Glycoside Hydrolase Family 36

Activities in Familyα-galactosidase (EC 3.2.1.22); α-N-acetylgalactosaminidase (EC 3.2.1.49); stachyose synthase (EC 2.4.1.67); raffinose synthase (EC 2.4.1.82)
Mechanism Retaining
ClanGH-D
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental)
NoteMechanistic commonality with family GH27 demonstrated by Comfort et al. (2007) Biochemistry, 46: 3319-3330 (PMID: 17323919)
External resourcesCAZypedia; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (3496); Uniprot accession (584); PDB accession (17); 3D entries (6); cryst (0)
All (3274) Archaea (31) Bacteria (3057) Eukaryota (185) unclassified (1) Structure (6) Characterized (66)
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 α-galactosidase (AgaB;AgaB1) 3.2.1.22 Geobacillus stearothermophilus KVE39 AAG49421.1 Q934H7
4FNQ[A] 1.80
 α-galactosidase (AgaA;GsAgaA;Aga1) 3.2.1.22 Geobacillus stearothermophilus KVE39 AAG49420.1 Q9ALJ4
4FNP[A,B,C,D] 2.80
4FNR[A,B,C,D] 3.20
4FNS[A,B,C,D] <carb_like_DGJ>
2.60
4FNT[A,B,C,D] α-D-Galp-(1-6)-α-D-Glcp-(1-2)-β-D-Fruf
2.60
4FNU[A,B,C,D] α-D-Galp-(1-6)-α-D-Galp-(1-6)-α-D-Glcp-(1-2)-β-D-Fruf
3.60
 α-galactosidase (MelA;Aga;LBA1438) 3.2.1.22 Lactobacillus acidophilus NCFM AAO21867.1
AAV43263.1
ACK31409.1
G1UB44
Q7WWP9
2XN0[A,B] 2.50
2XN1[A,B,C,D] 2.30
2XN2[A] α-D-Galp
1.58
 LVIS_1758 (LbR11)   Lactobacillus brevis ATCC 367 ABJ64825.1 Q03PP7
3MI6[A,B,C,D] 2.70
 α-galactosidase/sucrose kinase (AgaSK;RUGNEv3_61222) 3.2.1.22 Ruminococcus gnavus E1 CCA61959.1  
2YFN[A] 1.45
2YFO[A] α-D-Galp
1.35
 α-galactosidase (GalA;TmGalA;TmGal36A;Tm1192) (Gal36) 3.2.1.22 Thermotoga maritima MSB8 CAH68692.1
AAD36267.1
AAM56791.1
AGL50123.1
AHD18901.1
AKE28969.1
CAA04514.1
CAD29026.1
CAT81453.1
NP_228997.1
O33835
1ZY9[A] 2.34
5M0X[A] 1.80
5M12[A] 1.53
5M16[A] 1.62
5M1I[A] 1.55
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