Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (6022); Uniprot accession (681); PDB accession (152); 3D entries (21); cryst (0)
All (5781) Archaea (1) Bacteria (5317) Eukaryota (420) Viruses (35) unclassified (8) Structure (21) Characterized (97)
| 1 | ... | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | ... | 55 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 neuraminidase (Nana_1)   Streptococcus pneumoniae NCTC7465 COT17436.1    
 NCTC7466_01531 (NanB)   Streptococcus pneumoniae NCTC7466 SQG02559.1    
 NCTC7466_01531 (NanB)   Streptococcus pneumoniae NCTC7466 SQG02559.1    
 neuraminidase (Nana_3)   Streptococcus pneumoniae NCTC7466 SQG02564.1    
 SpnNT_01743 (NanB)   Streptococcus pneumoniae NT_110_58 AJD72676.1    
 SpnNT_01743 (NanB)   Streptococcus pneumoniae NT_110_58 AJD72676.1    
 SpnNT_01752 (Nana_4) (fragment)   Streptococcus pneumoniae NT_110_58 AJD72685.1    
 SPNU_1255 (Nanb_1)   Streptococcus pneumoniae NU83127 BBG35139.1    
 SPNU_1255 (Nanb_1)   Streptococcus pneumoniae NU83127 BBG35139.1    
 SPNU_1595 (Nanb_2)   Streptococcus pneumoniae NU83127 BBG35477.1    
 SPNU_1595 (Nanb_2)   Streptococcus pneumoniae NU83127 BBG35477.1    
 SPNU_1602 (Nana_3)   Streptococcus pneumoniae NU83127 BBG35484.1    
 SPNOXC_14830   Streptococcus pneumoniae OXC141 CBW33136.1 E1XCC8  
 SPNOXC_14830   Streptococcus pneumoniae OXC141 CBW33136.1 E1XCC8  
 SPNOXC_14880   Streptococcus pneumoniae OXC141 CBW33141.1 E1XCD3  
 neuraminidase (NanA)   Streptococcus pneumoniae OXC141 ACJ76924.1    
 SPP_1704   Streptococcus pneumoniae P1031 ACO21913.1 C1CM25  
 SPP_1704   Streptococcus pneumoniae P1031 ACO21913.1 C1CM25  
 neuraminidase   Streptococcus pneumoniae P1031 ACO21301.1    
 NanA   Streptococcus pneumoniae PCD8755 AMQ67145.1    
 neuraminidase (NanA) (fragment)   Streptococcus pneumoniae PN13 CAI94569.1 Q4LB78  
 NanA   Streptococcus pneumoniae PN8828 AMQ67147.1    
 sialidase A (NanA)   Streptococcus pneumoniae R6 AAL00340.1
ACJ76904.1
NP_359129.1
P62576 2VVZ[A,B]
2W20[A,B]
3H71[A,B]
3H72[A,B]
3H73[A,B]
 NanB   Streptococcus pneumoniae R6 AAL00335.1
NP_359124.1
Q8CWP8  
 NanB   Streptococcus pneumoniae R6 AAL00335.1
NP_359124.1
Q8CWP8  
 neuraminidase (NanB)   Streptococcus pneumoniae R6CIB17 QEL28833.1    
 neuraminidase (NanB)   Streptococcus pneumoniae R6CIB17 QEL28833.1    
 neuraminidase (NanA)   Streptococcus pneumoniae R6CIB17 QEL28838.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SP14-BS69 ACJ76929.1 B8XTV9  
 neuraminidase (NanA)   Streptococcus pneumoniae SP19-BS75 ACJ76931.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SP3-BS71 ACJ76925.1    
 BMJ42_01308   Streptococcus pneumoniae SP49 APJ30609.1    
 BMJ42_01308   Streptococcus pneumoniae SP49 APJ30609.1    
 BMJ42_01695   Streptococcus pneumoniae SP49 APJ30983.1    
 BMJ42_01695   Streptococcus pneumoniae SP49 APJ30983.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SP49 APJ30989.1    
 BOC71_01535 (Nana_2)   Streptococcus pneumoniae SP61 APJ33021.1    
 BOC71_01529 (NanB)   Streptococcus pneumoniae SP61 APJ33015.1    
 BOC71_01529 (NanB)   Streptococcus pneumoniae SP61 APJ33015.1    
 BOC72_01529   Streptococcus pneumoniae SP64 APJ35040.1    
 BOC72_01529   Streptococcus pneumoniae SP64 APJ35040.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SP64 APJ35046.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SP9-BS68 ACJ76927.1 B8XTV7  
 C1H54_08240   Streptococcus pneumoniae SPN XDR SMC1710-32 AXJ88890.1    
 C1H54_08215   Streptococcus pneumoniae SPN XDR SMC1710-32 AXJ88885.1    
 C1H54_08215   Streptococcus pneumoniae SPN XDR SMC1710-32 AXJ88885.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN034156 SNP034156 CCP36239.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN034156 SNP034156 CCP36239.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN034156 SNP034156 CCP36244.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN034183 SNP034183 CCP33190.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN034183 SNP034183 CCP33190.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN034183 SNP034183 CCP33195.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994038 SNP994038 CCP31205.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994038 SNP994038 CCP31205.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN994038 SNP994038 CCP31210.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994039 SNP994039 CCP35164.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994039 SNP994039 CCP35164.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN994039 SNP994039 CCP35169.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPNA45 CCM07843.1
CCM07838.1
   
 neuraminidase (NanB)   Streptococcus pneumoniae SPNA45 CCM07843.1
CCM07838.1
   
 MYY_1610   Streptococcus pneumoniae ST556 AFC95267.1    
 MYY_1610   Streptococcus pneumoniae ST556 AFC95267.1    
 neuraminidase   Streptococcus pneumoniae ST556 AFC95272.1    
 neuraminidase   Streptococcus pneumoniae Taiwan19F-14 ACO23538.1    
 SPT_1625   Streptococcus pneumoniae Taiwan19F-14 ACO22908.1 C1CSV0  
 SPT_1625   Streptococcus pneumoniae Taiwan19F-14 ACO22908.1 C1CSV0  
 HMPREF0837_11930 (NanB)   Streptococcus pneumoniae TCH8431/19A ADI70158.1 D6ZMP4  
 HMPREF0837_11930 (NanB)   Streptococcus pneumoniae TCH8431/19A ADI70158.1 D6ZMP4  
 HMPREF0837_11935   Streptococcus pneumoniae TCH8431/19A ADI70163.1 D6ZMP9  
 intramolecular trans-sialidase B (NanB;SP_1687) 4.2.2.15 Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1
Q54727 2JKB[A]
2VW0[A]
2VW1[A]
2VW2[A]
4FOQ[A]
4FOV[A]
4FOW[A]
4FOY[A]
4FP2[A]
4FP3[A]
4FPC[A]
4FPE[A]
4FPF[A]
4FPG[A]
4FPH[A]
4FPJ[A]
4FPK[A]
4FPL[A]
4FPO[B]
4FPY[A]
4FQ4[A]
4XE9[A]
4XHB[A]
4XHX[A]
4XIK[A]
4XIL[A]
4XIO[A]
4XJ8[A]
4XJ9[A]
4XJA[A]
4XJU[A]
4XJW[A]
4XJZ[A]
4XMA[A]
4XMI[A]
4XOG[A]
4XYX[A]
 intramolecular trans-sialidase B (NanB;SP_1687) 4.2.2.15 Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1
Q54727 2JKB[A]
2VW0[A]
2VW1[A]
2VW2[A]
4FOQ[A]
4FOV[A]
4FOW[A]
4FOY[A]
4FP2[A]
4FP3[A]
4FPC[A]
4FPE[A]
4FPF[A]
4FPG[A]
4FPH[A]
4FPJ[A]
4FPK[A]
4FPL[A]
4FPO[B]
4FPY[A]
4FQ4[A]
4XE9[A]
4XHB[A]
4XHX[A]
4XIK[A]
4XIL[A]
4XIO[A]
4XJ8[A]
4XJ9[A]
4XJA[A]
4XJU[A]
4XJW[A]
4XJZ[A]
4XMA[A]
4XMI[A]
4XOG[A]
4XYX[A]
 neuraminidase (NanA;SpneT_02001817)   Streptococcus pneumoniae TIGR4 ZP_01407762.1   2YA4[A,B]
2YA5[A,B]
2YA6[A,B]
2YA7[A,B,C,D]
2YA8[A,B]
 SP1326 (NanC)   Streptococcus pneumoniae TIGR4 AAK75424.1
NP_345784.1
Q97Q99  
 SP1326 (NanC)   Streptococcus pneumoniae TIGR4 AAK75424.1
ABA35893.1
NP_345784.1
Q97Q99  
 CXP32_06570   Streptococcus pneumoniae Xen35 AUF85063.1    
 CXP32_06570   Streptococcus pneumoniae Xen35 AUF85063.1    
 CXP32_08415   Streptococcus pneumoniae Xen35 AUF85392.1    
 CXP32_08415   Streptococcus pneumoniae Xen35 AUF85392.1    
 SPPN_08220   Streptococcus pseudopneumoniae IS7493 AEL11070.1    
 SPPN_08220   Streptococcus pseudopneumoniae IS7493 AEL11070.1    
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R82E6 ACJ76895.1 B8XTS5  
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R89G3 ACJ76897.1
ACJ76898.1
B8XTS7  
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R98A5 ACJ76899.1 B8XTS9  
 FY406_06980   Streptococcus ratti ATCC 31377 QEY07394.1    
 neuraminidase   Streptococcus sobrinus 10919 AWN21141.1    
 NCTC10921_01416 (NanB)   Streptococcus sobrinus NCTC10921 SQG20675.1    
 NCTC12279_01443 (NanB)   Streptococcus sobrinus NCTC12279 SQG13932.1    
 neuraminidase   Streptococcus sobrinus NIDR 6715-15 AWN61974.1    
 neuraminidase   Streptococcus sobrinus NIDR 6715-7 AWN63846.1    
 neuraminidase   Streptococcus sobrinus SL1 AWN18553.1    
 UKS_04740 (NanB)   Streptococcus sp. 116-D4 BBP09272.1    
 UKS_04740 (NanB)   Streptococcus sp. 116-D4 BBP09272.1    
 D7D53_06220   Streptococcus sp. ChDC B345 AYF96105.1    
 EGX96_03775   Streptococcus sp. FDAARGOS_520 AYZ04406.1    
 EGX72_02395   Streptococcus sp. FDAARGOS_521 AYY67889.1    
 EGX70_09275   Streptococcus sp. FDAARGOS_522 AYY64972.1    
 A6J68_10885   Streptococcus sp. group B FDAARGOS_229 ARC25603.1    
 SNAG_0542 (Nana_2)   Streptococcus sp. NPS 308 BAV79420.1    
 AXF18_00720   Streptococcus sp. oral taxon 064 W10853 ANR74557.1    
 AXE83_09040   Streptococcus sp. oral taxon 431 F0610 (5-114) AMD97713.1    
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