Glycoside Hydrolase Family 3

Activities in Familyβ-glucosidase (EC; xylan 1,4-β-xylosidase (EC; β-glucosylceramidase (EC; β-N-acetylhexosaminidase (EC; α-L-arabinofuranosidase (EC; glucan 1,3-β-glucosidase (EC; glucan 1,4-β-glucosidase (EC; isoprimeverose-producing oligoxyloglucan hydrolase (EC; coniferin β-glucosidase (EC; exo-1,3-1,4-glucanase (EC 3.2.1.-); β-N-acetylglucosaminide phosphorylases (EC 2.4.1.-)
Mechanism Retaining
Catalytic Nucleophile/BaseAsp (experimental);
Catalytic Proton DonorGlu for hydrolases (experimental); histidine for phosphorylases (experimental)
NoteA recent paper by Macdonald et al. (PMID=25533455) has shown that the enzymes that cleave b-hexosaminides are in fact retaining b-glycoside phosphorylases.
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX ;
Statistics GenBank accession (17817); Uniprot accession (2560); PDB accession (106); 3D entries (34); cryst (4)
All (16969) Archaea (94) Bacteria (15784) Eukaryota (990) Viruses (1) unclassified (100) Structure (34 - 4 cryst) Characterized (295)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
Protein Name EC#OrganismGenBank UniprotPDB/3D
 PICST_61725   Scheffersomyces stipitis CBS 6054 ABN67656.1
 PICST_41452   Scheffersomyces stipitis CBS 6054 ABN65244.1    
 PICST_77156   Scheffersomyces stipitis CBS 6054 ABN65475.1
 Smp_043390   Schistosoma mansoni Puerto Rico CCD81740.1
 β-glucosidase (fragment) Schizophyllum commune AAA33925.1 P29091  
 β-glucosidase bgl3a_2 (fragment)   Schizophyllum commune KUC9397 AKN57009.1    
 β-glucosidase bgl3a_1   Schizophyllum commune KUC9397 AKN57008.1    
 β-glucosidase (SPBC1683.04) Schizosaccharomyces pombe 972h- CAB91166.1
 sscle_03g022640   Sclerotinia sclerotiorum 1980 UF-70 APA07494.1    
 sscle_03g030980   Sclerotinia sclerotiorum 1980 UF-70 APA08328.1    
 sscle_02g012480   Sclerotinia sclerotiorum 1980 UF-70 APA06478.1    
 sscle_01g008460   Sclerotinia sclerotiorum 1980 UF-70 APA06076.1    
 sscle_08g066260   Sclerotinia sclerotiorum 1980 UF-70 APA11856.1    
 sscle_14g101370   Sclerotinia sclerotiorum 1980 UF-70 APA15367.1    
 sscle_06g051350   Sclerotinia sclerotiorum 1980 UF-70 APA10365.1    
 sscle_05g043280   Sclerotinia sclerotiorum 1980 UF-70 APA09558.1    
 sscle_10g079370   Sclerotinia sclerotiorum 1980 UF-70 APA13167.1    
 sscle_06g051500   Sclerotinia sclerotiorum 1980 UF-70 APA10380.1    
 sscle_08g063580   Sclerotinia sclerotiorum 1980 UF-70 APA11588.1    
 sscle_15g105550   Sclerotinia sclerotiorum 1980 UF-70 APA15785.1    
 sscle_11g082920   Sclerotinia sclerotiorum 1980 UF-70 APA13522.1    
 cell wall β-glucosidase   Secale cereale AAS97960.1 Q6PQF3  
 β-glucosidase (tomatinase;B2Tom) Septoria lycopersici AAB08445.1
Q99324 cryst
 PIIN_00201   Serendipita indica DSM 11827 CCA66516.1    
 PIIN_00392   Serendipita indica DSM 11827 CCA66712.1    
 PIIN_01553   Serendipita indica DSM 11827 CCA67726.1    
 PIIN_02711   Serendipita indica DSM 11827 CCA68850.1    
 PIIN_03039   Serendipita indica DSM 11827 CCA69140.1    
 PIIN_04111   Serendipita indica DSM 11827 CCA70172.1    
 PIIN_06333   Serendipita indica DSM 11827 CCA72399.1    
 PIIN_07416   Serendipita indica DSM 11827 CCA73462.1    
 β-xylosidase, partial (fragment)   Silene latifolia AEL98937.1    
 GH   Sinapis alba AFM39013.1
 β-xylosidase (LeXyl2;Xyl2) (fragment)   Solanum lycopersicum BAC98299.1 Q76MS4  
 β-xylosidase (LeXyl1;Xyl1)   Solanum lycopersicum BAC98298.1
 α-L-arabinofuranosidase / β-xylosidase (SlArf/Xyl2)   Solanum lycopersicum BAL44717.1    
 α-L-arabinofuranosidase / β-xylosidase (SlArf/Xyl3)   Solanum lycopersicum BAL44718.1    
 α-L-arabinofuranosidase / β-xylosidase (SlArf/Xyl4)   Solanum lycopersicum BAL44719.1    
 α-L-arabinofuranosidase / β-xylosidase (SlArf/Xyl1)   Solanum lycopersicum BAL44716.1    
 GH3 β-glucosidase (Sbgl3)   Solanum torvum APU53952.1    
 sr10116   Sporisorium reilianum SRZ2 CBQ67857.1    
 sr14937   Sporisorium reilianum SRZ2 CBQ68654.1    
 sr16700   Sporisorium reilianum SRZ2 CBQ71352.1    
 sr16869   Sporisorium reilianum SRZ2 CBQ71612.1    
 SPSC_03395   Sporisorium scitamineum SscI8 CDU24324.1    
 SPSC_02695   Sporisorium scitamineum SscI8 CDU24066.1    
 SPSC_05333   Sporisorium scitamineum SscI8 CDU25440.1    
 SPSC_00584   Sporisorium scitamineum SscI8 CDU21954.1    
 β-glucosidase (Bgl3;BglG;SmBGL3) Stachybotrys microspora A19 AFC40275.1    
 BGL1 (fragment)   Stemphylium xanthosomatis EGS17-137 AAR04473.1 Q69FF5  
 AWJ20_3051   Sugiyamaella lignohabitans CBS 10342 ANB15424.1    
 AWJ20_4023   Sugiyamaella lignohabitans CBS 10342 ANB11221.1    
 AWJ20_3079   Sugiyamaella lignohabitans CBS 10342 ANB15451.1    
 AWJ20_1374   Sugiyamaella lignohabitans CBS 10342 ANB13095.1    
 AWJ20_922   Sugiyamaella lignohabitans CBS 10342 ANB12660.1    
 β-glucosidase Talaromyces aculeatus ATCC 10409 AGA96121.1    
 β-xylosidase 1 (Bxtw1)   Talaromyces amestolkiae CIB AKJ79184.1    
 β-glucosidase 2, partial (BgL)   Talaromyces amestolkiae CIB AKK32386.1    
 β-glucosidase 3, partial (BgL)   Talaromyces amestolkiae CIB AKK32385.1    
 β-xylosidase (Bxy3A) Talaromyces cellulolyticus CF-2612 / FERM BP-5826 BAK96214.1    
 β-glucosidase 3A (TCE0_039f12945) (Bgl3A) Talaromyces cellulolyticus Y-94 GAM40530.1    
 β-glucosidase (Bgl3) (Bgl3A) Talaromyces funiculosus NCL1 AFU91382.1    
 Bgl2 (fragment)   Talaromyces funiculosus NCL1 AFU91384.1    
 β-glucosidase (Bgl3A) Talaromyces leycettanus JCM12802 AMR94085.1    
 β-glucosidase   Talaromyces piceae ATQ35958.1    
 β-glucosidase   Talaromyces piceae ATQ35961.1    
 β-glucosidase   Talaromyces piceae ATQ35957.1    
 β-glucosidase   Talaromyces piceae ATQ35964.1    
 β-glucosidase   Talaromyces piceae ATQ35956.1    
 β-glucosidase   Talaromyces piceae ATQ35960.1    
 β-glucosidase   Talaromyces piceae ATQ35965.1    
 β-glucosidase   Talaromyces piceae ATQ35959.1    
 β-xylosidase (Xyl2;XYL2)   Talaromyces purpureogenus ATCC MYA-38 AKH40279.1    
 β-glucosidase (Bgl3;Bgl) Talaromyces purpureogenus KJS506 (KACC 93053P) ACV87737.1 C9E9M9  
 β-glucosidase (Bgl2;BGLII;Bg2;BGII) Thermoascus aurantiacus IFO 9748 AAY33982.1
 β-glucosidase (Bgl1;Bg1;TaBgl1) Thermoascus aurantiacus IFO 9748 AAZ95587.1
 β-xylosidase   Thermoascus aurantiacus QS 7-2-4 AMW64957.1    
 β-glucosidase   Thermoascus aurantiacus RCK 2011 AFU51372.1    
 β-1,4-glucosidase (Bgl2)   Thermoascus aurantiacus var. levisporus ABX56926.1 A9QUC3  
 β-1,4-glucosidase (Bgl2)   Thermoascus aurantiacus var. levisporus ABX56927.1 A9QUC4  
 β-1,4-glucosidase (Bgl1)   Thermoascus aurantiacus var. levisporus ABX79552.1
 MYCTH_62925   Thermothelomyces thermophila ATCC 42464 AEO53892.1    
 MYCTH_2059579   Thermothelomyces thermophila ATCC 42464 AEO56238.1    
 β-glucosidase (MYCTH_80304)
Thermothelomyces thermophila ATCC 42464 AEO58175.1    
 β-glucosidase (MtBgl3a;MYCTH_66804) (Bgl3A) Thermothelomyces thermophila ATCC 42464 AEO58343.1    
 MYCTH_50705   Thermothelomyces thermophila ATCC 42464 AEO58346.1    
 MYCTH_2306784   Thermothelomyces thermophila ATCC 42464 AEO58968.1    
 MYCTH_104628   Thermothelomyces thermophila ATCC 42464 AEO60531.1    
 MYCTH_38200   Thermothelomyces thermophila ATCC 42464 AEO61246.1    
 MYCTH_104106   Thermothelomyces thermophila ATCC 42464 AEO61778.1    
 MYCTH_2308667 (fragment)   Thermothelomyces thermophila ATCC 42464 AEO59951.1    
 MYCTH_2129052 (fragment)   Thermothelomyces thermophila ATCC 42464 AEO59952.1    
 MYCTH_58882   Thermothelomyces thermophila ATCC 42464 AEO60477.1    
 THITE_2110159   Thielavia terrestris NRRL 8126 AEO64229.1    
 THITE_2110595   Thielavia terrestris NRRL 8126 AEO64446.1    
 THITE_2111169   Thielavia terrestris NRRL 8126 AEO64832.1    
 THITE_2113984   Thielavia terrestris NRRL 8126 AEO66128.1    
 THITE_2044936   Thielavia terrestris NRRL 8126 AEO67341.1    
 THITE_2144859   Thielavia terrestris NRRL 8126 AEO67512.1    
 THITE_2118136   Thielavia terrestris NRRL 8126 AEO68568.1    

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