Glycoside Hydrolase Family 38

Activities in Familyα-mannosidase (EC 3.2.1.24); mannosyl-oligosaccharide α-1,2-mannosidase (EC 3.2.1.113); mannosyl-oligosaccharide α-1,3-1,6-mannosidase (EC 3.2.1.114); α-2-O-mannosylglycerate hydrolase (EC 3.2.1.170); mannosyl-oligosaccharide α-1,3-mannosidase (EC 3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 7
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorNot known
External resourcesCAZypedia; MEGAZYME;
Statistics GenBank accession (3759); Uniprot accession (537); PDB accession (63); 3D entries (7); cryst (2)
All (3393) Archaea (59) Bacteria (2929) Eukaryota (403) unclassified (2) Structure (7 - 2 cryst) Characterized (45)
| 1 | 2 | 3 | 4 | 5 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 AMAN, partial (fragment)   Evaniella sp. 486 ASN78201.1    
 α-mannosidase (lysosomal) 3.2.1.24 Felis catus AAB97672.1 O46432  
 FFUJ_03041   Fusarium fujikuroi IMI 58289 CCT66046.1    
 FGRAMPH1_01T23287   Fusarium graminearum PH-1 SCB65125.1    
 RCJMB04_18f23 (fragment)   Gallus gallus CAH65326.1 Q5F3F8  
 ORF (short fragment)   Gladiolus grandiflorus ADM18311.1    
 α-mannosidase (fragment)   Glossina morsitans morsitans ADD18519.1 D3TLE1  
 α-1,2-mannosidase (LMann;GmLMann;LOC100806748) 3.2.1.113 Glycine max XP_003548841.1
AIX48008.1
   
 α-mannosidase II (Man2A1;ManA2) 3.2.1.114 Homo sapiens AAC50302.1
AAH43416.1
AAI42657.1
AAI42697.1
ACM84601.1
BAA10017.1
CAH33909.1
CAL47687.1
CBA12848.1
CBA34888.1
NP_002363.1
Q16706  
 α-mannosidase a (Man2B1;ManB;LaMan;LMann;HsLMann) (lysosomal) 3.2.1.113
3.2.1.24
Homo sapiens AAC51362.1
AAB03816.1
AAC34130.1
AAC50811.1
AAC50812.1
AAH00736.1
ABA84560.1
ACM80454.1
ACM82884.1
AIX48010.1
BAD93158.1
BAF84261.1
BAG64471.1
CAD68121.1
CAH33914.1
CBA12853.1
CBA34893.1
NP_000519.1
O00754
Q93093
 
 α-mannosidase IIx (Man2A2;Man2Ax) 3.2.1.114 Homo sapiens BAA09510.1
AAA92022.1
AAI36449.1
BAF82552.1
BAG57210.1
BAG58516.1
BAG61252.1
BAH14521.1
CAH33912.1
CBA12851.1
CBA34891.1
NP_006113.1
P49641  
 neutral α-mannosidase (Man2C1;6A8;6A8B) (cytosolic) 3.2.1.24 Homo sapiens AAC00190.2
AAC00568.1
AAH50550.1
AAH80191.1
ACM82923.1
AEE61026.1
BAD92378.1
BAG62758.1
CAB66810.1
CAH33915.1
CBA12854.1
CBA34894.1
NP_006706.1
Q13358
Q9NTJ4
 
 α-1,6-mannosidase (Man2B2;KIAA0935) 3.2.1.114 Homo sapiens CAD89971.1
AAH33307.1
AAH36836.1
AAH94773.1
BAA76779.1
BAA76779.2
BAG52093.1
BAH13490.1
CAF86562.1
NP_056089.1
XP_052620.6
Q9Y2E5
Q9Y2E5
 
 ORF   Hypocrella siamensis MTCC 10142 ANH56472.1    
 AMAN, partial (fragment)   Hyptia floridana ASN78193.1    
 AMAN, partial (fragment)   Hyptia sp. 232 ASN78175.1    
 AMAN, partial (fragment)   Hyptia sp. 487 ASN78202.1    
 AMAN, partial (fragment)   Hyptia sp. 501 ASN78205.1    
 AMAN, partial (fragment)   Hyptia sp. 511 ASN78206.1    
 ORF (Man2b1)   Ictalurus punctatus AHH39379.1    
 KAFR_0B04640 (Kafr0b04640)   Kazachstania africana CBS 2517 CCF56761.1    
 KNAG_0I00600 (Knag0i00600)   Kazachstania naganishii CBS 8797 type strain:CBS 8797 CCK71851.1    
 ATY40_BA7504519 (Ams1)   Komagataella pastoris ATCC 28485 ANZ77973.1    
 AT249_GQ6705181 (Ams1)   Komagataella phaffii ATCC 76273 AOA65028.1    
 PP7435_Chr4-0161 (Ams1)   Komagataella phaffii CBS 7435 CCA40336.1    
 PAS_chr4_0790   Komagataella phaffii GS115 CAY72059.1
AOA69506.1
C4R8Y4  
 KLTH0G11000g   Lachancea thermotolerans CBS 6340 CAR25074.1    
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX95677.1 E4ZVQ1  
 LRAMOSA06239   Lichtheimia ramosa CDS14068.1    
 LRAMOSA08895   Lichtheimia ramosa CDS06367.1    
 ORF (fragment)   Linum usitatissimum ADD54604.1 D4P875  
 α-mannosidase (MAN2B1)   Macaca fascicularis BAD51966.1 Q60HE9  
 unnamed protein product (fragment)   Macaca fascicularis BAE88765.1    
 epididymis-specific α-mannosidase precursor (Man2b2)   Macaca mulatta AFE67111.1    
 α-mannosidase 2 (Man2a1)   Macaca mulatta AFE66336.1
AFH29699.1
AFI34553.1
   
 α-mannosidase 2x (Man2a2)   Macaca mulatta AFE78271.1    
 α-mannosidase 2C1, partial (Man2c1) (fragment)   Macaca mulatta AFE70405.1
AFI33686.1
   
 lysosomal α-mannosidase isoform 1 precursor (Man2b1)   Macaca mulatta AFI37135.1    
 lysosomal α-mannosidase isoform 1 precursor (Man2b1)   Macaca mulatta AFJ71498.1    
 α-mannosidase (MG04464.4) (vacuolar)   Magnaporthe oryzae 70-15 EAA50705.1
XP_362019.1
G4MKK2  
 MGG_12735   Magnaporthe oryzae 70-15 XP_003716692.1
EAA51678.1
XP_360730.1
   
 α-D-mannosidase isoform 2, partial (fragment)   Mangifera indica AJZ77342.1    
 α-D-mannosidase isoform 3, partial (fragment)   Mangifera indica AJZ77343.1    
 α-D-mannosidase isoform 1, partial (fragment)   Mangifera indica AJZ77341.1    
 MTYFT1G-G-13 (fragment)   Medicago truncatula ACJ86251.1 B7FNB8  
 MtrDRAFT_AC141109g20v1   Medicago truncatula ABE79912.1
ABO80520.1
ABO80521.1
   
 α-1,2-mannosidase (LMann;MtLMann;MtrDRAFT_AC148217g19v1) 3.2.1.113 Medicago truncatula ABE88173.1
AIX48011.1
XP_003629280.1
G7LB83  
 BN887_02677   Melanopsichium pennsylvanicum 4 CDI51481.1    
 AMAN, partial (fragment)   Micrevania sp. 288 ASN78191.1    
 MICPUN_62552   Micromonas commoda sp. RCC299 ACO66199.1 C1EEA2  
 MICPUN_62591   Micromonas commoda sp. RCC299 ACO66520.1 C1EEE2  
 GNLVRS01_PISO0H05089g (Piso0_003109)   Millerozyma farinosa CBS 7064 CCE80778.1    
 GNLVRS01_PISO0G05088g (Piso0_003109)   Millerozyma farinosa CBS 7064 CCE80013.1    
 α-mannosidase (Man2c1;C330035A14;1110025H24) (cytosolic) 3.2.1.24 Mus musculus AAH16253.1
AAH39913.1
AAY53557.1
BAB23074.1
BAC33715.1
BAE32264.1
BAE42254.1
BAE42554.1
NP_082912.1
Q3ZCX9
Q80XU4
Q8BWY6
Q91W89
Q9CTD5
 
 α-mannosidase (Man2B2;Kiaa0935) 3.2.1.24 Mus musculus BAA24266.1
AAH66211.1
BAB23655.1
BAC30580.1
BAC53862.1
BAD32345.1
BAE30761.1
BAE31143.1
BAE38153.1
NP_032576.1
O54782  
 α-mannosidase (Man2b;LMann;MmLMann) (lysosomal) 3.2.1.24 Mus musculus NP_034894.2
AAC09470.1
AAC53369.1
AAC78560.1
AAH05430.1
AIX48012.1
BAB23588.1
BAE28235.1
BAE42071.1
BAE42288.1
BAE42419.1
NP_034894.1
O09159
Q3UGH3
 
 α-mannosidase II (Man2A1;ManA2) 3.2.1.114 Mus musculus CAA43480.1
AAI38373.1
BAC38329.1
CAH33910.1
CBA12849.1
CBA34889.1
NP_032575.1
P27046
Q8C4L1
 
 α-mannosidase IIx (Man2A2) 3.2.1.114 Mus musculus ABG02551.1
AAD20813.1
AAH55006.1
BAC31745.1
BAE36580.1
NP_766491.1
Q197W7
Q7TPQ0
Q8BRK9
Q9WU23
 
 ORF   Mus musculus C57BL/6J AQS27599.1    
 unnamed protein product (fragment)   Mus musculus C57BL/6J BAE23268.1 Q197W7
Q3UVK1
Q8BRK9
 
 ORF   Musca domestica ALHF AFP62178.1    
 ORF (fragment)   Musca domestica ALHF AFP62267.1    
 ORF (fragment)   Mustela putorius furo AES01501.1    
 ORF (fragment)   Mustela putorius furo AES01502.1    
 ORF (fragment)   Mustela putorius furo AES01503.1    
 ORF (fragment)   Mustela putorius furo AES01504.1    
 ORF (fragment)   Mustela putorius furo AES01506.1    
 ORF (fragment)   Mustela putorius furo AES01511.1    
 ORF (fragment)   Mustela putorius furo AES01512.1    
 ORF (fragment)   Mustela putorius furo AES01500.1    
 ORF (fragment)   Mustela putorius furo AES01505.1    
 ORF (fragment)   Mustela putorius furo AES01508.1    
 ORF (fragment)   Mustela putorius furo AES01509.1    
 NGATSA_3021300 (fragment)   Nannochloropsis gaditana CCMP526 AFJ68737.1    
 NGATSA_3022100 (fragment)   Nannochloropsis gaditana CCMP526 AFJ68858.1    
 NCAS_0D00720 (Ncas0d00720)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC69653.1    
 NDAI_0H03450 (Ndai0h03450)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD26518.1    
 ORF (fragment)   Neslia paniculata ADG39054.1 D6PRS2  
 NCU07404.1   Neurospora crassa OR74A EAA29252.1
XP_327690.1
Q7S1L0  
 ORF   Nilaparvata lugens ANJ04662.1    
 seminal fluid protein   Nilaparvata lugens APA33853.1    
 Os10g0140200   Oryza sativa Japonica Group AAL73068.1
AAM08418.1
AAP52066.1
BAF26054.1
BAT09841.1
Q7XGZ1
Q8W348
 
 OSJNAa0029P06.5 or OSJNBa0029P06.7 or OSJNBa0029P06.16   Oryza sativa Japonica Group AAK98651.1
AAL73069.1
AAM08419.1
AAP52067.1
Q7XGZ0  
 Os06g0245700   Oryza sativa Japonica Group BAD45807.1
BAF19191.1
BAS97024.1
Q654G0  
 Os11g0525600   Oryza sativa Japonica Group BAF28356.1
BAG90901.1
BAT14237.1
BAT14238.1
BAT14239.1
BAT14240.1
Q2R3E0  
 ORF (fragment)   Pan troglodytes BAK63507.1    
 AMAN, partial (fragment)   Parevania sp. 172 ASN78166.1    
 AMAN, partial (fragment)   Parevania sp. 174 ASN78167.1    
 AMAN, partial (fragment)   Parevania sp. 219 ASN78173.1    
 AMAN, partial (fragment)   Parevania sp. 295 ASN78197.1    
 Pc20g06780   Penicillium rubens Wisconsin 54-1255 CAP86007.1 B6HH84  
 PHATR_52108 (fragment)   Phaeodactylum tricornutum CCAP 1055/1 ACI65146.1 B5Y3K7  
 22_ppgam15_d08 (fragment)   Physcomitrella patens CAC43692.1    
 ORF (fragment)   Picea sitchensis ADM77756.1 E0ZHD1  
 ORF (fragment)   Picea sitchensis ADM77757.1 E0ZHD2  
 ORF (fragment)   Picea sitchensis ADM77758.1 E0ZHD3  
 ORF (fragment)   Picea sitchensis ADM77760.1 E0ZHD5  
 ORF (fragment)   Picea sitchensis ADM77762.1 E0ZHD7  
 ORF (fragment)   Picea sitchensis ADM77763.1 E0ZHD8  
 ORF (fragment)   Picea sitchensis ADM77783.1 E0ZHF8  
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