Glycoside Hydrolase Family 43

Activities in Familyβ-xylosidase (EC 3.2.1.37); α-L-arabinofuranosidase (EC 3.2.1.55); xylanase (EC 3.2.1.8); α-1,2-L-arabinofuranosidase (EC 3.2.1.-); exo-α-1,5-L-arabinofuranosidase (EC 3.2.1.-); [inverting] exo-α-1,5-L-arabinanase (EC 3.2.1.-); β-1,3-xylosidase (EC 3.2.1.-); [inverting] exo-α-1,5-L-arabinanase (EC 3.2.1.-); [inverting] endo-α-1,5-L-arabinanase (EC 3.2.1.99); exo-β-1,3-galactanase (EC 3.2.1.145); β-D-galactofuranosidase (EC 3.2.1.146)
Mechanism Inverting
ClanGH-F
3D Structure Status5-fold β-propeller
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorGlu
NoteMany members have been assigned to subfamilies as described by Mewis et al. (2016) Appl. Environm. Microbiol. 82:1686-1692 (PMID: 26729713).
External resourcesCAZypedia;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (15631); Uniprot accession (1416); PDB accession (101); 3D entries (46); cryst (2)
All (15016) Archaea (19) Bacteria (14465) Eukaryota (499) Viruses (5) unclassified (28) Structure (46 - 2 cryst) Characterized (182)
| 1 | 2 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 β-xylosidase (AmX;Amet_3317) 3.2.1.37 Alkaliphilus metalliredigens QYMF ABR49445.1 A6TTC7   11
 β-D-galactofuranosidase (weak activity) (AMED_5364) 3.2.1.146 Amycolatopsis mediterranei U32 ADJ47124.1 D8I4F0   37
 β-xylosidase (XynB;XylBH43;BH3683) 3.2.1.37 Bacillus halodurans C-125 BAB07402.1
NP_244550.1
Q9K6P5 1YRZ[A,B] 11
 BLi03029 or BL00353 3.2.1.99 Bacillus licheniformis DSM 13 = ATCC 14580 AAU41895.1
AAU24536.1
Q65GB9 6B7K[A,B,C,D] 5
 endo-α-1,5-L-arabinanase (AbnA;BLABNase;BLi01295;BL02653) 3.2.1.99 Bacillus licheniformis DSM 13 = ATCC 14580 AAU40201.1
AAU22854.1
AAU22854.2
Q65L63   5
 arabinoxylan α-arabinofuranosidase / AXH-m23 (XynD) (Arf43A=Axh43A) 3.2.1.55 Bacillus licheniformis SVD1 BAL45491.1     16
 β-xylosidase (BpX;XynB;E-BXSEBP) 3.2.1.37 Bacillus pumilus IPO CAA29235.1 P07129 5ZQJ[A,B]
5ZQS[A,B]
5ZQX[A,B,C,D]
11
 β-xylosidase (XynB) 3.2.1.37 Bacillus pumilus PLS AAC97375.1 Q9Z477 6IFE[A,B] 11
 arabinoxylan arabinofuranohydrolase (AXH) (Axh43A) 3.2.1.55 Bacillus sp. BP-7 AKF02745.1     16
 β-xylosidase (XylB) 3.2.1.37 Bacillus sp. KK-1 AAC27699.1 O52729   11
 endo-α-1,5-L-arabinanase 3.2.1.99 Bacillus subtilis IFO3134 BAA20372.1 O07078   5
 endo-α-1,5-L-arabinanase (Abn2;YxiA;J3A;BSU39330) (Arb43B) 3.2.1.99 Bacillus subtilis subsp. subtilis str. 168 CAB15969.2
ACB06752.1
AIY95249.1
AQR83975.1
AQR88190.1
CAB15969.1
NP_391812.1
B3FRL6
P42293
2X8F[A,B]
2X8S[A,B]
2X8T[A,B]
4COT[A]
4
 endo-α-1,5-L-arabinanase (AbnA;BSU28810) (Arb43A) 3.2.1.99 Bacillus subtilis subsp. subtilis str. 168 CAA99586.1
AAV87172.1
AIY94210.1
AQR82908.1
AQR87123.1
CAB14841.1
CAB14841.2
NP_390759.1
P94522 1UV4[A] 5
 β-1,4-xylosidase (BsX;XynB;YnaK;BSU17580) 3.2.1.37 Bacillus subtilis subsp. subtilis str. 168 AAB41091.1
AIY93062.1
AQR81741.1
AQR85955.1
CAB13642.1
CAB13642.2
NP_389640.1
P94489 1YIF[A,B,C,D] 11
 arabinoxylan α-L-1,3-arabinofuranohydrolase (XynD;BsAXH-m23;BSU18160) 3.2.1.55 Bacillus subtilis subsp. subtilis str. 168 CAB13699.1
AIY93126.1
AQR81807.1
AQR86021.1
NP_389698.1
Q45071 3C7E[A]
3C7F[A]
3C7G[A]
3C7H[A]
3C7O[A]
16
 α-L-arabinofuranosidase (BcellWH2_01652) 3.2.1.55 Bacteroides cellulosilyticus WH2 ALJ58905.1     19
 α-L-arabinofuranosidase (BcellWH2_01652) 3.2.1.55 Bacteroides cellulosilyticus WH2 ALJ58905.1     34
 β-D-galactofuranosidase (BcellWH2_02640;BACWH2_2462;Arba_1) 3.2.1.146 Bacteroides cellulosilyticus WH2 ALJ59879.1
WP_007211145.1
    3
 α-L-arabinofuranosidase (BcellWH2_04906;BACWH2_4625) 3.2.1.55 Bacteroides cellulosilyticus WH2 ALJ62115.1
WP_029328006.1
    18
 α-L-arabinofuranoside (weak activity) (BcellWH2_03560; BACWH2_3333) 3.2.1.55 Bacteroides cellulosilyticus WH2 ALJ60783.1
WP_029427512.1
    18
 β-xylosidase (BiXyl43A;BACINT_04203) (Xyl43A) 3.2.1.37 Bacteroides intestinalis DSM 17393 EDV05060.1     1
 bifunctional endo-β-1,4-xylanase / α-L-arabinofuranosidase (BiXyn10B/BiAra43A;BACINT_04202) (Xyn10B/Ara43A) 3.2.1.55
3.2.1.8
Bacteroides intestinalis DSM 17393 EDV05059.1     12
 α-L-arabinofuranosidase (BACOVA_03421;Bovatus_03717) 3.2.1.55 Bacteroides ovatus ATCC 8483 ALJ48322.1
EDO10788.1
    12
 α-L-arabinofuranosidase (BACOVA_03425;Bovatus_03721) 3.2.1.55 Bacteroides ovatus ATCC 8483 ALJ48326.1
EDO10792.1
    12
 double substituted xylan α-1,3-L-arabinofuranosidase (Bovatus_03715; Xynb_6; BACOVA_03417) 3.2.1.55 Bacteroides ovatus ATCC 8483 ALJ48320.1     10
 α-L-arabinofuranoside (Xynb_4;BoGH43A;BACOVA_02654;Bovatus_03073) 3.2.1.55 Bacteroides ovatus ATCC 8483 ALJ47681.1   5JOW[A,B]
5JOX[A,B]
5JOY[A,B]
12
 β-D-galactofuranosidase (Xsa_3;Bovatus_03644; revised model of BACOVA_03336 ZP_02066340.1) 3.2.1.146 Bacteroides ovatus ATCC 8483 ALJ48250.1     34
 α-L-arabinofuranoside (Xynb_5;BoGH43B;BACOVA_02656;Bovatus_03074) 3.2.1.55 Bacteroides ovatus ATCC 8483 ALJ47682.1   5JOZ[A,B] 12
 β-xylosidase / α-L-arabinofuranosidase (Xsa;XSA) 3.2.1.37
3.2.1.55
Bacteroides ovatus V975 AAB08024.1
ACA34973.1
B2KZK6
P49943
  1
 β-D-galactofuranosidase (HMPREF1071_01763) 3.2.1.146 Bacteroides salyersiae CL02T12C01 EIY66405.1     8
 endo-α-1,5-L-arabinanase (BT0360;BT_0360) (branched arabinan specific) 3.2.1.99 Bacteroides thetaiotaomicron VPI-5482 AAO75467.1
NP_809273.1
Q8AAV4   4
 endo-α-1,5-L-arabinanase (BT0367;BT_0367) (linear arabinan-specific) 3.2.1.99 Bacteroides thetaiotaomicron VPI-5482 AAO75474.1
NP_809280.1
Q8AAU7   4
 α-L-arabinofuranosidase (BT3675;BT_3675) 3.2.1.55 Bacteroides thetaiotaomicron VPI-5482 AAO78780.1
NP_812586.1
Q8A1I6 3QZ4[A,B] 34
 α-L-arabinofuranosidase (Bt3655;BT_3655) (single substitution specific) 3.2.1.55 Bacteroides thetaiotaomicron VPI-5482 AAO78760.1
NP_812566.1
Q8A1K6   19
 exo-β-1,3-galactanase (BT0265;BT_0265) 3.2.1.145 Bacteroides thetaiotaomicron VPI-5482 AAO75372.1
NP_809178.1
Q8AB46 6EUF[A,B,C,D]
6EUJ[A,B,C,D]
24
 α-L-arabinofuranosidase (cleaves L-Araf-α-1,3-D-GalpA; BT1021; BT_1021) (fragment) 3.2.1.55 Bacteroides thetaiotaomicron VPI-5482 AAO76128.1
NP_809934.1
Q8A8Z6   18
 α-L-arabinofuranosidase (Bt2852;BT_2852) (single substitution specific) 3.2.1.55 Bacteroides thetaiotaomicron VPI-5482 AAO77958.1
NP_811764.1
Q8A3V2   10
 α-1,2-L-arabinofuranosidase (BT0369;BT_0369) 3.2.1.- Bacteroides thetaiotaomicron VPI-5482 AAO75476.1
NP_809282.1
Q8AAU5   29
 (grape RGII active) α-L-arabinofuranosidase (BT3662;BT_3662) 3.2.1.55 Bacteroides thetaiotaomicron VPI-5482 AAO78767.1
NP_812573.1
Q8A1J9 5MSX[A,B,C] 34
 α-L-arabinofuranosidase (Bt3094;BT_3094) 3.2.1.55 Bacteroides thetaiotaomicron VPI-5482 AAO78200.1
NP_812006.1
Q8A361  
 β-D-galactofuranosidase (Belba_3293) 3.2.1.146 Belliella baltica DSM 15883 AFL85801.1     31
 double substituted xylan α-1,3-L-specific arabinofuranosidase d3 (AXHd3;AXH-d3;BaAXH-d3;BAD_0301;E-AFAM2) 3.2.1.55 Bifidobacterium adolescentis ATCC 15703 AAO67499.1
BAF39082.1
A1A049
Q5JB56
  10
 α-L-arabinofuranosidase (AXH-m;AbfA;BAD_0423) 3.2.1.55 Bifidobacterium adolescentis ATCC 15703 BAF39204.1 A1A0H1   12
 β-xylosidase C (XylC;XynB;BAD_0428) 3.2.1.37 Bifidobacterium adolescentis ATCC 15703 BAF39209.1 A1A0H6   11
 β-xylosidase (BAD_1527) 3.2.1.37 Bifidobacterium adolescentis ATCC 15703 BAF40308.1 A1A3M5   22
 β-xylosidase (BIF_00092) 3.2.1.37 Bifidobacterium animalis subsp. lactis BB-12 ADC85541.1 D3R467   11
 α-L-arabinofuranosidase (HypAA;BLLJ_0213) 3.2.1.55 Bifidobacterium longum subsp. longum JCM 1217 BAJ65883.1     29
 exo-β-1,3-galactanase (BLLJ_1840) 3.2.1.145 Bifidobacterium longum subsp. longum JCM 1217 BAJ67504.1     24
 α-L-arabinofuranosidase (BlArafC;BLLJ_1852) 3.2.1.55 Bifidobacterium longum subsp. longum JCM 1217 BAJ67516.1     27
 α-L-arabinofuranosidase (BlArafB;BLLJ_1853) 3.2.1.55 Bifidobacterium longum subsp. longum JCM 1217 BAJ67517.1     22
 α-L-arabinofuranosidase / β-xylosidase (XylB) 3.2.1.37
3.2.1.55
Butyrivibrio fibrisolvens GS 113 AAA63610.1 P45982   12
 α-L-arabinofuranosidase (Xsa43E;bpr_I2319) 3.2.1.37
3.2.1.55
Butyrivibrio proteoclasticus B316 ADL35052.1 E0RYY0 4NOV[A] 29
 α-L-arabinofuranosidase (Calow_2099) 3.2.1.55 Caldicellulosiruptor owensensis OL ADQ05609.1 E4Q6K2   17
 β-xylosidase / α-L-arabinofuranosidase (XynF) 3.2.1.37
3.2.1.55
Caldicellulosiruptor saccharolyticus AAB87371.1 O30426   16
 β-xylosidase / α-L-arabinofuranosidase (XynF) 3.2.1.37
3.2.1.55
Caldicellulosiruptor saccharolyticus AAB87371.1 O30426   10
 endo-α-1,5-L-arabinanase (Csac_1560) 3.2.1.99 Caldicellulosiruptor saccharolyticus DSM 8903 ABP67152.1 A4XJR7   4
 bifunctional α-L-arabinofuranosidase (XynF;Csac_2411) 3.2.1.55
3.2.1.55
Caldicellulosiruptor saccharolyticus DSM 8903 ABP67988.1 A4XM53   16
 bifunctional α-L-arabinofuranosidase (XynF;Csac_2411) 3.2.1.55
3.2.1.55
Caldicellulosiruptor saccharolyticus DSM 8903 ABP67988.1 A4XM53   10
 xylanase C (XynC) (multidomain protein) 3.2.1.8 Caldicellulosiruptor sp. Rt69B.1 AAB95326.1 O52374   16
 bifunctional β-1,4-xylanase / α-L-arabinosidase (XynA) 3.2.1.55
3.2.1.8
Caldicellulosiruptor sp. Tok7B.1 AAD30363.1 Q9X3P5   16
 bifunctional β-xylosidase I / α-L-arabinofuranosidase (XynB1;CCNA_01040) 3.2.1.37
3.2.1.55
Caulobacter vibrioides NA1000 ACL94505.1 B8H2V1   11
 β-xylosidase (CGSCsYakCAS_10615) (fragment) (Xyn43A) 3.2.1.- Cellulosilyticum ruminicola CGMCC 1.5065 ACZ98594.1 D2KFJ2   16
 endo-α-1,5-L-arabinanase / exo-α-1,5-L-arabinanase 43A (ArbA;CJA_0805) (Arb43A) 3.2.1.99
3.2.1.-
Cellvibrio japonicus Ueda107 ACE84667.1
CAA71485.1
B3PKP8
P95470
1GYD[B]
1GYE[B]
1GYH[A,B,C,D,E,F]
5
 β-xylosidase 43A (CJA_3070) (Xyl43A=Gly43G) 3.2.1.37 Cellvibrio japonicus Ueda107 ACE82692.1 B3PDB2   1
 exo-α-1,5-L-arabinofuranosidase 43K (CJA_3012) (Abf43K) 3.2.1.- Cellvibrio japonicus Ueda107 ACE82749.1 B3PD54   26
 α-1,2-L-arabinofuranosidase 43A (CJA_3018) (arabinan-specific) (Abf43A=Gly43N) 3.2.1.- Cellvibrio japonicus Ueda107 ACE83886.1 B3PD60 3QED[A,B,C,D]
3QEE[A,B]
3QEF[A,B]
29
 exo-α-1,5-L-arabinofuranosidase 43L (CJA_0806) (Abf43L) 3.2.1.- Cellvibrio japonicus Ueda107 ACE84379.1 B3PKP9   26
 α-L-arabinofuranosidase (Cpin_4501) 3.2.1.55 Chitinophaga pinensis DSM 2588 ACU61943.1 C7PJ75   2
 β-xylosidase (Xyl43) 3.2.1.37 Enterobacter sp. enrichment culture clone nf1B6 AFZ78871.1     11
 arabinoxylan α-L-arabinofuranosidase (Axh1;Fisuc_1769;FSU_2269) 3.2.1.55 Fibrobacter succinogenes subsp. succinogenes S85 ACX75362.1
ADL24843.1
C9RS26   10
 Fisuc_1994 / FSU_2517 3.2.1.99 Fibrobacter succinogenes subsp. succinogenes S85 ACX75582.1
ADL26080.1
C9RIW1   37
 β-xylosidase (BN863_22160) 3.2.1.37 Formosa agariphila KMM 3901 CDF79928.1     10
 β-xylosidase (XynB3;HUS_CDS105) 3.2.1.37 Geobacillus stearothermophilus T-6 NCIMB 40222 AAT98625.1
ABI49959.1
Q09LX0 2EXH[A,B,C,D]
2EXI[A,B,C,D]
2EXJ[A,B,C,D]
2EXK[A,B,C,D]
11
 α-1,5-L-arabinanase (AbnB;HUS_CDS25) (intracellular) 3.2.1.99 Geobacillus stearothermophilus T-6 NCIMB 40222 ACE73676.1 B3EYM8 3CU9[A]
3D5Y[A]
3D5Z[A]
3D60[A]
3D61[A]
6F1G[A]
5
 endo-α-1,5-L-arabinanase (AbnA) (extracellular) 3.2.1.99 Geobacillus stearothermophilus T-6 NCIMB 40222 ACE73680.1 B3EYN2 5HO0[A]
5HO2[A]
5HO9[A,B]
5HOF[A]
5HP6[A]
4
 endo-α-1,5-L-arabinanase (Abn-ts) 3.2.1.99 Geobacillus thermodenitrificans TS-3 BAB64339.1 Q93HT9 1WL7[A]
6A8H[A]
6A8I[A,B]
5
 β-xylosidase (Xyl;GbtXyl43A) (Xyl43A) 3.2.1.37 Geobacillus thermoleovorans IT-08 ABC75004.1 Q2I2N4 5Z5D[A]
5Z5F[A]
5Z5H[A]
5Z5I[A]
12
 β-xylosidase / exo-xylanase (GbtXyl43B) (Xyl43B) 3.2.1.37 Geobacillus thermoleovorans IT-08 ABD48561.1 Q27R94   27
 α-L-arabinofuranosidase (HoAraf43;Hore_20580) 3.2.1.55 Halothermothrix orenii H 168 ACL70803.1 B8CZV1 4QQS[A,B] 33
 [arabinogalactan] exo-β-1,3-galactanase (Ct1,3Gal43A;CtGH43;Cthe_0661) (1,3Gal43A) 3.2.1.145 Hungateiclostridium thermocellum ATCC 27405 ABN51896.1 A3DD67 3VSF[A,B,C,D,E,F]
3VSZ[A,B,C,D,E,F]
3VT0[A,B,C,D,E,F]
3VT1[A,B,C,D,E,F]
3VT2[A,B,C,D,E,F]
24
 α-L-arabinofuranosidase (Ct43Araf;CtAbf43A;CtGh43;Cthe_1271) (Abf43A) 3.2.1.55 Hungateiclostridium thermocellum ATCC 27405 ABN52503.1 A3DEX4 5A8C[A]
5A8D[A]
16
 β-xylosidase (XynB1) 3.2.1.37 Lactobacillus brevis ATCC 14869 = DSM 20054 AGT14429.1     11
 α-1,5-L-arabinofuranosidase (Abf3) 3.2.1.- Lactobacillus brevis ATCC 14869 = DSM 20054 AGT14430.1     26
 β-xylosidase 2 (XynB2) 3.2.1.37 Lactobacillus brevis ATCC 14869 = DSM 20054 AGT14431.1     11
 β-xylosidase (LbX;XynB2;LVIS_2285) 3.2.1.37 Lactobacillus brevis ATCC 367 ABJ65333.1 Q03N89   11
 α-L-arabinofuranosidase II (Araf43;LbAraf43;N624_1993) 3.2.1.- Lactobacillus brevis DSM 1269 / TMW 1.313 APU52333.1
KIO95879.1
  5M8B[A,B] 26
 β-D-galactofuranosidase (weak activity) (SAMN04515690_3677) 3.2.1.146 Leifsonia sp. 197AMF SDH69004.1     32
 α-L-arabinofuranoside (weak activity) (A3224_13575) 3.2.1.55 Microbulbifer thermotolerans DAU221 AMX03466.1     9
 α-L-arabinofuranosidase (GA0070618_4635) 3.2.1.55 Micromonospora echinospora DSM 43816 SCF26596.1     20
 β-D-galactofuranosidase (GA0074704_5727) 3.2.1.146 Micromonospora siamensis DSM 45097 SCG78792.1     30
 α-L-arabinofuranosidase (SAMN05216490_0716) 3.2.1.55 Mucilaginibacter mallensis MP1X4 SDS19757.1     2
 α-L-arabinofuranoside (weak activity) (B160DRAFT_01699) 3.2.1.55 Niabella aurantiaca WP_018628786.1     18
 β-xylosidase/α-L-arabinofuranosidase (XynA) 3.2.1.37
3.2.1.55
Niveispirillum irakense KBC1 AAF66622.1 Q9LAE3   11
 α-L-arabinofuranosidase (OB2087) 3.2.1.55 Oceanobacillus iheyensis HTE831 BAC14043.1
NP_693008.1
Q8EPL4   12
 α-L-arabinofuranoside (weak activity) (OPIT5_12740) 3.2.1.55 Opitutaceae bacterium TAV5 AHF90946.1     18
 β-D-galactofuranosidase (weak activity) (Oter_3903) 3.2.1.146 Opitutus terrae PB90-1 ACB77177.1 B1ZZA2   32
 α-L-arabinofuranosidase 43A (XynD) (formerly xylanase D) (Xyn43A) 3.2.1.55 Paenibacillus polymyxa ATCC 842 CAA40378.1 P45796   16
 endo-α-1,5-L-arabinanase (AbnZ3;YxiA3) 3.2.1.99 Paenibacillus polymyxa Z6 AHA50064.1     4
 endo-α-1,5-L-arabinanase (AbnZ2;Yxia1) 3.2.1.99 Paenibacillus polymyxa Z6 AHA50063.1     4
 endo-α-1,5-L-arabinanase (AbnZ1) 3.2.1.99 Paenibacillus polymyxa Z6 AHA50062.1     5
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