Glycoside Hydrolase Family 47

Activities in Familyα-mannosidase (EC 3.2.1.113)
Mechanism Inverting
3D Structure Status( α / α ) 7
Catalytic Nucleophile/BaseNot known
Catalytic Proton DonorGlu
External resourcesCAZypedia; HOMSTRAD; PRINTS;
Statistics GenBank accession (1482); Uniprot accession (225); PDB accession (22); 3D entries (6); cryst (0)
All (938) Bacteria (18) Eukaryota (920) Structure (6) Characterized (43)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 α-mannosidase (CkGH47;Caul_4035) 3.2.1.113 Caulobacter sp. K31 ABZ73160.1 B0SWV2
4AYO[A] 0.85
4AYP[A] α-D-Manp-(1-2)-α-D-Manp2S-(1-1)-methyl
0.85
4AYQ[A] <carb_like_MVL>
1.10
4AYR[A] <carb_like_IFL>
1.10
5MEH[A] <carb_like_DMJ>
0.95
5NE5[A] <carb_like_KIF>
1.05
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 ER mannosyl-oligosaccharide α-1,2-mannosidase I (Man1B1;ERManI;hERManI) 3.2.1.113 Homo sapiens AAF03215.1
AAD45504.1
AAH02953.1
AAH06079.1
AAQ88830.1
ABA31377.1
ABA36377.1
ABA37959.1
ABA68636.1
ABA69639.1
ABA70021.1
ABA70144.1
ABC03965.1
ABC16000.1
ABE23455.1
ABE26018.1
ABE26291.1
ABH64528.1
ABH64651.1
ABH64808.1
ABH66037.1
ABH70856.1
ABH70979.1
ABH72493.1
ABH75608.1
ABH99393.1
ABI02498.1
ABI07299.1
ABI10947.1
ABI12149.1
ABJ19332.1
ABJ34327.1
ABJ43225.1
ABL21769.1
ABN29858.1
ABN30045.1
ABP27825.1
ABX93887.1
ABX96180.1
ABX96490.1
ABX96800.1
ABY04954.1
ABY18690.1
ACC17223.1
ACC32395.1
ACE08681.1
ACG89592.1
ACH31821.1
ACJ99887.1
ACK30491.1
ACM94998.1
ACM96778.1
ACN08779.1
ACP73753.1
ACS06379.1
ACS08553.1
ACW23746.1
ATG31856.1
BAC11060.1
BAD92513.1
BAG51987.1
BAG54653.1
BAG54664.1
BAG60691.1
BAG61117.1
CAB53680.2
CAC27261.1
CAF85799.1
CAF86770.1
CAH72871.2
CAH72887.1
CAI12781.1
NP_009161.1
NP_057303.1
NP_057303.2
Q8N2P4
Q9UFZ8
Q9UKM7
1FMI[A] 1.90
1FO2[A] <carb_like_DMJ>
2.38
1FO3[A] <carb_like_KIF>
1.75
1X9D[A] α-D-Manp-(1-2)-α-D-Manp2S-(1-1)-methyl
1.41
5KIJ[A] α-D-Manp-(1-2)-α-D-Manp-(1-6)[α-D-Manp-(1-2)-α-D-Manp-(1-3)]-α-D-Manp-(1-6)[α-D-Manp-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-4)-D-1-deoxy-GlcpNAc
1.65
5KK7[A,B] α-D-Manp-(1-2)-α-D-Manp2S-(1-1)-methyl
1.73
 Golgi mannosyl-oligosaccharide 1,2-α-mannosidase IA (ManA1;Man1A;Man1A1;GMIA) 3.2.1.113 Mus musculus AAA17747.1
AAH15265.1
BAC27225.1
BAE28536.1
BAE32852.1
CAH33904.1
CAH33939.1
CAH56918.1
CBA11298.1
CBA12843.1
CBA34883.1
NP_032574.1
P45700
Q544T7
1NXC[A] 1.51
5KKB[A,B] α-D-Manp-(1-2)-α-D-Manp-(1-3)[α-D-Manp-(1-6)]-α-D-Manp-(1-6)[α-D-Manp-(1-2)-α-D-Manp-(1-2)-α-D-Manp-(1-3)]-β-D-Manp-(1-4)-β-D-GlcpNAc
1.77
 α-1,2-mannosidase (MsdC) 3.2.1.113 Penicillium citrinum BAA08275.1 P31723
1KKT[A,B] 2.20
1KRE[A,B] <carb_like_DMJ>
2.20
1KRF[A,B] <carb_like_KIF>
2.20
2RI8[A,B] 2.16
2RI9[A,B] α-D-Lyxp-(1-2)-α-D-Manp-(1-1)-methyl
1.95
 ER α-mannosidase (Mns1;ERManI;YJR131w;J2110) 3.2.1.113 Saccharomyces cerevisiae S288c AAA34799.1
CAA89662.1
CAY05981.1
CAY09741.1
CAY09788.1
NP_012665.1
P32906
1DL2[A] 1.54
1G6I[A] <carb_like_DMJ>
1.59
 α-1,2-mannosidase (Mds1;MDS1) (class-I) 3.2.1.113 Trichoderma reesei QM9414 AAF34579.1
CAY06025.1
CAY09785.1
Q9P8T8
1HCU[A,B,C,D] 2.37
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