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Glycoside Hydrolase Family 38

Known Activitiesα-mannosidase (EC 3.2.1.24) ; mannosyl-oligosaccharide α-1,3-1,6-mannosidase (EC 3.2.1.114); mannosyl-oligosaccharide α-1,3-mannosidase (EC 3.2.1.-)
Mechanism Retaining
3D Structure Status( β / α ) 7
Catalytic Nucleophile/BaseAsp
Catalytic Proton DonorNot known
External resourcesCAZypedia; InterPro; PFAM;
Statistics GenBank accession (1049); Uniprot accession (512); PDB accession (61); 3D entries (6); cryst (2)
Summary
All (764) Archaea (34) Bacteria (551) Eukaryota (178) unclassified (1) Structure (6 - 2 cryst) Characterized (37)
Eukaryota
Protein Name EC#OrganismGenBankUniprotPDB/3D
 ALNC14_000460 (Alnc14c1g41)   Albugo laibachii Nc14 CCA13903.1    
 Aa1_7515 (fragment)   Arabidopsis arenosa CARE-1 AAR15492.1 Q6V5C5  
 At3g26720 (α-mannosidase)   Arabidopsis thaliana AAK62592.1
AAM47314.1
AEE77203.1
AEE77204.1
BAB01735.1
BAH56863.1
CAA66821.1
CAA72432.1
NP_189306.1		 P94078  
 At5g13980   Arabidopsis thaliana AAM20555.1
AAN15620.1
AED91968.1
AED91969.1
AED91970.1
BAB11126.1
BAD93831.1
BAD94717.1
NP_196902.1		 Q8LPJ3
Q9FFX7		  
 At5g66150/K2A18.23   Arabidopsis thaliana AED98165.1
BAB10420.1
NP_201416.1		 Q9FKW9  
 α-mannosidase II (At5g14950) 3.2.1.114 Arabidopsis thaliana AAK96611.1
AAL38616.1
AAY90120.1
AED92095.1
CAC01814.1
CAH33905.1
CBA12844.1
CBA34884.1
NP_196999.1		 Q940T6
Q9LFR0		  
 ORF   Ascaris suum ADY40773.1    
 ORF   Ascaris suum ADY40800.1    
 ORF   Ascaris suum ADY41578.1    
 ORF   Ascaris suum ADY40731.1    
 ORF (fragment)   Ascaris suum ADY40786.1    
 ORF (fragment)   Ascaris suum ADY46025.1    
 ORF (fragment)   Ascaris suum ADY48332.1    
 FAGOS_FAGR385C   Ashbya gossypii FDAG1 AEY99207.1    
 mannosidase II (AfAms1)   Aspergillus fumigatus YJ-407 AAW49442.1 Q5I5K3  
 AN2936.2   Aspergillus nidulans FGSC A4 EAA63507.1    
 An02g11720   Aspergillus niger CBS 513.88 CAK37873.1 A2QEN9  
 AO090005001458   Aspergillus oryzae RIB40 BAE56379.1    
 ORF (fragment)   Belgica antarctica ABF72867.1    
 α-mannosidase (Man2B1;ManB) (lysosomal) 3.2.1.24 Bos taurus AAB67726.2
AAC48763.1
NP_776986.2		 Q29451.3 1O7D[A,B,C,D,E]
 α-mannosidase 3.2.1.24 Bos taurus AAE61905.1    
 Unknown (protein for MGC:127782)   Bos taurus HEREFORD AAI05161.1 A8YXY9  
 glycoside hydrolase family 38 protein (Bofut4_p162000.1)   Botryotinia fuckeliana CCD54911.1    
 p075G11_ORF1 (fragment)   Cadophora finlandica ACP19537.1 C3VES8  
 α-mannosidase (Aman-3;F48C1.1) 3.2.1.24 Caenorhabditis elegans Bristol N2 AAB52345.2
AAM81094.1
CCD62468.1
NP_491568.1
NP_740847.1
NP_740848.1		 O01574  
 α-mannosidase (Aman-1;F55D10.1) (lysosomal) 3.2.1.24 Caenorhabditis elegans Bristol N2 AAA81731.2
CCD67087.1
NP_508811.1		 Q20829  
 α-mannosidase II (Aman-2;F58H1.1) 3.2.1.114 Caenorhabditis elegans Bristol N2 CAB00104.1
CAH33906.1
CAJ55257.1
CBA12845.1
CBA34885.1
NP_505995.1		 Q21010
Q2PJ74		  
 MAN2B1-like protein (fragment)   Callithrix jacchus ABQ22594.1 A6MKK3  
 α-mannosidase (peptide fragment) 3.2.1.24 Canavalia ensiformis      
 CD36_42240   Candida dubliniensis CD36 CAX42104.1 B9WFT5  
 CAGL0E05148g   Candida glabrata CBS 138 CAG58831.1    
 CPAR2_500360   Candida parapsilosis CDC317 CCE43810.1    
 ORF (fragment)   Capsella grandiflora ADG39048.1 D6PRR6  
 ORF (fragment)   Capsella grandiflora ADG39049.1 D6PRR7  
 ORF (fragment)   Capsella grandiflora ADG39051.1 D6PRR9  
 ORF (fragment)   Capsella rubella AEN83007.1    
 ORF (fragment)   Capsella rubella AEN83012.1    
 α-mannosidase (α-Man) 3.2.1.24 Capsicum annuum ADU20406.1    
 α-mannosidase (ManB) (lysosomal) 3.2.1.24 Cavia porcellus AAL58982.1 Q8VHC8  
 unnamed protein product   Ciona intestinalis CAH33907.1
CBA12846.1
CBA34886.1		    
 CGB_A7550W   Cryptococcus bacillisporus WM276 ADV19851.1    
 CNA06750   Cryptococcus neoformans var. neoformans JEC21 AAW41087.1    
 Unknown (protein for MGC:110815)   Danio rerio AAH91843.1
AAI65679.1		 Q58EM3  
 CH211-131C14.1-001 (fragment)   Danio rerio CAM13190.1
CAM16361.1		 A2CED8  
 Unknown (protein for MGC:171587) (fragment)   Danio rerio AAI53981.1 A8KB62  
 DEHA0G18964g   Debaryomyces hansenii CBS767 CAG90819.1    
 α-mannosidase (ManA) 3.2.1.114 Dictyostelium discoideum AAA33224.1 P34098.2  
 α-mannosidase (α-Man-IIb) (CG4606) 3.2.1.114 Drosophila melanogaster AAF55228.2
AAM49872.1
BAA75817.1
BAC92711.1
NP_650494.2		 O97043
Q8MSX9
Q9VF33		  
 GlcNAcMan5GlcNAc2 α-1,6-mannosidase / GlcNAcMan4GlcNAc2 α-1,3-mannosidase / α-mannosidase II (GMII;α-Man-II;CG18474) 3.2.1.114 Drosophila melanogaster AAF54375.1
AAF54376.1
AAM50118.1
CAA10755.1
CAA54732.1
CAH33908.1
CBA12847.1
CBA34887.1
NP_524291.2		 Q24451.2 1HTY[A]
1HWW[A]
1HXK[A]
1PS3[A]
1QWN[A]
1QWU[A]
1QX1[A]
1R33[A]
1R34[A]
1TQS[A]
1TQT[A]
1TQU[A]
1TQV[A]
1TQW[A]
2ALW[A]
2F18[A]
2F1A[A]
2F1B[A]
2F7O[A]
2F7P[A]
2F7Q[A]
2F7R[A]
2FYV[A]
2OW6[A]
2OW7[A]
3BLB[A]
3BUB[A]
3BUD[A]
3BUI[A]
3BUP[A]
3BUQ[A]
3BVT[A]
3BVU[A]
3BVV[A]
3BVW[A]
3BVX[A]
3CV5[A]
3CZN[A]
3CZS[A]
3D4Y[A]
3D4Z[A]
3D50[A]
3D51[A]
3D52[A]
3DDF[A]
3DDG[A]
3DX0[A]
3DX1[A]
3DX2[A]
3DX3[A]
3DX4[A]
3EJP[A]
3EJQ[A]
3EJR[A]
3EJS[A]
3EJT[A]
3EJU[A]
 CG6206   Drosophila melanogaster AAD38576.1
AAF52958.1
AAF52958.2
AAN10754.1
NP_609408.1
NP_723591.1		 Q8IPB7
Q9VKV1		  
 CG9463   Drosophila melanogaster AAF52708.2
AAL48871.1
AAL48871.2
NP_609250.2		 Q8SYY1
Q9VLI2		  
 CG9465   Drosophila melanogaster AAF52709.1
AAF52709.2
NP_609251.1		 Q9VLI1  
 CG9466   Drosophila melanogaster AAF52710.1
AAL13500.1
NP_609252.1		 Q9VLI0  
 CG9468   Drosophila melanogaster AAF52711.2
AAM50967.1
NP_609253.1		 Q8MS44
Q9VLH9		  
 CG5322   Drosophila melanogaster AAF52957.1
ABC86349.1
NP_609407.1		 Q9VKV2  
 α-mannosidase   Emericella nidulans T222 AAB70514.1 O13344  
 ORF (fragment)   Equus caballus AEB61005.1    
 Ecym_3349   Eremothecium cymbalariae DBVPG#7215 AET38837.1    
 AGR385C   Eremothecium gossypii ATCC 10895 AAS54875.1
AAS54875.2		 Q74Z21  
 α-mannosidase (lysosomal) 3.2.1.24 Felis catus AAB97672.1 O46432.1  
 RCJMB04_18f23 (fragment)   Gallus gallus CAH65326.1 Q5F3F8  
 ORF (short fragment)   Gladiolus grandiflorus ADM18311.1    
 α-mannosidase (fragment)   Glossina morsitans morsitans ADD18519.1 D3TLE1  
 α-mannosidase II (Man2A1;ManA2) 3.2.1.114 Homo sapiens AAC50302.1
AAH43416.1
AAI42657.1
AAI42697.1
ACM84601.1
BAA10017.1
CAH33909.1
CAL47687.1
CBA12848.1
CBA34888.1
NP_002363.1		 Q16706.2  
 α-mannosidase a (lysosomal) (Man2B1;LaMan;ManB) 3.2.1.24 Homo sapiens AAB03816.1
AAC34130.1
AAC50811.1
AAC50812.1
AAC51362.1
AAH00736.1
ABA84560.1
ACM80454.1
ACM82884.1
BAD93158.1
BAF84261.1
BAG64471.1
CAD68121.1
CAH33914.1
CBA12853.1
CBA34893.1
NP_000519.1		 O00754.3
Q93093		  
 α-mannosidase IIx (Man2A2;Man2Ax) 3.2.1.114 Homo sapiens AAA92022.1
AAI36449.1
BAA09510.1
BAF82552.1
BAG57210.1
BAG58516.1
BAG61252.1
BAH14521.1
CAH33912.1
CBA12851.1
CBA34891.1
NP_006113.1		 P49641.2  
 neutral α-mannosidase (Man2C1;6A8;6A8B) (cytosolic) 3.2.1.24 Homo sapiens AAC00190.2
AAC00568.1
AAH50550.1
AAH80191.1
ACM82923.1
BAD92378.1
BAG62758.1
CAB66810.1
CAH33915.1
CBA12854.1
CBA34894.1
NP_006706.1		 Q13358
Q9NTJ4.1		  
 α-1,6-mannosidase (Man2B2;KIAA0935) 3.2.1.114 Homo sapiens AAH33307.1
AAH36836.1
AAH94773.1
BAA76779.1
BAA76779.2
BAG52093.1
BAH13490.1
CAD89971.1
CAF86562.1
NP_056089.1
XP_052620.6		 Q9Y2E5
Q9Y2E5.3		  
 KAFR_0B04640 (Kafr0b04640)   Kazachstania africana CBS 2517 type strain:CBS 2517 CCF56761.1    
 KLTH0G11000g   Lachancea thermotolerans CBS 6340 CAR25074.1    
 ORF   Leptosphaeria maculans v23.1.3 CBX95677.1 E4ZVQ1  
 ORF (fragment)   Linum usitatissimum ADD54604.1 D4P875  
 α-mannosidase (MAN2B1)   Macaca fascicularis BAD51966.1 Q60HE9  
 unnamed protein product (fragment)   Macaca fascicularis BAE88765.1    
 α-mannosidase (MG04464.4) (vacuolar)   Magnaporthe grisea 70-15 EAA50705.1
XP_362019.1		    
 MG03273.4   Magnaporthe grisea 70-15 EAA51678.1
XP_360730.1		    
 MTYFT1G-G-13 (fragment)   Medicago truncatula ACJ86251.1 B7FNB8  
 MtrDRAFT_AC141109g20v1   Medicago truncatula ABE79912.1
ABO80520.1
ABO80521.1		    
 MtrDRAFT_AC148217g19v1   Medicago truncatula ABE88173.1    
 MICPUN_62552   Micromonas sp. RCC299 ACO66199.1 C1EEA2  
 MICPUN_62591   Micromonas sp. RCC299 ACO66520.1 C1EEE2  
 GNLVRS01_PISO0H05089g (Piso0_003109)   Millerozyma farinosa CBS 7064 CCE80778.1    
 GNLVRS01_PISO0G05088g (Piso0_003109)   Millerozyma farinosa CBS 7064 CCE80013.1    
 α-mannosidase (Man2c1;C330035A14;1110025H24) (cytosolic) 3.2.1.24 Mus musculus AAH16253.1
AAH39913.1
AAY53557.1
BAB23074.1
BAC33715.1
BAE32264.1
BAE42254.1
BAE42554.1
NP_082912.1		 Q3ZCX9
Q80XU4
Q8BWY6
Q91W89
Q9CTD5		  
 α-mannosidase (Man2B2;Kiaa0935) 3.2.1.24 Mus musculus AAH66211.1
BAA24266.1
BAB23655.1
BAC30580.1
BAC53862.1
BAD32345.1
BAE30761.1
BAE31143.1
BAE38153.1
NP_032576.1		 O54782.2  
 α-mannosidase (lysosomal) (Man2b) 3.2.1.24 Mus musculus AAC09470.1
AAC53369.1
AAC78560.1
AAH05430.1
BAB23588.1
BAE28235.1
BAE42071.1
BAE42288.1
BAE42419.1
NP_034894.1
NP_034894.2		 O09159.3
Q3UGH3		  
 α-mannosidase II (Man2A1;ManA2) 3.2.1.114 Mus musculus AAI38373.1
BAC38329.1
CAA43480.1
CAH33910.1
CBA12849.1
CBA34889.1
NP_032575.1		 P27046.1
Q8C4L1		  
 α-mannosidase IIx (Man2A2) 3.2.1.114 Mus musculus AAD20813.1
AAH55006.1
ABG02551.1
BAC31745.1
BAE36580.1
NP_766491.1		 Q197W7
Q7TPQ0
Q8BRK9
Q9WU23		  
 unnamed protein product (fragment)   Mus musculus C57BL/6J BAE23268.1 Q3UVK1  
 ORF (fragment)   Mustela putorius furo AES01501.1    
 ORF (fragment)   Mustela putorius furo AES01502.1    
 ORF (fragment)   Mustela putorius furo AES01503.1    
 ORF (fragment)   Mustela putorius furo AES01504.1    
 ORF (fragment)   Mustela putorius furo AES01506.1    
 ORF (fragment)   Mustela putorius furo AES01511.1    
 ORF (fragment)   Mustela putorius furo AES01512.1    
 ORF (fragment)   Mustela putorius furo AES01500.1    
 ORF (fragment)   Mustela putorius furo AES01505.1    
 ORF (fragment)   Mustela putorius furo AES01508.1    
 ORF (fragment)   Mustela putorius furo AES01509.1    
 MYCTH_2295939   Myceliophthora thermophila ATCC 42464 AEO53968.1    
 NCAS_0D00720 (Ncas0d00720)   Naumovozyma castellii CBS 4309 type strain:CBS 4309 CCC69653.1    
 NDAI_0H03450 (Ndai0h03450)   Naumovozyma dairenensis CBS 421 type strain:CBS 421 CCD26518.1    
 ORF (fragment)   Neslia paniculata ADG39054.1 D6PRS2  
 NCU07404.1   Neurospora crassa OR74A EAA29252.1
XP_327690.1		    
 Os10g0140200   Oryza sativa Japonica Group AAL73068.1
AAM08418.1
AAP52066.1
BAF26054.1		 Q7XGZ1  
 OSJNAa0029P06.5 or OSJNBa0029P06.7 or OSJNBa0029P06.16   Oryza sativa Japonica Group AAK98651.1
AAL73069.1
AAM08419.1
AAP52067.1		 Q7XGZ0  
 Os06g0245700   Oryza sativa Japonica Group BAD45807.1
BAF19191.1		 Q654G0  
 Os11g0525600   Oryza sativa Japonica Group BAF28356.1
BAG90901.1		 Q2R3E0  
 ORF (fragment)   Pan troglodytes BAK63507.1    
 Pc20g06780   Penicillium chrysogenum Wisconsin 54-1255 CAP86007.1 B6HH84  
 PHATR_52108 (fragment)   Phaeodactylum tricornutum CCAP 1055/1 ACI65146.1 B5Y3K7  
 22_ppgam15_d08 (fragment)   Physcomitrella patens CAC43692.1    
 ORF (fragment)   Picea sitchensis ADM77756.1 E0ZHD1  
 ORF (fragment)   Picea sitchensis ADM77757.1 E0ZHD2  
 ORF (fragment)   Picea sitchensis ADM77758.1 E0ZHD3  
 ORF (fragment)   Picea sitchensis ADM77760.1 E0ZHD5  
 ORF (fragment)   Picea sitchensis ADM77762.1 E0ZHD7  
 ORF (fragment)   Picea sitchensis ADM77763.1 E0ZHD8  
 ORF (fragment)   Picea sitchensis ADM77783.1 E0ZHF8  
 ORF (fragment)   Picea sitchensis ADM77794.1 E0ZHG9  
 ORF (fragment)   Picea sitchensis ADM77795.1 E0ZHH0  
 PP7435_Chr4-0161 (Ams1)   Pichia pastoris CBS 7435 CCA40336.1    
 PAS_chr4_0790   Pichia pastoris GS115 CAY72059.1 C4R8Y4  
 PICST_83621   Pichia stipitis CBS 6054 ABN66418.1
ABN66418.2		    
 ORF (fragment)   Pipa carvalhoi AEQ17242.1    
 PIIN_08957   Piriformospora indica CCA74977.1    
 unnamed protein product   Podospora anserina S mat+ CAP69371.1 B2AY97  
 DKFZp459L1030   Pongo abelii CAH90164.1 Q5RDJ3  
 DKFZp469I0514   Pongo abelii CAH91346.1 Q5RA64  
 DKFZp459I171   Pongo abelii CAH91437.1 Q5R9X3  
 unknown (fragment)   Populus trichocarpa ABK95358.1 A9PG55  
 unknown (WS01225_C23) (fragment)   Populus trichocarpa ABK94980.1 A9PF27  
 Unknown (protein for MGC:188563)   Rattus norvegicus AAI68692.1 B5DEJ3  
 Ab2-450   Rattus norvegicus AAP92617.1 Q7TP34  
 Aa2-111 (fragment)   Rattus norvegicus AAP92563.1 Q7TP82  
 ORF   Rattus norvegicus AAH61819.1
NP_955436.1		 Q6P762  
 unnamed protein product   Rattus norvegicus CAH33911.1
CBA12850.1
CBA34890.1		    
 α-mannosidase 1 (Man2C1) 3.2.1.24 Rattus norvegicus AAA41565.1
AAH86989.1
NP_640349.1		 P21139.1  
 α-mannosidase 2 (fragment) 3.2.1.114 Rattus norvegicus AAA66457.1 P28494.1  
 EC1118_1G1_1244g   Saccharomyces cerevisiae EC1118 Lalvin EC1118 CAY79611.1 C8Z895  
 α-mannosidase (Ams1;YGL156W;G1861) 3.2.1.24 Saccharomyces cerevisiae S288c AAA34422.1
AAA34423.1
CAA88536.1
CAA96868.1
NP_011359.1		 P22855.2 cryst
 α-mannosidase (Ma2b2) (epididymis-specific) (fragment)   Salmo salar ACM09460.1 B9EPL3  
 MA2B2   Salmo salar ACN10977.1 C0HAA8  
 1,3-1,6-α-mannosidase (fragment) 3.2.1.114 Scherffelia dubia CAC20908.1 Q9FET3  
 SJCHGC06403 (fragment)   Schistosoma japonicum AAX26929.1
AAX26929.2		 Q5C096  
 SJCHGC06744 (fragment)   Schistosoma japonicum AAX26642.2 Q5C133  
 SJCHGC07986 (fragment)   Schistosoma japonicum AAX27337.2 Q5BZ38  
 Smp_160310   Schistosoma mansoni CAY17076.1
CAY19055.1
CCD83038.1		 C1LZP7  
 Smp_143430   Schistosoma mansoni CAZ31514.1 C4Q7T3  
 Smp_131580 (possible fragment)   Schistosoma mansoni CAZ29423.1
CCD83046.1		 C4Q1R8  
 α-mannosidase (Mns2;SPAC513.05) (ER) 3.2.1.24 Schizosaccharomyces pombe 972h- CAB58728.1
NP_593979.1		 Q9UT61  
 α-mannosidase (α-Man) 3.2.1.113
3.2.1.114		 Solanum lycopersicum ABY83271.1
ADK66339.1		 D3TI68  
 α-mannosidase II   Spodoptera frugiperda AAB62719.1
AAN93484.1
CAH33913.1
CBA12852.1
CBA34892.1		 O18497  
 sr11837   Sporisorium reilianum SRZ2 CBQ67971.1    
 α-mannosidase (Man2B2) 3.2.1.24 Sus scrofa AAX82987.1
AAX82988.1
AAX82989.1
ABY58116.1
ABY58117.1
ABY58118.1
ABY58119.1
ABY58120.1
BAA05877.1		 Q28949  
 TPHA_0G00880 (Tpha0g00880)   Tetrapisispora phaffii CBS 4417 type strain:CBS 4417 CCE63924.1    
 THAPS_263310   Thalassiosira pseudonana CCMP1335 ACI64715.1 B5YNY8  
 THITE_2113839   Thielavia terrestris NRRL 8126 AEO66050.1    
 TDEL_0G02410 (Tdel0g02410)   Torulaspora delbrueckii type strain:CBS 1146 CCE93608.1    
 TbgDal_X3200   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH15235.1 D0A1U2  
 UHO_0382 (ams1)   Ustilago hordei 364 CAJ42004.1 Q2A720  
 VITISV_040416   Vitis vinifera CAN65410.1 A5B9Y9  
 VITISV_032907 (fragment)   Vitis vinifera CAN60239.1 A5AHH3  
 Unknown (protein for MGC:89555)   Xenopus (Silurana) tropicalis AAH75578.1 Q6DIG4  
 Unknown (protein for MGC:145520)   Xenopus (Silurana) tropicalis AAI21883.1 Q0P4W0  
 TGas133o07.1-001 (man2a1)   Xenopus (Silurana) tropicalis AAI25786.1
AAI57507.1
CAL49415.1		 A9UM36  
 Unknown (protein for MGC:146757)   Xenopus (Silurana) tropicalis AAI27333.1 A0JPA7  
 Unknown (protein for MGC:173061)   Xenopus (Silurana) tropicalis AAI54723.1 A8WGI3  
 Unknown (protein for MGC:83821)   Xenopus laevis AAH70781.1 Q6NRG9  
 Unknown (protein for MGC:80473)   Xenopus laevis AAH72937.1 Q6GQ11  
 YALI0D21890g   Yarrowia lipolytica CLIB122 CLIB99 CAG81327.1    
 unknown (fragment)   Zea mays ACG27827.1    
 α-mannosidase 1 (Ama1) (fragment) 3.2.1.24 Zea mays BAA06405.1 Q43249  
 unknown (fragment)   Zea mays B73 ACL53976.1 B8A1C7  
 unknown (fragment)   Zea mays B73 ACR38218.1 C4JAL8  
 unknown (ZM_BFb0107C07) (fragment)   Zea mays B73 ACF81330.1 B4FGT7  
 ZYRO0A02486g   Zygosaccharomyces rouxii CBS 732 CAR25546.1    




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AFMB - CNRS - Universités Aix-Marseille I & II