Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (5863); Uniprot accession (681); PDB accession (152); 3D entries (21); cryst (0)
All (5623) Archaea (1) Bacteria (5166) Eukaryota (415) Viruses (35) unclassified (6) Structure (21) Characterized (97)
| 1 | ... | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | ... | 53 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 BOC71_01529 (NanB)   Streptococcus pneumoniae SP61 APJ33015.1    
 BOC72_01529   Streptococcus pneumoniae SP64 APJ35040.1    
 BOC72_01529   Streptococcus pneumoniae SP64 APJ35040.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SP64 APJ35046.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SP9-BS68 ACJ76927.1 B8XTV7  
 C1H54_08240   Streptococcus pneumoniae SPN XDR SMC1710-32 AXJ88890.1    
 C1H54_08215   Streptococcus pneumoniae SPN XDR SMC1710-32 AXJ88885.1    
 C1H54_08215   Streptococcus pneumoniae SPN XDR SMC1710-32 AXJ88885.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN034156 SNP034156 CCP36239.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN034156 SNP034156 CCP36239.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN034156 SNP034156 CCP36244.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN034183 SNP034183 CCP33190.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN034183 SNP034183 CCP33190.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN034183 SNP034183 CCP33195.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994038 SNP994038 CCP31205.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994038 SNP994038 CCP31205.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN994038 SNP994038 CCP31210.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994039 SNP994039 CCP35164.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPN994039 SNP994039 CCP35164.1    
 neuraminidase (NanA)   Streptococcus pneumoniae SPN994039 SNP994039 CCP35169.1    
 neuraminidase (NanB)   Streptococcus pneumoniae SPNA45 CCM07843.1
CCM07838.1
   
 neuraminidase (NanB)   Streptococcus pneumoniae SPNA45 CCM07843.1
CCM07838.1
   
 MYY_1610   Streptococcus pneumoniae ST556 AFC95267.1    
 MYY_1610   Streptococcus pneumoniae ST556 AFC95267.1    
 neuraminidase   Streptococcus pneumoniae ST556 AFC95272.1    
 neuraminidase   Streptococcus pneumoniae Taiwan19F-14 ACO23538.1    
 SPT_1625   Streptococcus pneumoniae Taiwan19F-14 ACO22908.1 C1CSV0  
 SPT_1625   Streptococcus pneumoniae Taiwan19F-14 ACO22908.1 C1CSV0  
 HMPREF0837_11930 (NanB)   Streptococcus pneumoniae TCH8431/19A ADI70158.1 D6ZMP4  
 HMPREF0837_11930 (NanB)   Streptococcus pneumoniae TCH8431/19A ADI70158.1 D6ZMP4  
 HMPREF0837_11935   Streptococcus pneumoniae TCH8431/19A ADI70163.1 D6ZMP9  
 intramolecular trans-sialidase B (NanB;SP_1687) 4.2.2.15 Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1
Q54727 2JKB[A]
2VW0[A]
2VW1[A]
2VW2[A]
4FOQ[A]
4FOV[A]
4FOW[A]
4FOY[A]
4FP2[A]
4FP3[A]
4FPC[A]
4FPE[A]
4FPF[A]
4FPG[A]
4FPH[A]
4FPJ[A]
4FPK[A]
4FPL[A]
4FPO[B]
4FPY[A]
4FQ4[A]
4XE9[A]
4XHB[A]
4XHX[A]
4XIK[A]
4XIL[A]
4XIO[A]
4XJ8[A]
4XJ9[A]
4XJA[A]
4XJU[A]
4XJW[A]
4XJZ[A]
4XMA[A]
4XMI[A]
4XOG[A]
4XYX[A]
 intramolecular trans-sialidase B (NanB;SP_1687) 4.2.2.15 Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1
Q54727 2JKB[A]
2VW0[A]
2VW1[A]
2VW2[A]
4FOQ[A]
4FOV[A]
4FOW[A]
4FOY[A]
4FP2[A]
4FP3[A]
4FPC[A]
4FPE[A]
4FPF[A]
4FPG[A]
4FPH[A]
4FPJ[A]
4FPK[A]
4FPL[A]
4FPO[B]
4FPY[A]
4FQ4[A]
4XE9[A]
4XHB[A]
4XHX[A]
4XIK[A]
4XIL[A]
4XIO[A]
4XJ8[A]
4XJ9[A]
4XJA[A]
4XJU[A]
4XJW[A]
4XJZ[A]
4XMA[A]
4XMI[A]
4XOG[A]
4XYX[A]
 neuraminidase (NanA;SpneT_02001817)   Streptococcus pneumoniae TIGR4 ZP_01407762.1   2YA4[A,B]
2YA5[A,B]
2YA6[A,B]
2YA7[A,B,C,D]
2YA8[A,B]
 SP1326 (NanC)   Streptococcus pneumoniae TIGR4 AAK75424.1
NP_345784.1
Q97Q99  
 SP1326 (NanC)   Streptococcus pneumoniae TIGR4 AAK75424.1
ABA35893.1
NP_345784.1
Q97Q99  
 CXP32_06570   Streptococcus pneumoniae Xen35 AUF85063.1    
 CXP32_06570   Streptococcus pneumoniae Xen35 AUF85063.1    
 CXP32_08415   Streptococcus pneumoniae Xen35 AUF85392.1    
 CXP32_08415   Streptococcus pneumoniae Xen35 AUF85392.1    
 SPPN_08220   Streptococcus pseudopneumoniae IS7493 AEL11070.1    
 SPPN_08220   Streptococcus pseudopneumoniae IS7493 AEL11070.1    
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R82E6 ACJ76895.1 B8XTS5  
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R89G3 ACJ76897.1
ACJ76898.1
B8XTS7  
 neuraminidase (NanA)   Streptococcus pseudopneumoniae R98A5 ACJ76899.1 B8XTS9  
 FY406_06980   Streptococcus ratti ATCC 31377 QEY07394.1    
 neuraminidase   Streptococcus sobrinus 10919 AWN21141.1    
 NCTC10921_01416 (NanB)   Streptococcus sobrinus NCTC10921 SQG20675.1    
 NCTC12279_01443 (NanB)   Streptococcus sobrinus NCTC12279 SQG13932.1    
 neuraminidase   Streptococcus sobrinus NIDR 6715-15 AWN61974.1    
 neuraminidase   Streptococcus sobrinus NIDR 6715-7 AWN63846.1    
 neuraminidase   Streptococcus sobrinus SL1 AWN18553.1    
 D7D53_06220   Streptococcus sp. ChDC B345 AYF96105.1    
 EGX96_03775   Streptococcus sp. FDAARGOS_520 AYZ04406.1    
 EGX72_02395   Streptococcus sp. FDAARGOS_521 AYY67889.1    
 EGX70_09275   Streptococcus sp. FDAARGOS_522 AYY64972.1    
 A6J68_10885   Streptococcus sp. group B FDAARGOS_229 ARC25603.1    
 SNAG_0542 (Nana_2)   Streptococcus sp. NPS 308 BAV79420.1    
 AXF18_00720   Streptococcus sp. oral taxon 064 W10853 ANR74557.1    
 AXE83_09040   Streptococcus sp. oral taxon 431 F0610 (5-114) AMD97713.1    
 AXE83_09045   Streptococcus sp. oral taxon 431 F0610 (5-114) AMD97714.1    
 V470_02445   Streptococcus sp. VT 162 AHZ47303.1    
 SSUA7_0867   Streptococcus suis A7 AER44191.1    
 CVO91_07205   Streptococcus suis CZ130302 ATZ03709.1    
 NCTC13766_01481 (fragment)   Streptococcus urinalis NCTC13766 VEF32371.1    
 FE156_28995   Streptomyces albidoflavus UYFA156 QDD61952.1    
 SMD11_1190   Streptomyces albireticuli SMD11 ARZ66851.1    
 SMD44_02481 (fragment)   Streptomyces alboflavus MDJK44 ARX83067.1    
 SMD44_02810   Streptomyces alboflavus MDJK44 ARX83392.1    
 SMD44_07111   Streptomyces alboflavus MDJK44 ARX87630.1    
 CP975_30580   Streptomyces alboniger ATCC 12461 QEV21310.1    
 CP975_09995   Streptomyces alboniger ATCC 12461 QEV17794.1    
 neuraminidase   Streptomyces albulus NK660 AIA06974.1    
 neuraminidase   Streptomyces albulus ZPM AKA06828.1    
 SLNHY_5338   Streptomyces albus BK3-25 AOU80029.1    
 neuraminidase   Streptomyces albus BK3-25 AOU75114.1    
 SLNHY_5610   Streptomyces albus BK3-25 AOU80301.1    
 neuraminidase   Streptomyces albus DSM 41398 AJE80803.1    
 SLNWT_5351   Streptomyces albus DSM 41398 AJE85727.1    
 SLNWT_5623   Streptomyces albus DSM 41398 AJE85999.1    
 Salbus254_6115 (NedA)   Streptomyces albus SM254 AMM12544.1    
 DUI70_5251   Streptomyces albus ZD11 AYN35747.1    
 DUI70_5518   Streptomyces albus ZD11 AYN36013.1    
 DUI70_0417   Streptomyces albus ZD11 AYN30920.1    
 SAM23877_6257   Streptomyces ambofaciens ATCC 23877 AKZ59302.1    
 SAM40697_5614   Streptomyces ambofaciens DSM 40697 ANB09570.1    
 DVA86_13855   Streptomyces armeniacus ATCC 15676 AXK33574.1    
 DVA86_09365   Streptomyces armeniacus ATCC 15676 AXK32828.1    
 BV401_14365   Streptomyces autolyticus CGMCC0516 AQA11494.1    
 BV401_38265   Streptomyces autolyticus CGMCC0516 AQA15388.1    
 BV401_34675   Streptomyces autolyticus CGMCC0516 AQA14795.1    
 SAV1842 (NanH)   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC69553.1
NP_823018.1
   
 SAV5934   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC73646.1
NP_827111.1
   
 SAV5606   Streptomyces avermitilis MA-4680 = NBRC 14893 BAC73318.1
NP_826783.1
   
 SAVMC3_64050   Streptomyces avermitilis MC3 BBJ53776.1    
 SAVMC3_67640   Streptomyces avermitilis MC3 BBJ54135.1    
 neuraminidase   Streptomyces avermitilis MC3 BBJ49565.1    
 SBI_02735   Streptomyces bingchenggensis BCW-1 ADI05856.1 D7C0Y4  
 SBI_07687   Streptomyces bingchenggensis BCW-1 ADI10807.1 D7CCW0  
 SBI_08925   Streptomyces bingchenggensis BCW-1 ADI12043.1 D7C003  
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