Glycoside Hydrolase Family 42

Known Activities	β-galactosidase (EC 3.2.1.23)
Mechanism	Retaining
Clan	GH-A
3D Structure Status	( β / α ) ₈
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Identification of the catalytic residues in doi:10.1016/j.febslet.2007.04.053
External resources	CAZypedia; InterPro; PFAM;
Statistics	GenBank accession (552); Uniprot accession (352); PDB accession (2); 3D entries (2); cryst (1)

Summary

All (513) Archaea (6) Bacteria (503) Eukaryota (3) unclassified (1) Structure (2 - 1 cryst) Characterized (42)

Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
β-galactosidase (BgaH)	3.2.1.23	Haloferax lucentense SB1	AAB40123.2	P94804
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
β-galactosidase (GalB;LacB;Bgly;Aaci_2891)	3.2.1.23	Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446	AAZ81841.1 ABI84370.1 ACV59895.1	C8WV58 Q06GJ1
β-galactosidase	3.2.1.23	Arthrobacter sp. 32c	ACU00913.1	C7ASJ5
β-galactosidase 12 (LacG) (possible fragment)	3.2.1.23	Arthrobacter sp. B7	AAA75601.1	Q44233
β-galactosidase (GalB)	3.2.1.23	Arthrobacter sp. ON14	ADJ18282.1	D9IU57
β-galactosidase (BgaB)	3.2.1.23	Bacillus circulans G1	AAA22260.1	Q45093
β-galactosidase (LacZ)	3.2.1.23	Bacillus coagulans DSM 1	ADF47156.1	D5JGG0
β-galactosidase (LacA;BLi04277;BL00264)	3.2.1.23	Bacillus licheniformis ATCC 14580 / DSM13	AAU25712.1 AAU43090.1 ACP63807.1	Q65CX4
β-galactosidase (YesZ;BSU07080)	3.2.1.23	Bacillus subtilis subsp. subtilis str. 168	CAB12527.1 NP_388589.1	O31529
β-galactosidase (LacA;YvfN;BSU34130)	3.2.1.23	Bacillus subtilis subsp. subtilis str. 168	CAB08008.1 CAB15418.1 NP_391293.1	O07012
β-galactosidase (BgalII)	3.2.1.23	Bifidobacterium adolescentis DSM 20083	AAR24113.1	Q5J883
β-galactosidase P2 (BbgII)	3.2.1.23	Bifidobacterium bifidum NCIMB 41171	ABP87597.1	A5A2I5
β-galactosidase (Bgal;GalA;LacA)	3.2.1.23	Bifidobacterium breve ATCC 15698 / B24	AAU00556.1	Q68GW3
β-galactosidase (LacA1;BLD_0926)	3.2.1.23	Bifidobacterium longum DJO10A	ACD98372.1	B3DTA3
β-galactosidase 42A (Blon_2016) (Bga42A)	3.2.1.23	Bifidobacterium longum subsp. infantis ATCC 15697	ACJ53083.1	B7GUD7
β-galactosidase 42B (Blon_2123) (Bga42B)	3.2.1.23	Bifidobacterium longum subsp. infantis ATCC 15697	ACJ53184.1	B7GUN8
β-galactosidase 42C (Blon_2416) (Bga42C)	3.2.1.23	Bifidobacterium longum subsp. infantis ATCC 15697	ACJ53470.1	B7GNW4
β-galactosidase (INF1)	3.2.1.23	Bifidobacterium longum subsp. infantis DSM20088	CAC14567.1	Q9F4C8
β-galactosidase III (β-GalIII)	3.2.1.23	Bifidobacterium longum subsp. infantis HL96	AAL02053.1	Q93GI5
β-galactosidase (BgaA)	3.2.1.23	Caldicellulosiruptor 14B	CAA10365.1
β-galactosidase (Csac_1018)	3.2.1.23	Caldicellulosiruptor saccharolyticus DSM 8903	ABP66632.1	A4XI97
β-galactosidase (BgaA)	3.2.1.23	Caldicellulosiruptor sp. YI5	ABA18805.1	Q0R0N2
β-galactosidase (BgaB)	3.2.1.23	Carnobacterium maltaromaticum BA	AAF16519.1	Q9RFN0
β-galactosidase / α-L-arabinopyranosidase (BgaA)	3.2.1.- 3.2.1.23	Clostridium cellulovorans	AAN05452.1	Q8GEE3
β-galactosidase (Pbg)	3.2.1.23	Clostridium perfringens	BAA08485.1 CAA66274.1	Q59312
β-galactosidase (Dgeo_2829)	3.2.1.23	Deinococcus geothermalis DSM 11300	ABF44258.1 YP_594332.1	Q1J2M6
β-galactosidase / exo-β-1,4-galactanase (GanB;LacB;Dda3937_02393)	3.2.1.23	Dickeya dadantii 3937	ADM99399.1
β-galactosidase I (BgaB)	3.2.1.23	Geobacillus stearothermophilus KVE39	AAA22262.1	P19668.1
β-galactosidase (thermostable)	3.2.1.23	Geobacillus thermocatenulatus KNOUC105	AAW56416.1	Q5I201
β-galactosidase (LacZ)	3.2.1.23	Lactobacillus acidophilus ATCC 4356	ACC38288.1	Q5FJ41
β-galactosidase (LacA)	3.2.1.23	Lactobacillus acidophilus FUA3191	CAZ66938.1	C6H178
β-galactosidase (LacZ;LBA1462)	3.2.1.23	Lactobacillus acidophilus NCFM	AAV43283.1 CAN87410.1
β-galactosidase (BgaP1)	3.2.1.23	Paenibacillus sp. K1	ACE62913.1	B3VBH7
β-galactosidase (BgaA)	3.2.1.23	Planococcus sp. 'SOS Orange' SOS ORANGE	AAF75984.1	Q9KI47
β-galactosidase (BgaP)	3.2.1.23	Planococcus sp. L4	ABI64125.1	Q09HN2	cryst
β-galactosidase (BgalC;TM1195)	3.2.1.23	Thermotoga maritima MSB8	AAA50596.1 AAD36270.1 NP_229000.1	Q56306 Q9X0S2
β-galactosidase (BgalB;TM0310)	3.2.1.23	Thermotoga maritima MSB8	AAD35398.1 NP_228122.1	Q9WYE6
β-galactosidase (BgalA)	3.2.1.23	Thermotoga neapolitana	AAC24217.1	O85248
β-galactosidase	3.2.1.23	Thermus sp. A4	BAA28362.1	O69315	1KWG[A] 1KWK[A]
β-galactosidase (BgaA)	3.2.1.23	Thermus sp. IB-21	AAN05443.1	Q8GEA9
β-galactosidase	3.2.1.23	Thermus sp. T2	CAB07810.1	O54315
β-galactosidase	3.2.1.23	Thermus thermophilus KNOUC112	ABI35985.1	Q0GA06

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.