Glycoside Hydrolase Family 3

Activities in Familyβ-glucosidase (EC 3.2.1.21); xylan 1,4-β-xylosidase (EC 3.2.1.37); β-glucosylceramidase (EC 3.2.1.45); β-N-acetylhexosaminidase (EC 3.2.1.52); α-L-arabinofuranosidase (EC 3.2.1.55); glucan 1,3-β-glucosidase (EC 3.2.1.58); glucan 1,4-β-glucosidase (EC 3.2.1.74); isoprimeverose-producing oligoxyloglucan hydrolase (EC 3.2.1.120); coniferin β-glucosidase (EC 3.2.1.126); exo-1,3-1,4-glucanase (EC 3.2.1.-); β-N-acetylglucosaminide phosphorylases (EC 2.4.1.-)
Mechanism Retaining
Catalytic Nucleophile/BaseAsp (experimental);
Catalytic Proton DonorGlu for hydrolases (experimental); histidine for phosphorylases (experimental)
NoteA recent paper by Macdonald et al. (PMID=25533455) has shown that the enzymes that cleave b-hexosaminides are in fact retaining b-glycoside phosphorylases.
External resourcesCAZypedia; HOMSTRAD; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX ;
Statistics GenBank accession (17417); Uniprot accession (2560); PDB accession (105); 3D entries (33); cryst (4)
All (16564) Archaea (94) Bacteria (15420) Eukaryota (949) Viruses (1) unclassified (100) Structure (33 - 4 cryst) Characterized (295)
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ASAC_1378   Acidilobus saccharovorans 345-15 ADL19783.1    
 Cmaq_1217   Caldivirga maquilingensis IC-167 ABW02044.1 A8ME38  
 Cmaq_1311   Caldivirga maquilingensis IC-167 ABW02138.1 A8M8R9  
 CPM_1642   Cuniculiplasma divulgatum PM4 (=JCM 30641; =VKM B-2940) SJK85429.1    
 CSP5_1676   Cuniculiplasma divulgatum S5(T) (=JCM 30642; =VKM B-2941) SIM80601.1    
 HacjB3_02060   Halalkalicoccus jeotgali B3 ADJ13805.1 D8J5Z9  
 HacjB3_15155   Halalkalicoccus jeotgali B3 ADJ16410.1 D8J9S1  
 HAH_0924 (Bglx-1)   Haloarcula hispanica ATCC 33960 CGMCC 1.2049 AEM56542.1    
 HAH_1720 (Bglx-2)   Haloarcula hispanica ATCC 33960 CGMCC 1.2049 AEM57322.1    
 HAH_4339 (NagZ)   Haloarcula hispanica ATCC 33960 CGMCC 1.2049 AEM59010.1    
 HISP_16920   Haloarcula hispanica N601 AHB67706.1    
 HISP_04760   Haloarcula hispanica N601 AHB65348.1    
 HISP_08780   Haloarcula hispanica N601 AHB66088.1    
 rrnAC0173 (BglX-1)   Haloarcula marismortui ATCC 43049 AAV45239.1 Q5V5G3  
 rrnAC1113 (BglX-2)   Haloarcula marismortui ATCC 43049 AAV46070.1 Q5V332  
 SG26_12450   Haloarcula sp. CBA1115 AJF26480.1    
 SG26_00660   Haloarcula sp. CBA1115 AJF24341.1    
 SG26_16515   Haloarcula sp. CBA1115 AJF27220.1    
 Hhub_1804   Halobacterium hubeiense JI20-1 CQH52072.1    
 Hhub_4033   Halobacterium hubeiense JI20-1 CQH63296.1    
 ABY42_15105   Haloferax gibbonsii ARA6 AKU09139.1    
 ABY42_10385   Haloferax gibbonsii ARA6 AKU08130.1    
 ABY42_10160   Haloferax gibbonsii ARA6 AKU08087.1    
 ABY42_10380   Haloferax gibbonsii ARA6 AKU08129.1    
 BM92_18860   Haloferax mediterranei ATCC 33500 AHZ24265.1    
 HFX_5029 (Amy6;GlyAHme) 3.2.1.- Haloferax mediterranei ATCC 33500 CGMCC 1.2087 AFK20866.1    
 HVO_2087   Haloferax volcanii DS2 ADE03343.1 D4GUN5  
 HVO_2088 (XloA)   Haloferax volcanii DS2 ADE02994.1 D4GUN6  
 Hbor_33610   Halogeometricum borinquense DSM 11551 ADQ68885.1 E4NVK1  
 Hmuk_3174   Halomicrobium mukohataei DSM 12286 ACV49279.1 C7P2G4  
 Halxa_3779   Halopiger xanaduensis SH-6 AEH38385.1    
 Halxa_4062   Halopiger xanaduensis SH-6 AEH38667.1    
 Halxa_0372   Halopiger xanaduensis SH-6 AEH38975.1    
 Halxa_0375   Halopiger xanaduensis SH-6 AEH38978.1    
 Halxa_0663   Halopiger xanaduensis SH-6 AEH39240.1    
 Halxa_2401   Halopiger xanaduensis SH-6 AEH37020.1    
 Halxa_0358   Halopiger xanaduensis SH-6 AEH38961.1    
 Halxa_0665   Halopiger xanaduensis SH-6 AEH39242.1    
 HTIA_0724   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ32864.1    
 HTIA_1091   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33229.1    
 HTIA_1246   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33380.1    
 HTIA_1431   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33558.1    
 HTIA_2742   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ34845.1    
 HTIA_0904   Halorhabdus tiamatea SARL4B type strain: SARL4B CCQ33043.1    
 Huta_1370   Halorhabdus utahensis DSM 12940 ACV11546.1 C7NNE6  
 Huta_2836   Halorhabdus utahensis DSM 12940 ACV12997.1 C7NQI0  
 Huta_1163   Halorhabdus utahensis DSM 12940 ACV11339.1 C7NMM6  
 Huta_1047   Halorhabdus utahensis DSM 12940 ACV11230.1 C7NVE6  
 Huta_0155   Halorhabdus utahensis DSM 12940 ACV10343.1 C7NP52  
 Huta_0867   Halorhabdus utahensis DSM 12940 ACV11050.1 C7NUF3  
 Huta_1607   Halorhabdus utahensis DSM 12940 ACV11781.1 C7NQ37  
 HALLA_12845   Halostagnicola larsenii XH-48 AHF99545.1    
 HALLA_01775   Halostagnicola larsenii XH-48 AHG02057.1    
 HALLA_03250   Halostagnicola larsenii XH-48 AHG01417.1    
 Htur_2157   Haloterrigena turkmenica DSM 5511 ADB61039.1 D2RTT8  
 Htur_2399   Haloterrigena turkmenica DSM 5511 ADB61277.1 D2RV76  
 Halru_2625   Halovivax ruber XH-70 AGB17203.1    
 Igag_0910   Ignisphaera aggregans DSM 17230 ADM27726.1 E0STW0  
 Igag_0941   Ignisphaera aggregans DSM 17230 ADM27757.1 E0STZ1  
 Igag_1800   Ignisphaera aggregans DSM 17230 ADM28597.1 E0SSL2  
 LRC258   Methanocella arvoryzae MRE50 CAJ35242.1 Q0W8Q1  
 MCP_1311   Methanocella paludicola SANAE BAI61383.1 D1YY61  
 Mpet_1533   Methanolacinia petrolearia DSM 11571 ADN36290.1 E1RG55  
 NJ7G_2704   Natrinema sp. J7-2 AFO57933.1    
 Natoc_3156   Natronococcus occultus SP4 AGB38896.1    
 Natoc_1547   Natronococcus occultus SP4 AGB37354.1    
 PTO0020   Picrophilus torridus DSM 9790 AAT42605.1 Q6L346  
 L593_01725   Salinarchaeum sp. Harcht-Bsk1 AGN00298.1    
 L593_08905   Salinarchaeum sp. Harcht-Bsk1 AGN01726.1    
 L593_07345   Salinarchaeum sp. Harcht-Bsk1 AGN01414.1    
 SiH_2262   Sulfolobus islandicus HVE10/4 ADX83603.1    
 LD85_2613   Sulfolobus islandicus L.D.8.5 ADB88231.1 D2PG91  
 LS215_2494   Sulfolobus islandicus L.S.2.15 ACP36454.1 C3ML52  
 SiL_2171   Sulfolobus islandicus LAL14/1 AGJ63611.1    
 M1425_2322   Sulfolobus islandicus M.14.25 ACP39052.1 C3MSA9  
 M1627_2401   Sulfolobus islandicus M.16.27 ACP56257.1 C3N1N0  
 M164_2324   Sulfolobus islandicus M.16.4 ACR42924.1 C4KKR2  
 SiRe_2208   Sulfolobus islandicus REY15A ADX86262.1    
 YG5714_2461   Sulfolobus islandicus Y.G.57.14 ACP46703.1 C3NAB0  
 YN1551_0446   Sulfolobus islandicus Y.N.15.51 ACP47608.1 C3NL94  
 Ssol98_010100007971   Sulfolobus solfataricus 98/2 AET42953.1    
 SULC_0810   Sulfolobus solfataricus 98/2 SULC AKA75874.1    
 SSOP1_3127 (fragment)   Sulfolobus solfataricus P1 SAI86681.1    
 SSOP1_3128 (fragment)   Sulfolobus solfataricus P1 SAI86682.1    
 β-xylosidase / α-L-arabinosidase (XarS;SSO3032) 3.2.1.37
3.2.1.55
Sulfolobus solfataricus P2 AAK43134.1
NP_344344.1
Q97UI4  
 SULA_0810   Sulfolobus solfataricus SULA AKA78566.1    
 SULB_0812   Sulfolobus solfataricus SULB AKA73176.1    
 BFU36_07155   Sulfolobus sp. A20 AOL16510.1    
 N186_00235   Thermofilum adornatus 1910b AGT34445.1    
 TCARB_1127   Thermofilum carboxyditrophus 1505 AJB42175.1    
 β-glucosidase (Bgl;TpBgl;Tpen_1494) 3.2.1.21 Thermofilum pendens Hrk 5 ABL78891.1 A1S0B1  
 MA03_03765   Thermofilum uzonense 1807-2 AKG38579.1    
 ALOHA_HF4000APKG10I20ctg7g21   uncultured marine crenarchaeote HF4000_APKG10I20 ABZ10240.1 B3TCC5  
 ALOHA_HF4000APKG8D22ctg7g1   uncultured marine crenarchaeote HF4000_APKG8D22 ABZ09512.1 B3TAA3  
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