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Glycoside Hydrolase Family 43

Activities in Familyα-1,2-L-arabinofuranosidase (EC 3.2.1.-);
α-1,3-L-arabinofuranosidase (EC 3.2.1.-);
α-1,4-L-arabinofuranosidase (EC 3.2.1.-);
Exo-1,4-β-xylosidase (EC 3.2.1.-);
Exo-α-1,5-L-arabinofuranosidase (EC 3.2.1.-);
Exo-β-1,3-galactanase (EC 3.2.1.145);
β-D-galactofuranosidase (EC 3.2.1.146);
Xylan β-1,4-xylosidase (EC 3.2.1.37);
α-L-arabinofuranosidase (EC 3.2.1.55);
β-1,3-xylosidase (EC 3.2.1.72);
Endo-β-1,4-xylanase (EC 3.2.1.8);
[inverting] endo-α-1,5-L-arabinanase (EC 3.2.1.99);
Mechanism Inverting e
ClanGH-F
3D Structure Status5-fold β-propeller
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorGlu
NoteMany members have been assigned to subfamilies as described by Mewis et al. (2016) Appl. Environm. Microbiol. 82:1686-1692 (PMID: 26729713).
External resourcesCAZypedia;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (40578); Uniprot accession (244); PDB accession (113); 3D entries (51); cryst (1)
Summary
Download GH43 (50241) Taxonomic display Structure (51 - 1 cryst) Characterized (229)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 Subf
 [arabinogalactan] exo-β-1,3-galactanase (Ct1,3Gal43A; CtGH43; Cthe_0661) (1,3Gal43A) 3.2.1.145 Acetivibrio thermocellus ATCC 27405 ABN51896.1 A3DD67
3VSF[A,B,C,D,E,F] 2.76
3VSZ[A,B,C,D,E,F] β-D-Galp-(1-3)-β-D-Galp
β-D-Galp-(1-3)-β-D-Galp-(1-3)-β-D-Galp
 2.89
3VT0[A,B,C,D,E,F] β-D-Galp-(1-4)-β-D-Glcp
 2.91
3VT1[A,B,C,D,E,F] β-D-Galp
 3.19
3VT2[A,B,C,D,E,F] β-D-Galp1S-(1-1)-<non_carb>
 3.00
24
 α-L-arabinofuranosidase (Ct43Araf;CtAbf43A;CtGh43;Cthe_1271) (Abf43A) 3.2.1.55 Acetivibrio thermocellus ATCC 27405 ABN52503.1 A3DEX4
5A8C[A] 0.97
5A8D[A] 1.65
16
 BLi04220 / BL00219 (YxiA)   Bacillus licheniformis DSM 13 = ATCC 14580 AAU43033.1
AAU25654.1
AAU25654.2
ACR87831.1
CAF05510.1
CAV28398.1		  
3LV4[A,B] 1.70
4
 endo-α-1,5-L-arabinanase (BlAbn1; BLi03029; BL00353) 3.2.1.99 Bacillus licheniformis DSM 13 = ATCC 14580 AAU41895.1
AAU24536.1		 Q65GB9
6B7K[A,B,C,D] 2.55
5
 BLi00864 or BL03023 (XynB)   Bacillus licheniformis DSM 13 = ATCC 14580 AAU39798.1
AAU22449.1		  
6MS2[A] 2.49
6MS3[A,B] 1.95
12
 β-xylosidase (BpX;XynB;E-BXSEBP) 3.2.1.37 Bacillus pumilus IPO CAA29235.1 P07129
5ZQJ[A,B] 1.73
5ZQS[A,B] β-D-Xylp
β-D-Xylp-(1-4)-β-D-Xylp
 1.78
5ZQX[A,B,C,D] β-D-Xylp-(1-4)-β-D-Xylp
 2.00
11
 β-xylosidase (XynB) 3.2.1.37 Bacillus pumilus PLS AAC97375.1 A0A4V8GZZ0
Q9Z477
6IFE[A,B] 1.80
11
 endo-α-1,5-L-arabinanase (Abn2;YxiA;J3A;BSU39330) (Arb43B) 3.2.1.99 Bacillus subtilis subsp. subtilis str. 168 CAB15969.2
ACB06752.1
AIY95249.1
AQR83975.1
AQR88190.1
CAB15969.1
NP_391812.1		 A0A6M4JQW9
B3FRL6
P42293
2X8F[A,B] 1.90
2X8S[A,B] α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf
 1.50
2X8T[A,B] 1.79
4COT[A] 1.90
4
 endo-α-1,5-L-arabinanase (AbnA;BSU28810) (Arb43A) 3.2.1.99 Bacillus subtilis subsp. subtilis str. 168 CAA99586.1
AAV87172.1
AIY94210.1
AQR82908.1
AQR87123.1
CAB14841.1
CAB14841.2
NP_390759.1		 A0A6M3ZJV7
P94522
1UV4[A] 1.50
5
 β-1,4-xylosidase (BsX;XynB;YnaK;BSU17580) 3.2.1.37 Bacillus subtilis subsp. subtilis str. 168 AAB41091.1
AIY93062.1
AQR81741.1
AQR85955.1
CAB13642.1
CAB13642.2
NP_389640.1		 A0A6M3ZBF4
P94489
1YIF[A,B,C,D] 1.80
11
 arabinoxylan α-L-1,3-arabinofuranohydrolase (XynD;BsAXH-m23;BSU18160) 3.2.1.55 Bacillus subtilis subsp. subtilis str. 168 CAB13699.1
AIY93126.1
AQR81807.1
AQR86021.1
NP_389698.1		 A0A6M4JGV3
Q45071
Q798P3
3C7E[A] 2.00
3C7F[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
 1.55
3C7G[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
 2.02
3C7H[A] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
 2.00
3C7O[A] β-D-Glcp-(1-4)-β-D-Galp-(1-4)-β-D-Glcp-(1-4)-β-D-Glcp
 1.80
16
 α-L-arabinofuranosidase (BACEGG_01304) 3.2.1.55 Bacteroides eggerthii DSM 20697 ZP_03458529.1 E5WZQ7
6MLY[A,B,C,D] 2.70
10
 I1224_01990   Bacteroides intestinalis APC919/174 substr. 8W UCB40241.1  
7ERL[A,B] 1.89
12
 bifunctional xyloglucan α-1,2-L-arabinofuranoside and β-1,2-xylosidase 43A (Xynb_4; BoGH43A; BACOVA_02654; Bovatus_03073) 3.2.1.55 Bacteroides ovatus ATCC 8483 ALJ47681.1 A7LXT8
5JOW[A,B] 1.60
5JOX[A,B] <carb_like_EDG>
 1.80
5JOY[A,B] α-L-Araf1N-(1-1)-<non_carb>
β-L-Araf1N-(1-1)-<non_carb>
 1.90
12
 α-L-arabinofuranoside (Xynb_5;BoGH43B;BACOVA_02656;Bovatus_03074) 3.2.1.55 Bacteroides ovatus ATCC 8483 ALJ47682.1 A7LXU0
5JOZ[A,B] 2.28
12
 α-L-arabinofuranosidase (BT3675; BT_3675) 3.2.1.55 Bacteroides thetaiotaomicron VPI-5482 AAO78780.1
NP_812586.1		 Q8A1I6
3QZ4[A,B] 1.74
34
 BT2959 / BT_2959   Bacteroides thetaiotaomicron VPI-5482 AAO78065.1
NP_811871.1		  
3NQH[A] 2.11
24
 endo-arabinase (BT1873)   Bacteroides thetaiotaomicron VPI-5482 AAO76980.1
NP_810786.1		  
5C0P[A] 1.53
17
 exo-β-1,3-galactanase (BT0265;BT_0265) 3.2.1.145 Bacteroides thetaiotaomicron VPI-5482 AAO75372.1
NP_809178.1		 Q8AB46
6EUF[A,B,C,D] α-L-Rhap-(1-4)-β-D-GlcpA-(1-6)[α-L-Araf-(1-4)][α-L-Araf-(1-3)]-β-D-Galp-(1-6)-β-D-Galp
β-D-GlcpA-(1-6)[α-L-Araf-(1-3)][<non_carb>-(1-4)]-β-D-Galp-(1-6)-β-D-Galp
β-D-GlcpA-(1-6)[α-L-Araf-(1-4)][α-L-Araf-(1-3)]-β-D-Galp-(1-6)-β-D-Galp
 2.20
6EUJ[A,B,C,D] 2.75
24
 BT2895   Bacteroides thetaiotaomicron VPI-5482 AAO78001.1
NP_811807.1		  
3KST[A,B] 1.70
31
 β-1,3-galactosidase (BT3683)   Bacteroides thetaiotaomicron VPI-5482 AAO78788.1
NP_812594.1		  
6EUG[A] <carb_like_GIM>
 1.61
6EUH[A,B,C] <carb_like_DGJ>
 2.00
6EUI[A] β-D-Galp
 1.76
24
 (grape RGII active) α-L-arabinofuranosidase (cleaves L-Araf-α-1,3-D-GalA) (BT3662;BT_3662) 3.2.1.55 Bacteroides thetaiotaomicron VPI-5482 AAO78767.1
NP_812573.1		 Q8A1J9
5MSX[A,B,C] 2.10
34
 exo-β-1,3-galactanase (BBIF_0009)   Bifidobacterium bifidum S17 ADO52214.1  
5FLW[A,B] 1.40
24
 α-L-arabinofuranosidase (Xsa43E;bpr_I2319) 3.2.1.37
3.2.1.55		 Butyrivibrio proteoclasticus B316 ADL35052.1 E0RYY0
4NOV[A] 1.33
29
 endo-α-1,5-L-arabinanase / exo-α-1,5-L-arabinanase 43A (ArbA; CJA_0805) (Arb43A) 3.2.1.99
3.2.1.-		 Cellvibrio japonicus Ueda107 ACE84667.1
CAA71485.1		 B3PKP8
P95470
1GYD[B] 2.05
1GYE[B] α-L-Araf-(1-5)-α-L-Araf
 2.5
1GYH[A,B,C,D,E,F] 1.89
5
 α-1,2-L-arabinofuranosidase 43A (CJA_3018) (arabinan-specific) (Abf43A=Gly43N) 3.2.1.- Cellvibrio japonicus Ueda107 ACE83886.1 B3PD60
3QED[A,B,C,D] 2.99
3QEE[A,B] 1.64
3QEF[A,B] α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf
α-L-Araf-(1-5)[α-L-Araf-(1-3)]-α-L-Araf-(1-5)-α-L-Araf
 1.79
29
 β-xylosidase (XynD;CAC3452)   Clostridium acetobutylicum ATCC 824 AAK81382.1
NP_350042.1		  
1Y7B[A,B,C,D] 1.60
1YI7[A,B,C,D] 1.90
11
 β-xylosidase (Abf2;CAC1529)   Clostridium acetobutylicum ATCC 824 AAK79496.1
NP_348156.1		  
3CPN[A] 1.55
3K1U[A] 1.55
26
 β-xylosidase (Xyl43) 3.2.1.37 Enterobacter sp. enrichment culture clone nf1B6 AFZ78871.1 V5J3M5
7K1R[A,B,C,D] 2.40
8UWS[A,B,C,D] 2.65
11
 β-xylosidase (XynB3;HUS_CDS105) 3.2.1.37 Geobacillus stearothermophilus T-6 NCIMB 40222 AAT98625.1
ABI49959.1		 Q09LX0
2EXH[A,B,C,D] 1.88
2EXI[A,B,C,D] 2.15
2EXJ[A,B,C,D] β-D-Xylp-(1-4)-β-D-Xylp
 2.20
2EXK[A,B,C,D] β-D-Xylp-(1-4)-β-D-Xylp
 2.20
11
 α-1,5-L-arabinanase (AbnB;HUS_CDS25) (intracellular) 3.2.1.99 Geobacillus stearothermophilus T-6 NCIMB 40222 ACE73676.1 B3EYM8
3CU9[A] 1.06
3D5Y[A] 1.22
3D5Z[A] α-L-Araf-(1-5)-α-L-Araf-(1-5)-β-L-Araf
 1.90
3D60[A] 1.90
3D61[A] α-L-Araf-(1-5)-β-L-Araf
 1.95
6F1G[A] α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf
 1.67
5
 endo-α-1,5-L-arabinanase (AbnA) (extracellular) 3.2.1.99 Geobacillus stearothermophilus T-6 NCIMB 40222 ACE73680.1 B3EYN2
5HO0[A] 2.35
5HO2[A] 2.37
5HO9[A,B] α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf
 2.85
5HOF[A] α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf
 2.96
5HP6[A] 2.09
4
 endo-α-1,5-L-arabinanase (Abn-ts) 3.2.1.99 Geobacillus thermodenitrificans TS-3 BAB64339.1 Q93HT9
1WL7[A] 1.90
6A8H[A] α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf
 1.65
6A8I[A,B] α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf
α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf-(1-5)-α-L-Araf
 1.90
5
 β-xylosidase (Xyl;GbtXyl43A) (Xyl43A) 3.2.1.37 Geobacillus thermoleovorans IT-08 ABC75004.1 Q2I2N4
5Z5D[A] 1.70
5Z5F[A] β-L-Araf
 2.10
5Z5H[A] α-D-Xylp
 1.90
5Z5I[A] α-D-Xylp
β-D-Xylp
β-L-Araf
 1.70
12
 β-xylosidase (XynB;XylBH43;BH3683) 3.2.1.37 Halalkalibacterium halodurans C-125 BAB07402.1
NP_244550.1		 Q9K6P5
1YRZ[A,B] 2.00
11
 α-L-arabinofuranosidase (HoAraf43;Hore_20580) 3.2.1.55 Halothermothrix orenii H 168 ACL70803.1 B8CZV1
4QQS[A,B] 1.10
33
 α-L-arabinofuranosidase II (Araf43;LbAraf43;N624_1993) 3.2.1.- Levilactobacillus brevis DSM 1269 / TMW 1.313 APU52333.1
KIO95879.1		 A0A5B7Y0Z3
5M8B[A,B] 1.90
26
 Pedsa_2569   Pseudopedobacter saltans DSM 12145 ADY53113.1  
8HCJ[A,B,C,D,E,F,G,H] 2.57
29
 β-xylosidase / α-L-arabinofuranosidase (Xsa; Sxa; SXA; SrXyl43) 3.2.1.37
3.2.1.55		 Selenomonas ruminantium GA192 AAB97967.1 O52575
3C2U[A,B,C,D] 1.30
11
 exo-α-1,5-L-arabinofuranosidase (SaAraf43A; SAV1043) (Araf43A) 3.2.1.- Streptomyces avermitilis MA-4680 = NBRC 14893 BAC68753.1
NP_822218.1		 Q82P90
3AKF[A] 2.20
3AKG[A] α-L-Araf
α-L-Araf-(1-5)-α-L-Araf
 1.80
3AKH[A] α-L-Araf
α-L-Araf-(1-5)-α-L-Araf
 1.70
3AKI[A] α-L-Araf1N-(1-1)-<non_carb>
 2.00
26
 endo-α-1,5-L-arabinanase (AbnA;TpABN;Tpet_0637) 3.2.1.99 Thermotoga petrophila RKU-1 ABQ46657.1 A5IKD4
4KC7[A,B,C] 1.75
4KC8[A,B,C] 1.76
4
 β-xylosidase / α-L-arabinofuranosidase (CoXyl43) 3.2.1.37
3.2.1.55		 uncultured bacterium BAS02080.1 A0A0H5BL38
5GLK[A,B] 1.70
5GLL[A,B] 1.80
5GLM[A,B] β-D-Xylp-(1-4)-β-D-Xylp
β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
 1.80
5GLN[A,B] α-D-Xylp
β-D-Xylp
β-D-Xylp-(1-4)-β-D-Xylp
β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
 1.70
5GLO[A,B] α-L-Arap
β-L-Araf
 1.80
5GLP[A,B] α-L-Arap
 1.80
5GLQ[A,B] β-D-Xylp-(1-4)-β-D-Xylp
β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
β-L-Araf
 1.70
5GLR[A,B] β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
β-L-Araf
 1.70
1
 exo-α-1,5-L-arabinanase (Arn3;ARN3) 3.2.1.- uncultured bacterium ADB43999.1 D2XML8
4KCB[A,B] 2.90
5
 endo-α-1,5-L-arabinanase (Arn2;ARN2) (partial) 3.2.1.99 uncultured rumen bacterium    
4KCA[A] 1.90
4KCA[B] 1.90
4
 α-L-arabinofuranosidase (Araf43;WAraf43) 3.2.1.- Weissella sp. 142 APU52332.1 A0A0D1M7L2
A0A1L7HA00
5M8E[A,B] 2.00
26
 xylan 1,4-β-xylosidase (XAC4258 (Xsa)) 3.2.1.37 Xanthomonas citri pv. citri str. 306 AAM39093.1
NP_644557.1		 Q8PET2
6XN0[A,B] 1.71
6XN1[A,B] β-D-Xylp
 1.80
6XN2[A,B] β-D-Xylp
β-D-Xylp-(1-4)-β-D-Xylp-(1-4)-β-D-Xylp
 1.65
1
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 Subf
 double substituted xylan α-1,3-L-arabinofuranosidase (α-araF; AXHd3; HiAXHd3; Abf II; HiABF43_36a; ABF-d3) 3.2.1.55 Humicola insolens DSM 18000 CAL81199.1  
3ZXJ[A,B] 1.85
3ZXK[A,B] β-D-Xylp-(1-4)[α-L-Araf-(1-2)]-β-D-Xylp-(1-4)-β-D-Xylp
 1.44
3ZXL[A,B] 1.87
36
 endo-α-1,5-L-arabinanase (AbnS1) 3.2.1.99 Penicillium chrysogenum 31B BAD89094.2
BAD89094.1
BAJ49868.1		 Q5H7M8
cryst    
6
 exo-β-1,3-galactanase (Pc1,3Gal43A) (1,3Gal43A) 3.2.1.145 Phanerochaete chrysosporium BAD98241.1 Q50KB2
7BYS[A,B] 1.40
7BYT[A] α-D-Galp
β-D-Galp
 1.50
7BYV[A] β-D-Galp
β-D-Galp-(1-3)-β-D-Galp-(1-3)-β-D-Galp
 2.50
7BYX[A,B,C,D] β-D-Galp-(1-3)-β-D-Galp-(1-3)-β-D-Galp
 2.30
24
unclassified
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 Subf
 α-L-arabinofuranosidase (CapGH43_12) 3.2.1.55 metagenome UMW87593.1  
7JVH[A,B,C,D,E,F] 2.48
12
 β-xylosidase (RS223-BX) 3.2.1.37 uncultured organism AFP23142.1 I7EUE2
4MLG[A,B,C,D,E,F,G,H,I,J, 2.70
1
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