Glycoside Hydrolase Family 48

Activities in Familyreducing end-acting cellobiohydrolase (EC 3.2.1.176); endo-β-1,4-glucanase (EC 3.2.1.4); chitinase (EC 3.2.1.14)
Mechanism Inverting
ClanGH-M
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
Noteformerly known as cellulase family L. Some cellobiohydrolases of this family have been reported to act from the reducing ends of cellulose (EC 3.2.1.-), while others have been reported to operate from the non-reducing ends to liberate cellobiose or cellotriose or cellotetraose (EC 3.2.1.-). This family also contains endo-processive cellulases (EC 3.2.1.-), whose activity is hard to distinguish from that of cellobiohydrolases.
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Commercial Enzyme Provider(s)NZYTech;
Statistics GenBank accession (1146); Uniprot accession (114); PDB accession (26); 3D entries (7); cryst (0)
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 glycoside hydrolase family protein 48 (Gh48-1)   Chrysomela tremulae ADU33283.1    
 glycoside hydrolase family protein 48 (Gh48-2)   Chrysomela tremulae ADU33284.1    
 glycoside hydrolase family protein 48 (Gh48-2)   Dendroctonus ponderosae ADU33297.1    
 glycoside hydrolase family protein 48 (Gh48-1)   Dendroctonus ponderosae ADU33296.1    
 glycoside hydrolase family protein 48 (Gh48-3)   Dendroctonus ponderosae ADU33298.1    
 glycoside hydrolase family protein 48 (Gh48-4)   Dendroctonus ponderosae ADU33299.1
AEE63589.1
   
 glycoside hydrolase family protein 48 (Gh48-5)   Dendroctonus ponderosae ADU33300.1
AEE61736.1
   
 glycoside hydrolase family protein 48 (Gh48-6)   Dendroctonus ponderosae ADU33301.1    
 chitinase (active phase-associated protein I) (Apap1) 3.2.1.14 Gastrophysa atrocyanea BAE94320.1 Q1JUL1  
 active phase-associated protein II (Apap2)   Gastrophysa atrocyanea BAE94321.1 Q1JUL0  
 glycoside hydrolase family protein 48 (Gh48-1)   Gastrophysa viridula ADU33335.1    
 glycoside hydrolase family protein 48 (Gh48-2)   Gastrophysa viridula ADU33336.1    
 glycoside hydrolase family protein 48 (Gh48-3)   Gastrophysa viridula ADU33337.1    
 glycoside hydrolase family protein 48 (Gh48-1)   Leptinotarsa decemlineata ADU33352.1    
 glycoside hydrolase family protein 48 (Gh48-2)   Leptinotarsa decemlineata ADU33353.1    
 glycoside hydrolase family protein 48 (Gh48-3)   Leptinotarsa decemlineata ADU33354.1    
 exoglucanase (W5-CAT26-68)   Neocallimastix patriciarum W5 AEX92722.1    
 Cel48   Orpinomyces sp. C1A ANS13826.1    
 cellobiohydrolase (Cbh1)   Otiorhynchus sulcatus CAH25542.1
CAH25543.1
Q5CC74  
 cellulase Cel48A (Cel48A)   Piromyces equi AAN76735.1 Q8J1E2  
 cellulase Cel48A (Cel48A)   Piromyces sp. E2 AAN76734.1 Q8J1E3  
 glycoside hydrolase family 48, partial (fragment)   Rhynchophorus ferrugineus AMK48631.1    
 glycosyl hydrolase family 48, partial (fragment)   Rhynchophorus ferrugineus AMK48568.1    
 glycoside hydrolase family 48, partial (fragment)   Rhynchophorus ferrugineus AMK48558.1    
 glycoside hydrolase family 48, partial (fragment)   Rhynchophorus ferrugineus AMK48585.1    
 glycoside hydrolase family 48, partial (fragment)   Rhynchophorus ferrugineus AMK48653.1    
 glycoside hydrolase family 48, partial (fragment)   Rhynchophorus ferrugineus AMK48640.1    
 glycoside hydrolase family 48, partial (fragment)   Rhynchophorus ferrugineus AMK48560.1    
 glycoside hydrolase family 48, partial (fragment)   Rhynchophorus ferrugineus AMK48634.1    
 glycoside hydrolase family protein 48 (Gh48-1)   Sitophilus oryzae ADU33251.1    
 glycoside hydrolase family protein 48 (Gh48-2)   Sitophilus oryzae ADU33252.1    
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