| Activities in Family | β-1,2-glucan synthetase (elongation) (EC 2.4.1.391); β-1,3-galactosidase (EC 3.2.1.-); Exo-β-1,4-galactanase (EC 3.2.1.-); Exo-β-1,4-glucosaminidase (EC 3.2.1.165); β-galactosidase (EC 3.2.1.23); |
|---|---|
| Mechanism | Retaining (inferred) e |
| Clan | GH-A |
| 3D Structure Status | ( β / α ) 8 barrel |
| Catalytic Nucleophile/Base | Glu (experimental) |
| Catalytic Proton Donor | Glu (inferred) |
| External resources | CAZypedia; PRINTS; PROSITE; |
| Commercial Enzyme Provider(s) | MEGAZYME; |
| Statistics | GenBank accession (11284); Uniprot accession (135); PDB accession (68); 3D entries (24); cryst (0) |
| Archaea | |||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | |
| β-galactosidase (DKAM_0402) | 3.2.1.23 | pubmed |
Desulfurococcus amylolyticus 1221n | ACL10728.1 | 8QQH[A,B] | ||
| exo-β-glucosaminidase (BglC;PH0511.1;PH0511) | 3.2.1.165 | pubmed |
Pyrococcus horikoshii OT3 | BAA29599.1 NP_142480.1 |
O58247 | 5GSL[A,B] | |
| exo-β-glucosaminidase (GlmA; GlmATK; TK-Glm; TK1754) | 3.2.1.165 | pubmed |
Thermococcus kodakarensis KOD1 | BAC82164.1 BAD85943.1 CAT72344.1 |
Q76HN4 | 5GSM[A,B] | |
| Bacteria | |||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | |
| β-galactosidase (Amuc_0771; Am0874) | 3.2.1.23 | pubmed |
Akkermansia muciniphila ATCC BAA-835 | ACD04606.1 QTD81396.1 |
B2UQ71 | ||
| β-galactosidase | 3.2.1.23 | pubmed |
Arthrobacter sp. | AAC45218.1 | P96567 | ||
| β-galactosidase (BT0290; BT_0290) | 3.2.1.23 | pubmed |
Bacteroides thetaiotaomicron VPI-5482 | AAO75397.1 NP_809203.1 |
Q8AB22 | 3D3A[A] 6EON[A] |
|
| β-galactosidase (BT4160;BT_4160) | 3.2.1.23 | pubmed |
Bacteroides thetaiotaomicron VPI-5482 | AAO79265.1 NP_813071.1 |
Q8A061 | ||
| β-galactosidase (BgaC) | 3.2.1.23 | pubmed |
Carnobacterium maltaromaticum | AAL27306.1 | Q93DW7 | ||
| β-galactosidase 35A (CjBgl35A;CJA_2707) (Bgl35A) | 3.2.1.23 | pubmed |
Cellvibrio japonicus Ueda107 | ACE85180.1 | B3PBE0 | 4D1I[A,B,C,D,E,F,G,H] 4D1J[A,B,C,D,E,F,G,H] 5JAW[A,B,C,D,E,F,G,H] 6TBF[A,B,C,D,E,F,G,H] 6TBG[A,B,C,D,E,F,G,H] 6TBH[A,B,C,D,E,F,G,H] 6TBI[A,B,C,D,E,F,G,H] 6TBJ[A,B,C,D,E,F,G,H] 6TBK[A,B,C,D,E,F,G,H] 8PEJ[A,B,C,D,E,F,G,H] |
|
| sophorohydrolase / β-1,2-glucooligosaccharide:β-glucosyltransferase (IaSGT; IALB_1185) | 3.2.1.214 2.4.1.391 |
pubmed pubmed |
Ignavibacterium album JCM 16511 | AFH48896.1 | I0AIT9 | 7VKW[A,B] 7VKX[A,B] 7VKY[A,B] 7VKZ[A,B] 7VL0[A,B] 7VL1[A,B] 7VL2[A,B] 7VL3[A,B] 7VL4[A,B] 7VL5[A,B] 7VL6[A,B] 7VL7[A,B] 7X87[A,B] |
|
| β-galactosidase (LzBgal35A; FEI14_06495) (Bgal35A) | 3.2.1.23 | pubmed |
Lacticaseibacillus zeae CRBIP24.58 | TLF42530.1 WP_138117930.1 |
A0A5R8LYW9 | ||
| β-1,3-galactosidase (LBCZ_0230) | 3.2.1.- | pubmed |
Lactobacillus casei subsp. casei ATCC 393 | BAN73398.1 | A0A5R8LFD3 A0AAD1ERL1 |
8H25[A,B,C,D] | |
| β-galactosidase (BgaC;β-gal-3) | 3.2.1.23 | pubmed |
Niallia circulans ATCC 31382 | BAA21669.1 | O31341 | 4MAD[A,B] | |
| β-galactosidase (GalF) | 3.2.1.23 | pubmed |
Paenibacillus thiaminolyticus | CAZ44333.1 | C7U109 | ||
| β-galactosidase (BgaC;SPD0065;SPD_0065) | 3.2.1.23 | pubmed |
Streptococcus pneumoniae D39 | ABJ55509.1 | A0A0H2ZQE5 Q04N11 |
||
| β-1,3-galactosidase (BgaC) | 3.2.1.23 3.2.1.- |
pubmed pubmed |
Streptococcus pneumoniae R6 | AAK98863.1 NP_357653.1 |
Q8DRL4 | ||
| β-1,3-galactosidase (BgaC;SP0060) | 3.2.1.23 | pubmed |
Streptococcus pneumoniae TIGR4 | AAK74249.1 NP_344609.1 |
A0A0H2UN19 Q97T90 |
4E8C[A,B] 4E8D[A,B] |
|
| β-galactosidase (BgaC;SSU05_0449) | 3.2.1.23 3.2.1.- |
pubmed pubmed |
Streptococcus suis 05ZYH33 | ABP89415.1 | A4VTH6 | ||
| β-galactosidase 35A (Bga35A; BgA; Cst_c22720) | 3.2.1.23 | pubmed |
Thermoclostridium stercorarium subsp. stercorarium DSM 8532 | AGC69232.1 AGI40203.1 |
L7VR11 | ||
| β-galactosidase (Gal35I;GalC) | 3.2.1.23 | pubmed |
Xanthomonas campestris pv. campestris | AAP86763.1 | Q6X1E5 | ||
| β-galactosidase (GalD) | 3.2.1.23 | pubmed |
Xanthomonas campestris pv. campestris | ABA39423.1 | Q0H932 | ||
| β-galactosidase (XC1214; XC_1214) | 3.2.1.23 | pubmed |
Xanthomonas campestris pv. campestris str. 8004 | AAY48283.1 | A0A0H2X5I1 | ||
| β-galactosidase (Bga;NixL;XCC2895) | 3.2.1.23 | pubmed |
Xanthomonas campestris pv. campestris str. ATCC 33913 | AAM42167.1 NP_638243.1 |
Q8P6S0 | 8FA5[A,B] | |
| β-galactosidase (XacGalD; XAC1772) | 3.2.1.23 | doi |
Xanthomonas citri pv. citri str. 306 | AAM36636.1 NP_642100.1 WP_033485297.1 |
A0A7S6Z096 A0A9X6GJQ7 Q8PLM3 |
7KMN[A] 7KMO[A] |
|
| β-galactosidase (BGA;BgaX) | 3.2.1.23 | pubmed |
Xanthomonas phaseoli pv. manihotis | AAC41485.1 | P48982 | ||
| Eukaryota | |||||||
| Protein Name | EC# | Reference | Organism | GenBank | Uniprot | PDB/3D | |
| β-galactosidase (Bgal12; Gal-12; At4g26140) | 3.2.1.23 | pubmed |
Arabidopsis thaliana | CAB39679.1 AAM20463.1 AAN15586.1 AEE85162.1 AEE85163.1 ANM67745.1 ANM67746.1 ANM67747.1 ANM67748.1 ANM67749.1 ANM67750.1 ANM67751.1 CAB64748.1 CAB79469.1 CAW88956.1 CAW88979.1 CAW89080.1 CAW93222.1 CAW93243.1 CAW93335.1 CAW98456.1 CAW98482.1 CAW98580.1 CAX05313.1 CAX05323.1 CAX05391.1 CBD12062.1 CBD12081.1 CBD12162.1 NP_194344.1 NP_194344.2 NP_849553.1 |
A0A1P8B827 A0A1P8B828 A0A1P8B829 A0A1P8B834 A0A1P8B849 A0A654FSX5 Q9SCV0 |
||
| xyloglucan β-galactosidase (Bgal10;AtBGAL10;At5g63810) | 3.2.1.23 | pubmed |
Arabidopsis thaliana | CAB64746.1 AAM13117.1 AAQ56781.1 AED97800.1 BAB11029.1 BAF00686.1 CAW88961.1 CAW89068.1 CAW93226.1 CAW93324.1 CAW98461.1 CAW98568.1 CAX05315.1 CAX05381.1 CBD12066.1 CBD12152.1 NP_201186.1 |
A0A654GDW4 Q0WQB3 Q9FN08 Q9SCV2 |
||
| β-galactosidase (Bgal6;Mum2;At5g63800) | 3.2.1.23 | pubmed |
Arabidopsis thaliana | CAB64742.1 AAL24374.1 AAM13351.1 AED97799.1 BAB10473.1 BAF01618.1 CAW88973.1 CAW89070.1 CAW93237.1 CAW93327.1 CAW98472.1 CAW98570.1 CAX05320.1 CAX05383.1 CBD12076.1 CBD12154.1 NP_568978.1 |
A0A178URV0 Q93YP1 Q9FFN4 Q9SCV6 |
||
| β-galactosidase (Bgal5; Gal-5; At1g45130) | 3.2.1.23 | doi |
Arabidopsis thaliana | CAB64741.1 AAF69162.1 AAL24206.1 AAL47461.1 AAM16238.1 AEE32082.1 ANM58003.1 CAW88944.1 CAW89053.1 CAW89073.1 CAW93210.1 CAW93309.1 CAW93329.1 CAW98443.1 CAW98552.1 CAW98573.1 CAX05308.1 CAX05367.1 CAX05385.1 CBD12052.1 CBD12139.1 CBD12156.1 NP_175127.1 |
A0A1P8AMY9 Q93Z63 Q9MAJ7 Q9SCV7 |
||
| β-galactosidase (Bgal4; Gal-4; AtBGAL4; At5g56870) | 3.2.1.23 | pubmed |
Arabidopsis thaliana | BAA97206.1 AAK96780.1 AAL47393.1 AED96817.1 BAD94489.1 BAH20357.1 CAB64740.1 CAW88958.1 CAW89050.1 CAW93223.1 CAW93307.1 CAW98458.1 CAW98548.1 CAX05314.1 CAX05365.1 CBD12064.1 CBD12137.1 NP_200498.1 |
A0A654GBW8 B9DHZ0 Q56ZL0 Q9SCV8 |
||
| β-galactosidase (Bgal3; Gal-3; At4g36360) | 3.2.1.23 | pubmed |
Arabidopsis thaliana | CAB64739.1 AAL07134.1 AAM14371.1 AEE86646.1 AEE86647.1 BAF01862.1 CAA18137.1 CAB16852.1 CAB80302.1 CAW88968.1 CAW88977.1 CAW89001.1 CAW89012.1 CAW93233.1 CAW93241.1 CAW93263.1 CAW93273.1 CAW98468.1 CAW98504.1 CAW98514.1 CAX05318.1 CAX05334.1 CAX05338.1 CBD12072.1 CBD12080.1 CBD12099.1 CBD12107.1 NP_568001.1 |
A0A178UZW3 Q42150 Q56WA4 Q9SCV9 |
||
| β-galactosidase (Bgal2; Glα-2; At3g52840) | 3.2.1.23 | doi |
Arabidopsis thaliana | CAB64738.1 AAK32914.1 AAN18080.1 AAN60229.1 AEE78999.1 ANM63664.1 CAB86888.1 CAW88953.1 CAW89075.1 CAW93219.1 CAW93331.1 CAW98453.1 CAW98575.1 CAX05312.1 CAX05387.1 CBD12060.1 CBD12158.1 NP_190852.1 |
A0A1I9LM56 A0A654FFD6 Q8H7H7 Q9LFA6 |
||
| β-galactosidase (Bgal1;Gal-1;At3g13750) | 3.2.1.23 | pubmed |
Arabidopsis thaliana | BAB01923.1 AAM13196.1 AAN60233.1 AEE75407.1 BAF02242.1 BAH20412.1 CAB64737.1 CAW88951.1 CAW89034.1 CAW93217.1 CAW93293.1 CAW98450.1 CAW98534.1 CAX05311.1 CAX05353.1 CBD12058.1 CBD12125.1 NP_187988.1 |
B9DI45 Q0WKW5 Q8H7H4 Q8RWC1 Q9SCW1 |
||
| β-galactosidase | 3.2.1.23 | pubmed |
Arion vulgaris | CEK83299.1 | A0A0B7AQJ9 | ||
| β-galactosidase (LacB) | 3.2.1.23 | pubmed |
Aspergillus candidus 88 | CAD24293.1 | Q8TFE6 | ||
| β-galactosidase A (LacA) (partial) | 3.2.1.23 | pubmed |
Aspergillus nidulans A713 | AGS42422.1 | T1SCX8 | ||
| β-galactosidase B (LacB) (partial) | 3.2.1.23 | pubmed |
Aspergillus nidulans A713 | AGS42423.1 | T1SCI0 | ||
| β-galactosidase A (LacA) (partial) | 3.2.1.23 | pubmed |
Aspergillus niger ATCC 1015 | AGS42424.1 | T1SCG0 | ||
| β-galactosidase (An01g12150) | 3.2.1.23 | pubmed |
Aspergillus niger CBS 513.88 | CAK44114.1 AAE23229.1 |
A2QAN3 | 5IFP[A] 5IFT[A] 5IHR[A] 5JUV[A] 5MGC[A] 5MGD[A] |
|
| β-galactosidase (LacA) | 3.2.1.23 | pubmed |
Aspergillus niger VTT D80144 | AAA32696.1 AAC60538.1 CAA00105.1 |
P29853 | ||
| β-galactosidase (Lac) | 3.2.1.23 | pubmed |
Aspergillus oryzae 112 | AHI44625.1 | W5ZSH9 | ||
| β-galactosidase (Ao-β-Gal;LacA;AO090012000445) | 3.2.1.23 | pubmed |
Aspergillus oryzae RIB40 | BAE60622.1 | Q2UCU3 | 4IUG[A] | |
| β-galactosidase (APGL) | 3.2.1.23 | pubmed |
Aspergillus phoenicis AS.3.3143 | AAY21925.1 | Q4ZHV7 | ||
| β-galactosidase (BgalA) | 3.2.1.23 | pubmed |
Bispora sp. MEY-1 | ACR78153.1 | C7SLY9 | ||
| β-galactosidase (Glb1) | 3.2.1.23 | pubmed |
Canis lupus familiaris | AAE53102.1 AAB50770.1 AAC12775.1 AAT65211.1 AAU05604.1 AAU05608.1 AAU05610.1 AAV32505.1 ABA43388.1 |
Q5UD52 Q670P7 Q670P9 Q670Q3 Q6DW09 Q6DWK1 Q9TRY9 |
||
| β-galactosidase (Pbg1;Bg1) | 3.2.1.23 | pubmed |
Capsicum annuum | AAK40304.1 BAC10578.2 CAW89031.1 CAW89047.1 CAW93291.1 CAW93305.1 CAW98532.1 CAW98546.1 CAX05350.1 CAX05363.1 CBD12123.1 CBD12135.1 |
Q8LP12 Q93XM4 |
||
| β-galactosidase (CpGAL;CanBGal-5) | 3.2.1.23 | pubmed |
Cicer arietinum | CAA10128.1 | Q9ZRV9 | ||
| β-galactosidase (bIII-Gal;CanBGal-3) | 3.2.1.23 | pubmed |
Cicer arietinum | CAA06309.1 | O65736 | ||
| β-galactosidase (BgaL) | 3.2.1.23 | pubmed |
Coffea arabica | ADX59436.1 | F1CGY8 | ||
| β-galactosidase (Glb1;Bgal ) | 3.2.1.23 | pubmed |
Felis catus | AAB81350.1 AAB86405.1 |
O19015 | ||
| β-galactosidase 3 (FabGal3) | 3.2.1.23 | pubmed |
Fragaria x ananassa | CAC44502.1 CAW89039.1 CAW93298.1 CAW98540.1 CAX05357.1 CBD12129.1 |
Q93X56 | ||
| β-galactosidase 2 (FabGal2) | 3.2.1.23 | pubmed |
Fragaria x ananassa | CAC44501.1 CAW89042.1 CAW93300.1 CAW98542.1 CAX05359.1 CBD12131.1 |
Q93X57 | ||
| β-galactosidase 1 (FabGal1) | 3.2.1.23 | pubmed |
Fragaria x ananassa | CAC44500.1 CAW89045.1 CAW93302.1 CAW98544.1 CAX05361.1 CBD12133.1 |
Q93X58 | ||
| β-galactosidase (Glb1) | 3.2.1.23 | pubmed |
Homo sapiens | AAA51819.1 AAA35599.1 AAA51822.1 AAA51823.1 AAH07493.1 AAP35811.1 ACM84364.1 BAD96483.1 BAD96811.1 BAH12915.1 BAH13196.1 BAH13341.1 CBA12839.1 NP_000395.1 |
B7Z5H9 B7Z6Q5 P16278 P16279 Q53G40 Q53H18 |
3THC[A,B,C,D] 3THD[A,B,C,D] 3WEZ[A,B,C,D] 3WF0[A,B,C,D] 3WF1[A,B,C,D] 3WF2[A,B,C,D] 3WF3[A,B,C,D] 3WF4[A,B,C,D] |
|
| β-galactosidase (Bgal1) | 3.2.1.23 | pubmed |
Linum usitatissimum | AEG76892.1 AEG76893.1 |
F6LC68 | ||
| β-galactosidase isoform X4 (Loc105340763) | 3.2.1.23 | pubmed |
Magallana gigas | XP_034310761.1 WMP40582.1 |
|||
| β-galactosidase | 3.2.1.23 | pubmed |
Malus domestica | AAA62324.1 CAW89089.1 CAW93345.1 CAW98590.1 CAX05399.1 CBD12169.1 |
P48981 | ||
| β-galactosidase | 3.2.1.23 | pubmed |
Mus musculus | AAA37293.1 AAA37292.1 AAH03998.1 AAH28875.1 BAC31151.1 BAC33344.1 BAC36375.1 BAE42549.1 NP_033882.1 |
P23780 Q3TAW7 Q8C659 Q8C847 Q8C9H8 Q8K131 Q99KV2 |
7KDV[A,C,E,G,I,K] | |
| β-galactosidase (OsBgal1;Os03g0165400) | 3.2.1.23 | doi |
Oryza sativa Japonica Group | AAM22973.1 AAM34271.1 BAF10982.1 BAG95436.1 BAS82468.1 BAS82469.1 |
A0A0P0VTJ4 B7EST9 B8ANX7 Q10RB4 |
||
| β-galactosidase (OsBGal2;Os06g0573600) | 3.2.1.23 | doi |
Oryza sativa Japonica Group | BAD61846.1 BAF19834.1 BAS98330.1 BAS98331.1 BAS98332.1 |
A0A0P0WY55 A0A0P0WYA9 Q5Z7L0 |
||
| β-galactosidase (OsBgal8; Os03g0255100) | 3.2.1.23 | pubmed |
Oryza sativa Japonica Group | BAF11505.1 BAG90437.1 BAS83320.1 BAS83321.1 |
A0A0N7KGY6 B7EDJ0 Q10NX8 |
||
| β-galactosidase (BgaS) | 3.2.1.23 | pubmed |
Penicillium canescens VKPM F178 | CAA49852.2 1915314A |
Q12660 | ||
| exo-β-1,4-galactanase (Galx35C;PcGALX35C) | 3.2.1.- | pubmed |
Penicillium chrysogenum 31B | BAM09150.1 | I0IV51 | ||
| β-galactosidase / galactoligosaccharide synthase | 3.2.1.23 | pubmed |
Penicillium expansum F3 | ACD75821.1 | B8QGZ3 | ||
| β-galactosidase (PoβGal35A; PDE_00282) (Gal35A) | 3.2.1.23 | pubmed |
Penicillium oxalicum 114-2 | EPS25349.1 | S7Z5H6 | ||
| β-galactosidase (Lac) | 3.2.1.23 | pubmed |
Penicillium sp. | CAF32457.1 | Q700S9 | 1TG7[A] 1XC6[A] |
|
| β-galactosidase (Av-Gal1) | 3.2.1.23 | doi |
Persea americana | BAB83260.1 CAW89037.1 CAW93296.1 CAW98537.1 CAX05354.1 CBD12127.1 |
Q8W3Y6 | ||
| β-galactosidase (Gal1;Pp-Gal1;JP-Gal) | 3.2.1.23 | pubmed |
Pyrus pyrifolia | BAB21492.1 | Q9AYS1 | ||
| exo-β-1,3-,1,6-galactosidase / β-galactosidase (RsBGal1) | 3.2.1.23 | pubmed |
Raphanus sativus | BAD20774.2 BAD20774.1 |
Q6L619 | ||
| β-galactosidase (GAL1) | 3.2.1.23 | doi |
Sandersonia aurantiaca | AAQ21369.1 | Q6EM02 | ||
| β-galactosidase II / β-galactosidase 4 / exo-β-1,4-galactanase (Tbg4;TBG4) | 3.2.1.23 | pubmed |
Solanum lycopersicum | AAC25984.1 AAY07928.1 ADO34789.1 CAW88940.1 CAW93206.1 CAW98438.1 CAX05306.1 CBD12048.1 |
E3UVW6 O81100 |
3W5F[A,B] 3W5G[A,B] 6IK5[A,B] 6IK6[A,B] 6IK7[A,B] 6IK8[A,B] |
|
| β-galactosidase 1 / exo-β-1,4-galactanase (Tbg1) | 3.2.1.23 | pubmed |
Solanum lycopersicum | AAF21626.1 AAY07925.1 CAA58734.1 CAW88934.1 CAW93202.1 CAW98433.1 CAX05304.1 CBD12045.1 |
P48980 Q546T5 |
||
| β-galactosidase 5 / exo-β-1,3/6-galactanase (Tbg5;STBG5) | 3.2.1.23 | pubmed |
Solanum lycopersicum | AAF70824.1 AAY07929.1 ADO34790.1 ADO34790.2 ADO34790.3 CAW89064.1 CAW93320.1 CAW98563.1 CAX05376.1 CBD12148.1 |
E3UVW7 Q9LLT0 |
||
| β-galactosidase (GalA;PaGalA) | 3.2.1.23 | doi |
Talaromyces aerugineus GY701 / CGMCC 2733 | ADW66246.1 | G8ZAH2 | ||
| β-galactosidase (TtbGal1; THITE_2047729) | 3.2.1.23 | pubmed |
Thermothielavioides terrestris NRRL 8126 | AEO66390.1 | G2QZR1 | ||
| β-galactosidase / galacto-β-galactanase (Bga1) | 3.2.1.23 | pubmed |
Trichoderma reesei | CAD70669.1 | Q70SY0 | 3OG2[A] 3OGR[A] 3OGS[A] 3OGV[A] |
|
| xyloglucan-specific β-galactosidase | 3.2.1.23 | pubmed |
Tropaeolum majus | CAW88932.1 CAW93199.1 CAW98431.1 CAX05303.1 CBD12043.1 |
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