEH39051.1    
 Halxa_0505   Halopiger xanaduensis SH-6 AEH39104.1    
 HTIA_0721   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ32861.1    
 Huta_0159   Halorhabdus utahensis DSM 12940 ACV10347.1 C7NP56  
 Huta_0863   Halorhabdus utahensis DSM 12940 ACV11046.1 C7NUE9  
 HALLA_02985   Halostagnicola larsenii XH-48 AHG01365.1    
 HALLA_04390   Halostagnicola larsenii XH-48 AHG01644.1    
 HALLA_04620   Halostagnicola larsenii XH-48 AHG01689.1    
 Htur_3895   Haloterrigena turkmenica DSM 5511 ADB62753.1 D2S056  
 Htur_4484   Haloterrigena turkmenica DSM 5511 ADB63295.1 D2S1P8  
 Htur_4649   Haloterrigena turkmenica DSM 5511 ADB63434.1 D2S237  
 Htur_4787   Haloterrigena turkmenica DSM 5511 ADB63559.1 D2S2G2  
 Igag_0370   Ignisphaera aggregans DSM 17230 ADM27212.1 E0SR63  
 PAP_04140   Palaeococcus pacificus DY20341 AIF69243.1    
 Shell_0087   Staphylothermus hellenicus DSM 12710 ADI31235.1 D7DAN8  
 Smar_0706   Staphylothermus marinus F1 ABN69809.1 A3DME9  
 TBCH5v1_1156   Thermococcus barophilus CH5 ALM75090.1    
 TERMP_00967   Thermococcus barophilus MP ADT83943.1    
 A3L01_07400   Thermococcus barossii SHCK-94 ASJ05204.1    
 A3L11_00610   Thermococcus siculi RG-20 ASJ07805.1    
 CDI07_08175   Thermococcus sp. 5-4 ASA78270.1    
 A3L14_09730   Thermococcus thioreducens OGL-20P ASJ13149.1    
 N186_08855   Thermofilum adornatus 1910b AGT36107.1    
 TCARB_0849   Thermofilum carboxyditrophus 1505 AJB41901.1    
 Tpen_1511   Thermofilum pendens Hrk 5 ABL78908.1 A1S0C8  
 MA03_03630   Thermofilum uzonense 1807-2 AKG38554.1    
 Tagg_1191   Thermosphaera aggregans DSM 11486 ADG91459.1 D5U2V9  
 alpha galactosidase (GaL) (fragment)   uncultured archaeon CAZ66676.1 C6H104  
 alpha galactosidase (GaL) (fragment)   uncultured archaeon CAZ66677.1 C6H105  
 α-galactosidase (GaL) (fragment)   uncultured archaeon CAZ66678.1 C6H106  
 alpha galactosidase (GaL) (fragment)   uncultured archaeon CAZ66679.1 C6H107  
 GaL (frament) (fragment)   uncultured archaeon CCF72381.1    
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