Activities in Family	β-1,2-glucan synthetase (elongation) (EC 2.4.1.391); β-1,3-galactosidase (EC 3.2.1.-); Exo-β-1,4-galactanase (EC 3.2.1.-); Exo-β-1,4-glucosaminidase (EC 3.2.1.165); β-galactosidase (EC 3.2.1.23);
Mechanism	Retaining (inferred) e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (inferred)
External resources	CAZypedia; PRINTS; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (11284); Uniprot accession (135); PDB accession (68); 3D entries (24); cryst (0)

Archaea
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
β-galactosidase (DKAM_0402)	3.2.1.23	Desulfurococcus amylolyticus 1221n	ACL10728.1		8QQH[A,B]
putative exo-β-glucosaminidase (GlmA; GlmAPf; BglC; PF0363)		Pyrococcus furiosus DSM 3638	AAL80487.1 NP_578092.1		6JOW[A,B,C,D] 1.75
exo-β-glucosaminidase (BglC;PH0511.1;PH0511)	3.2.1.165	Pyrococcus horikoshii OT3	BAA29599.1 NP_142480.1	O58247	5GSL[A,B] 2.60
CHITON_1401		Thermococcus chitonophagus DSM 10152	CUX78180.1		8OUG[A] 2.10
exo-β-glucosaminidase (GlmA; GlmATK; TK-Glm; TK1754)	3.2.1.165	Thermococcus kodakarensis KOD1	BAC82164.1 BAD85943.1 CAT72344.1	Q76HN4	5GSM[A,B] β-D-GlcpN 1.27
Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
β-galactosidase (BT0290; BT_0290)	3.2.1.23	Bacteroides thetaiotaomicron VPI-5482	AAO75397.1 NP_809203.1	Q8AB22	3D3A[A] 2.15 6EON[A] α-D-Galp 1.75
CC0788		Caulobacter vibrioides CB15	AAK22773.1 NP_419605.1		3U7V[A] 1.80
β-galactosidase 35A (CjBgl35A;CJA_2707) (Bgl35A)	3.2.1.23	Cellvibrio japonicus Ueda107	ACE85180.1	B3PBE0	4D1I[A,B,C,D,E,F,G,H] 1.80 4D1J[A,B,C,D,E,F,G,H] <carb_like_DGJ> 1.80 5JAW[A,B,C,D,E,F,G,H] 1.60 6TBF[A,B,C,D,E,F,G,H] 1.50 6TBG[A,B,C,D,E,F,G,H] 1.50 6TBH[A,B,C,D,E,F,G,H] 1.50 6TBI[A,B,C,D,E,F,G,H] <carb_like_N8V> 1.46 6TBJ[A,B,C,D,E,F,G,H] 1.50 6TBK[A,B,C,D,E,F,G,H] 1.60 8PEJ[A,B,C,D,E,F,G,H] 1.50
sophorohydrolase / β-1,2-glucooligosaccharide:β-glucosyltransferase (IaSGT; IALB_1185)	3.2.1.214 2.4.1.391	Ignavibacterium album JCM 16511	AFH48896.1	I0AIT9	7VKW[A,B] 1.75 7VKX[A,B] β-D-Glcp 1.56 7VKY[A,B] β-D-Glcp-(1-2)-α-D-Glcp β-D-Glcp-(1-2)-β-D-Glcp 2.00 7VKZ[A,B] <carb_like_NOJ> 2.00 7VL0[A,B] α-D-Glcp-(1-1)-<non_carb> 1.79 7VL1[A,B] α-D-Glcp-(1-1)-methyl 1.60 7VL2[A,B] α-D-Glcp-(1-1)-ethyl 1.80 7VL3[A,B] α-D-Glcp-(1-1)-<non_carb> 1.82 7VL4[A,B] β-D-Glcp-(1-1)-methyl 1.83 7VL5[A,B] β-D-Glcp-(1-1)-octyl 1.93 7VL6[A,B] β-D-Glcp-(1-1)-<non_carb> 1.75 7VL7[A,B] β-D-Glcp-(1-1)-<non_carb> 1.89 7X87[A,B] β-D-Glcp-(1-2)-β-D-Glcp 1.79
β-1,3-galactosidase (LBCZ_0230)	3.2.1.-	Lactobacillus casei subsp. casei ATCC 393	BAN73398.1	A0A5R8LFD3 A0AAD1ERL1	8H25[A,B,C,D] 2.30
β-galactosidase (BgaC;β-gal-3)	3.2.1.23	Niallia circulans ATCC 31382	BAA21669.1	O31341	4MAD[A,B] 1.80
β-1,3-galactosidase (BgaC;SP0060)	3.2.1.23	Streptococcus pneumoniae TIGR4	AAK74249.1 NP_344609.1	A0A0H2UN19 Q97T90	4E8C[A,B] β-D-Galp 1.95 4E8D[A,B] 1.80
JH305_13120		Xanthomonas campestris pv. campestris 42-2	WDK85776.1		8FAA[A,B,C,D,E,F,G,H,I,J, 2.50
XC_2481		Xanthomonas campestris pv. campestris str. 8004	AAY49531.1		8FA4[A,B] 1.70
XCC2404		Xanthomonas campestris pv. campestris str. ATCC 33913	AAM41682.1 NP_637758.1		8FAA[A,B,C,D,E,F,G,H,I,J, 2.50
β-galactosidase (Bga;NixL;XCC2895)	3.2.1.23	Xanthomonas campestris pv. campestris str. ATCC 33913	AAM42167.1 NP_638243.1	Q8P6S0	8FA5[A,B] 1.70
β-galactosidase (XacGalD; XAC1772)	3.2.1.23	Xanthomonas citri pv. citri str. 306	AAM36636.1 NP_642100.1 WP_033485297.1	A0A7S6Z096 A0A9X6GJQ7 Q8PLM3	7KMN[A] 1.80 7KMO[A] α-D-Galp 1.75
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D Carbohydrate Ligands Resolution (Å)
β-galactosidase (An01g12150)	3.2.1.23	Aspergillus niger CBS 513.88	CAK44114.1 AAE23229.1	A2QAN3	5IFP[A] 1.71 5IFT[A] β-D-Galp-(1-3)-α-D-Glcp 2.45 5IHR[A] β-D-Galp-(1-6)-α-D-Glcp 2.40 5JUV[A] β-D-Galp-(1-6)-β-D-Galp 2.27 5MGC[A] β-D-Galp-(1-4)-β-D-Galp-(1-4)-α-D-Glcp 2.30 5MGD[A] β-D-Galp-(1-6)-β-D-Galp-(1-4)-α-D-Glcp 2.15
β-galactosidase (Ao-β-Gal;LacA;AO090012000445)	3.2.1.23	Aspergillus oryzae RIB40	BAE60622.1	Q2UCU3	4IUG[A] β-D-Galp β-D-GlcpNAc-(1-4)-β-D-Manp-(1-3)-β-D-GlcpNAc-(1-4)-β-D-Manp-(1-3)-β-D-GlcpNAc-(1-4)-β-D-Manp-(1-3)-β-D-GlcpNAc-(1-4)-β-D-Manp-(1-4)-β-D-Manp 2.60
β-galactosidase (Glb1)	3.2.1.23	Homo sapiens	AAA51819.1 AAA35599.1 AAA51822.1 AAA51823.1 AAH07493.1 AAP35811.1 ACM84364.1 BAD96483.1 BAD96811.1 BAH12915.1 BAH13196.1 BAH13341.1 CBA12839.1 NP_000395.1	B7Z5H9 B7Z6Q5 P16278 P16279 Q53G40 Q53H18	3THC[A,B,C,D] β-D-Galp 1.80 3THD[A,B,C,D] <carb_like_DGJ> 1.79 3WEZ[A,B,C,D] <carb_like_N8V> 2.11 3WF0[A,B,C,D] <carb_like_6DJ> 2.20 3WF1[A,B,C,D] <carb_like_6GJ> 2.00 3WF2[A,B,C,D] <carb_like_NDJ> 2.30 3WF3[A,B,C,D] β-D-Galp 2.15 3WF4[A,B,C,D] <carb_like_6DJ> 2.30
β-galactosidase	3.2.1.23	Mus musculus	AAA37293.1 AAA37292.1 AAH03998.1 AAH28875.1 BAC31151.1 BAC33344.1 BAC36375.1 BAE42549.1 NP_033882.1	P23780 Q3TAW7 Q8C659 Q8C847 Q8C9H8 Q8K131 Q99KV2	7KDV[A,C,E,G,I,K] 4.59
β-galactosidase (Lac)	3.2.1.23	Penicillium sp.	CAF32457.1	Q700S9	1TG7[A] 1.90 1XC6[A] β-D-Galp 2.10
β-galactosidase II / β-galactosidase 4 / exo-β-1,4-galactanase (Tbg4;TBG4)	3.2.1.23	Solanum lycopersicum	AAC25984.1 AAY07928.1 ADO34789.1 CAW88940.1 CAW93206.1 CAW98438.1 CAX05306.1 CBD12048.1	E3UVW6 O81100	3W5F[A,B] 1.65 3W5G[A,B] β-D-Galp 3.00 6IK5[A,B] β-D-Galp 1.82 6IK6[A,B] β-D-Galp-(1-4)-β-D-Galp β-D-GlcpNAc-(1-4)-β-D-GlcpNAc 2.79 6IK7[A,B] β-D-Galp-(1-3)-β-D-Galp 3.10 6IK8[A,B] β-D-Galp β-D-Galp-(1-6)-β-D-Galp 2.80
β-galactosidase / galacto-β-galactanase (Bga1)	3.2.1.23	Trichoderma reesei	CAD70669.1	Q70SY0	3OG2[A] 1.20 3OGR[A] β-D-Galp 1.50 3OGS[A] β-D-Galp1S-(1-1)-<non_carb> 1.75 3OGV[A] β-D-Galp1S-(1-1)-<non_carb> 1.40
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