Glycoside Hydrolase Family 37

Activities in Familyα,α-trehalase (EC 3.2.1.28).
Mechanism Inverting
ClanGH-G
3D Structure Status( α / α ) 6
Catalytic Nucleophile/BaseGlu (inferred)
Catalytic Proton DonorAsp (inferred)
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (4075); Uniprot accession (511); PDB accession (8); 3D entries (2); cryst (0)
All (3822) Archaea (3) Bacteria (3101) Eukaryota (715) unclassified (3) Structure (2) Characterized (42)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 trehalase (TreF;b3519) 3.2.1.28 Escherichia coli str. K-12 substr. MG1655 AAC76544.1
AAB18495.1
AIZ89480.1
ALI38799.1
AMC96401.1
NP_417976.1
P37196  
 α,α-trehalase (periplasmic) (TreA;OsmA) (Tre37A) 3.2.1.28 Escherichia coli str. K-12 substr. MG1655 AAC74281.1
AIZ91689.1
ALI41026.1
AMC98407.1
CAA33878.1
NP_415715.1
P13482 2JF4[A]
2JG0[A]
2JJB[A,B,C,D]
2WYN[A,B,C,D]
 trehalase (TreH) 3.2.1.28 Nostoc punctiforme IAM M-15 BAG85338.1
BAG70920.1
B5MF70
B6ZIV1
 
 trehalase (TreA;Rmar_0119) (periplasmic) 3.2.1.28 Rhodothermus marinus DSM 4252 ABC59065.1
ACY47027.1
D0MCR7  
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α,α-trehalase 3.2.1.28 Apis mellifera BAF81545.1 A8J4S9  
 membrane-bound trehalase (ALTre-2) 3.2.1.28 Apolygus lucorum AGL34007.2
AGL34007.1
   
 soluble trehalase (ALTre-1) 3.2.1.28 Apolygus lucorum AGK89798.1    
 trehalase (AtTre1;At4g24040/T19F6.30) (plasma membrane-bound) 3.2.1.28 Arabidopsis thaliana CAB51647.1
AAB63620.1
AAF22127.1
AAR23702.1
AEE84844.1
BAC43016.1
CAB69265.1
CAB81322.1
NP_194135.1
O22986
Q9SEH9
Q9SU50
 
 α,α-trehalase (TreB;AN5635.2) 3.2.1.28 Aspergillus nidulans FGSC A4 AAB99831.1
EAA62728.1
O42777  
 trehalase B (TreB;An01g09290) 3.2.1.28 Aspergillus niger CBS 513.88 CAK43979.1 A2Q9W0  
 neutral trehalase (Nth1;BbNTH1) 3.2.1.28 Beauveria bassiana ARSEF2860 ABM16911.1    
 trehalase (Treh1) 3.2.1.28 Bombyx mori BAA02909.1
AAC60507.1
BAA13042.1
P32358  
 trehalase 2 (Treh2;Treh-2) 3.2.1.28 Bombyx mori KINSHU X SHOWA BAE45249.1 Q3MV18  
 neutral trehalase (Ntc1;CaNTC1) 3.2.1.28 Candida albicans 3153A CAA64476.1 P52494  
 trehalase (Tre-1) 3.2.1.28 Chironomus riparius ADT91708.1    
 neutral trehalase (Nth1;CNAG_03785) 3.2.1.28 Cryptococcus neoformans var. grubii H99 DAA05786.1
AFR93292.1
AFR93292.2
Q059G5  
 neutral trehalase 2 (NTH2;CNG00690) 3.2.1.28 Cryptococcus neoformans var. neoformans JEC21 AAW44482.1
AAW44482.2
Q5KEF4  
 neutral trehalase 1 (NTH1;CNB02790) 3.2.1.28 Cryptococcus neoformans var. neoformans JEC21 AAW41560.1 Q5KM64  
 trehalase 1 (Tre1) 3.2.1.28 Glycine max AAD22970.1 Q9XEY7  
 trehalase (TreA;TreH) 3.2.1.28 Homo sapiens BAA24381.1
AAB50778.1
AAI09207.1
ABA67142.1
BAD96860.1
BAD96863.1
BAG52455.1
NP_009111.1
O43280  
 neutral trehalase (Nth1) 3.2.1.28 Kluyveromyces lactis CAA57181.1 P49381  
 neutral trehalase (TreA;KLLA0E17325g) 3.2.1.28 Kluyveromyces lactis NRRL Y-1140 CAG99815.1 P49381  
 trehalase 3.2.1.28 Magnaporthe grisea 4091-5-8 AAB88889.1 O42622  
 neutral trehalase (NTH1) 3.2.1.28 Magnaporthe grisea GUY11 AAN46743.1 O42622  
 neutral trehalase (NTH1;MG09471.4) 3.2.1.28 Magnaporthe oryzae 70-15 EAA53721.1
XP_364626.1
O42622  
 neutral trehalase (Ntl) 3.2.1.28 Metarhizium acridum CQM102 AAS67888.1
AAS67889.1
Q6Q5X7  
 neutral trehalase (NTL) 3.2.1.28 Metarhizium anisopliae var. anisopliae 2575 AAT68667.1 Q9HDE9  
 neutral trehalase (Nthi;Ntl1) 3.2.1.28 Metarhizium anisopliae var. anisopliae ME1 CAC17620.1
CAC17619.1
Q9HDE9  
 trehalase 3.2.1.28 Mus musculus AAF61430.1
AAH19214.1
AAK97631.1
AAT24328.1
BAB25963.1
NP_067456.1
Q8VCS8
Q9JLT2
 
 trehalase (TreB) 3.2.1.28 Neurospora crassa AAC01744.1 O42783
O42783
 
 trehalase (Tre-1) (soluble) 3.2.1.28 Nilaparvata lugens ACN85420.1
AGE93908.1
AGE93909.1
AGE93910.1
AGE93911.1
AGE93912.1
APA33854.1
C0LZJ6  
 trehalase 1 (Treh-1) 3.2.1.28 Omphisa fuscidentalis ABO20846.1 A3RLQ5  
 trehalase (TreH;TreA) 3.2.1.28 Oryctolagus cuniculus AAA63460.1 P19813  
 neutral trehalase 1 (Nth1;Nth;YDR001c;YD8119.07c) 3.2.1.28 Saccharomyces cerevisiae S288c AAV19867.1
AAA66896.1
AAN20051.1
CAA46718.1
CAA88061.1
NP_010284.1
P32356
Q05216
5JTA[A]
5M4A[A]
5N6N[C]
5NIS[A]
 neutral trehalase 2 (Nth2;YBR001c;YBR0106) 3.2.1.28 Saccharomyces cerevisiae S288c CAA81270.1
CAA84937.1
NP_009555.1
P35172  
 neutral trehalase (Ntp1;SPBC660.07) 3.2.1.28 Schizosaccharomyces pombe 972h- CAA11904.1
CAA22527.1
NP_595086.1
O42893  
 trehalase 2 (Tre-2;Treh-2;SeTre-2) 3.2.1.28 Spodoptera exigua ABU95354.1 A7XZC0  
 trehalase-1 (Tre-1;SeTre-1) 3.2.1.28 Spodoptera exigua ABY86218.1 B0M0J3  
 trehalase (SfTre2) 3.2.1.28 Spodoptera frugiperda ACF94698.1 B5ATV4  
 trehalase (SfTre1) (soluble; midgut) 3.2.1.28 Spodoptera frugiperda ABE27189.1 Q0ZIF5  
 trehalase 3.2.1.28 Tenebrio molitor BAA01951.1 P32359  
 trehalase (Tre1;TmTre1) (soluble; midgut) 3.2.1.28 Tenebrio molitor AGO32658.1    
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