Glycoside Hydrolase Family 44

Activities in Familyendoglucanase (EC 3.2.1.4); xyloglucanase (EC 3.2.1.151)
Mechanism Retaining
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu
Catalytic Proton DonorGlu
Noteformerly known as cellulase family J. Note that the stereochemistry of the reaction has recently been corrected : Kitago et al., J. Biol. Chem. 282(2007)35703-11 (PMID: 17905739)
External resourcesCAZypedia;
Commercial Enzyme Provider(s)NZYTech; PROZOMIX;
Statistics GenBank accession (161); Uniprot accession (39); PDB accession (14); 3D entries (4); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 bifunctional mannanase / endoglucanase (CbMan5A/Cel44A;Athe_1859;Cbes_1859;ORF1946) (Man5A-Cel44A) 3.2.1.4
3.2.1.78
Caldicellulosiruptor bescii DSM 6725 ACM60947.1 B9MKT9  
 bifunctional β-mannanase / endo-β-1,4-glucanase (ManA) 3.2.1.4
3.2.1.78
Caldicellulosiruptor saccharolyticus AAA71887.1 P22533  
 endoglucanase (EG;CAC0915) 3.2.1.4
3.2.1.8
Clostridium acetobutylicum ATCC 824 AAK78891.1
NP_347551.1
Q977Y3 3IK2[A]
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Paenibacillus lautus PL236 AAA22303.1
CAA01933.1
P29719  
 xyloglucanase 3.2.1.151 Paenibacillus pabuli AAW12878.1
ACE10761.1
   
 xyloglucanase 3.2.1.151 Paenibacillus polymyxa AAW12877.1
ACE10760.1
   
 xyloglucanase / β-mannanase (Cel44C-Man26A) 3.2.1.151
3.2.1.4
3.2.1.78
Paenibacillus polymyxa GS01 AAW12876.1
ABC88431.1
ACE10759.1
  2YIH[A]
2YJQ[A,B]
2YKK[A]
3ZQ9[A]
 broad substrate-specificity xyloglucanase J / processive endoglucanase (CelJ;Cthe_0624) (Cel9D/Cel9J+Cel44A) 3.2.1.151
3.2.1.151
Ruminiclostridium thermocellum ATCC 27405 ABN51859.1 A3DD30  
 endoglucanase J (CelJ) (Cel9D-Cel44A) 3.2.1.4 Ruminiclostridium thermocellum F1 BAA12070.1 P71140 2D8G[nd]
2E0P[A]
2E4T[A]
2EEX[A]
2EJ1[A]
2EO7[A]
2EQD[A]
 xyloglucanase (GH44A;RUM_05910) (Xeg44A) 3.2.1.151 Ruminococcus champanellensis 18P13 = JCM 17042 CBL16808.1 D4LB13  
 cellulase (EndB) 3.2.1.4 Ruminococcus flavefaciens 17 CAC83072.1 Q934F9  
 xyloglucanase / endo-β-1,4-glucanase B (CelB) 3.2.1.151
3.2.1.4
Ruminococcus flavefaciens FD-1 AAA95959.1 Q52743  
 bifunctional glucanase-xylanase (CelM2) 3.2.1.- uncultured bacterium ABL11223.1 A1E9A6 3FW6[A]
3II1[A]
 cellulase (Lc-CelH) 3.2.1.4 uncultured bacterium AHL27901.1    
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 endoglucanase (37GP1) 3.2.1.4 Bankia gouldi CAH68691.1
AAM56790.1
ABW61101.1
ABY00380.1
CAT81451.1
   
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 endoglucanase (MgCel44) (Cel44) 3.2.1.4 uncultured microorganism AGZ87466.1    
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