Glycoside Hydrolase Family 3

Activities in Familyβ-glucosidase (EC 3.2.1.21); xylan 1,4-β-xylosidase (EC 3.2.1.37); β-glucosylceramidase (EC 3.2.1.45); β-N-acetylhexosaminidase (EC 3.2.1.52); α-L-arabinofuranosidase (EC 3.2.1.55); glucan 1,3-β-glucosidase (EC 3.2.1.58); glucan 1,4-β-glucosidase (EC 3.2.1.74); isoprimeverose-producing oligoxyloglucan hydrolase (EC 3.2.1.120); coniferin β-glucosidase (EC 3.2.1.126); exo-1,3-1,4-glucanase (EC 3.2.1.-); β-N-acetylglucosaminide phosphorylases (EC 2.4.1.-)
Mechanism Retaining
Catalytic Nucleophile/BaseAsp (experimental);
Catalytic Proton DonorGlu for hydrolases (experimental); histidine for phosphorylases (experimental)
NoteA recent paper by Macdonald et al. (PMID=25533455) has shown that the enzymes that cleave b-hexosaminides are in fact retaining b-glycoside phosphorylases.
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX ;
Statistics GenBank accession (17417); Uniprot accession (2560); PDB accession (105); 3D entries (33); cryst (4)
All (16564) Archaea (94) Bacteria (15420) Eukaryota (949) Viruses (1) unclassified (100) Structure (33 - 4 cryst) Characterized (295)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 β-D-xylosidase   Acacia mangium BAO45878.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55944.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56284.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG55915.1    
 secreted protein (fragment)   Achlya hypogyna ATCC 48635 AIG55963.1    
 secreted protein   Achlya hypogyna ATCC 48635 AIG56285.1    
 glycoside hydrolase family 3 protein, partial (fragment)   Acidomyces sp. APF32768.1    
 α-L-arabinofuranosidase/β-D-xylosidase (Arf/xyl1) (fragment)   Actinidia deliciosa var. deliciosa ADV41671.1    
 Bg1   Agaricus bisporus D649 CAC03462.1 Q9HGX2  
 ALNC14_075190 (Alnc14c120g6656)   Albugo laibachii Nc14 CCA21376.1    
 ALNC14_132290   Albugo laibachii Nc14 CCA27085.1    
 ALNC14_138810   Albugo laibachii Nc14 CCA27737.1    
 ALNC14_075200   Albugo laibachii Nc14 CCA21377.1    
 At5g20940   Arabidopsis thaliana AAM12998.1
AED92909.1
NP_197594.1
Q8RWM4  
 At5g20950   Arabidopsis thaliana NP_197595.1
AAL58902.1
AAM13848.1
AAN13217.1
AED92910.1
AED92911.1
ANM70545.1
NP_851048.1
Q8W112  
 At5g04885   Arabidopsis thaliana BAF01189.1
AED90799.1
ANM68360.1
ANM68361.1
BAC42711.1
Q0WNW0
Q8GXR7
 
 AT5G09700 (fragment)   Arabidopsis thaliana AED91435.1    
 At3g47050/F13I12.100   Arabidopsis thaliana CAB61951.1
AEE78237.1
AEE78238.1
AEE78238.2
BAF00158.1
NP_190289.1
Q9SD68  
 At3g47040   Arabidopsis thaliana CAB61950.1
AEE78235.1
AEE78236.1
ANM64867.1
ANM64868.1
NP_190288.1
Q9SD69  
 At3g47010   Arabidopsis thaliana CAB61947.1
AAY25449.1
AEE78231.1
AEE78232.1
ANM63709.1
ANM63710.1
BAF00739.1
NP_190285.1
Q9SD72  
 At3g47000   Arabidopsis thaliana CAB61946.1
AAL32794.1
AAM13073.1
AAM13345.1
AAP37725.1
AEE78230.1
ANM65076.1
ANM65077.1
NP_190284.1
Q9SD73  
 At1g78060/F28K19.27 (AtBXL7)   Arabidopsis thaliana AAL57631.1
AAF17692.1
AEE36063.1
CAM55400.1
CAW52615.1
CAW52648.1
CBC23857.1
CBC23926.1
NP_177929.1
Q8VZG5
Q9SGZ5
 
 At3g62710   Arabidopsis thaliana CAB83121.1
AAL32734.1
AAM13308.1
AEE80382.1
NP_191830.1
Q9LZJ4  
 At5g10560/F12B17_90   Arabidopsis thaliana CAB89387.1
AAL09717.1
AED91563.1
BAC41913.1
CAW52617.1
CAW52642.1
CBC23862.1
CBC23914.1
NP_196618.1
Q8GZ32
Q9LXA8
 
 α-L-arabinofuranosidase / β-1,4-xylosidase (Xyl3;AtBX3;At5g09730) 3.2.1.37
3.2.1.55
Arabidopsis thaliana CAB89357.1
AAK96639.1
AED91439.1
BAB09531.1
CAL81217.1
CAW52616.1
CBC23860.1
NP_196535.1
Q9LXD6  
 At3g19620/MMB12.9   Arabidopsis thaliana BAB02547.1
AEE76268.1
CAW52610.1
CBC23847.1
CBD33470.1
NP_188596.1
Q9LJN4  
 α-L-arabinofuranosidase / β-D-xylosidase (Xyl1;BXL1;AtBXL1;At5g49360) 3.2.1.37
3.2.1.55
Arabidopsis thaliana BAB09906.1
AAM53325.1
AED95802.1
BAF00595.1
CAW52618.1
CAW96520.1
CAW96683.1
CAX01897.1
CAX07251.1
CBC23864.1
CBD30887.1
NP_199747.1
Q9FGY1  
 At1g02640 (Bxl2)   Arabidopsis thaliana AAK56255.1
AAG10624.1
AAN28891.1
AEE27453.1
CAW52620.1
CAW52646.1
CBC23868.1
CBC23922.1
NP_563659.1
Q94KD8
Q9FWY2
 
 β-xylosidase (Xyl4;AtBXL4;At5g64570) 3.2.1.37 Arabidopsis thaliana BAB11424.1
AED97922.1
ANM70278.1
ANM70279.1
BAD94481.1
CAW52619.1
CBC23866.1
NP_201262.1
Q9FLG1  
 EGX50909.1   Arthrobotrys oligospora ATCC 24927 EGX50909.1    
 EGX50684.1   Arthrobotrys oligospora ATCC 24927 EGX50684.1    
 EGX50141.1   Arthrobotrys oligospora ATCC 24927 EGX50141.1    
 EGX47439.1   Arthrobotrys oligospora ATCC 24927 EGX47439.1    
 EGX47431.1   Arthrobotrys oligospora ATCC 24927 EGX47431.1    
 EGX47427.1   Arthrobotrys oligospora ATCC 24927 EGX47427.1    
 EGX44387.1   Arthrobotrys oligospora ATCC 24927 EGX44387.1    
 EGX43696.1   Arthrobotrys oligospora ATCC 24927 EGX43696.1    
 EGX45322.1   Arthrobotrys oligospora ATCC 24927 EGX45322.1    
 β-xylosidase (Xyl1)   Aspergillus aculeatus F-50 BAH30674.1 C0STH3  
 β-xylosidase (Xyl2)   Aspergillus aculeatus F-50 BAH30675.1 C0STH4  
 β-glucosidase 1 (Bgl1;AaBGL1;AaBg1;Aa?G) 3.2.1.21 Aspergillus aculeatus F-50 BAA10968.1
AER93027.1
P48825 4IIB[A,B]
4IIC[A,B]
4IID[A,B]
4IIE[A,B]
4IIF[A,B]
4IIG[A,B]
4IIH[A,B]
 extracellular β-glucosidase (Bgl1)   Aspergillus avenaceus AAX39011.1 Q58IJ4  
 β-glucosidase (BglX) (fragment)   Aspergillus awamori BTMFW032 ACT98608.1 C7F6Y0  
 β-xylosidase (Xyl) 3.2.1.37 Aspergillus awamori K4 BAE19756.1
CAW52633.1
CBC23895.1
Q4AEG8  
 β-xylosidase (Xylx100) 3.2.1.37 Aspergillus awamori X-100 ACF61038.1 B5AK91
Q4AEG8
 
 β-glucosidase (Bgl1;NfBGL1) 3.2.1.21 Aspergillus fischeri P1 / CGMCC 3.15369 AIM56897.1    
 AFLA70_20g004951   Aspergillus flavus AF70 KOC10525.1    
 β-xylosidase   Aspergillus fumigatus ADH95739.1 D7RH17  
 β-1,4-xylosidase (Xld) 3.2.1.37 Aspergillus fumigatus ABA40420.1 Q0H905
Q4WRB0
 
 β-glucosidase (AfG;AFUA_8G02100) 3.2.1.21 Aspergillus fumigatus Af293 EAL84958.1    
 β-glucosidase (AfBG;AFUA_1G17410;Afu1g17410) 3.2.1.21 Aspergillus fumigatus Af293 EAL91070.1 Q4WR62  
 β-glucosidase 1 (Afum-Bgl101;Af?G;AFUA_1G05770;Afu1g05770) 3.2.1.21 Aspergillus fumigatus Af293 EAL88289.1
ABU35789.1
ACE10248.1
ACH05254.1
ACJ91428.1
Q4WJJ3 5FJI[A,B]
 β-glucosidase (BglW)   Aspergillus fumigatus WL002 AJA36818.1    
 β-glucosidase / cellulase (Bgl3) 3.2.1.21 Aspergillus fumigatus Z5 ADX78143.1    
 β-1,4-xylosidase (XylA) 3.2.1.37 Aspergillus japonicus MU-2 BAG82824.1 B6EY09  
 β-glucosidase A (BglA) 3.2.1.21 Aspergillus kawachii IFO4308 BAA19913.1 P87076  
 β-xylosidase (XlnD) 3.2.1.37 Aspergillus nidulans CAA73902.1 O42810
Q5BAS1
 
 AN2217.2   Aspergillus nidulans FGSC A4 EAA63874.1 C8VMK8
Q5BB63
 
 AN6652 (Anid-Bgl101)   Aspergillus nidulans FGSC A4 EAA58181.1 C8V1D9
Q5AYH8
 
 AN7396.2   Aspergillus nidulans FGSC A4 EAA61767.1 C8VCE8
Q5AWD4
 
 AN7915.2   Aspergillus nidulans FGSC A4 EAA59569.1 Q5AUW5  
 β-glucosidase (AN1804.2) 3.2.1.21 Aspergillus nidulans FGSC A4 EAA64969.1 Q5BCC6  
 AN3360.2   Aspergillus nidulans FGSC A4 EAA63328.1 C8VHR7
Q5B7X0
 
 AN3949.2   Aspergillus nidulans FGSC A4 EAA59258.1 C8V626
Q5B681
 
 AN4102.2   Aspergillus nidulans FGSC A4 EAA59363.1 Q5B5S8  
 AN2612.2   Aspergillus nidulans FGSC A4 EAA64717.1
ABF50857.1
C8VKN4
Q5BA18
 
 AN1416.2   Aspergillus nidulans FGSC A4 EAA64546.1 C8VM29
Q5BDG4
 
 β-xylosidase / α-L-arabinofuranosidase (BxlB;AnXA;AN8401.2) 3.2.1.37
3.2.1.55
Aspergillus nidulans FGSC A4 EAA67023.1 Q5ATH9  
 AN3903.2 (fragment)   Aspergillus nidulans FGSC A4 EAA58834.1 C8V6A3
Q5B6C7
 
 AN2227.2   Aspergillus nidulans FGSC A4 EAA63912.1
ABF50853.1
C8VML9
Q5BB53
 
 β-xylosidase (BxlA;XlnD;AN2359.2) 3.2.1.37 Aspergillus nidulans FGSC A4 EAA64470.1 Q5BAS1  
 β-glucosidase (AN0712.2) 3.2.1.21 Aspergillus nidulans FGSC A4 EAA65189.1
ABF50843.1
Q5BFG8  
 AN5976.2   Aspergillus nidulans FGSC A4 EAA57725.1 Q5B0F4  
 AN3904.2   Aspergillus nidulans FGSC A4 EAA58835.1 Q5B6C6  
 β-glucosidase (AN2828) 3.2.1.21 Aspergillus nidulans FGSC A4 EAA63399.1 C8VJG1
Q5B9F2
 
 AN7865.2   Aspergillus nidulans FGSC A4 EAA58910.1 C8V7D6
Q5AV15
 
 AN0479.2   Aspergillus nidulans FGSC A4 EAA66578.1 C8VT50
Q5BG51
 
 β-glucosidase (SP188;AnBgl1;AnCel3A) (peptide fragment) (Cel3A) 3.2.1.21 Aspergillus niger AAB27405.1    
 β-xylosidase, partial (fragment)   Aspergillus niger AHG30998.1    
 β-xylosidase (XlnD;AnXlnD;Asp n 14;P1.1) 3.2.1.37 Aspergillus niger 90196 AAD13106.1
CAW52630.1
CBC23888.1
O00089
O93933
 
 β-glucosidase (Bgl1;Bgl)   Aspergillus niger AS3.350 ABB29285.1
ABG46337.1
Q30BH9  
 β-glucosidase (Bgl)   Aspergillus niger AS3.796 ABW87793.1 A8WE01  
 β-glucosidase (P1.2) (partial) 3.2.1.21 Aspergillus niger ASKU28 AFW98805.1    
 β-glucosidase   Aspergillus niger ATCC 10574 ANT73244.1    
 β-glucosidase   Aspergillus niger ATCC 10574 ANT73245.1    
 β-glucosidase (Bgl1;BG3;BGs) 3.2.1.21 Aspergillus niger B1 CAB75696.1 Q9P8F4  
 β-glucosidase (Bgl1)   Aspergillus niger B2 AIF75101.1
AIK19764.1
   
 β-glucosidase II   Aspergillus niger BCRC 31494 ACV91073.1 C9E8N1  
 β-xylosidase (XlnD;AnXln3D) (Xln3D) 3.2.1.37 Aspergillus niger BE-2 AIC36733.1    
 β-glucosidase (Bg1)   Aspergillus niger BE-2 AIE48478.1    
 β-glucosidase (Bgl1)   Aspergillus niger C112 AKC02207.1    
 β-xylosidase (XlnD;Asp n 14;AnXlnD) 3.2.1.37 Aspergillus niger CBS 120.49 / NW147 AAQ80268.1
CAB06417.1
CAB59162.1
CAW52627.1
CBC23882.1
O00089  
 β-xylosidase (XlnD;An01g09960) 3.2.1.37 Aspergillus niger CBS 513.88 CAK37179.1 A2QA27  
 An02g07590   Aspergillus niger CBS 513.88 CAK37722.1 A2QDM1  
 An03g05330   Aspergillus niger CBS 513.88 CAK49185.1 A2QH25  
 An06g02040   Aspergillus niger CBS 513.88 CAK48047.1 A2QLQ2  
 An06g02460   Aspergillus niger CBS 513.88 CAK39213.1 A2QLU4  
 An07g07630   Aspergillus niger CBS 513.88 CAK39579.1 A5AAW4  
 An07g09760   Aspergillus niger CBS 513.88 CAK39741.1 A2QPK4  
 An08g08240   Aspergillus niger CBS 513.88 CAK40026.1 A2QS42  
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