Activities in Family	Mannosyl-oligosaccharide α-1,2-mannosidase (EC 3.2.1.113);
Mechanism	Inverting a
3D Structure Status	( α / α ) 7 barrel
Catalytic Nucleophile/Base	Not known
Catalytic Proton Donor	Glu
External resources	CAZypedia; HOMSTRAD; PRINTS;
Statistics	GenBank accession (3084); Uniprot accession (69); PDB accession (23); 3D entries (6); cryst (0)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
α-mannosidase (CkGH47;Caul_4035)	3.2.1.113	Caulobacter sp. K31	ABZ73160.1	B0SWV2	4AYO[A] 0.85 4AYP[A] α-D-Manp-(1-2)-α-D-Manp2S-(1-1)-methyl 0.85 4AYQ[A] <carb_like_MVL> 1.10 4AYR[A] <carb_like_IFL> 1.10 5MEH[A] <carb_like_DMJ> 0.95 5NE5[A] <carb_like_KIF> 1.05 8B5M[A] 0.97
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
ER mannosyl-oligosaccharide α-1,2-mannosidase I (Man1B1;ERManI;hERManI)	3.2.1.113	Homo sapiens	AAF03215.1 AAD45504.1 AAH02953.1 AAH06079.1 AAQ88830.1 ABA31377.1 ABA36377.1 ABA37959.1 ABA68636.1 ABA69639.1 ABA70021.1 ABA70144.1 ABC03965.1 ABC16000.1 ABE23455.1 ABE26018.1 ABE26291.1 ABH64528.1 ABH64651.1 ABH64808.1 ABH66037.1 ABH70856.1 ABH70979.1 ABH72493.1 ABH75608.1 ABH99393.1 ABI02498.1 ABI07299.1 ABI10947.1 ABI12149.1 ABJ19332.1 ABJ34327.1 ABJ43225.1 ABL21769.1 ABN29858.1 ABN30045.1 ABP27825.1 ABX93887.1 ABX96180.1 ABX96490.1 ABX96800.1 ABY04954.1 ABY18690.1 ACC17223.1 ACC32395.1 ACE08681.1 ACG89592.1 ACH31821.1 ACJ99887.1 ACK30491.1 ACM94998.1 ACM96778.1 ACN08779.1 ACP73753.1 ACS06379.1 ACS08553.1 ACW23746.1 ATG31856.1 BAC11060.1 BAD92513.1 BAG51987.1 BAG54653.1 BAG54664.1 BAG60691.1 BAG61117.1 CAB53680.2 CAC27261.1 CAF85799.1 CAF86770.1 CAH72871.2 CAH72887.1 CAI12781.1 NP_009161.1 NP_057303.1 NP_057303.2	A0A291FGE6 B3KQC5 B3KXZ1 B4DPS9 B4DR05 Q8N2P4 Q9UFZ8 Q9UKM7	1FMI[A] 1.90 1FO2[A] <carb_like_DMJ> 2.38 1FO3[A] <carb_like_KIF> 1.75 1X9D[A] α-D-Manp-(1-2)-α-D-Manp2S-(1-1)-methyl 1.41 5KIJ[A] α-D-Manp-(1-2)-α-D-Manp-(1-6)[α-D-Manp-(1-2)-α-D-Manp-(1-3)]-α-D-Manp-(1-6)[α-D-Manp-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-4)-D-1-deoxy-GlcpNAc 1.65 5KK7[A,B] α-D-Manp-(1-2)-α-D-Manp2S-(1-1)-methyl 1.73
Golgi mannosyl-oligosaccharide 1,2-α-mannosidase IA (ManA1;Man1A;Man1A1;GMIA)	3.2.1.113	Mus musculus	AAA17747.1 AAH15265.1 BAC27225.1 BAE28536.1 BAE32852.1 CAH33904.1 CAH33939.1 CAH56918.1 CBA11298.1 CBA12843.1 CBA34883.1 NP_032574.1	P45700 Q3UFM4 Q544T7	1NXC[A] 1.51 5KKB[A,B] α-D-Manp-(1-2)-α-D-Manp-(1-3)[α-D-Manp-(1-6)]-α-D-Manp-(1-6)[α-D-Manp-(1-2)-α-D-Manp-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-4)-β-D-GlcpNAc 1.77
α-1,2-mannosidase (MsdC)	3.2.1.113	Penicillium citrinum	BAA08275.1	P31723	1KKT[A,B] 2.20 1KRE[A,B] <carb_like_DMJ> 2.20 1KRF[A,B] <carb_like_KIF> 2.20 2RI8[A,B] 2.16 2RI9[A,B] α-D-Lyxp-(1-2)-α-D-Manp-(1-1)-methyl 1.95
ER α-mannosidase (Mns1;ERManI;YJR131w;J2110)	3.2.1.113	Saccharomyces cerevisiae S288c	AAA34799.1 CAA89662.1 CAY05981.1 CAY09741.1 CAY09788.1 NP_012665.1	P32906	1DL2[A] 1.54 1G6I[A] <carb_like_DMJ> 1.59
α-1,2-mannosidase (Mds1;MDS1) (class-I)	3.2.1.113	Trichoderma reesei QM9414	AAF34579.1 CAY06025.1 CAY09785.1	Q9P8T8	1HCU[A,B,C,D] 2.37
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