Activities in Family	Exo-α-sialidase (EC 3.2.1.18);
Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	Not known
External resources	CAZypedia; HOMSTRAD; ProteinSpotlight;
Statistics	GenBank accession (138704); Uniprot accession (46); PDB accession (247); 3D entries (57); cryst (0)

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Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
neuraminidase (NA) (fragment)		Influenza A virus A/China/YF087/2016	QFY15131.1
neuraminidase (NA) (fragment)		Influenza A virus A/China/YF090/2016	QFY15132.1
neuraminidase (NA) (fragment)		Influenza A virus A/China/YF099/2017	QFY15133.1
neuraminidase (NA) (fragment)		Influenza A virus A/China/YF109/2017	QFY15134.1
neuraminidase (NA) (fragment)		Influenza A virus A/China/YF116/2017	QFY15135.1
neuraminidase (NA)		Influenza A virus A/China/ZJHL32/2018	QVX33339.1
neuraminidase (NA)		Influenza A virus A/China/ZJHL65/2018	QVX33340.1
neuraminidase (NA)		Influenza A virus A/China/ZJTZ17/2015	QVX26848.1
neuraminidase (NA)		Influenza A virus A/China/ZJTZ6/2015	QVX26849.1
neuraminidase (NA)		Influenza A virus A/China/ZJTZ72/2015	QVX26850.1
neuraminidase (NA)		Influenza A virus A/China/ZJWZ118/2018	QVX33333.1
neuraminidase (NA)		Influenza A virus A/China/ZJWZ123/2018	QVX33334.1
neuraminidase (NA)		Influenza A virus A/China/ZJWZ127/2018	QVX33335.1
neuraminidase (NA)		Influenza A virus A/China/ZJWZ128/2018	QVX33336.1
neuraminidase (NA)		Influenza A virus A/China/ZJWZ44/2017	QVX33337.1
neuraminidase (NA)		Influenza A virus A/China/ZMD-22-2/2022	UPM56599.1
neuraminidase (NA)		Influenza A virus A/chinstrap penguin/Antarctica/HP04/2018	QDA17769.1
neuraminidase (NA)		Influenza A virus A/chinstrap penguin/Cape Shirreff/P10S/2017	AXK59073.1
neuraminidase (NA)		Influenza A virus A/chinstrap penguin/Cape Shirreff/P11S/2017	AXK59074.1
neuraminidase (NA)		Influenza A virus A/chinstrap penguin/Cape Shirreff/P13S/2017	AXK59026.1
neuraminidase (NA)		Influenza A virus A/chinstrap penguin/Cape Shirreff/P19S/2017	QUD20107.1
neuraminidase (NA)		Influenza A virus A/chinstrap penguin/Cape Shirreff/P36S/2017	QUD20090.1
neuraminidase (NA)		Influenza A virus A/chinstrap penguin/Cape Shirreff/P8S/2017	AXK59076.1
neuraminidase (NA)		Influenza A virus A/chinstrap_penguin/Antarctica/P5/2017	AWW20624.1
neuraminidase (NA)		Influenza A virus A/Chittur/INDNCH16.6/2017	AZB51165.1
neuraminidase (NA)		Influenza A virus A/Chlamydotis undulata/United Arab Emirates/20-342/2019	WOE88015.1
neuraminidase (NA)		Influenza A virus A/Chlidonias hybrida/Hubei/55/2020	QQV44216.1
neuraminidase (NA)		Influenza A virus A/Ciba/DS6-1/2015	BBF41197.1
neuraminidase (NA)		Influenza A virus A/Ciba/DS6-15/2016	BBF41195.1
neuraminidase (NA)		Influenza A virus A/Ciba/DS7-125/2016	BBF41106.1
neuraminidase (NA)		Influenza A virus A/Ciba/DS7-52/2016	BBF41158.1
neuraminidase (NA)		Influenza A virus A/Ciba/DS7-78/2016	BBF41172.1
neuraminidase (NA)		Influenza A virus A/cinnamon teal/Argentina/CIP051-1588/2009	AYM51383.1
neuraminidase (NA)		Influenza A virus A/cinnamon teal/Argentina/CIP051-432/2011	AYM51395.1
neuraminidase (NA)		Influenza A virus A/Cinnamon Teal/California/D1714969/2017	QCW09610.1
neuraminidase (NA)		Influenza A virus A/Cinnamon Teal/California/D1715700/2017	QCW09627.1
neuraminidase (NA)		Influenza A virus A/Cinnamon Teal/California/D1715700/2017	QCW09626.1
neuraminidase (NA)		Influenza A virus A/Cinnamon Teal/California/D1800496/2018	QCW09649.1
neuraminidase (NA)		Influenza A virus A/cinnamon teal/Chile/C19368/2016	AXF49841.1
neuraminidase (NA)		Influenza A virus A/cinnamon teal/Chile/C38108/2018	UZU89137.1
neuraminidase (NA)		Influenza A virus A/cinnamon teal/Utah/AH0166335/2021	UEM45929.1
neuraminidase (NA)		Influenza A virus A/Ckicken/Luxor/313/2019	QLI41796.1
neuraminidase (NA)		Influenza A virus A/Colorado/01/2018	AVP08497.1
neuraminidase (NA)		Influenza A virus A/Colorado/01/2019	QBM03340.1
neuraminidase (NA)		Influenza A virus A/Colorado/01/2020	QIQ46076.1
neuraminidase (NA)		Influenza A virus A/Colorado/01/2021	UZO38189.1
neuraminidase (NA)		Influenza A virus A/Colorado/01/2022	UZO38201.1
neuraminidase (NA)		Influenza A virus A/Colorado/02/2018	AVP06536.1
neuraminidase (NA)		Influenza A virus A/Colorado/02/2019	QBS20816.1 QCW13679.1
neuraminidase (NA)		Influenza A virus A/Colorado/02/2020	QIQ44452.1
neuraminidase (NA)		Influenza A virus A/Colorado/02/2021	UZO38213.1
neuraminidase (NA)		Influenza A virus A/Colorado/02/2022	UZO38225.1
neuraminidase (NA)		Influenza A virus A/Colorado/03/2018	AVP03928.1
neuraminidase (NA)		Influenza A virus A/Colorado/03/2019	QBS20828.1 QCW13691.1
neuraminidase (NA)		Influenza A virus A/Colorado/03/2020	QIQ44486.1
neuraminidase (NA)		Influenza A virus A/Colorado/03/2021	UZO38237.1
neuraminidase (NA)		Influenza A virus A/Colorado/03/2022	UPP05070.1
neuraminidase (NA)		Influenza A virus A/Colorado/04/2018	AVP03556.1
neuraminidase (NA)		Influenza A virus A/Colorado/04/2019	QBM03357.1
neuraminidase (NA)		Influenza A virus A/Colorado/04/2020	QIQ44501.1
neuraminidase (NA)		Influenza A virus A/Colorado/04/2021	UZO38249.1
neuraminidase (NA)		Influenza A virus A/Colorado/04/2022	UPP05082.1
neuraminidase (NA)		Influenza A virus A/Colorado/05/2018	AVP03856.1
neuraminidase (NA)		Influenza A virus A/Colorado/05/2019	QBM03368.1
neuraminidase (NA)		Influenza A virus A/Colorado/05/2020	QIQ44506.1
neuraminidase (NA)		Influenza A virus A/Colorado/05/2021	UZO38261.1
neuraminidase (NA)		Influenza A virus A/Colorado/05/2022	UPP05094.1
neuraminidase (NA)		Influenza A virus A/Colorado/06/2018	AVP03563.1
neuraminidase (NA)		Influenza A virus A/Colorado/06/2020	QIZ32087.1
neuraminidase (NA)		Influenza A virus A/Colorado/06/2021	UZO38273.1
neuraminidase (NA)		Influenza A virus A/Colorado/06/2022	UPP05106.1
neuraminidase (NA)		Influenza A virus A/Colorado/07/2018	AVR40788.1
neuraminidase (NA)		Influenza A virus A/Colorado/07/2019	QBQ86407.1
neuraminidase (NA)		Influenza A virus A/Colorado/07/2020	QIZ32098.1
neuraminidase (NA)		Influenza A virus A/Colorado/07/2022	UPP05118.1
neuraminidase (NA)		Influenza A virus A/Colorado/08/2018	AVR41914.1
neuraminidase (NA)		Influenza A virus A/Colorado/08/2019	QBQ86418.1
neuraminidase (NA)		Influenza A virus A/Colorado/08/2020	QIZ32105.1
neuraminidase (NA)		Influenza A virus A/Colorado/08/2022	UPP05130.1
neuraminidase (NA)		Influenza A virus A/Colorado/09/2018	AVR41919.1 AXQ12510.1
neuraminidase (NA)		Influenza A virus A/Colorado/09/2019	QBS20041.1 QDX11776.1
neuraminidase (NA)		Influenza A virus A/Colorado/09/2020	QIZ32122.1
neuraminidase (NA)		Influenza A virus A/Colorado/10/2018	AVR40801.1
neuraminidase (NA)		Influenza A virus A/Colorado/10/2019	QBS20053.1 QDX11788.1
neuraminidase (NA)		Influenza A virus A/Colorado/10/2022	UXG50063.1
neuraminidase (NA)		Influenza A virus A/Colorado/11/2018	AVX28703.1
neuraminidase (NA)		Influenza A virus A/Colorado/11/2019	QBY33881.1
neuraminidase (NA)		Influenza A virus A/Colorado/11/2022	UXG50075.1
neuraminidase (NA)		Influenza A virus A/Colorado/12/2018	AWB13418.1 AXY84259.1
neuraminidase (NA)		Influenza A virus A/Colorado/12/2019	QBY32660.1 QDX11800.1
neuraminidase (NA)		Influenza A virus A/Colorado/12/2022	USW61030.1
neuraminidase (NA)		Influenza A virus A/Colorado/12584/2021	UUB20473.1
neuraminidase (NA)		Influenza A virus A/Colorado/12585/2021	UUB20485.1
neuraminidase (NA)		Influenza A virus A/Colorado/12756/2022	UUB78274.1
neuraminidase (NA)		Influenza A virus A/Colorado/12757/2022	UUB78286.1
neuraminidase (NA)		Influenza A virus A/Colorado/12758/2022	UUB78298.1
neuraminidase (NA)		Influenza A virus A/Colorado/12759/2022	UUB77650.1
neuraminidase (NA)		Influenza A virus A/Colorado/13/2018	AVX28582.1
neuraminidase (NA)		Influenza A virus A/Colorado/13/2019	QBY32672.1 QCW13703.1
neuraminidase (NA)		Influenza A virus A/Colorado/13337/2022	UVI03413.1
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