Glycoside Hydrolase Family 3

Activities in Familyβ-glucosidase (EC 3.2.1.21); xylan 1,4-β-xylosidase (EC 3.2.1.37); β-glucosylceramidase (EC 3.2.1.45); β-N-acetylhexosaminidase (EC 3.2.1.52); α-L-arabinofuranosidase (EC 3.2.1.55); glucan 1,3-β-glucosidase (EC 3.2.1.58); glucan 1,4-β-glucosidase (EC 3.2.1.74); isoprimeverose-producing oligoxyloglucan hydrolase (EC 3.2.1.120); coniferin β-glucosidase (EC 3.2.1.126); exo-1,3-1,4-glucanase (EC 3.2.1.-); β-N-acetylglucosaminide phosphorylases (EC 2.4.1.-)
Mechanism Retaining
Catalytic Nucleophile/BaseAsp (experimental);
Catalytic Proton DonorGlu for hydrolases (experimental); histidine for phosphorylases (experimental)
NoteA recent paper by Macdonald et al. (PMID=25533455) has shown that the enzymes that cleave b-hexosaminides are in fact retaining b-glycoside phosphorylases.
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX ;
Statistics GenBank accession (17417); Uniprot accession (2560); PDB accession (105); 3D entries (33); cryst (4)
All (16564) Archaea (94) Bacteria (15420) Eukaryota (949) Viruses (1) unclassified (100) Structure (33 - 4 cryst) Characterized (295)
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-glucosidase (JMB19063) 3.2.1.21 compost metagenome     3U48[B]
3U4A[A,B]
3U48[A]
 broad-specificity β-glucosidase/β-xylosidase (GlyA1) (partial) 3.2.1.21
3.2.1.37
metagenome     5K6M[A]
5K6N[A]
5K6O[A]
5K6L[A]
 BN138_752   termite gut metagenome CCO21564.1    
 BN138_65   termite gut metagenome CCO20877.1    
 BN138_74   termite gut metagenome CCO20886.1    
 BN138_93   termite gut metagenome CCO20905.1    
 BN138_603   termite gut metagenome CCO21415.1    
 BN138_655   termite gut metagenome CCO21467.1    
 BN138_712   termite gut metagenome CCO21524.1    
 BN138_720   termite gut metagenome CCO21532.1    
 BN138_743   termite gut metagenome CCO21555.1    
 BN138_627 (fragment)   termite gut metagenome CCO21439.1    
 BN138_680 (fragment)   termite gut metagenome CCO21492.1    
 BN138_919 (fragment)   termite gut metagenome CCO21731.1    
 BN138_931 (fragment)   termite gut metagenome CCO21743.1    
 BN138_959 (fragment)   termite gut metagenome CCO21771.1    
 BN138_981   termite gut metagenome CCO21793.1    
 BN138_1030 (fragment)   termite gut metagenome CCO21842.1    
 ALOHA_HF4000006O13ctg1g23   uncultured marine microorganism HF4000_006O13 ABZ06177.1 B3T0R8  
 ALOHA_HF4000141E02ctg1g21   uncultured marine microorganism HF4000_141E02 ABZ06719.1 B3T2B0  
 β-glucosidase (UmCel3H) (Cel3H)   uncultured microorganism ADB80109.1 D3JVU0  
 BT-09   uncultured microorganism ADR64671.1 E5F2L6  
 β-glucosidase (Unglu135B12;TY-135-138) 3.2.1.21 uncultured microorganism AFX98011.1    
 β-glucosidase (MgSY-1)   uncultured microorganism AGZ87467.1    
 ORF   uncultured microorganism AHI07415.1    
 ORF   uncultured microorganism AHI07417.1    
 ORF   uncultured microorganism AHI07416.1    
 β-glucosidase (UmCel3G) 3.2.1.21 uncultured microorganism ABU68675.1 A7Y421  
 β-xylosidase (G06-24) 3.2.1.- uncultured organism ACY24766.1 D8VMY1  
 ORF   uncultured organism ADD61859.1 D9ZEV5  
 ORF   uncultured organism ADD61397.1
ADD62002.1
D9ZDJ3  
 ORF   uncultured organism ADD61875.1 D9ZEX1  
 ORF   uncultured organism ADD61980.1 D9ZF76  
 ORF   uncultured organism ADD61876.1 D9ZEX2  
 β-glucanase 3.2.1.- uncultured organism ADD62001.1 D9ZF97  
 SARM_0020 / 4206209_75510 / TW-52   uncultured organism ADX05691.1    
 SARM_0011 / 3871318_57040 / TX-9   uncultured organism ADX05682.1    
 SARM_0077 / 0_03232 / TW-71 (fragment; probable frameshift) 3.2.1.- uncultured organism ADX05759.1    
 SARM_0089 / 0_01460 / TX-11 (fragment)   uncultured organism ADX05758.1    
 SARM_0088 / 0_01267 / TX-10   uncultured organism ADX05754.1    
 SARM_0079 / 0_10651 / TX-7   uncultured organism ADX05749.1    
 SARM_0078 / 0_01993 / TX-6   uncultured organism ADX05748.1    
 SARM_0073 / 3775571_83240 / TW-76 (fragment)   uncultured organism ADX05744.1    
 SARM_0072 / 3533064_50320 / TW-72   uncultured organism ADX05743.1    
 SARM_0070 / 3326974_01430 / TX-5 (fragment)   uncultured organism ADX05741.1    
 SARM_0035 / 727087_119880 / TW-80   uncultured organism ADX05706.1    
 SARM_0033 / 669807_07550 / TW-43 (possible fragment)   uncultured organism ADX05704.1    
 SARM_0031 / 498404_123650 / TX-8   uncultured organism ADX05702.1    
 SARM_0018 / 4178865_28470 / TW-53 (fragment)   uncultured organism ADX05689.1    
 SARM_0001 / 3586341_29100 / TW-77 (fragment)   uncultured organism ADX05672.1    
 β-glucosidase (BgID520)   uncultured organism AFD23677.1    
 β-glucosidase (BgIY1)   uncultured organism AFD23678.1    
 CelEx-SF301   uncultured organism AGK74984.1    
 c53_8 3.2.1.37 uncultured organism AGU11176.1    
 ORF   uncultured organism AGU09898.1    
 ORF   uncultured organism AGU09899.1    
 ORF   uncultured organism AGU09904.1    
 ORF   uncultured organism AGU10256.1    
 ORF   uncultured organism AGU10289.1    
 ORF   uncultured organism AGU10570.1    
 ORF   uncultured organism AGU10868.1    
 ORF   uncultured organism AGU10876.1    
 ORF   uncultured organism AGU11053.1    
 ORF   uncultured organism AGU11101.1    
 ORF   uncultured organism AGU11178.1    
 ORF   uncultured organism AGU11260.1    
 ORF   uncultured organism AGU11392.1    
 ORF   uncultured organism AGU11413.1    
 ORF   uncultured organism AGU11727.1    
 ORF   uncultured organism AGU11871.1    
 ORF   uncultured organism AGU11872.1    
 c84_2 3.2.1.21
3.2.1.37
uncultured organism AGU12029.1    
 ORF   uncultured organism AGU12233.1    
 ORF (fragment)   uncultured organism AGU12298.1    
 ORF (1_11)   uncultured organism AGU09726.1    
 ORF (1_11)   uncultured organism AGU09729.1    
 ORF (4_1)   uncultured organism AGU09784.1    
 ORF   uncultured organism AGU09791.1    
 ORF   uncultured organism AGU09821.1    
 ORF   uncultured organism AGU09963.1    
 ORF (fragment)   uncultured organism AGU10196.1    
 ORF (fragment)   uncultured organism AGU10355.1    
 ORF   uncultured organism AGU10528.1    
 ORF (fragment)   uncultured organism AGU10693.1    
 ORF   uncultured organism AGU10986.1    
 ORF   uncultured organism AGU11080.1    
 ORF   uncultured organism AGU11898.1    
 ORF   uncultured organism AGU11944.1    
 ORF   uncultured organism AGU12141.1    
 ORF (fragment)   uncultured organism AGU10699.1    
 MedDCM-OCT-S01-C81-cds3   uncultured organism MedDCM-OCT-S01-C81 ADD95913.1 D6PJL2  
 ORF (fragment)   uncultured prokaryote CRY95280.1    
 Sequence 44 from patent US 7465571.   unidentified ACM94274.1    
 Sequence 28257 from patent US 7504490.   unidentified ACP96039.1    
 Sequence 36438 from patent US 7504490.   unidentified ACQ04221.1    
 β-xylosidase / xylanase E2 3.2.1.37 unidentified AEF56854.1    
 β-glucosidase A3 3.2.1.21 unidentified AEF56853.1    
 β-glucanase (RR.02;RR.06-2) (fragment)   unidentified microorganism CAJ19141.1 Q2YI62  
 β-glucosidase (UmCelC7;Cb1) 3.2.1.21 unidentified microorganism ABX76049.1 A9UGW5  
 β-glucosidase (UmCelS19;Sb1) 3.2.1.21 unidentified microorganism ABX76051.1 A9UID4  
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