Glycoside Hydrolase Family 37

Known Activities	α,α-trehalase (EC 3.2.1.28).
Mechanism	Inverting
Clan	GH-G
3D Structure Status	( α / α ) ₆
Catalytic Nucleophile/Base	Glu (inferred)
Catalytic Proton Donor	Asp (inferred)
External resources	CAZypedia; InterPro; PFAM; PRINTS; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (898); Uniprot accession (489); PDB accession (4); 3D entries (1); cryst (0)

Summary

All (727) Archaea (1) Bacteria (370) Eukaryota (354) unclassified (2) Structure (1 ) Characterized (35)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
trehalase (TreF)	3.2.1.28	Escherichia coli K-12 MG1655	AAB18495.1 AAC76544.1 NP_417976.1	P37196
α,α-trehalase (periplasmic) (TreA;OsmA) (Tre37A)	3.2.1.28	Escherichia coli K-12 MG1655	AAC74281.1 BAA36054.1 CAA33878.1 NP_415715.1	P13482.1	2JF4[A] 2JG0[A] 2JJB[A,B,C,D] 2WYN[A,B,C,D]
trehalase (TreH)	3.2.1.28	Nostoc punctiforme IAM M-15	BAG70920.1 BAG85338.1	B5MF70 B6ZIV1
trehalase (TreA;Rmar_0119) (periplasmic)	3.2.1.28	Rhodothermus marinus DSM 4252	ABC59065.1 ACY47027.1	D0MCR7
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
α,α-trehalase	3.2.1.28	Apis mellifera	BAF81545.1	A8J4S9
trehalase (AtTre1;At4g24040/T19F6.30) (plasma membrane-bound)	3.2.1.28	Arabidopsis thaliana	AAB63620.1 AAF22127.1 AAR23702.1 AEE84844.1 BAC43016.1 CAB51647.1 CAB69265.1 CAB81322.1 NP_194135.1	O22986 Q9SEH9 Q9SU50
α,α-trehalase (TreB;AN5635.2)	3.2.1.28	Aspergillus nidulans FGSC A4	AAB99831.1 EAA62728.1	O42777.1
neutral trehalase (Nth1;BbNTH1)	3.2.1.28	Beauveria bassiana ARSEF2860	ABM16911.1
trehalase (Treh1)	3.2.1.28	Bombyx mori	AAC60507.1 BAA02909.1 BAA13042.1	P32358.1
trehalase 2 (Treh2;Treh-2)	3.2.1.28	Bombyx mori KINSHU X SHOWA	BAE45249.1	Q3MV18
trehalase (Ntc1)	3.2.1.28	Candida albicans 3153A	CAA64476.1	P52494
neutral trehalase (Nth1)	3.2.1.28	Cryptococcus neoformans var. grubii H99	DAA05786.1	Q059G5
trehalase 1 (Tre1)	3.2.1.28	Glycine max	AAD22970.1	Q9XEY7
trehalase (TreA;TreH)	3.2.1.28	Homo sapiens	AAB50778.1 AAI09207.1 ABA67142.1 BAA24381.1 BAD96860.1 BAD96863.1 BAG52455.1 NP_009111.1	O43280.1
neutral trehalase (Nth1)	3.2.1.28	Kluyveromyces lactis	CAA57181.1	P49381
neutral trehalase (TreA;KLLA0E17325g)	3.2.1.28	Kluyveromyces lactis NRRL Y-1140	CAG99815.1
trehalase	3.2.1.28	Magnaporthe grisea 4091-5-8	AAB88889.1	O42622
neutral trehalase (NTH1;MG09471.4)	3.2.1.28	Magnaporthe grisea 70-15	EAA53721.1 XP_364626.1
neutral trehalase (NTH1)	3.2.1.28	Magnaporthe grisea GUY11	AAN46743.1	O42622
neutral trehalase (Ntl)	3.2.1.28	Metarhizium acridum CQM102	AAS67888.1 AAS67889.1	Q6Q5X7
neutral trehalase (NTL)	3.2.1.28	Metarhizium anisopliae var. anisopliae 2575	AAT68667.1	Q9HDE9
neutral trehalase (Nthi;Ntl1)	3.2.1.28	Metarhizium anisopliae var. anisopliae ME1	CAC17619.1 CAC17620.1	Q9HDE9
trehalase	3.2.1.28	Mus musculus	AAF61430.1 AAH19214.1 AAK97631.1 AAT24328.1 BAB25963.1 NP_067456.1	Q8VCS8 Q9JLT2.1
trehalase (TreB)	3.2.1.28	Neurospora crassa	AAC01744.1	O42783 O42783.2
trehalase (Tre-1) (soluble)	3.2.1.28	Nilaparvata lugens	ACN85420.1	C0LZJ6
trehalase 1 (Treh-1)	3.2.1.28	Omphisa fuscidentalis	ABO20846.1	A3RLQ5
trehalase (TreH;TreA)	3.2.1.28	Oryctolagus cuniculus	AAA63460.1	P19813.1
neutral trehalase 1 (Nth1;Nth;YDR001c;YD8119.07c)	3.2.1.28	Saccharomyces cerevisiae S288c	AAA66896.1 AAN20051.1 AAV19867.1 CAA46718.1 CAA88061.1 NP_010284.1	P32356.3 Q05216
neutral trehalase 2 (Nth2;YBR001c;YBR0106)	3.2.1.28	Saccharomyces cerevisiae S288c	CAA81270.1 CAA84937.1 NP_009555.1	P35172.1
neutral trehalase (Ntp1;SPBC660.07)	3.2.1.28	Schizosaccharomyces pombe 972h-	CAA11904.1 CAA22527.1 NP_595086.1	O42893.1
trehalase 2 (Tre-2;Treh-2)	3.2.1.28	Spodoptera exigua	ABU95354.1	A7XZC0
trehalase-1 (Tre-1)	3.2.1.28	Spodoptera exigua	ABY86218.1	B0M0J3
trehalase (SfTre2)	3.2.1.28	Spodoptera frugiperda	ACF94698.1	B5ATV4
trehalase (SfTre1) (midgut)	3.2.1.28	Spodoptera frugiperda	ABE27189.1	Q0ZIF5
trehalase	3.2.1.28	Tenebrio molitor	BAA01951.1	P32359.1

Footnotes

Experimental characterization exclusively covers enzyme activities at present. If you are aware of any missing experimental characterization that should be mentioned here, we encourage you to send your comment and support of the experimental evidence, including an electronic copy or appropriate link to the support material (i.e., article(s), thesis, database, etc), to cazy@afmb.univ-mrs.fr.