Glycoside Hydrolase Family 35

Activities in Familyβ-galactosidase (EC 3.2.1.23); exo-β-glucosaminidase (EC 3.2.1.165); exo-β-1,4-galactanase (EC 3.2.1.-); β-1,3-galactosidase (EC 3.2.1.-)
Mechanism Retaining (inferred)
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (inferred)
External resourcesCAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (2785); Uniprot accession (531); PDB accession (27); 3D entries (12); cryst (0)
All (1937) Archaea (22) Bacteria (1452) Eukaryota (459) unclassified (4) Structure (12) Characterized (72)
Archaea
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 exo-β-glucosaminidase (BglC;PH0511.1;PH0511) 3.2.1.165 Pyrococcus horikoshii OT3 BAA29599.1
NP_142480.1
O58247
5GSL[A,B] 2.60
 exo-β-glucosaminidase (GlmA;GlmATK;TK-Glm;TK1754) 3.2.1.165 Thermococcus kodakarensis KOD1 BAC82164.1
BAD85943.1
CAT72344.1
Q76HN4
5GSM[A,B] β-D-GlcpN
1.27
Bacteria
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 β-galactosidase (BgaC;β-gal-3) 3.2.1.23 Bacillus circulans ATCC 31382 BAA21669.1 O31341
4MAD[A,B] 1.80
 BT0290   Bacteroides thetaiotaomicron VPI-5482 AAO75397.1
NP_809203.1
Q8AB22
3D3A[A] 2.15
 CC0788   Caulobacter crescentus CB15 AAK22773.1
NP_419605.1
Q9AA20
3U7V[A] 1.80
 β-galactosidase 35A (CjBgl35A;CJA_2707) (Bgl35A) 3.2.1.23 Cellvibrio japonicus Ueda107 ACE85180.1 B3PBE0
4D1I[A,B,C,D,E,F,G,H] 1.80
4D1J[A,B,C,D,E,F,G,H] <carb_like_DGJ>
1.80
5JAW[A,B,C,D,E,F,G,H] 1.60
 β-1,3-galactosidase (BgaC;SP0060) 3.2.1.23 Streptococcus pneumoniae TIGR4 AAK74249.1
NP_344609.1
Q97T90
4E8C[A,B] β-D-Galp
1.95
4E8D[A,B] 1.80
Eukaryota
Protein Name EC#OrganismGenBankUniprot
PDB/3D Carbohydrate Ligands Resolution (Å)
 β-galactosidase (Ao-β-Gal;LacA;AO090012000445) 3.2.1.23 Aspergillus oryzae RIB40 BAE60622.1 Q2UCU3
4IUG[A] β-D-Galp
β-D-GlcpNAc-(1-4)-β-D-Manp-(1-3)-β-D-GlcpNAc-(1-4)-β-D-Manp-(1-3)-β-D-GlcpNAc-(1-4)-β-D-Manp-(1-3)-β-D-GlcpNAc-(1-4)-β-D-Manp-(1-4)-β-D-Manp
2.60
 β-galactosidase (Glb1) 3.2.1.23 Homo sapiens AAA51819.1
AAA35599.1
AAA51822.1
AAA51823.1
AAH07493.1
AAP35811.1
ACM84364.1
BAD96483.1
BAD96811.1
BAH12915.1
BAH13196.1
BAH13341.1
CBA12839.1
NP_000395.1
P16278
P16279
3THC[A,B,C,D] β-D-Galp
1.80
3THD[A,B,C,D] <carb_like_DGJ>
1.79
3WEZ[A,B,C,D] <carb_like_N8V>
2.11
3WF0[A,B,C,D] <carb_like_6DJ>
2.20
3WF1[A,B,C,D] <carb_like_6GJ>
2.00
3WF2[A,B,C,D] <carb_like_NDJ>
2.30
3WF3[A,B,C,D] β-D-Galp
2.15
3WF4[A,B,C,D] <carb_like_6DJ>
2.30
 β-galactosidase (Lac) 3.2.1.23 Penicillium sp. CAF32457.1 Q700S9
1TG7[A] 1.90
1XC6[A] β-D-Galp
2.10
 β-galactosidase II / β-galactosidase 4 / exo-β-1,4-galactanase (Tbg4;TBG4) 3.2.1.23 Solanum lycopersicum AAC25984.1
AAY07928.1
ADO34789.1
CAW88940.1
CAW93206.1
CAW98438.1
CAX05306.1
CBD12048.1
O81100
3W5F[A,B] 1.65
3W5G[A,B] β-D-Galp
3.00
 β-galactosidase / galacto-β-galactanase (Bga1) 3.2.1.23 Trichoderma reesei CAD70669.1 Q70SY0
3OG2[A] 1.20
3OGR[A] β-D-Galp
1.50
3OGS[A] β-D-Galp1S-(1-1)-<non_carb>
1.75
3OGV[A] β-D-Galp1S-(1-1)-<non_carb>
1.40
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