Glycoside Hydrolase Family 36

Known Activitiesα-galactosidase (EC 3.2.1.22); α-N-acetylgalactosaminidase (EC 3.2.1.49); stachyose synthase (EC 2.4.1.67); raffinose synthase (EC 2.4.1.82)
Mechanism Retaining
ClanGH-D
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental)
NoteMechanistic commonality with family GH27 demonstrated by Comfort et al. (2007) Biochemistry, 46: 3319-3330 (PMID: 17323919)
External resourcesCAZypedia; InterPro; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (714); Uniprot accession (255); PDB accession (2); 3D entries (4); cryst (2)
All (566) Archaea (14) Bacteria (454) Eukaryota (98) Structure (4 - 2 cryst) Characterized (58)
Bacteria
Protein Name EC#OrganismGenBankUniprotPDB/3D
 α-galactosidase (AgaB;AgaB1) 3.2.1.22 Geobacillus stearothermophilus KVE39 AAG49421.1 Q934H7 cryst
 α-galactosidase (AgaA;Aga1) 3.2.1.22 Geobacillus stearothermophilus KVE39 AAG49420.1 Q9ALJ4 cryst
 LVIS_1758 (LbR11)   Lactobacillus brevis ATCC 367 ABJ64825.1 Q03PP7 3MI6[A,B,C,D]
 α-galactosidase (GalA;Tm1192) (Gal36) 3.2.1.22 Thermotoga maritima MSB8 AAD36267.1
AAM56791.1
CAA04514.1
CAD29026.1
CAH68692.1
CAT81453.1
NP_228997.1
O33835 1ZY9[A]