Activities in Family	Exo-α-sialidase (EC 3.2.1.18);
Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	Not known
External resources	CAZypedia; HOMSTRAD; ProteinSpotlight;
Statistics	GenBank accession (138704); Uniprot accession (46); PDB accession (247); 3D entries (57); cryst (0)

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Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
neuraminidase (NA)		Influenza A virus (A/Alaska/63/2017(H3N2))	ATP80718.1 ATZ78207.1
neuraminidase (NA)		Influenza A virus (A/Alaska/64/2015(H3N2))	ANE25768.1
neuraminidase (NA)		Influenza A virus (A/Alaska/64/2017(H3N2))	ATP80730.1 ATZ78219.1
neuraminidase (NA)		Influenza A virus (A/Alaska/65/2015(H3N2))	ALH37774.1
neuraminidase (NA)		Influenza A virus (A/Alaska/65/2017(H3N2))	ATX61576.1
neuraminidase (NA)		Influenza A virus (A/Alaska/66/2015(H3N2))	ALH36829.1
neuraminidase (NA)		Influenza A virus (A/Alaska/67/2015(H3N2))	AMB67367.1
neuraminidase (NA)		Influenza A virus (A/Alaska/67/2017(H1N1))	AUH29965.1
neuraminidase (NA)		Influenza A virus (A/Alaska/68/2015(H3N2))	ALH36908.1
neuraminidase (NA)		Influenza A virus (A/Alaska/69/2015(H3N2))	ALH36929.1
neuraminidase (NA)		Influenza A virus (A/Alaska/69/2017(H3N2))	AUH29977.1
neuraminidase (NA)		Influenza A virus (A/Alaska/70/2015(H3N2))	APB89890.1
neuraminidase (NA)		Influenza A virus (A/Alaska/70/2017(H1N1))	AUH31773.1
neuraminidase (NA)		Influenza A virus (A/Alaska/71/2017(H3N2))	AUH31785.1
neuraminidase (NA)		Influenza A virus (A/Alaska/72/2017(H3N2))	AUH31797.1
neuraminidase (NA)		Influenza A virus (A/Alaska/73/2017(H3N2))	AUH31809.1
neuraminidase (NA)		Influenza A virus (A/Alaska/74/2017(H3N2))	AUH31821.1
neuraminidase (NA)		Influenza A virus (A/Alaska/75/2015(H3N2))	ANE25780.1
neuraminidase (NA)		Influenza A virus (A/Alaska/75/2017(H3N2))	AUP49174.1
neuraminidase (NA)		Influenza A virus (A/Alaska/76/2017(H1N1))	AUP49208.1
neuraminidase (NA)		Influenza A virus (A/Alaska/77/2015(H3N2))	ANE25792.1
neuraminidase (NA)		Influenza A virus (A/Alaska/77/2017(H1N1))	AUP49185.1
neuraminidase (NA)		Influenza A virus (A/Alaska/78/2017(H3N2))	AUP49197.1
neuraminidase (NA)		Influenza A virus (A/Alaska/79/2015(H3N2))	ANE25804.1
neuraminidase (NA)		Influenza A virus (A/Alaska/79/2017(H1N1))	AUP49241.1
neuraminidase		Influenza A virus (A/Alaska/8/2001(N2))	ABU50441.1
neuraminidase (NA)		Influenza A virus (A/Alaska/80/2015(H3N2))	ANE25816.1
neuraminidase (NA)		Influenza A virus (A/Alaska/83/2015(H3N2))	ANE25828.1
neuraminidase (NA)		Influenza A virus (A/Alaska/86/2015(H3N2))	ANE25840.1
neuraminidase (NA)		Influenza A virus (A/Alaska/93/2015(H3N2))	ANE25852.1
neuraminidase (NA)		Influenza A virus (A/Alaska/96/2015(H3N2))	ANE25864.1
neuraminidase (NA)		Influenza A virus (A/Alaska/97/2015(H3N2))	ANE25876.1
neuraminidase (NA)		Influenza A virus (A/Alaska/98/2015(H3N2))	ANE25888.1
neuraminidase (NA)		Influenza A virus (A/Alaska/99/2015(H3N2))	ANE25900.1
neuraminidase (NA)		Influenza A virus (A/Alaska/WRAIR1114P/2009(H1N1))	ADL39249.1
neuraminidase (NA)		Influenza A virus (A/Alaska/WRAIR1145P/2009(H3N2))	ADL39359.1
neuraminidase (NA)		Influenza A virus (A/Alaska/WRAIR1172P/2009(H3N2))	ADL39403.1
neuraminidase		Influenza A virus (A/Albany/1/1958(H2N2))	ABP49473.1
neuraminidase		Influenza A virus (A/Albany/1/1959(H2N2))	ABO44093.1
neuraminidase		Influenza A virus (A/Albany/1/1960(H2N2))	ABQ01358.1
neuraminidase		Influenza A virus (A/Albany/1/1968(H2N2))	ABO52250.1
neuraminidase		Influenza A virus (A/Albany/1/1969(H3N2))	ABN51113.1
neuraminidase		Influenza A virus (A/Albany/1/1970(H3N2))	ABS49902.1
neuraminidase		Influenza A virus (A/Albany/1/1976(H3N2))	ABQ01369.1
neuraminidase		Influenza A virus (A/Albany/1/63(H2N2))	AAO46226.1
neuraminidase		Influenza A virus (A/Albany/1/65(H2N2))	AAO46231.1
neuraminidase		Influenza A virus (A/Albany/10/1968(H3N2))	ABP49517.1
neuraminidase		Influenza A virus (A/Albany/11/1968(H3N2))	ABN51102.1
neuraminidase		Influenza A virus (A/Albany/12/1951(H1N1))	ABP49484.1
neuraminidase		Influenza A virus (A/Albany/13/1951(H1N1))	ABR15811.1
neuraminidase		Influenza A virus (A/Albany/14/1951(H1N1))	ABQ44474.1
neuraminidase		Influenza A virus (A/Albany/14/1978(H3N2))	ABO33072.1
neuraminidase		Influenza A virus (A/Albany/15/1976(H3N2))	ABP49495.1
neuraminidase		Influenza A virus (A/Albany/1618/1951(H1N1))	ABQ01314.1
neuraminidase		Influenza A virus (A/Albany/17/1968(H3N2))	ABO52360.1
neuraminidase		Influenza A virus (A/Albany/18/1968(H3N2))	ABO44071.1
neuraminidase		Influenza A virus (A/Albany/19/1968(H3N2))	ABN51124.1
neuraminidase		Influenza A virus (A/Albany/2/1958(H2N2))	ABO38101.1
neuraminidase		Influenza A virus (A/Albany/2/1968(H2N2))	ABO38737.1
neuraminidase		Influenza A virus (A/Albany/2/1970(H3N2))	ABO52327.1
neuraminidase		Influenza A virus (A/Albany/20/1957(H2N2))	ABQ44463.1
neuraminidase		Influenza A virus (A/Albany/20/1974(H3N2))	ABO52338.1
neuraminidase		Influenza A virus (A/Albany/20/1978(H1N1))	ABP49451.1
neuraminidase (NA)		Influenza A virus (A/Albany/21/1957(mixed))	AEM53459.1
neuraminidase		Influenza A virus (A/Albany/22/1957(H2N2))	ABP49462.1
neuraminidase		Influenza A virus (A/Albany/24/1958(H2N2))	ABP49440.1
neuraminidase		Influenza A virus (A/Albany/26/1957(H2N2))	ABO38310.1
neuraminidase		Influenza A virus (A/Albany/3/1958(H2N2))	ABO52305.1
neuraminidase		Influenza A virus (A/Albany/3/1967(H2N2))	ABO38726.1
neuraminidase		Influenza A virus (A/Albany/3/1969(H3N2))	ABN51135.1
neuraminidase		Influenza A virus (A/Albany/3/1970(H3N2))	ABS49913.1
neuraminidase		Influenza A virus (A/Albany/4/1958(H2N2))	ABO38299.1
neuraminidase		Influenza A virus (A/Albany/4/1967(H2N2))	ABQ44441.1
neuraminidase		Influenza A virus (A/Albany/4/1969(H3N2))	ABP49506.1
neuraminidase		Influenza A virus (A/Albany/4/1977(H3N2))	ABO52349.1
neuraminidase		Influenza A virus (A/Albany/42/1975(H3N2))	ABO52316.1
neuraminidase		Influenza A virus (A/Albany/4835/1948(H1N1))	ABN59404.1
neuraminidase		Influenza A virus (A/Albany/4836/1950(H1N1))	ABP49319.1
neuraminidase		Influenza A virus (A/Albany/5/1958(H2N2))	ABO52239.1
neuraminidase (NA)		Influenza A virus (A/Albany/5/1967(mixed))	AEM53471.1
neuraminidase		Influenza A virus (A/Albany/6/1967(H2N2))	ABO38704.1
neuraminidase		Influenza A virus (A/Albany/6/1968(H3N2))	ABR15800.1
neuraminidase		Influenza A virus (A/Albany/6/1970(H3N2))	ABO52371.1
neuraminidase		Influenza A virus (A/Albany/6/58(H2N2))	AAO46215.1
neuraminidase		Influenza A virus (A/Albany/7/1967(H2N2))	ABO38715.1
neuraminidase		Influenza A virus (A/Albany/8/1967(H2N2))	ABO44104.1
neuraminidase		Influenza A virus (A/Albany/8/1979(H1N1))	ABW36314.1
neuraminidase		Influenza A virus (A/Albany/9/1967(H2N2))	ABO44060.1
neuraminidase (NA)		Influenza A virus (A/Alborz/1095/2012(H3N2))	AGK63036.1
neuraminidase (NA)		Influenza A virus (A/Alborz/5293/2011(H1N1))	AGJ73352.1
neuraminidase (NA)		Influenza A virus (A/Alborz/5733/2011(H1N1))	AGJ73368.1
neuraminidase (NA)		Influenza A virus (A/Alborz/609/2012(H3N2))	AGK62994.1
neuraminidase (NA)		Influenza A virus (A/Alborz/72205/2014(H3N2))	APO40435.1
neuraminidase (NA)		Influenza A virus (A/Alborz/927/2012(H3N2))	AGK63020.1
neuraminidase (NA)		Influenza A virus (A/Alborz/99/2011(H1N1))	AGJ73336.1
neuraminidase (NA)		Influenza A virus (A/Alchi/2/1968(H3N2))	APC57891.1
neuraminidase (NA)		Influenza A virus (A/Alegrete/LACENRS-1453/2009(H1N1))	ARI68329.1
neuraminidase (NA)		Influenza A virus (A/Alegrete/LACENRS-1624/2014(H3N2))	ARI68339.1
neuraminidase (fragment)		Influenza A virus (A/Alexandroupolis/130/2006(H3N2))	ACD93139.1
neuraminidase (fragment)		Influenza A virus (A/Alexandroupolis/99/2007(H3N2))	ACD93141.1
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