Glycoside Hydrolase Family 39

Activities in Familyα-L-iduronidase (EC 3.2.1.76); β-xylosidase (EC 3.2.1.37); α-L-arabinofuranosidase (EC 3.2.1.55); β-glucosidase (EC 3.2.1.21); β-galactosidase (EC 3.2.1.23)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)PROZOMIX;
Statistics GenBank accession (3335); Uniprot accession (261); PDB accession (26); 3D entries (9); cryst (0)
All (3274) Archaea (13) Bacteria (3187) Eukaryota (70) Viruses (1) unclassified (3) Structure (9) Characterized (21)
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 AN7117.2   Aspergillus nidulans FGSC A4 EAA61322.1 C8VDB5
Q5AX63
 
 IduA (short fragment)   Balaenoptera musculus AAX07735.1 Q5EC67  
 BCIN_09g04790   Botrytis cinerea B05.10 ATZ53683.1    
 glycoside hydrolase family 39 protein (Bofut4_p013400.1)   Botrytis cinerea T4 CCD43231.1    
 ORF (fragment)   Callorhinchus milii AFP02881.1    
 α-L-iduronidase (IduA) 3.2.1.76 Canis lupus familiaris AAA51455.1 Q01634  
 CSTEINMANNI_LOCUS890697 (fragment)   Coregonus sp. balchen CAB1319923.1    
 CSTEINMANNI_LOCUS1150772 (fragment)   Coregonus sp. balchen CAB1322122.1    
 CH211-12E13.9-001   Danio rerio CAM46905.1
CAM13182.1
CAM13182.2
A2ARH2  
 Dbus_chr2Lg1829   Drosophila busckii ALC39744.1    
 CG6201   Drosophila melanogaster AAF53070.2
AAQ22532.1
NP_609489.1
Q9VKJ8  
 α-L-iduronidase (IduA;IDUA) 3.2.1.76 Felis catus AIT52923.1    
 CEK26_009398   Fusarium fujikuroi Augusto2 QGI96329.1    
 CEK26_010737   Fusarium fujikuroi Augusto2 QGI97668.1    
 CEK26_011651   Fusarium fujikuroi Augusto2 QGI98582.1    
 CEK26_009253 (fragment)   Fusarium fujikuroi Augusto2 QGI96184.1    
 CEK26_002695   Fusarium fujikuroi Augusto2 QGJ01251.1    
 CEK27_009273   Fusarium fujikuroi CSV1 QGI65302.1    
 CEK27_009419   Fusarium fujikuroi CSV1 QGI65448.1    
 CEK27_002691   Fusarium fujikuroi CSV1 QGI70362.1    
 CEK27_010753 (fragment)   Fusarium fujikuroi CSV1 QGI66782.1    
 CEK27_011668   Fusarium fujikuroi CSV1 QGI67697.1    
 CEK25_009280   Fusarium fujikuroi I1.3 QGI82551.1    
 CEK25_009429   Fusarium fujikuroi I1.3 QGI82700.1    
 CEK25_011658 (fragment)   Fusarium fujikuroi I1.3 QGI84929.1    
 CEK25_002676   Fusarium fujikuroi I1.3 QGI87720.1    
 CEK25_010748 (fragment)   Fusarium fujikuroi I1.3 QGI84019.1    
 FFUJ_05361   Fusarium fujikuroi IMI 58289 CCT69473.1    
 FFUJ_05526   Fusarium fujikuroi IMI 58289 CCT69625.1    
 FFUJ_08897   Fusarium fujikuroi IMI 58289 CCT71063.1    
 FFUJ_11044   Fusarium fujikuroi IMI 58289 CCT74970.1    
 FFUJ_13957   Fusarium fujikuroi IMI 58289 CCT72047.1    
 FGRAMCML3066_01t11499.1   Fusarium graminearum CZS80807.1    
 FGRAMCML3066_01t04287.1   Fusarium graminearum CZS77201.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF77514.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF73933.1    
 FOBC_09631   Fusarium oxysporum Fo47 QKD55516.1    
 FOBC_02743   Fusarium oxysporum Fo47 QKD48733.1    
 FOBC_09480   Fusarium oxysporum Fo47 QKD55367.1    
 FOBC_14529   Fusarium oxysporum Fo47 QKD60357.1    
 FVRRES_02095   Fusarium venenatum A3/5 CEI65583.1    
 FVRRES_05719   Fusarium venenatum A3/5 CEI61283.1    
 RCJMB04_31l23   Gallus gallus CAH65418.1 Q5F366  
 α-L-iduronidase (IduA) 3.2.1.76 Homo sapiens AAA81589.1
AAA51698.1
AAE53576.1
AAE72581.1
AAH29959.1
AAN25812.1
AAQ32908.1
AAQ46779.1
AAT18792.1
AAY01759.1
ABH73761.1
ABL21590.1
ACG93377.1
ACH14961.1
ACK10791.1
AFR32586.1
ASX95248.1
ASX95249.1
BAD92138.1
BAF84505.1
BAG54168.1
NP_000194.1
XP_042678.2
P35475 3W81[A,B]
4JXO[A,B]
4JXP[A]
4KGJ[A,B]
4KGL[A,B]
4KH2[A,B]
4MJ2[A,B]
4MJ4[A]
4OBR[A,B]
4OBS[A]
6I6R[A,B]
6I6X[A,B]
 ORF   Leptosphaeria maculans JN3 CBX99018.1 E5A5X3  
 α-L-iduronidase (IduA) (fragment)   Macaca mulatta AFE73120.1    
 α-L-iduronidase (IduA) 3.2.1.76 Mus musculus AAC42044.1
AAH57935.1
BAC27393.1
BAC32313.1
BAE33353.1
BAE41504.1
NP_032351.1
P48441
Q8BLF6
Q8BMG0
 
 ORF (fragment)   Mustela putorius furo AES00039.1    
 D-galacto-(α-1,2)-L-arabinosidase (NF2523) 3.2.1.55 Neocallimastix frontalis ASF57709.1    
 α-L-(β-1,2)-arabinofuranobiosidase (NF2152) 3.2.1.55 Neocallimastix frontalis ASF57707.1   5U22[A]
 NF2215   Neocallimastix frontalis ASF57708.1    
 multifunctional β-glycoside hydrolase (Bgxg1) 3.2.1.21
3.2.1.23
3.2.1.37
Orpinomyces sp. C1A ALT07805.1    
 AMS68_002250 (fragment)   Peltaster fructicola LNHT1506 QIW96732.1    
 Pc16g05200   Penicillium rubens Wisconsin 54-1255 CAP93190.1 B6H9H4  
 Pc24g00260 (fragment)   Penicillium rubens Wisconsin 54-1255 CAP86934.1 B6HWI8  
 PR2455   Piromyces rhizinflatus ASF57710.1    
 PoMZ_13510   Pyricularia oryzae QBZ66531.1    
 MG09606.4   Pyricularia oryzae 70-15 XP_364761.1 Q2KHF2  
 MGCH7_ch7g33   Pyricularia oryzae 70-15 EAQ70626.1    
 SMAX5B_018736   Scophthalmus maximus AWP06535.1    
 SMAX5B_018736   Scophthalmus maximus AWP06536.1    
 EYB26_007503 (fragment)   Talaromyces marneffei QGA19808.1    
 TRUGW13939_11888   Talaromyces rugulosus W13939 QKX64712.1    
 THITE_2115890 (fragment)   Thermothielavioides terrestris NRRL 8126 AEO67095.1    
 THITE_2115891 (fragment)   Thermothielavioides terrestris NRRL 8126 AEO67096.1    
 IduA-prov (MGC:80842)   Xenopus laevis AAH77919.1 Q6DCS7  
 ZT1A5_G1793   Zymoseptoria tritici ST99CH_1A5 SMY20358.1    
 ZT1E4_G1803   Zymoseptoria tritici ST99CH_1E4 SMR43025.1    
 ZT3D1_G1776   Zymoseptoria tritici ST99CH_3D1 SMR45193.1    
 ZT3D7_G1815   Zymoseptoria tritici ST99CH_3D7 SMQ46669.1    
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