Glycoside Hydrolase Family 43

Activities in Familyβ-xylosidase (EC 3.2.1.37); α-L-arabinofuranosidase (EC 3.2.1.55); arabinanase (EC 3.2.1.99); xylanase (EC 3.2.1.8); galactan 1,3-β-galactosidase (EC 3.2.1.145); α-1,2-L-arabinofuranosidase (EC 3.2.1.-); exo-α-1,5-L-arabinofuranosidase (EC 3.2.1.-); [inverting] exo-α-1,5-L-arabinanase (EC 3.2.1.-); β-1,3-xylosidase (EC 3.2.1.-)
Mechanism Inverting
ClanGH-F
3D Structure Status5-fold β-propeller
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorGlu
NoteMany members have been assigned to subfamilies as described by Mewis et al. (2016) Appl. Environm. Microbiol. in press (PMID: 26729713).
External resourcesCAZypedia;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (9168); Uniprot accession (1416); PDB accession (81); 3D entries (39); cryst (3)
All (8596) Archaea (17) Bacteria (8175) Eukaryota (372) Viruses (5) unclassified (27) Structure (39 - 3 cryst) Characterized (151)
| 1 | 2 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 β-xylosidase (AmX;Amet_3317) 3.2.1.37 Alkaliphilus metalliredigens QYMF ABR49445.1 A6TTC7   11
 β-xylosidase (XynB;XylBH43;BH3683) 3.2.1.37 Bacillus halodurans C-125 BAB07402.1
NP_244550.1
Q9K6P5 1YRZ[A,B] 11
 endo-α-1,5-L-arabinanase (AbnA;BLABNase;BLi01295;BL02653) 3.2.1.99 Bacillus licheniformis DSM 13 = ATCC 14580 AAU40201.1
AAU22854.1
AAU22854.2
Q65L63   5
 arabinoxylan α-arabinofuranosidase / AXH-m23 (XynD) (Arf43A=Axh43A) 3.2.1.55 Bacillus licheniformis SVD1 BAL45491.1     16
 β-xylosidase (BpX;XynB;E-BXSEBP) 3.2.1.37 Bacillus pumilus IPO CAA29235.1 P07129   11
 β-xylosidase (XynB) 3.2.1.37 Bacillus pumilus PLS AAC97375.1 Q9Z477   11
 arabinoxylan arabinofuranohydrolase (AXH) (Axh43A) 3.2.1.55 Bacillus sp. BP-7 AKF02745.1     16
 β-xylosidase (XylB) 3.2.1.37 Bacillus sp. KK-1 AAC27699.1 O52729   11
 endo-α-1,5-L-arabinanase 3.2.1.99 Bacillus subtilis IFO3134 BAA20372.1 O07078   5
 endo-α-1,5-L-arabinanase (Abn2;YxiA;J3A;BSU39330) (Arb43B) 3.2.1.99 Bacillus subtilis subsp. subtilis str. 168 CAB15969.2
ACB06752.1
AIY95249.1
AQR83975.1
AQR88190.1
CAB15969.1
NP_391812.1
B3FRL6
P42293
2X8F[A,B]
2X8S[A,B]
2X8T[A,B]
4COT[A]
4
 endo-α-1,5-L-arabinanase (AbnA;BSU28810) (Arb43A) 3.2.1.99 Bacillus subtilis subsp. subtilis str. 168 CAA99586.1
AAV87172.1
AIY94210.1
AQR82908.1
AQR87123.1
CAB14841.1
CAB14841.2
NP_390759.1
P94522 1UV4[A] 5
 β-1,4-xylosidase (BsX;XynB;YnaK;BSU17580) 3.2.1.37 Bacillus subtilis subsp. subtilis str. 168 AAB41091.1
AIY93062.1
AQR81741.1
AQR85955.1
CAB13642.1
CAB13642.2
NP_389640.1
P94489 1YIF[A,B,C,D] 11
 arabinoxylan α-L-1,3-arabinofuranohydrolase (XynD;BsAXH-m23;BSU18160) 3.2.1.55 Bacillus subtilis subsp. subtilis str. 168 CAB13699.1
AIY93126.1
AQR81807.1
AQR86021.1
NP_389698.1
Q45071 3C7E[A]
3C7F[A]
3C7G[A]
3C7H[A]
3C7O[A]
16
 β-xylosidase (BiXyl43A;BACINT_04203) (Xyl43A) 3.2.1.37 Bacteroides intestinalis DSM 17393 EDV05060.1     1
 bifunctional endo-β-1,4-xylanase / α-L-arabinofuranosidase (BiXyn10B/BiAra43A;BACINT_04202) (Xyn10B/Ara43A) 3.2.1.55
3.2.1.8
Bacteroides intestinalis DSM 17393 EDV05059.1     12
 double substituted xylan α-1,3-L-arabinofuranosidase (BACOVA_03417) 3.2.1.55 Bacteroides ovatus ATCC 8483 EDO10784.1     10
 α-L-arabinofuranosidase (BACOVA_03421) 3.2.1.55 Bacteroides ovatus ATCC 8483 EDO10788.1     12
 α-L-arabinofuranosidase (BACOVA_03425) 3.2.1.55 Bacteroides ovatus ATCC 8483 EDO10792.1     12
 α-L-arabinofuranoside (Xynb_4;BoGH43A;BACOVA_02654;Bovatus_03073) 3.2.1.55 Bacteroides ovatus ATCC 8483 ALJ47681.1   5JOW[A,B]
5JOX[A,B]
5JOY[A,B]
12
 α-L-arabinofuranoside (Xynb_5;BoGH43B;BACOVA_02656;Bovatus_03074) 3.2.1.55 Bacteroides ovatus ATCC 8483 ALJ47682.1   5JOZ[A,B] 12
 β-xylosidase / α-L-arabinofuranosidase (Xsa;XSA) 3.2.1.37
3.2.1.55
Bacteroides ovatus V975 AAB08024.1
ACA34973.1
B2KZK6
P49943
  1
 endo-α-1,5-L-arabinanase (Bt0360;BT_0360) (branched arabinan specific) 3.2.1.99 Bacteroides thetaiotaomicron VPI-5482 AAO75467.1
NP_809273.1
Q8AAV4   4
 endo-α-1,5-L-arabinanase (Bt0367;BT_0367) (linear arabinan-specific) 3.2.1.99 Bacteroides thetaiotaomicron VPI-5482 AAO75474.1
NP_809280.1
Q8AAU7   4
 α-L-arabinofuranosidase (BT3675;BT_3675) 3.2.1.55 Bacteroides thetaiotaomicron VPI-5482 AAO78780.1
NP_812586.1
Q8A1I6 3QZ4[A,B] 34
 α-L-arabinofuranosidase (Bt3655;BT_3655) (single substitution specific) 3.2.1.55 Bacteroides thetaiotaomicron VPI-5482 AAO78760.1
NP_812566.1
Q8A1K6   19
 exo-β-1,3-galactanase (BT0265;BT_0265) 3.2.1.145 Bacteroides thetaiotaomicron VPI-5482 AAO75372.1
NP_809178.1
Q8AB46   24
 α-L-arabinofuranosidase (Bt2852;BT_2852) (single substitution specific) 3.2.1.55 Bacteroides thetaiotaomicron VPI-5482 AAO77958.1
NP_811764.1
Q8A3V2   10
 α-1,2-L-arabinofuranosidase (Bt0369;BT_0369) 3.2.1.- Bacteroides thetaiotaomicron VPI-5482 AAO75476.1
NP_809282.1
Q8AAU5   29
 (grape RGII active) α-L-arabinofuranosidase (BT3662;BT_3662) 3.2.1.55 Bacteroides thetaiotaomicron VPI-5482 AAO78767.1
NP_812573.1
Q8A1J9 5MSX[A,B,C] 34
 α-L-arabinofuranosidase (Bt3094;BT_3094) 3.2.1.55 Bacteroides thetaiotaomicron VPI-5482 AAO78200.1
NP_812006.1
Q8A361  
 double substituted xylan α-1,3-L-arabinofuranosidase d3 (AXHd3;AXH-d3;BaAXH-d3;BAD_0301;E-AFAM2) 3.2.1.55 Bifidobacterium adolescentis ATCC 15703 AAO67499.1
BAF39082.1
A1A049
Q5JB56
  10
 α-L-arabinofuranosidase (AXH-m;AbfA;BAD_0423) 3.2.1.55 Bifidobacterium adolescentis ATCC 15703 BAF39204.1 A1A0H1   12
 β-xylosidase C (XylC;XynB;BAD_0428) 3.2.1.37 Bifidobacterium adolescentis ATCC 15703 BAF39209.1 A1A0H6   11
 β-xylosidase (BAD_1527) 3.2.1.37 Bifidobacterium adolescentis ATCC 15703 BAF40308.1 A1A3M5   22
 β-xylosidase (BIF_00092) 3.2.1.37 Bifidobacterium animalis subsp. lactis BB-12 ADC85541.1 D3R467   11
 α-L-arabinofuranosidase (HypAA;BLLJ_0213) 3.2.1.55 Bifidobacterium longum subsp. longum JCM 1217 BAJ65883.1     29
 exo-β-1,3-galactanase (BLLJ_1840) 3.2.1.145 Bifidobacterium longum subsp. longum JCM 1217 BAJ67504.1     24
 α-L-arabinofuranosidase / β-xylosidase (XylB) 3.2.1.37
3.2.1.55
Butyrivibrio fibrisolvens GS 113 AAA63610.1 P45982   12
 α-L-arabinofuranosidase (Xsa43E;bpr_I2319) 3.2.1.37
3.2.1.55
Butyrivibrio proteoclasticus B316 ADL35052.1 E0RYY0 4NOV[A] 29
 β-xylosidase / α-L-arabinofuranosidase (XynF) 3.2.1.37
3.2.1.55
Caldicellulosiruptor saccharolyticus AAB87371.1 O30426   16
 β-xylosidase / α-L-arabinofuranosidase (XynF) 3.2.1.37
3.2.1.55
Caldicellulosiruptor saccharolyticus AAB87371.1 O30426   10
 endo-α-1,5-L-arabinanase (Csac_1560) 3.2.1.99 Caldicellulosiruptor saccharolyticus DSM 8903 ABP67152.1 A4XJR7   4
 bifunctional α-L-arabinofuranosidase (XynF;Csac_2411) 3.2.1.55 Caldicellulosiruptor saccharolyticus DSM 8903 ABP67988.1 A4XM53   16
 bifunctional α-L-arabinofuranosidase (XynF;Csac_2411) 3.2.1.55 Caldicellulosiruptor saccharolyticus DSM 8903 ABP67988.1 A4XM53   10
 xylanase C (XynC) (multidomain protein) 3.2.1.8 Caldicellulosiruptor sp. Rt69B.1 AAB95326.1 O52374   16
 bifunctional β-1,4-xylanase / α-L-arabinosidase (XynA) 3.2.1.55
3.2.1.8
Caldicellulosiruptor sp. Tok7B.1 AAD30363.1 Q9X3P5   16
 bifunctional β-xylosidase I / α-L-arabinofuranosidase (XynB1;CCNA_01040) 3.2.1.37
3.2.1.55
Caulobacter crescentus NA1000 ACL94505.1 B8H2V1   11
 β-xylosidase (CGSCsYakCAS_10615) (fragment) (Xyn43A) 3.2.1.- Cellulosilyticum ruminicola CGMCC 1.5065 ACZ98594.1 D2KFJ2   16
 endo-α-1,5-L-arabinanase / exo-α-1,5-L-arabinanase 43A (ArbA;CJA_0805) (Arb43A) 3.2.1.99
3.2.1.-
Cellvibrio japonicus Ueda107 ACE84667.1
CAA71485.1
B3PKP8
P95470
1GYD[B]
1GYE[B]
1GYH[A,B,C,D,E,F]
5
 β-xylosidase 43A (CJA_3070) (Xyl43A=Gly43G) 3.2.1.37 Cellvibrio japonicus Ueda107 ACE82692.1 B3PDB2   1
 exo-α-1,5-L-arabinofuranosidase 43K (CJA_3012) (Abf43K) 3.2.1.- Cellvibrio japonicus Ueda107 ACE82749.1 B3PD54   26
 α-1,2-L-arabinofuranosidase 43A (CJA_3018) (arabinan-specific) (Abf43A=Gly43N) 3.2.1.- Cellvibrio japonicus Ueda107 ACE83886.1 B3PD60 3QED[A,B,C,D]
3QEE[A,B]
3QEF[A,B]
29
 exo-α-1,5-L-arabinofuranosidase 43L (CJA_0806) (Abf43L) 3.2.1.- Cellvibrio japonicus Ueda107 ACE84379.1 B3PKP9   26
 β-xylosidase / α-L-arabinofuranosidase 3.2.1.37
3.2.1.55
Clostridium stercorarium BAA02527.1 P48790   35
 β-xylosidase (Xyl43B) (Xyl43B) 3.2.1.37 Clostridium stercorarium F-9 BAC87941.1 Q76EC8   10
 α-arabinofuranosidase (ArfA) (fragment) (Arf43A) 3.2.1.55 Clostridium stercorarium NCIMB 11745 CAD48310.1 Q8GJ41   10
 β-xylosidase (Xyl43) 3.2.1.37 Enterobacter sp. enrichment culture clone nf1B6 AFZ78871.1     11
 arabinoxylan α-L-arabinofuranosidase (Axh1;Fisuc_1769;FSU_2269) 3.2.1.55 Fibrobacter succinogenes subsp. succinogenes S85 ACX75362.1
ADL24843.1
C9RS26   10
 Fisuc_1994 / FSU_2517 3.2.1.99 Fibrobacter succinogenes subsp. succinogenes S85 ACX75582.1
ADL26080.1
C9RIW1   37
 β-xylosidase (XynB3;HUS_CDS105) 3.2.1.37 Geobacillus stearothermophilus T-6 NCIMB 40222 AAT98625.1
ABI49959.1
Q09LX0 2EXH[A,B,C,D]
2EXI[A,B,C,D]
2EXJ[A,B,C,D]
2EXK[A,B,C,D]
11
 α-1,5-L-arabinanase (AbnB;HUS_CDS25) (intracellular) 3.2.1.99 Geobacillus stearothermophilus T-6 NCIMB 40222 ACE73676.1 B3EYM8 3CU9[A]
3D5Y[A]
3D5Z[A]
3D60[A]
3D61[A]
5
 endo-α-1,5-L-arabinanase (AbnA) (extracellular) 3.2.1.99 Geobacillus stearothermophilus T-6 NCIMB 40222 ACE73680.1 B3EYN2 5HO0[A]
5HO2[A]
5HO9[A,B]
5HOF[A]
5HP6[A]
4
 endo-α-1,5-L-arabinanase (Abn-ts) 3.2.1.99 Geobacillus thermodenitrificans TS-3 BAB64339.1 Q93HT9 1WL7[A] 5
 β-xylosidase (Xyl;GbtXyl43A) (Xyl43A) 3.2.1.37 Geobacillus thermoleovorans IT-08 ABC75004.1 Q2I2N4 cryst 12
 β-xylosidase / exo-xylanase (GbtXyl43B) (Xyl43B) 3.2.1.37 Geobacillus thermoleovorans IT-08 ABD48561.1 Q27R94   27
 α-L-arabinofuranosidase (HoAraf43;Hore_20580) 3.2.1.55 Halothermothrix orenii H 168 ACL70803.1 B8CZV1 4QQS[A,B] 33
 β-xylosidase (XynB1) 3.2.1.37 Lactobacillus brevis ATCC 14869 = DSM 20054 AGT14429.1     11
 α-1,5-L-arabinofuranosidase (Abf3) 3.2.1.- Lactobacillus brevis ATCC 14869 = DSM 20054 AGT14430.1     26
 β-xylosidase 2 (XynB2) 3.2.1.37 Lactobacillus brevis ATCC 14869 = DSM 20054 AGT14431.1     11
 β-xylosidase (LbX;XynB2;LVIS_2285) 3.2.1.37 Lactobacillus brevis ATCC 367 ABJ65333.1 Q03N89   11
 α-L-arabinofuranosidase II (Araf43;LbAraf43;N624_1993) 3.2.1.- Lactobacillus brevis DSM 1269 / TMW 1.313 APU52333.1
KIO95879.1
  5M8B[A,B] 26
 β-xylosidase/α-L-arabinofuranosidase (XynA) 3.2.1.37
3.2.1.55
Niveispirillum irakense KBC1 AAF66622.1 Q9LAE3   11
 α-L-arabinofuranosidase (OB2087) 3.2.1.55 Oceanobacillus iheyensis HTE831 BAC14043.1
NP_693008.1
Q8EPL4   12
 α-L-arabinofuranosidase 43A (XynD) (formerly xylanase D) (Xyn43A) 3.2.1.55 Paenibacillus polymyxa ATCC 842 CAA40378.1 P45796   16
 endo-α-1,5-L-arabinanase (AbnZ3;YxiA3) 3.2.1.99 Paenibacillus polymyxa Z6 AHA50064.1     4
 endo-α-1,5-L-arabinanase (AbnZ2;Yxia1) 3.2.1.99 Paenibacillus polymyxa Z6 AHA50063.1     4
 endo-α-1,5-L-arabinanase (AbnZ1) 3.2.1.99 Paenibacillus polymyxa Z6 AHA50062.1     5
 α-L-arabinofuranosidase (Abf43A) 3.2.1.55 Paenibacillus sp. E18 ACY69973.1 D6BQP5   10
 α-L-arabinofuranosidase (Abf43B) 3.2.1.55 Paenibacillus sp. E18 AFC38437.1     27
 β-xylosidase /α-L-arabinofuranosidase (XylC) 3.2.1.37
3.2.1.55
Paenibacillus woosongensis ADV16404.1     35
 β-xylosidase (XynB;Orf0389;00389-GPBOY;PBR_0394) 3.2.1.37 Prevotella bryantii B14 CAA89208.1
CAD21010.1
P48791
Q7AUW6
  1
 arabinoxylan arabinofuranohydrolase (ORF2351) (Ara43A) 3.2.1.55 Prevotella bryantii B14 ADI70680.1 D7SFH6   12
 endo-arabinanase (Abn;Tth Abn;Theth_1128) 3.2.1.99 Pseudothermotoga thermarum DSM 5069 AEH51204.1     4
 [arabinogalactan] exo-β-1,3-galactanase (Ct1,3Gal43A;CtGH43;Cthe_0661) (1,3Gal43A) 3.2.1.145 Ruminiclostridium thermocellum ATCC 27405 ABN51896.1 A3DD67 3VSF[A,B,C,D,E,F]
3VSZ[A,B,C,D,E,F]
3VT0[A,B,C,D,E,F]
3VT1[A,B,C,D,E,F]
3VT2[A,B,C,D,E,F]
24
 α-L-arabinofuranosidase (Ct43Araf;CtAbf43A;CtGh43;Cthe_1271) (Abf43A) 3.2.1.55 Ruminiclostridium thermocellum ATCC 27405 ABN52503.1 A3DEX4 5A8C[A]
5A8D[A]
16
 arabinanase (GH43D;RUM_09280) (Ara43D) 3.2.1.99 Ruminococcus champanellensis 18P13 = JCM 17042 CBL17100.1 D4LBV5   4
 arabinanase (GH43A;RUM_09320) (Ara43A) 3.2.1.99 Ruminococcus champanellensis 18P13 = JCM 17042 CBL17103.1 D4LBV8   37
 α-L-arabinofuranosidase (GH43B;RUM_14020) (Abf43B) 3.2.1.55 Ruminococcus champanellensis 18P13 = JCM 17042 CBL17514.1 D4LD19   16
 bifunctional xylanase α-L-arabinofuranosidase (GH10B;GH43E;RUM_15940) (Xyn10B-Abf43E) 3.2.1.55
3.2.1.8
Ruminococcus champanellensis 18P13 = JCM 17042 CBL17682.1 D4LDI7   16
 β-xylosidase / α-L-arabinofuranosidase (Xsa;Sxa;SXA) 3.2.1.37
3.2.1.55
Selenomonas ruminantium GA192 AAB97967.1 O52575 3C2U[A,B,C,D] 11
 β-xylosidase (Xyl455) 3.2.1.37 Sphingobacterium sp. HP455 AGL51118.1     1
 exo-α-1,5-L-arabinofuranosidase (SaAraf43A;SAV1043) (Araf43A) 3.2.1.- Streptomyces avermitilis MA-4680 = NBRC 14893 BAC68753.1
NP_822218.1
  3AKF[A]
3AKG[A]
3AKH[A]
3AKI[A]
26
 exo-β-1,3-galactanase (Sa1,3Gal43A;SAV2109) (1,3Gal43A) 3.2.1.145 Streptomyces avermitilis MA-4680 = NBRC 14893 BAC69820.1
NP_823285.1
    24
 exo-α-1,5-L-arabinofuranosidase II (AFase II) 3.2.1.- Streptomyces chartreusis GS901 BAA90772.1
B59296
P82594   26
 exo-β-1,3-galactanase (SGalase2) 3.2.1.145 Streptomyces sp. 19(2012) AFH55135.1     24
 exo-β-1,3-galactanase (SGalase1) (partial) 3.2.1.145 Streptomyces sp. 19(2012) AFH55134.1     24
 β-xylosidase (TfBXyl43) (Xyl43A) 3.2.1.37 Thermobifida fusca TM51 AEF28829.1     11
 β-xylosidase (Tfu_1616) (Xyl43A) 3.2.1.37 Thermobifida fusca YX AAZ55651.1 Q47PG8   11
 endo-α-1,5-L-arabinanase (AbnA;TpABN;Tpet_0637) 3.2.1.99 Thermotoga petrophila RKU-1 ABQ46657.1 A5IKD4 4KC7[A,B,C]
4KC8[A,B,C]
4
 β-xylosidase / α-L-arabinofuranosidase (CoXyl43) 3.2.1.37
3.2.1.55
uncultured bacterium BAS02080.1   5GLK[A,B]
5GLL[A,B]
5GLM[A,B]
5GLN[A,B]
5GLO[A,B]
5GLP[A,B]
5GLQ[A,B]
5GLR[A,B]
1
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