Glycoside Hydrolase Family 36

Activities in Familyα-galactosidase (EC 3.2.1.22); α-N-acetylgalactosaminidase (EC 3.2.1.49); stachyose synthase (EC 2.4.1.67); raffinose synthase (EC 2.4.1.82)
Mechanism Retaining
ClanGH-D
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseAsp (experimental)
Catalytic Proton DonorAsp (experimental)
NoteMechanistic commonality with family GH27 demonstrated by Comfort et al. (2007) Biochemistry, 46: 3319-3330 (PMID: 17323919)
External resourcesCAZypedia; PRINTS;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (3496); Uniprot accession (584); PDB accession (17); 3D entries (6); cryst (0)
All (3274) Archaea (31) Bacteria (3057) Eukaryota (185) unclassified (1) Structure (6) Characterized (66)
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-galactosidase (SSO3127) 3.2.1.22 Sulfolobus solfataricus P2 AAK43227.1
CAC24100.1
NP_344437.1
Q97U94  
 α-galactosidase (ST2554) 3.2.1.22 Sulfolobus tokodaii str. 7 BAB67666.1
BAK54821.1
NP_378557.1
Q96XG2  
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 α-galactosidase (agaAGN14) 3.2.1.22 Arthrobacter sp. GN14 AFE82294.1    
 galactomannan-specific α-galactosidase (Rafa_1;BoGal36A;Bovatus_02926;BACOVA_02091) (Gal36A) 3.2.1.22 Bacteroides ovatus ATCC 8483 ALJ47535.1
EDO12201.1
   
 α-galactosidase (Aga) 3.2.1.22 Bifidobacterium adolescentis DSM 20083 AAD30994.2
AAD30994.1
Q9XCX2  
 α-galactosidase (MelA) 3.2.1.22 Bifidobacterium bifidum NCIMB 41171 ABD96085.1 Q1KTD9  
 α-galactosidase (Aga) 3.2.1.22 Bifidobacterium breve 203 AAK96217.2 Q93CM6  
 α-galactosidase (Aga2) 3.2.1.22 Bifidobacterium breve 203 ABB76662.1 Q2XQ11  
 α-galactosidase I (GalA1;BLD_1483) 3.2.1.22 Bifidobacterium longum DJO10A ACD98928.1 B3DP69  
 α-galactosidase I (AgA;BL1518) 3.2.1.22 Bifidobacterium longum NCC2705 AAN25312.1
NP_696676.1
G8K028  
 α-galactosidase (AglL) 3.2.1.22 Bifidobacterium longum VMKB44 AAG02023.1 Q9F9W6  
 α-galactosidase (AgaA) 3.2.1.22 Carnobacterium maltaromaticum AAL27305.1 Q93DW8  
 α-N-acetylgalactosaminidase (AagA) 3.2.1.49 Clostridium perfringens ATCC 10543 AAM55479.1
ABI01263.1
Q8XNK8  
 α-galactosidase (Aga36A) (Aga36A) 3.2.1.22 Clostridium stercorarium F-9 BAC56887.1 Q84IQ0  
 α-galactosidase (RafA;Dda3937_03029) 3.2.1.22 Dickeya dadantii 3937 ADM97865.1 E0SII4  
 α-galactosidase (Dtur_1670) 3.2.1.22 Dictyoglomus turgidum DSM 6724 ACK42942.1 B8E368  
 α-galactosidase (AgaB;AgaN;EfmE980_0219) 3.2.1.22 Enterococcus faecium E980 EFF38777.1 D4QHE9  
 α-galactosidase (RafA) 3.2.1.22 Escherichia coli str. K-12 substr. MG1655 AAA24497.1 P16551  
 α-galactosidase (GalA17) 3.2.1.22 Flavobacterium sp. TN17 ADK91093.1 E5DWL9  
 α-galactosidase (AgaB;AgaB1) 3.2.1.22 Geobacillus stearothermophilus KVE39 AAG49421.1 Q934H7 4FNQ[A]
 α-galactosidase (AgaA;GsAgaA;Aga1) 3.2.1.22 Geobacillus stearothermophilus KVE39 AAG49420.1 Q9ALJ4 4FNP[A,B,C,D]
4FNR[A,B,C,D]
4FNS[A,B,C,D]
4FNT[A,B,C,D]
4FNU[A,B,C,D]
 α-galactosidase (AgaN) 3.2.1.22 Geobacillus stearothermophilus NUB3621 AAD23585.1 Q9X624  
 α-galactosidase (MelA;Aga;LBA1438) 3.2.1.22 Lactobacillus acidophilus NCFM AAO21867.1
AAV43263.1
ACK31409.1
G1UB44
Q7WWP9
2XN0[A,B]
2XN1[A,B,C,D]
2XN2[A]
 α-galactosidase (MelA) 3.2.1.22 Lactobacillus fermentum CRL722 AAT37673.1 Q6IYF5  
 α-galactosidase (MelA) 3.2.1.22 Lactobacillus plantarum ATCC 8014 AAF02774.3 Q9L905  
 α-galactosidase (MelA) 3.2.1.22 Lactobacillus plantarum DSM 20205 CAI60220.1 Q5DU70  
 α-galactosidase (Aga) 3.2.1.22 Lactococcus raffinolactis ATCC 43920 AAO26321.1
AAM18789.1
CAD60129.1
Q7X1P3  
 α-galactosidase (AGA) 3.2.1.22 Leuconostoc mesenteroides SY1 AAU94931.1 Q5XLI6  
 α-galactosidase (AgaA;AgaAJB07) 3.2.1.22 Mesorhizobium sp. JB07 AFE82290.1    
 α-galactosidase (Agα-MJ11) 3.2.1.22 Pedobacter nyackensis MJ11 CGMCC 2503 ACN78884.1 D2DFB2  
 α-galactosidase (?-PsGal) 3.2.1.22 Pseudoalteromonas sp. KMM 701 (VKM B-2135 D) ABF72189.2
ABF72189.1
Q19AX0  
 α-galactosidase (Aga1;Agae1) 3.2.1.22 Ruminococcus gnavus E1 ACL13770.1 B8X9S5  
 α-galactosidase/sucrose kinase (AgaSK;RUGNEv3_61222) 3.2.1.22 Ruminococcus gnavus E1 CCA61959.1   2YFN[A]
2YFO[A]
 α-galactosidase (Aga2;RUGNE_61258) 3.2.1.22 Ruminococcus gnavus E1 CCG93504.1    
 α-galactosidase (AgaA;AgaAJB13) 3.2.1.22 Sphingomonas sp. JB13 AFE82291.1    
 α-galactosidase (Aga) 3.2.1.22 Streptococcus mutans INGBRITT AAA26933.1 P27756  
 α-galactosidase (SCO0274;SCF85.02) 3.2.1.22 Streptomyces coelicolor A3(2) CAB54159.1
NP_624603.1
Q9S2D9  
 α-galactosidase (AgaA;AgaAHJG4) 3.2.1.22 Streptomyces sp. HJG4 AJG06892.1    
 α-galactosidase (Aga) 3.2.1.22 Streptomyces sp. S27 ACCC 41168 ACN78885.1
ADK91095.1
D2DFB3  
 α-galactosidase (GalA;TmGalA;TmGal36A;Tm1192) (Gal36) 3.2.1.22 Thermotoga maritima MSB8 CAH68692.1
AAD36267.1
AAM56791.1
AGL50123.1
AHD18901.1
AKE28969.1
CAA04514.1
CAD29026.1
CAT81453.1
NP_228997.1
O33835 1ZY9[A]
5M0X[A]
5M12[A]
5M16[A]
5M1I[A]
 α-galactosidase (AglA) 3.2.1.22 Thermotoga neapolitana 5068 AAC38607.1 Q9R7H1  
 α-galactosidase (AgaT) 3.2.1.22 Thermus brockianus ITI360 AAD33668.1 Q9X6C7  
 α-galactosidase (AglA) 3.2.1.22 Thermus sp. T2 BAA76597.1
CAB65477.1
Q9WXC1  
 α-galactosidase (AgaT;TTP0072) 3.2.1.22 Thermus thermophilus HB27 AAS82402.1 Q746I3  
 α-galactosidase (AgaT) 3.2.1.22 Thermus thermophilus TH125 AAD32628.1 Q9X6D2  
 α-galactosidase (AgaY;Agα-Y;GalA;YP1469) 3.2.1.22 Yersinia pestis biovar Microtus str. 91001 AAS61708.1
ACH90515.1
NP_992831.1
   
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 alkaline α-galactosidase (Sip2;AtSip2;At3g57520) 3.2.1.22 Arabidopsis thaliana CAB66109.1
AAK92707.1
AEE79665.1
AEE79666.1
AEE79667.1
BAE98518.1
NP_191311.1
Q94A08
Q9SCM1
 
 α-galactosidase (AglC;AN8138.2) 3.2.1.22 Aspergillus nidulans FGSC A4 EAA58775.1
ABF50891.1
C8V6Q1
Q5AU92
 
 α-galactosidase C / I (AglC) 3.2.1.22 Aspergillus niger CBS 120.49 / N400 CAB63901.1 Q9UUZ4  
 α-galactosidase (seed imbibition protein;Sip) (fragment) 3.2.1.22 Cicer arietinum CAA65125.1 Q39466  
 alkaline α-galactosidase I (Aga1) 3.2.1.22 Cucumis melo AAM75139.1 Q84NI7  
 alkaline α-galactosidase II (Aga2) 3.2.1.22 Cucumis melo AAM75140.1 Q84NI6  
 raffinose synthase (Rfs;CsRS) 2.4.1.82 Cucumis sativus AAD02832.1
AAY72809.1
ABD72603.1
ACK26659.1
ACW21481.1
Q9ZT62  
 α-galactosidase (Agα-F75) 3.2.1.22 Gibberella sp. F75 / CGMCC 2499 ACQ72829.1
ACS12899.1
C6FJG8  
 α-galactosidase 3.2.1.22 Lichtheimia corymbifera IFO 8084 AAF68953.1
ABB43117.1
Q9P8N4  
 raffinose synthase (P0583G08.2;OJ1276_B06.31;OJ1276_B06.38) 2.4.1.82 Oryza sativa Japonica Group BAB64768.1
BAB92522.1
BAD68247.1
BAD68321.1
BAF04051.1
BAS70608.1
   
 alkaline α-galactosidase (OsAkaGal;Osh69;Os08g0495800) 3.2.1.22 Oryza sativa Japonica Group BAD10122.1
AAL65392.2
BAD10121.1
BAF24047.1
BAT06058.1
BAT06059.1
Q8W2G5  
 α-galactosidase 3.2.1.22 Penicillium janczewskii zalesk ACN38386.1
ACN38387.1
C0L3L3  
 α-galactosidase (Agl1) 3.2.1.22 Penicillium sp. F63 / CGMCC1669 ABC70181.1 A4Z4V0  
 raffinose synthase (Rfs) 2.4.1.82 Pisum sativum CAD20127.2 Q8VWN6  
 stachyose synthase (Sts1) 2.4.1.67 Pisum sativum CAC38094.1
CAD55555.1
Q93XK2  
 α-galactosidase (RmGal36) 3.2.1.22 Rhizomucor miehei CAU432 AEB22139.1    
 α-galactosidase (GalB;RmGalB) 3.2.1.22 Rhizomucor miehei CAU432 AGC24357.1    
 α-galactosidase (Agα-F78) 3.2.1.22 Rhizopus sp. ACCC 30795 / F78 ACM48349.1 C7SEV1  
 α-galactosidase 2 / II (Agl2;AGLII) 3.2.1.22 Trichoderma reesei RUTC-30 CAA93245.1 Q92457  
 stachyose synthase 2.4.1.67 Vigna angularis CAB64363.1 Q9SBZ0  
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